Hepatocyte transplantation for the treatment of human disease

Seminars in Liver Disease

Volumn 19, Issue 1, 1999, Pages 39-48

  Strom, Stephen C ^c   Roy Chowdhury, Jayanta ^a   Fox, Ira J ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatocyte; Transplantation

Indexed keywords

ALPHA 1 ANTITRYPSIN; BILIRUBIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

CELL ISOLATION; CELL REGENERATION; CELL TRANSPLANTATION; CRYOPRESERVATION; GENE THERAPY; HOST CELL; HUMAN; HYPERBILIRUBINEMIA; HYPERLIPIDEMIA; IMMUNOSUPPRESSIVE TREATMENT; INBORN ERROR OF METABOLISM; LIVER CELL; LIVER DISEASE; LIVER FAILURE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SURVIVAL TIME;

EID: 0344142526     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007096     Document Type: Review

References (80)

1. Gupta S, Roy Chowdhury J. Hepatocyte transplantation: Back to the future. Hepatology 1992;15:156-162
2. Holzman MD, Rozga J, Neuzil DF, et al. Selective intraportal hepatocyte transplantation in analbuminemic and Gunn rats. Transplantation 1993;55:1213-1219
3. Mito M, Hidetaka E, Kusano M, et al. Morphology and function of isolated hepatocytes transplanted into rat spleen. Transplantation 1997;28:499-505
4. Kusano M, Mito M. Observations on the fine structure of long-survived isolated hepatocytes inoculated into rat spleen. Gastroenterology 1982;82:616-628
5. Demetriou AA, Whiting JF, Feldman D, et al. Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science 1986;233:1190-1192
6. Moscioni AD, Roy Chowdhury J, Barbour R, et al. Human liver cell transplantation: Prolonged function in athymic-gunn and athymic-analbuminiemic hybrid rat. Gastroenterology 1989;96: 1546-1551
7. Vroemen JPAM, Buurman WA, Heirwegh KPM, et al. Hepatocyte transplantation for enzyme deficiency disease in congenic rats. Transplantation 1986;42:130-135
8. Hamaguchi H, Yamaguchi Y, Goto M, et al. Hepatic biliary transport after hepatocyte transplantation in Eizai hyperbilirubinemic rats. Hepatology 1994;20:220-224
9. Mito M, Kusano M. Hepatocyte transplantation in man. Cell Transplant 1993;2:65-74
10. Takeshita K, Ishibashi H, Suzuki M, et al. Hepatocellular transplantation for metabolic support in experimental acute ischemic liver failure in rats. Cell Transplant 1993;2:319-324
11. Habibullah CM, Syed IH, Qamar A, et al. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994;58:951-977
12. Schumacher IK, Okamoto T, Kim BH, et al. Transplantation of conditionally immortalized hepatocytes to treat hepatic encephalopathy. Hepatology 1996;24:337-343
13. Maganto P, Traber PG, Rusnell C, et al. Long-term maintenance of the adult pattern of liver-specific expression for P-450b, P450e, albumin and α-fetoprotein genes in intra splenically transplanted hepatocytes. Hepatology 1990;11:585-593
14. Groth CG, Arborgh B, Bjorken C, et al. Correction of hyperbilirubinemia in the glucuronyltransferase-deficient rat by intraportal hepatocyte transplantation. Transplant Proc 1977;9:313-319
15. Matas AJ, Sutherland DER, Steffes MW, et al. Hepatocellular transplantation for metabolic deficiencies: Decrease of plasma bilirubin in gunn rats. Science 1976;192:892-894
16. Moscioni AD, Rozga J, Chen S, et al. Long term correction of albumin levels in the Nagase analbuminemic rat: Repopulation of the liver by transplanted normal hepatocytes under a regeneration response. Cell Transplant 1996;5:499-503
17. Gunsalus JR, Brady DA, Coulter SM, et al. Reduction of serum cholesterol in Watanabe rabbits by xenogenic hepatocellular transplantation. Nat Med 1997;3:48-53
18. Eguchi S, Rozga J, Lebow LT, et al. Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus. Transplantation 1996;62:588-593
19. Rozga J, and Demetriou AA. Intraportal hepatocyte transplantation. In: Mito M, Sawa M (eds). Hepatocyte Transplantation. Karger Landes Systems, 1997, pp 47-66 Basel, Switzerland
20. Sutherland DER, Numata M, Matas AJ, et al. Hepatocellular transplantation in acute liver failure. Surgery 1977;82:124-132
21. Sommer BG, Sutherland DER, Matas AJ, et al. Hepatocellular transplantation for treatment of D-galactosamine-induced acute liver failure in rats. Transplant Proc 1979;9:578-583
22. Makowka L, Rotstein LE, Falk RE, et al. Studies into the mechanism of reversal of experimental acute hepatic failure by hepatocyte transplantation. Can J Surg 1981;24:39-44
23. Mito M, Susano M, Sawa M. Hepatocyte transplantation for hepatic failure. Transplant Rev 1993;7:35-43
24. Demetriou AA, Reisner A, Sanchez J, et al. Transplantation of microcarrier-attached hepatocytes into 90% partially hepatectomized rats. Hepatology 1988;8:1006-1009
25. Ribeiro J, Nordlinger B, Ballet F, et al. Intrasplenic hepatocellular transplantation corrects hepatic encephalopathy in portacaval-shunted rats. Hepatology 1992;15:12-18
26. Arkadopoulos N, Chen SC, Khalili TM, et al.Transplantation of hepatocytes for prevention of intracranial hypertension in pigs with ischemic liver failure. Cell Transplant 1998;7:357-363
27. Rhim JA, Sandgren EP, Degen JL, et al. Replacement of diseased mouse liver by hepatic cell transplantation. Science 1994;263:1149-1152
28. Rhim JA, Sandgren EP, Palmiter RD, et al. Complete reconstitution of mouse liver with xenogeneic hepatocytes. Proc Natl Acad Sci U S A 1995;92:4942-4946
29. Overturf KJ, Al-Dhalimy M, Tanquay R, et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type 1. Nat Genet 1996;12:266-273
30. Overturf K, Al-Dhalimy M, Ou CN, et al. Serial transplantation reveals the stem-cell-like regenterative potential of adult mouse hepatocytes. Am J Pathol 1997;151:1273-1280
31. Strom SC, Fisher RA, Rubinstein WS, et al. Transplantation of human hepatocytes. Transplant Proc 1997;29:2103-2106
32. Fisher RA, Strom SC. Human hepatocyte transplantation: Biology and therapy. In: Berry M, Edwards A (eds). Hepatocyte: Biology, Methodology and Application. London: Kluwer Academic Publishers, (in press)
33. Soriano HE, Wood RP, Kang DC, et al. Hepatocellular transplantation (HCT) in children with fulminant liver failure (FLF). Hepatology 1997;26:239A(443)
34. Strom SC, Fisher RA, Thompson MT, et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997;63:559-569
35. Bilir B, Durham JD, Kristal J, et al. Transjugular intraportal transplantation of cryopreserved human hepatocytes in a patient with acute liver failure. Hepatology 1996;24:728
36. Bilir BM, Guenette D, Ostrowska A, et al. Percutaneous hepatocyte transplantation (PHT) in liver failure. Hepatology 1997;26: 494
37. Fox IJ, Roy Chowdhury J, Kaufman SS, et al. Treatment of the Crigler-Njjar syndrome type 1 with hepatocyte transplantation. N Engl J Med 1998;338:1422-1426
38. Roy Chowdhury JR, Strom SC, Roy Chowdhury NR, et al. Hepatocyte transplanation in humans: Gene therapy and more. Pediatrics 1998;102:647-648
39. Vroemen JPAM, Buurman WA, Schutte B, et al.The cytokinetic behavior of donor hepatocytes after syngeneic transplantation into the spleen. Transplantation 1988;45:600-607
40. Gupta S, Johnstone R, Darby H, et al. Transplanted isolated hepatocytes: effect of partial hepatectomy on proliferation of long-term syngeneic implants in rat spleen. Pathology 1987;19:28-30
41. Jirtle RL, Michalopoulos G. Effects of partial hepatocetomy on transplanted hepatocytes. Cancer Res 1982;42:300-304
42. Strom SC, Jirtle RL, Jones RS, et al. Isolation, culture and transplantation of human hepatocytes. J Natl Cancer Inst 1982;68: 771-778
43. Ponder KP, Gupta S, LeLand F, et al. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci USA 1991;38:1217-1221
44. Gupta S, Aragona E, Vemuru RP, et al. Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and liver repopulation. Hepatology 1991;14: 144-149
45. Patel A, Roy Chowdhury N, Wajsman R, et al. Long-term correction of genetic defect of liver function in rat by transplantation of liver cells after ultra violet irradiation. Mol Biol Med 1989;6:187-196
46. Raper S, Wilson JM. Cell transplantation in liver-directed gene therapy. Cell Transplant 1993;2:381-400
47. Roy Chowdhury J, Grossman M, Gupta S, et al. Long term improvement of hypercholesterolemia after ex vivo gene therapy in LDL-receptor deficient rabbits. Science 1991;254:1802-1805
48. Grossman M, Raper SE, Kozarsky K, et al. Successful ex vivo gene therapy directed to the liver in a patient with familial hypercholesterolemia. Nat Genet 1994;6:335-341
49. Grossman M, Rader DJ, Muller D, et al. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia. Nature Med 1995;1:1148-1154
50. Raper SE, Grossman BS, Rader DJ, et al. Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Ann Surg 1995;223:116-126
51. Gerber MA, Thung SN, Shen S, et al. Phenotypic characterization of hepatic proliferation: Antigen expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis and nodular transformation of the liver. Am J Pathol 1983;110:70-74
52. Wolf H, Michalopoulos G. Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: A study of proliferating cell nuclear antigen expression. Hepatology 1992;15:707-713
53. Kayano K, Yasunaga M, Kubota M, et al. Detection of proliferating hepatocytes by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in patients with acute liver faulure. Liver 1992;12:132-136
54. Koukoulis G, Rayner A, Tan K-C, et al. Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining. J Pathol 1992;166:359-368
55. Sesiki S, Sakaguchi H, Kawakita T, et al. Detection of proliferating cells in various diseases by a monoclonal antibody against DNA polymerase-alpha: With special emphasis on the relationship between hepatocytes and sinusoidal cells. Hepatology 1991;14:781-788
56. Shimizu I, Ichihara A, Nakamura T. Hepatocyte growth factor in ascites from patients with cirrhosis. J Biochem 1991;109:14-18
57. TomiyaT, Nagoshi S, Fujiwara K. Significance of serum human hepatocyte growth factor levels in patients with hepatic failure. Hepatology 1992;15:1-4
58. Tomiya T, Tani M, Yamada S, et al. Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients. Gastroenterology 1992;103:1621-1624
59. Nishizaki T, Takenaka K, Yoshizumi T, et al. Alteration in levels of human hepatocyte growth factor following hepatectomy. J Am Coll Surg 1995;181:6-10
60. Rozga J, Holzman M, Moscioni AD, et al. Repeated intraportal hepatocyte transplantation in analbuminemic rats. Cell Transplant 1995;4:237-243
61. Strom SC, Fisher RA, Thompson MT, et al. Human hepatocyte transplantation. In: Mito M, Sawa M (eds). Hepatocyte Transplantation. Karger Landes Systems, 1997, pp 325-341 Basel, Switzerland
62. Fox I, Roy Chowdhury N, Gupta S, et al. Conditional immortalization of Gunn rat hepatocytes: an ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer. Hepatology 1995;21:837-846
63. Kim BH, Takahashi M, Tada K, et al. Cell and gene therapy for inherited deficiency of bilirubin glucuronidation. J Perinatol 1996;16:567-572
64. Nakamura J, Okamoto T, Schumacher IK, et al. Treatment of surgically induced acute liver failure by transplantation of conditionally immortalized hepatocytes. Transplantation 1997;63: 1541-1547
65. Schumacher IK, Okamoto T, Kim BH, et al. Transplantation of conditionally immortalized hepatocytes to treat hepatic encephalopathy. Hepatology 1996;24:337-343
66. Tada K, Roy Chowdhury N, Prasad VR, et al. Long-term amelioration of bilirubin glucuronidation defect in Gunn rats by transplanting genetically modified immortalized autologous hepatocytes. Cell Transplant 1998;7:607-616
67. Okuyama T, Fujino M, Li X-K, et al. Efficient Fas-ligand gene expression in rodent liver after intravenous injection of a recombinant adenovirus by the use of a Cre-mediated switching system. Gene Ther 1998;5:1047-1053
68. Sato Y, Tanaka K, Lee G, et al. Enhanced and specific gene expression via tissue-specific production of Cre recombinase using adenovirus vector. Biochem Biophys Res Commun 1998;244: 455-462
69. Patel A, Roy Chowdhury N, Wajsman R, et al. Long-term correction of genetic defect of liver function in rat by transplantation of liver cells after ultra violet irradiation. Mol Biol Med 1989;6:187-196
70. Fabrega AJ, Bommineni VR, Blanchard J, et al. The amelioration of analbuminemia by transplantation of allogeneic hepatocytes in tolerized rats. Transplantation 1995;59:1362-1364
71. Bluestone JA. New perspectives of CD28-B7 mediated T cell costimulation. Immunity 1995;2:555-559
72. Hathcock KS, Laszlo G, Dickler HB, et al. Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function. Science 1993;262:905-909
73. Wallace PM, Rodgers JN, Leytze GM, et al. Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment. J Immunol 1995;154: 5885-5895
74. Lee MG, Abina MA, Haddada H, et al. The constitutive expression of the immunomodulatory gp 19K protein in E1-, E3-adenoviral vectors strongly reduce the host cytotoxic T cell response against the vector. Gene Ther 1995;2:256-262
75. Feuerbach D, Etteldorf S, Ebenau-Jehle C, et al. Identification of amino acids within the MHC molecule important for the interaction with the adenovirus protein E3/19K. J Immunol 1994; 153:1626-1636
76. Li Y, Rang J, Horwitz MS. Interaction of an adenovirus 14.7 kDa protein inhibitor of TNFαcytolysis with a new member of the GT-Pase superfamily of signal transducers. J Virol 1996;56: 734-741
77. Turariello JM, Sangho C, Horwitz M.S. Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolis, increases the virulence of vaccinia virus in severe combined immunodeficient mice. Proc Natl Acad Sci USA 1994;91: 10987-1099
78. Efrat S, Fejer M, Brownlee G, et al. Prolonged survival of pancreatic islet allograft mediated by adenovirus immunoregulatory transgenes. Proc Natl Acad Sci U S A 1995;92:6947-6951
79. Polier W, Schneider-Rasp S, Liebert U, et al. Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host. Gene Ther 1996;63:521-530
80. Ilan Y, Sauter B, Roy Chowdhury N, et al. Expression of adenoviral E3 gene production in normal rat hepatocytes prevents their rejection upon transplantation into allogeneic Gunn rats. Hepatology 1997;26:490A.