Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

Journal of Hepatology

Volumn 62, Issue 3, 2015, Pages 581-589

  Baxter, Melissa ^a   Withey, Sarah ^a   Harrison, Sean ^a   Segeritz, Charis Patricia ^b,c   Zhang, Fang ^d   Atkinson Dell, Rebecca ^a   Rowe, Cliff ^a,d   Gerrard, Dave T ^a,e   Sison Young, Rowena ^d   Jenkins, Roz ^d   Henry, Joanne ^d   Berry, Andrew A ^a   Mohamet, Lisa ^f   Best, Marie ^g   Fenwick, Stephen W ^h   Malik, Hassan ^h   Kitteringham, Neil R ^d   Goldring, Chris E ^d   Piper Hanley, Karen ^a   Vallier, Ludovic ^b,c   Hanley, Neil A ^a,i   more..

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b University of Cambridge   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

^e Bioinformatics   (United Kingdom)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^h ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

ⁱ MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Embryo; Hepatic; Hepatotoxicity; Human embryonic stem cell; Liver

Indexed keywords

ACTIVIN A; ALBUMIN; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; BRACHYURY PROTEIN; CARBOXYLYASE; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; DEXTRORPHAN; DIMETHYLANILINE MONOOXYGENASE; GLUTAMATE AMMONIA LIGASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; HEAT SHOCK PROTEIN 47; HEPATOCYTE NUCLEAR FACTOR 3BETA; NICOTINAMIDE METHYLTRANSFERASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE 2; PROTEIN; TESTOSTERONE; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG; UREA; WNT3A PROTEIN; PROTEOME;

ADULT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; EMBRYONIC STEM CELL; FETUS; HEPATOCYTE LIKE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; LIVER CELL; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; ADULT STEM CELL; BIOLOGICAL MODEL; CELL LINE; CELL LINEAGE; CYTOLOGY; FETAL STEM CELL; HUMAN EMBRYONIC STEM CELL; METABOLISM; METABOLOME;

ADULT; ADULT STEM CELLS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; FETAL STEM CELLS; HEPATOCYTES; HUMAN EMBRYONIC STEM CELLS; HUMANS; METABOLOME; MODELS, BIOLOGICAL; PHENOTYPE; PLURIPOTENT STEM CELLS; PROTEOME;

EID: 84923035739     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.10.016     Document Type: Article

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