Concise review: Alchemy of biology: Generating desired cell types from abundant and accessible cells

Stem Cells

Volumn 29, Issue 12, 2011, Pages 1933-1941

  Pournasr, Behshad ^a,b   Khaloughi, Keynoush ^a   Salekdeh, Ghasem Hosseini ^a   Totonchi, Mehdi ^a   Shahbazi, Ebrahim ^a   Baharvand, Hossein ^a,b  

^a ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^b UNIVERSITY OF SCIENCE AND CULTURE   (Iran)

Author keywords

Epigenetics; Reprogramming; Transcription factor; Transdifferentiation

Indexed keywords

TRANSCRIPTION FACTOR;

CELL FUNCTION; CELL MATURATION; CELL TRANSDIFFERENTIATION; CELL TYPE; EPIGENETICS; HUMAN; IMMUNOGENICITY; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SOMATIC CELL; STEM CELL; STEM CELL NICHE;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELL TRANSDIFFERENTIATION; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; REGENERATIVE MEDICINE; STEM CELL NICHE; TRANSCRIPTION FACTORS;

EID: 81855168305     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.760     Document Type: Review

References (98)

1. Goldberg AD, Allis CD, Bernstein E. Epigenetics: A landscape takes shape. Cell 2007;128(4):635-638. (Pubitemid 46273578)
2. Hochedlinger K, Plath K. Epigenetic reprogramming and induced pluripotency. Development 2009;136(4):509-523.
3. Huang S. Reprogramming cell fates: Reconciling rarity with robustness. Bioessays 2009;31(5):546-560.
4. Davis RL, Weintraub H, Lassar AB. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 1987;51(6):987-1000.
5. Graf T, Enver T. Forcing cells to change lineages. Nature 2009;462(7273):587-594.
6. Selman K, Kafatos FC. Transdifferentiation in the labial gland of silk moths: Is DNA required for cellular metamorphosis? Cell Differ 1974;3(2):81-94.
7. Orkin SH, Zon LI. Hematopoiesis: An evolving paradigm for stem cell biology. Cell 2008;132(4):631-644. (Pubitemid 351260057)
8. Zhou Q, Melton DA. Extreme makeover: Converting one cell into another. Cell Stem Cell 2008;3(4):382-388.
9. Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell 2004;116(5):639-648. (Pubitemid 38326723)
10. Slack JM. Metaplasia and transdifferentiation: From pure biology to the clinic. Nat Rev Mol Cell Biol 2007;8(5):369-378. (Pubitemid 46643236)
11. Stadtfeld M, Hochedlinger K. Induced pluripotency: History, mechanisms, and applications. Genes Dev 2010;24(20):2239-2263.
12. Gonzalez F, Boue S, Belmonte JC. Methods for making induced pluripotent stem cells: Reprogramming a la carte. Nat Rev Genet 2011;12(4):231-242.
13. Gurdon JB, Melton DA. Nuclear reprogramming in cells. Science 2008;322(5909):1811-1815.
14. Jopling C, Sleep E, Raya M et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 2010;464(7288):606- 609.
15. Kragl M, Knapp D, Nacu E et al. Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 2009;460(7251):60-65.
16. McClure KD, Schubiger G. Transdetermination: Drosophila imaginal disc cells exhibit stem cell-like potency. Int J Biochem Cell Biol 2007;39(6):1105-1118. (Pubitemid 46819131)
17. Chen MJ, Yokomizo T, Zeigler BM et al. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 2009;457(7231):887-891.
18. Lancrin C, Sroczynska P, Stephenson C et al. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature 2009;457(7231):892-895.
19. Szabo E, Rampalli S, Risueno RM et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 2010;468(7323):521-526.
20. Kim J, Efe JA, Zhu S et al. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci USA 2011;108(19):7838-7843.
21. Efe JA, Hilcove S, Kim J et al. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol 2011;13(3):215-222.
22. Choi J, Costa ML, Mermelstein CS et al. MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes. Proc Natl Acad Sci USA 1990;87(20):7988-7992.
23. Tachibana M, Takeda K, Nobukuni Y et al. Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics. Nat Genet 1996;14(1):50-54.
24. Heins N, Malatesta P, Cecconi F et al. Glial cells generate neurons: The role of the transcription factor Pax6. Nat Neurosci 2002;5(4):308-315. (Pubitemid 34279810)
25. Nerlov C, Graf T. PU. 1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev 1998;12(15):2403-2412. (Pubitemid 28371359)
26. Xie H, Ye M, Feng R et al. Stepwise reprogramming of B cells into macrophages. Cell 2004;117(5):663-676. (Pubitemid 38692531)
27. Motoyama H, Ogawa S, Kubo A et al. In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors. Biochem Biophys Res Commun 2009;385(1):123-128.
28. Feng R, Desbordes SC, Xie H et al. PU. 1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci USA 2008;105(16):6057-6062. (Pubitemid 351758398)
29. Ieda M, Fu JD, Delgado-Olguin P et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010;142(3):375-386.
30. Huang P, He Z, Ji S et al. Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 2011;475(7356):386-389.
31. Sekiya S, Suzuki A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 2011;475(7356):390-393.
32. Vierbuchen T, Ostermeier A, Pang ZP et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010;463(7284):1035-1041.
33. Pang ZP, Yang N, Vierbuchen T et al. Induction of human neuronal cells by defined transcription factors. Nature 2011;476(7359):220-223.
34. Yoo AS, Sun AX, Li L et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011;476(7359):228-231.
35. Ambasudhan R, Talantova M, Coleman R et al. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 2011;9(2):113-118.
36. Pfisterer U, Kirkeby A, Torper O et al. Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci USA 2011;108(25):10343- 10348.
37. Caiazzo M, Dell'Anno MT, Dvoretskova E et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011;476(7359):224-227.
38. Cobaleda C, Jochum W, Busslinger M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 2007;449(7161):473-477. (Pubitemid 47509547)
39. Rhodes J, Hagen A, Hsu K et al. Interplay of pu. 1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Dev Cell 2005;8(1):97-108. (Pubitemid 40058009)
40. Ferber S, Halkin A, Cohen H et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6(5):568-572. (Pubitemid 30305908)
41. Zhou Q, Brown J, Kanarek A et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455(7213):627-632.
42. Izumikawa M, Minoda R, Kawamoto K et al. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med 2005;11(3):271-276. (Pubitemid 40460554)
43. Takeuchi JK, Bruneau BG. Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature 2009;459(7247):708-711.
44. Uhlenhaut NH, Jakob S, Anlag K et al. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 2009;139(6):1130-1142.
45. Hiramatsu K, Sasagawa S, Outani H et al. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest 2011;121(2):640-657.
46. Ang YS, Gaspar-Maia A, Lemischka IR et al. Stem cells and reprogramming: Breaking the epigenetic barrier? Trends Pharmacol Sci 2011;32(7):394-401.
47. Maki N, Suetsugu-Maki R, Tarui H et al. Expression of stem cell pluripotency factors during regeneration in newts. Dev Dyn 2009;238(6):1613- 1616.
48. Meshorer E, Yellajoshula D, George E et al. Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell 2006;10(1):105-116. (Pubitemid 43025681)
49. Artyomov MN, Meissner A, Chakraborty AK. A model for genetic and epigenetic regulatory networks identifies rare pathways for transcription factor induced pluripotency. PLoS Comput Biol 2010;6(5):e1000785.
50. Jones DL, Wagers AJ. No place like home: Anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol 2008;9(1):11-21.
51. Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell 2007;128(4):669-681. (Pubitemid 46273573)
52. Iwasaki H, Mizuno S, Arinobu Y et al. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev 2006;20(21):3010-3021. (Pubitemid 44771735)
53. Kulessa H, Frampton J, Graf T. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev 1995;9(10):1250-1262.
54. Visvader JE, Elefanty AG, Strasser A et al. GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J 1992;11(12):4557-4564.
55. Bussmann LH, Schubert A, Vu Manh TP et al. A robust and highly efficient immune cell reprogramming system. Cell Stem Cell 2009;5(5):554-566.
56. Cohen DE, Melton D. Turning straw into gold: Directing cell fate for regenerative medicine. Nat Rev Genet 2011;12(4):243-252.
57. Selvaraj V, Plane JM, Williams AJ et al. Switching cell fate: The remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies. Trends Biotechnol 2010;28(4):214-223.
58. Kondo M, Scherer DC, Miyamoto T et al. Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature 2000;407(6802):383-386.
59. Thorel F, Nepote V, Avril I et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010;464(7292):1149-1154.
60. Gaspar-Maia A, Alajem A, Polesso F et al. Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature 2009;460(7257):863-868.
61. Singhal N, Graumann J, Wu G et al. Chromatin-remodeling components of the BAF complex facilitate reprogramming. Cell 2010;141(6):943-955.
62. Fisher CL, Fisher AG. Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr Opin Genet Dev 2011;21(2):140-146.
63. Maherali N, Hochedlinger K. Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell 2008;3(6):595-605.
64. Park IH, Lerou PH, Zhao R et al. Generation of human-induced pluripotent stem cells. Nat Protoc 2008;3(7):1180-1186.
65. Liu J, Sumer H, Leung J et al. Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation. Cell Transplant 2011;20(2):193-203.
66. Miura K, Okada Y, Aoi T et al. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol 2009;27(8):743-745.
67. Gore A, Li Z, Fung HL et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 2011;471(7336):63-67.
68. Seifinejad A, Tabebordbar M, Baharvand H et al. Progress and promise towards safe induced pluripotent stem cells for therapy. Stem Cell Rev 2010;6(2):297-306.
69. Nishimura K, Sano M, Ohtaka M et al. Development of defective and persistent Sendai virus vector: A unique gene delivery/expression system ideal for cell reprogramming. J Biol Chem 2010;286(6):4760-4771.
70. Stadtfeld M, Nagaya M, Utikal J et al. Induced pluripotent stem cells generated without viral integration. Science 2008;322(5903):945-949.
71. Zhou W, Freed CR. Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells 2009;27(11):2667-2674.
72. Kim D, Kim CH, Moon JI et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009;4(6):472-476.
73. Woltjen K, Michael IP, Mohseni P et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009;458(7239):766-770.
74. Okita K, Nakagawa M, Hyenjong H et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008;322(5903):949-953.
75. Si-Tayeb K, Noto FK, Sepac A et al. Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. BMC Dev Biol 2010;10:81.
76. Yu J, Hu K, Smuga-Otto K et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009;324(5928):797-801.
77. Warren L, Manos PD, Ahfeldt T et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010;7(5):618-630.
78. Lin SL, Chang DC, Lin CH et al. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res 2011;39(3):1054-1065.
79. Tian Y, Zhang Y, Hurd L et al. Regulation of lung endoderm progenitor cell behavior by miR302/367. Development 2011;138(7):1235-1245.
80. Stadtfeld M, Maherali N, Breault DT et al. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008;2(3):230-240.
81. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448(7151):313-317. (Pubitemid 47080336)
82. Hu Q, Friedrich AM, Johnson LV et al. Memory in induced pluripotent stem cells: Reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells 2010;28(11):1981-1991.
83. Marchetto MC, Yeo GW, Kainohana O et al. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One 2009;4(9):e7076.
84. Ji H, Ehrlich LI, Seita J et al. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature 2010;467(7313):338-342.
85. Kim K, Doi A, Wen B et al. Epigenetic memory in induced pluripotent stem cells. Nature 2010;467(7313):285-290.
86. Lister R, Pelizzola M, Kida YS et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011;471(7336):68-73.
87. Polo JM, Liu S, Figueroa ME et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol 2010;28(8):848-855.
88. Zhao T, Zhang ZN, Rong Z et al. Immunogenicity of induced pluripotent stem cells. Nature 2011;474(7350):212-215.
89. Singh H, Medina KL, Pongubala JM. Contingent gene regulatory networks and B cell fate specification. Proc Natl Acad Sci USA 2005;102(14):4949-4953.
90. Kitajima K, Zheng J, Yen H et al. Multipotential differentiation ability of GATA-1-null erythroid-committed cells. Genes Dev 2006;20(6):654-659.
91. Nutt SL, Heavey B, Rolink AG et al. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999;401(6753):556-562.
92. Judson RL, Babiarz JE, Venere M et al. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol 2009;27(5):459-461.
93. Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science 2008;320(5872):97-100. (Pubitemid 351490762)
94. Feng B, Ng JH, Heng JC et al. Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell 2009;4(4):301-312.
95. Yuan X, Li W, Ding S. Small molecules in cellular reprogramming and differentiation. Prog Drug Res 2011;67:253-266.
96. Li W, Ding S. Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol Sci 2010;31(1):36-45.
97. Efe JA, Ding S. The evolving biology of small molecules: Controlling cell fate and identity. Philos Trans R Soc Lond B: Biol Sci 2011;366(1575):2208- 2221.
98. Lyssiotis CA, Lairson LL, Boitano AE et al. Chemical control of stem cell fate and developmental potential. Angew Chem Int Ed Engl 2011;50(1):200-242.