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Volumn 59, Issue 1, 2016, Pages 2-15

Patient-Specific Induced Pluripotent Stem Cells for Disease Modeling and Phenotypic Drug Discovery

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BARTH SYNDROME; BONE DISEASE; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONGESTIVE CARDIOMYOPATHY; DIABETIC CARDIOMYOPATHY; DISEASES; DYSAUTONOMIA; HEMATOLOGIC DISEASE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; LIVER DISEASE; LONG QT SYNDROME; MACHADO JOSEPH DISEASE; PARKINSON DISEASE; PHENOTYPE; PHENOTYPIC DRUG DISCOVERY; PLURIPOTENT STEM CELL; RETT SYNDROME; SCHIZOPHRENIA; SPINAL MUSCULAR ATROPHY; ANIMAL; BIOLOGICAL MODEL; DRUG DEVELOPMENT; INDUCED PLURIPOTENT STEM CELL; PERSONALIZED MEDICINE; PROCEDURES; STEM CELL TRANSPLANTATION;

EID: 84955291040     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00789     Document Type: Article
Times cited : (28)

References (113)
  • 1
    • 84907943686 scopus 로고    scopus 로고
    • Polypharmacology: Challenges and opportunities in drug discovery
    • Anighoro, A.; Bajorath, J.; Rastelli, G. Polypharmacology: challenges and opportunities in drug discovery J. Med. Chem. 2014, 57, 7874-7887 10.1021/jm5006463
    • (2014) J. Med. Chem. , vol.57 , pp. 7874-7887
    • Anighoro, A.1    Bajorath, J.2    Rastelli, G.3
  • 2
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • Swinney, D. C.; Anthony, J. How were new medicines discovered? Nat. Rev. Drug Discovery 2011, 10, 507-519 10.1038/nrd3480
    • (2011) Nat. Rev. Drug Discovery , vol.10 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 3
    • 84900026507 scopus 로고    scopus 로고
    • Cancer cell lines for drug discovery and development
    • Wilding, J. L.; Bodmer, W. F. Cancer cell lines for drug discovery and development Cancer Res. 2014, 74, 2377-2384 10.1158/0008-5472.CAN-13-2971
    • (2014) Cancer Res. , vol.74 , pp. 2377-2384
    • Wilding, J.L.1    Bodmer, W.F.2
  • 4
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K.; Tanabe, K.; Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.; Yamanaka, S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 2007, 131, 861-872 10.1016/j.cell.2007.11.019
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 6
    • 79952899995 scopus 로고    scopus 로고
    • Methods for making induced pluripotent stem cells: Reprogramming à la carte
    • González, F.; Boué, S.; Izpisúa Belmonte, J. C. Methods for making induced pluripotent stem cells: reprogramming à la carte Nat. Rev. Genet. 2011, 12, 231-242 10.1038/nrg2937
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 231-242
    • González, F.1    Boué, S.2    Izpisúa Belmonte, J.C.3
  • 7
    • 84898486639 scopus 로고    scopus 로고
    • Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD
    • Kim, D.-S.; Ross, P. J.; Zaslavsky, K.; Ellis, J. Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD Front. Cell. Neurosci. 2014, 8, 109 10.3389/fncel.2014.00109
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 109
    • Kim, D.-S.1    Ross, P.J.2    Zaslavsky, K.3    Ellis, J.4
  • 8
    • 84872016692 scopus 로고    scopus 로고
    • Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
    • Lian, X.; Zhang, J.; Azarin, S. M.; Zhu, K.; Hazeltine, L. B.; Bao, X.; Hsiao, C.; Kamp, T. J.; Palecek, S. P. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions Nat. Protoc. 2013, 8, 162-175 10.1038/nprot.2012.150
    • (2013) Nat. Protoc. , vol.8 , pp. 162-175
    • Lian, X.1    Zhang, J.2    Azarin, S.M.3    Zhu, K.4    Hazeltine, L.B.5    Bao, X.6    Hsiao, C.7    Kamp, T.J.8    Palecek, S.P.9
  • 11
    • 84878852415 scopus 로고    scopus 로고
    • Modeling human disease with pluripotent stem cells: From genome association to function
    • Merkle, F. T.; Eggan, K. Modeling human disease with pluripotent stem cells: from genome association to function Cell Stem Cell 2013, 12, 656-668 10.1016/j.stem.2013.05.016
    • (2013) Cell Stem Cell , vol.12 , pp. 656-668
    • Merkle, F.T.1    Eggan, K.2
  • 12
    • 84906319803 scopus 로고    scopus 로고
    • Investigating human disease using stem cell models
    • Sterneckert, J. L.; Reinhardt, P.; Schöler, H. R. Investigating human disease using stem cell models Nat. Rev. Genet. 2014, 15, 625-639 10.1038/nrg3764
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 625-639
    • Sterneckert, J.L.1    Reinhardt, P.2    Schöler, H.R.3
  • 13
    • 84913531044 scopus 로고    scopus 로고
    • Concise review: Modeling central nervous system diseases using induced pluripotent stem cells
    • Zeng, X.; Hunsberger, J. G.; Simeonov, A.; Malik, N.; Pei, Y.; Rao, M. Concise review: modeling central nervous system diseases using induced pluripotent stem cells Stem Cells Transl. Med. 2014, 3, 1418-1428 10.5966/sctm.2014-0102
    • (2014) Stem Cells Transl. Med. , vol.3 , pp. 1418-1428
    • Zeng, X.1    Hunsberger, J.G.2    Simeonov, A.3    Malik, N.4    Pei, Y.5    Rao, M.6
  • 14
    • 84879255268 scopus 로고    scopus 로고
    • Remodeling neurodegeneration: Somatic cell reprogramming-based models of adult neurological disorders
    • Qiang, L.; Fujita, R.; Abeliovich, A. Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders Neuron 2013, 78, 957-969 10.1016/j.neuron.2013.06.002
    • (2013) Neuron , vol.78 , pp. 957-969
    • Qiang, L.1    Fujita, R.2    Abeliovich, A.3
  • 15
    • 84906829737 scopus 로고    scopus 로고
    • Human-induced pluripotent stem cells: Potential for neurodegenerative diseases
    • Ross, C. A.; Akimov, S. S. Human-induced pluripotent stem cells: potential for neurodegenerative diseases Hum. Mol. Genet. 2014, 23, R17-R26 10.1093/hmg/ddu204
    • (2014) Hum. Mol. Genet. , vol.23 , pp. R17-R26
    • Ross, C.A.1    Akimov, S.S.2
  • 19
    • 80051554264 scopus 로고    scopus 로고
    • Spinal muscular atrophy: A timely review
    • Kolb, S. J.; Kissel, J. T. Spinal muscular atrophy: a timely review Arch. Neurol. 2011, 68, 979-984 10.1001/archneurol.2011.74
    • (2011) Arch. Neurol. , vol.68 , pp. 979-984
    • Kolb, S.J.1    Kissel, J.T.2
  • 20
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert, A. D.; Yu, J.; Rose, F. F., Jr.; Mattis, V. B.; Lorson, C. L.; Thomson, J. A.; Svendsen, C. N. Induced pluripotent stem cells from a spinal muscular atrophy patient Nature 2009, 457, 277-280 10.1038/nature07677
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1    Yu, J.2    Rose, F.F.3    Mattis, V.B.4    Lorson, C.L.5    Thomson, J.A.6    Svendsen, C.N.7
  • 21
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir, R. E.; Van den Veyver, I. B.; Wan, M.; Tran, C. Q.; Francke, U.; Zoghbi, H. Y. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 Nat. Genet. 1999, 23, 185-188 10.1038/13810
    • (1999) Nat. Genet. , vol.23 , pp. 185-188
    • Amir, R.E.1    Van Den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 22
    • 34748831111 scopus 로고    scopus 로고
    • MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number
    • Chao, H. T.; Zoghbi, H. Y.; Rosenmund, C. MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number Neuron 2007, 56, 58-65 10.1016/j.neuron.2007.08.018
    • (2007) Neuron , vol.56 , pp. 58-65
    • Chao, H.T.1    Zoghbi, H.Y.2    Rosenmund, C.3
  • 23
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto, M. C.; Carromeu, C.; Acab, A.; Yu, D.; Yeo, G. W.; Mu, Y.; Chen, G.; Gage, F. H.; Muotri, A. R. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells Cell 2010, 143, 527-539 10.1016/j.cell.2010.10.016
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6    Chen, G.7    Gage, F.H.8    Muotri, A.R.9
  • 25
    • 0035205379 scopus 로고    scopus 로고
    • Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method
    • Camp, N. J.; Neuhausen, S. L.; Tiobech, J.; Polloi, A.; Coon, H.; Myles-Worsley, M. Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method Am. J. Hum. Genet. 2001, 69, 1278-1289 10.1086/324590
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 1278-1289
    • Camp, N.J.1    Neuhausen, S.L.2    Tiobech, J.3    Polloi, A.4    Coon, H.5    Myles-Worsley, M.6
  • 26
    • 84870057403 scopus 로고    scopus 로고
    • Pharmacological treatment of schizophrenia: A critical review of the pharmacology and clinical effects of current and future therapeutic agents
    • Miyamoto, S.; Miyake, N.; Jarskog, L. F.; Fleischhacker, W. W.; Lieberman, J. A. Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents Mol. Psychiatry 2012, 17, 1206-1227 10.1038/mp.2012.47
    • (2012) Mol. Psychiatry , vol.17 , pp. 1206-1227
    • Miyamoto, S.1    Miyake, N.2    Jarskog, L.F.3    Fleischhacker, W.W.4    Lieberman, J.A.5
  • 29
    • 84855926937 scopus 로고    scopus 로고
    • The genetic architecture of schizophrenia: New mutations and emerging paradigms
    • Rodriguez-Murillo, L.; Gogos, J. A.; Karayiorgou, M. The genetic architecture of schizophrenia: new mutations and emerging paradigms Annu. Rev. Med. 2012, 63, 63-80 10.1146/annurev-med-072010-091100
    • (2012) Annu. Rev. Med. , vol.63 , pp. 63-80
    • Rodriguez-Murillo, L.1    Gogos, J.A.2    Karayiorgou, M.3
  • 30
    • 84875441083 scopus 로고    scopus 로고
    • The changing scene of amyotrophic lateral sclerosis
    • Robberecht, W.; Philips, T. The changing scene of amyotrophic lateral sclerosis Nat. Rev. Neurosci. 2013, 14, 248-264 10.1038/nrn3430
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 248-264
    • Robberecht, W.1    Philips, T.2
  • 33
    • 23844538993 scopus 로고    scopus 로고
    • The pathobiology of amyotrophic lateral sclerosis: A proteinopathy?
    • Strong, M. J.; Kesavapany, S.; Pant, H. C. The pathobiology of amyotrophic lateral sclerosis: a proteinopathy? J. Neuropathol. Exp. Neurol. 2005, 64, 649-664 10.1097/01.jnen.0000173889.71434.ea
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 649-664
    • Strong, M.J.1    Kesavapany, S.2    Pant, H.C.3
  • 36
    • 33747605320 scopus 로고    scopus 로고
    • Molecular biology of amyotrophic lateral sclerosis: Insights from genetics
    • Pasinelli, P.; Brown, R. H. Molecular biology of amyotrophic lateral sclerosis: insights from genetics Nat. Rev. Neurosci. 2006, 7, 710-723 10.1038/nrn1971
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 710-723
    • Pasinelli, P.1    Brown, R.H.2
  • 37
    • 0035516124 scopus 로고    scopus 로고
    • From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
    • Cleveland, D. W.; Rothstein, J. D. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS Nat. Rev. Neurosci. 2001, 2, 806-819 10.1038/35097565
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 806-819
    • Cleveland, D.W.1    Rothstein, J.D.2
  • 39
    • 33745919520 scopus 로고    scopus 로고
    • Epidemiology of Parkinsons disease
    • de Lau, L. M.; Breteler, M. M. Epidemiology of Parkinsons disease Lancet Neurol. 2006, 5, 525-535 10.1016/S1474-4422(06)70471-9
    • (2006) Lancet Neurol. , vol.5 , pp. 525-535
    • De Lau, L.M.1    Breteler, M.M.2
  • 40
    • 84898775157 scopus 로고    scopus 로고
    • Pharmacological treatment of Parkinson disease: A review
    • Connolly, B. S.; Lang, A. E. Pharmacological treatment of Parkinson disease: a review J. Am. Med. Assoc. 2014, 311, 1670-1683 10.1001/jama.2014.3654
    • (2014) J. Am. Med. Assoc. , vol.311 , pp. 1670-1683
    • Connolly, B.S.1    Lang, A.E.2
  • 41
    • 84906706633 scopus 로고    scopus 로고
    • Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinsons disease
    • Hall, H.; Reyes, S.; Landeck, N.; Bye, C.; Leanza, G.; Double, K.; Thompson, L.; Halliday, G.; Kirik, D. Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinsons disease Brain 2014, 137, 2493-2508 10.1093/brain/awu193
    • (2014) Brain , vol.137 , pp. 2493-2508
    • Hall, H.1    Reyes, S.2    Landeck, N.3    Bye, C.4    Leanza, G.5    Double, K.6    Thompson, L.7    Halliday, G.8    Kirik, D.9
  • 42
    • 84864150600 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinsons disease: Molecular mechanisms and pathophysiological consequences
    • Exner, N.; Lutz, A. K.; Haass, C.; Winklhofer, K. F. Mitochondrial dysfunction in Parkinsons disease: molecular mechanisms and pathophysiological consequences EMBO J. 2012, 31, 3038-3062 10.1038/emboj.2012.170
    • (2012) EMBO J. , vol.31 , pp. 3038-3062
    • Exner, N.1    Lutz, A.K.2    Haass, C.3    Winklhofer, K.F.4
  • 43
    • 55849122639 scopus 로고    scopus 로고
    • Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
    • Henchcliffe, C.; Beal, M. F. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis Nat. Clin. Pract. Neurol. 2008, 4, 600-609 10.1038/ncpneuro0924
    • (2008) Nat. Clin. Pract. Neurol. , vol.4 , pp. 600-609
    • Henchcliffe, C.1    Beal, M.F.2
  • 47
    • 84883174947 scopus 로고    scopus 로고
    • Parkinsons disease dementia: Convergence of α-synuclein, tau and amyloid-β pathologies
    • Irwin, D. J.; Lee, V. M. Y.; Trojanowski, J. Q. Parkinsons disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies Nat. Rev. Neurosci. 2013, 14, 626-636 10.1038/nrn3549
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 626-636
    • Irwin, D.J.1    Lee, V.M.Y.2    Trojanowski, J.Q.3
  • 48
    • 84875699450 scopus 로고    scopus 로고
    • Toxicity of extracellular secreted α-synuclein: Its role in nitrosative stress and neurodegeneration
    • Wilkaniec, A.; Strosznajder, J. B.; Adamczyk, A. Toxicity of extracellular secreted α-synuclein: Its role in nitrosative stress and neurodegeneration Neurochem. Int. 2013, 62, 776-783 10.1016/j.neuint.2013.02.004
    • (2013) Neurochem. Int. , vol.62 , pp. 776-783
    • Wilkaniec, A.1    Strosznajder, J.B.2    Adamczyk, A.3
  • 51
    • 84891871121 scopus 로고    scopus 로고
    • Emerging therapeutics for Alzheimers disease
    • Chiang, K.; Koo, E. H. Emerging therapeutics for Alzheimers disease Annu. Rev. Pharmacol. Toxicol. 2014, 54, 381-405 10.1146/annurev-pharmtox-011613-135932
    • (2014) Annu. Rev. Pharmacol. Toxicol. , vol.54 , pp. 381-405
    • Chiang, K.1    Koo, E.H.2
  • 52
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang, Y.; Mucke, L. Alzheimer mechanisms and therapeutic strategies Cell 2012, 148, 1204-1222 10.1016/j.cell.2012.02.040
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 53
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: Back to the future
    • Bertram, L.; Lill, C. M.; Tanzi, R. E. The genetics of Alzheimer disease: back to the future Neuron 2010, 68, 270-281 10.1016/j.neuron.2010.10.013
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 55
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimers disease amyloid hypothesis: A genetic perspective
    • Tanzi, R. E.; Bertram, L. Twenty years of the Alzheimers disease amyloid hypothesis: a genetic perspective Cell 2005, 120, 545-555 10.1016/j.cell.2005.02.008
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 60
    • 84864243791 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: A methods overview
    • Mummery, C. L.; Zhang, J.; Ng, E. S.; Elliott, D. A.; Elefanty, A. G.; Kamp, T. J. Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview Circ. Res. 2012, 111, 344-358 10.1161/CIRCRESAHA.110.227512
    • (2012) Circ. Res. , vol.111 , pp. 344-358
    • Mummery, C.L.1    Zhang, J.2    Ng, E.S.3    Elliott, D.A.4    Elefanty, A.G.5    Kamp, T.J.6
  • 61
    • 84903196154 scopus 로고    scopus 로고
    • Human stem cells for modeling heart disease and for drug discovery
    • Matsa, E.; Burridge, P. W.; Wu, J. C. Human stem cells for modeling heart disease and for drug discovery Sci. Transl. Med. 2014, 6, 239ps6 10.1126/scitranslmed.3008921
    • (2014) Sci. Transl. Med. , vol.6 , pp. 239ps6
    • Matsa, E.1    Burridge, P.W.2    Wu, J.C.3
  • 63
    • 84873353816 scopus 로고    scopus 로고
    • Induced pluripotent stem cells in cardiovascular drug discovery
    • Mercola, M.; Colas, A.; Willems, E. Induced pluripotent stem cells in cardiovascular drug discovery Circ. Res. 2013, 112, 534-548 10.1161/CIRCRESAHA.111.250266
    • (2013) Circ. Res. , vol.112 , pp. 534-548
    • Mercola, M.1    Colas, A.2    Willems, E.3
  • 64
    • 84902549826 scopus 로고    scopus 로고
    • Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing
    • Sinnecker, D.; Laugwitz, K. L.; Moretti, A. Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing Pharmacol. Ther. 2014, 143, 246-252 10.1016/j.pharmthera.2014.03.004
    • (2014) Pharmacol. Ther. , vol.143 , pp. 246-252
    • Sinnecker, D.1    Laugwitz, K.L.2    Moretti, A.3
  • 65
    • 84872599837 scopus 로고    scopus 로고
    • A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards
    • Mordwinkin, N. M.; Burridge, P. W.; Wu, J. C. A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards J. Cardiovasc. Transl. Res. 2013, 6, 22-30 10.1007/s12265-012-9423-2
    • (2013) J. Cardiovasc. Transl. Res. , vol.6 , pp. 22-30
    • Mordwinkin, N.M.1    Burridge, P.W.2    Wu, J.C.3
  • 67
    • 23644452804 scopus 로고    scopus 로고
    • Long QT syndrome: From channels to cardiac arrhythmias
    • Moss, A. J.; Kass, R. S. Long QT syndrome: from channels to cardiac arrhythmias J. Clin. Invest. 2005, 115, 2018-2024 10.1172/JCI25537
    • (2005) J. Clin. Invest. , vol.115 , pp. 2018-2024
    • Moss, A.J.1    Kass, R.S.2
  • 69
    • 79954523845 scopus 로고    scopus 로고
    • Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
    • Matsa, E.; Rajamohan, D.; Dick, E.; Young, L.; Mellor, I.; Staniforth, A.; Denning, C. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation Eur. Heart J. 2011, 32, 952-962 10.1093/eurheartj/ehr073
    • (2011) Eur. Heart J. , vol.32 , pp. 952-962
    • Matsa, E.1    Rajamohan, D.2    Dick, E.3    Young, L.4    Mellor, I.5    Staniforth, A.6    Denning, C.7
  • 72
    • 84887150722 scopus 로고    scopus 로고
    • Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells
    • Ma, D.; Wei, H.; Zhao, Y.; Lu, J.; Li, G.; Sahib, N. B. E.; Tan, T. H.; Wong, K. Y.; Shim, W.; Wong, P.; Cook, S. A.; Liew, R. Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells Int. J. Cardiol. 2013, 168, 5277-5286 10.1016/j.ijcard.2013.08.015
    • (2013) Int. J. Cardiol. , vol.168 , pp. 5277-5286
    • Ma, D.1    Wei, H.2    Zhao, Y.3    Lu, J.4    Li, G.5    Sahib, N.B.E.6    Tan, T.H.7    Wong, K.Y.8    Shim, W.9    Wong, P.10    Cook, S.A.11    Liew, R.12
  • 74
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
    • Yazawa, M.; Hsueh, B.; Jia, X.; Pasca, A. M.; Bernstein, J. A.; Hallmayer, J.; Dolmetsch, R. E. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome Nature 2011, 471, 230-234 10.1038/nature09855
    • (2011) Nature , vol.471 , pp. 230-234
    • Yazawa, M.1    Hsueh, B.2    Jia, X.3    Pasca, A.M.4    Bernstein, J.A.5    Hallmayer, J.6    Dolmetsch, R.E.7
  • 77
    • 33646693410 scopus 로고    scopus 로고
    • Contemporary definitions and classification of the cardiomyopathies. An American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; And Council on Epidemiology and Prevention
    • Maron, B. J.; Towbin, J. A.; Thiene, G.; Antzelevitch, C.; Corrado, D.; Arnett, D.; Moss, A. J.; Seidman, C. E.; Young, J. B. Contemporary definitions and classification of the cardiomyopathies. An American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention Circulation 2006, 113, 1807-1816 10.1161/CIRCULATIONAHA.106.174287
    • (2006) Circulation , vol.113 , pp. 1807-1816
    • Maron, B.J.1    Towbin, J.A.2    Thiene, G.3    Antzelevitch, C.4    Corrado, D.5    Arnett, D.6    Moss, A.J.7    Seidman, C.E.8    Young, J.B.9
  • 79
    • 0029083650 scopus 로고
    • Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults
    • Maron, B. J.; Gardin, J. M.; Flack, J. M.; Gidding, S. S.; Kurosaki, T. T.; Bild, D. E. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults Circulation 1995, 92, 785-789 10.1161/01.CIR.92.4.785
    • (1995) Circulation , vol.92 , pp. 785-789
    • Maron, B.J.1    Gardin, J.M.2    Flack, J.M.3    Gidding, S.S.4    Kurosaki, T.T.5    Bild, D.E.6
  • 80
    • 0035936792 scopus 로고    scopus 로고
    • The genetic basis for cardiomyopathy: From mutation identification to mechanistic paradigms
    • Seidman, J. G.; Seidman, C. The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms Cell 2001, 104, 557-567 10.1016/S0092-8674(01)00242-2
    • (2001) Cell , vol.104 , pp. 557-567
    • Seidman, J.G.1    Seidman, C.2
  • 83
    • 33846272138 scopus 로고    scopus 로고
    • Role of cardiolipin alterations in mitochondrial dysfunction and disease
    • Chicco, A. J.; Sparagna, G. C. Role of cardiolipin alterations in mitochondrial dysfunction and disease Am. J. Physiol.: Cell Physiol. 2007, 292, C33-C44 10.1152/ajpcell.00243.2006
    • (2007) Am. J. Physiol.: Cell Physiol. , vol.292 , pp. C33-C44
    • Chicco, A.J.1    Sparagna, G.C.2
  • 86
    • 84862849950 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy
    • Yi, F.; Liu, G. H.; Izpisúa Belmonte, J. C. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy Protein Cell 2012, 3, 246-250 10.1007/s13238-012-2918-4
    • (2012) Protein Cell , vol.3 , pp. 246-250
    • Yi, F.1    Liu, G.H.2    Izpisúa Belmonte, J.C.3
  • 89
    • 84879116702 scopus 로고    scopus 로고
    • Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells
    • Choi, S. M.; Kim, Y.; Shim, J. S.; Park, J. T.; Wang, R. H.; Leach, S. D.; Liu, J. O.; Deng, C.; Ye, Z.; Jang, Y. Y. Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells Hepatology 2013, 57, 2458-2468 10.1002/hep.26237
    • (2013) Hepatology , vol.57 , pp. 2458-2468
    • Choi, S.M.1    Kim, Y.2    Shim, J.S.3    Park, J.T.4    Wang, R.H.5    Leach, S.D.6    Liu, J.O.7    Deng, C.8    Ye, Z.9    Jang, Y.Y.10
  • 93
    • 72149119542 scopus 로고    scopus 로고
    • How the fanconi anemia pathway guards the genome
    • Moldovan, G. L.; DAndrea, A. D. How the fanconi anemia pathway guards the genome Annu. Rev. Genet. 2009, 43, 223-249 10.1146/annurev-genet-102108-134222
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 223-249
    • Moldovan, G.L.1    DAndrea, A.D.2
  • 100
    • 0034464005 scopus 로고    scopus 로고
    • The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: The achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans
    • Vajo, Z.; Francomano, C. A.; Wilkin, D. J. The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans Endocr. Rev. 2000, 21, 23-39 10.1210/edrv.21.1.0387
    • (2000) Endocr. Rev. , vol.21 , pp. 23-39
    • Vajo, Z.1    Francomano, C.A.2    Wilkin, D.J.3
  • 101
    • 84876714423 scopus 로고    scopus 로고
    • Technological overview of iPS induction from human adult somatic cells
    • Bayart, E.; Cohen-Haguenauer, O. Technological overview of iPS induction from human adult somatic cells Curr. Gene Ther. 2013, 13, 73-92 10.2174/1566523211313020002
    • (2013) Curr. Gene Ther. , vol.13 , pp. 73-92
    • Bayart, E.1    Cohen-Haguenauer, O.2
  • 102
    • 84878878364 scopus 로고    scopus 로고
    • Integrating human pluripotent stem cells into drug development
    • Engle, S. J.; Puppala, D. Integrating human pluripotent stem cells into drug development Cell Stem Cell 2013, 12, 669-677 10.1016/j.stem.2013.05.011
    • (2013) Cell Stem Cell , vol.12 , pp. 669-677
    • Engle, S.J.1    Puppala, D.2
  • 103
    • 84894160639 scopus 로고    scopus 로고
    • Engineering adolescence: Maturation of human pluripotent stem cell-derived cardiomyocytes
    • Yang, X.; Pabon, L.; Murry, C. E. Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes Circ. Res. 2014, 114, 511-523 10.1161/CIRCRESAHA.114.300558
    • (2014) Circ. Res. , vol.114 , pp. 511-523
    • Yang, X.1    Pabon, L.2    Murry, C.E.3
  • 105
    • 84880026566 scopus 로고    scopus 로고
    • Genome editing of human pluripotent stem cells to generate human cellular disease models
    • Musunuru, K. Genome editing of human pluripotent stem cells to generate human cellular disease models Dis. Models & Mech. 2013, 6, 896-904 10.1242/dmm.012054
    • (2013) Dis. Models & Mech. , vol.6 , pp. 896-904
    • Musunuru, K.1
  • 107
    • 84874875145 scopus 로고    scopus 로고
    • Concise review: The relevance of human stem cell-derived organoid models for epithelial translational medicine
    • Hynds, R. E.; Giangreco, A. Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine Stem Cells 2013, 31, 417-422 10.1002/stem.1290
    • (2013) Stem Cells , vol.31 , pp. 417-422
    • Hynds, R.E.1    Giangreco, A.2
  • 111
    • 84906044118 scopus 로고    scopus 로고
    • Three-dimensional cell culture technique and pathophysiology
    • Matsusaki, M.; Case, C. P.; Akashi, M. Three-dimensional cell culture technique and pathophysiology Adv. Drug Delivery Rev. 2014, 74, 95-103 10.1016/j.addr.2014.01.003
    • (2014) Adv. Drug Delivery Rev. , vol.74 , pp. 95-103
    • Matsusaki, M.1    Case, C.P.2    Akashi, M.3
  • 113
    • 84897110013 scopus 로고    scopus 로고
    • Phenotypic screening: A more rapid route to target deconvolution
    • Harrison, C. Phenotypic screening: A more rapid route to target deconvolution Nat. Rev. Drug Discovery 2014, 13, 102-103 10.1038/nrd4243
    • (2014) Nat. Rev. Drug Discovery , vol.13 , pp. 102-103
    • Harrison, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.