Randomized placebo-controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis

Liver International

Volumn 33, Issue 10, 2013, Pages 1490-1496

  Mohamadnejad, Mehdi ^a   Alimoghaddam, Kamran ^b   Bagheri, Mohammad ^a   Ashrafi, Mandana ^a   Abdollahzadeh, Leila ^a   Akhlaghpoor, Shahram ^c   Bashtar, Maryam ^b   Ghavamzadeh, Ardeshir ^b   Malekzadeh, Reza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Noor Medical Imaging Center   (Iran)

Author keywords

Cirrhosis; Stem cell; Transplantation

Indexed keywords

ALBUMIN; AMINOTRANSFERASE;

ADULT; ALBUMIN BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DECOMPENSATED LIVER CIRRHOSIS; FEMALE; FOLLOW UP; HUMAN; LIVER FUNCTION TEST; LIVER WEIGHT; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; PERIPHERAL VEIN; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

CIRRHOSIS; STEM CELL; TRANSPLANTATION;

ADULT; BILIRUBIN; BONE MARROW CELLS; CREATININE; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE AGED; PROSPECTIVE STUDIES; PROTHROMBIN TIME; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84885185290     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12228     Document Type: Article

References (32)

1. Malekzadeh R, Mohamadnejad M, Rakhshani N, et al. Reversibility of cirrhosis in chronic hepatitis B. Clin Gastroenterol Hepatol 2004; 2: 344-7.
2. Pol S, Carnot F, Nalpas B, et al. Reversibility of hepatitis C virus-related cirrhosis. Hum Pathol 2004; 35: 107-12.
3. Mohamadnejad M, Malekzadeh R, Nasseri-Moghaddam S, et al. Impact of immunosuppressive treatment on liver fibrosis in autoimmune hepatitis. Dig Dis Sci 2005; 50: 547-51.
4. Falize L, Guillygomarc'h A, Perrin M, et al. Reversibility of hepatic fibrosis in treated genetic hemochromatosis: a study of 36 cases. Hepatology 2006; 44: 472-7.
5. Murray KF, Carithers RL. AASLD practice guidelines: evaluation of the patient for liver transplantation. Hepatology 2005; 41: 1407-32.
6. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology 2000; 32: 11-6.
7. Takami T, Terai S, Sakaida I. Stem cell therapy in chronic liver disease. Curr Opin Gastroenterol 2012; 28: 203-8.
8. Vassilopoulos G, Wang PR, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature 2003; 422: 901-4.
9. Wang X, Willenbring H, Akkari Y, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003; 422: 897-901.
10. Houlihan DD, Newsome PN. Critical review of clinical trials of bone marrow stem cells in liver disease. Gastroenterology 2008; 135: 438-50.
11. Sakaida I, Terai S, Yamamoto N, et al. Transplantation of bone marrow cells reduces CCL4-induced liver fibrosis in mice. Hepatology 2004; 40: 1304-11.
12. Wang D, Zhang H, Liang J, et al. Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model. Clin Exp Med 2011; 11: 25-32.
13. Russo FP, Alison MR, Bigger BW, et al. The bone marrow functionally contributes to liver fibrosis. Gastroenterology 2006; 130: 1807-21.
14. Kisseleva T, Uchinami H, Feirt N, et al. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 2006;45: 429-38.
15. Gordon MY, Levicar N, Pai M, et al. Characterization and clinical application of human CD34 + stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. Stem Cells 2006; 24:1822-30.
16. Pai M, Zacharoulis D, Milicevic MN, et al. Autologous infusion of expanded mobilized adult bone marrow-derived CD34 + cells into patients with alcoholic liver cirrhosis. Am J Gastroenterol 2008; 103: 1952-8.
17. Salama H, Zekri AR, Zern M, et al. Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases. Cell Transplant 2010; 19: 1475-86.
18. Mohamadnejad M, Namiri M, Bagheri M, et al. Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis. World J Gastroenterol 2007; 13: 3359-63.
19. Levicar N, Pai M, Habib NA, et al. Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34 + cells in patients with chronic liver disease. Cell Prolif 2008; 41(Suppl. 1): 115-25.
20. Terai S, Ishikawa T, Omori K, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells 2006; 24: 2292-8.
21. Kim JK, Park YN, Kim JS, et al. Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis. Cell Transplant 2010; 19: 1237-46.
22. Zhao DC, Lei JX, Chen R, et al. Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats. World J Gastroenterol 2005; 11: 3431-40.
23. Zhao W, Li JJ, Cao DY, et al. Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis. World J Gastroenterol 2012; 18: 1048-58.
24. Mohamadnejad M, Alimoghaddam K, Mohyeddin-Bonab M, et al. Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. Arch Iran Med 2007; 10: 459-66.
25. Kharaziha P, Hellström PM, Noorinayer B, et al. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cells injection: a phase I-II clinical trial. Eur J Gastroenterol Hepatol 2009; 21: 1199-205.
26. Korbling M, Katz RL, Khanna A, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002; 346: 738-46.
27. Parekkadan B, van Poll D, Megeed Z, et al. Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun 2007; 363: 247-52.
28. Bernardi M, Gitto S, Biselli M. The MELD score in patients awaiting liver transplant: strengths and weaknesses. J Hepatol 2011; 54: 1297-306.
29. Coombes JM, Trotter JF. Development of the allocation system for deceased donor liver transplantation. Clin Med Res 2005; 3: 87-92.
30. Peng L, Xie D, Lin B, et al. Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology 2011; 54: 820-8.
31. Gholamrezanezhad A, Mirpour S, Bagheri M, et al. In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis. Nucl Med Biol 2011; 38: 961-7.
32. Eggenhofer E, Benseler V, Kroemer A, et al. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Front Immunol 2012; 3: 297.