Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules

Biomaterials

Volumn 70, Issue , 2015, Pages 115-125

  Tasnim, Farah ^a   Phan, Derek ^a   Toh, Yi Chin ^a,g   Yu, Hanry ^a,b,c,d,e,f  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^f Massachusetts Institute of Technology   (United States)

^g Faculty of Engineering   (Singapore)

Author keywords

Cost effective; Hepatocytes; Hepatotoxicity; Small molecules; Stem cells

Indexed keywords

BIOACTIVITY; COST EFFECTIVENESS; COST REDUCTION; CYTOLOGY; DIAGNOSIS; DIMETHYL SULFOXIDE; DISEASE CONTROL; MOLECULES; ORGANIC SOLVENTS; SODIUM COMPOUNDS; STEM CELLS; UREA;

COST EFFECTIVE; DIFFERENTIATION STRATEGIES; DIMETHYL SULFOXIDE (DMSO); HEPATOCYTES; HEPATOTOXICITY; HUMAN EMBRYONIC STEM CELLS; HUMAN PRIMARY HEPATOCYTES; SMALL MOLECULES;

CELL ENGINEERING;

2 MORPHOLINO 8 PHENYLCHROMONE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIVIN A; ALBUMIN; BONE MORPHOGENETIC PROTEIN 4; BUTYRIC ACID; CHLORPROMAZINE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; DICLOFENAC; DIGOXIN; DIMETHYL SULFOXIDE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8; OCTAMER TRANSCRIPTION FACTOR 4; PARACETAMOL; QUINIDINE; TROGLITAZONE; UREA; WNT3A PROTEIN; ACTIVIN; MOLECULAR LIBRARY; SIGNAL PEPTIDE;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG SCREENING; EMBRYONIC STEM CELL; ENDODERM; ENZYME ACTIVITY; HEPATIC PROGENITOR CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER DEVELOPMENT; LIVER TOXICITY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UREA CYCLE; ANIMAL; CELL CULTURE TECHNIQUE; CELL LINE; COST BENEFIT ANALYSIS; CYTOLOGY; DRUG EFFECTS; ECONOMICS; HUMAN EMBRYONIC STEM CELL; IC50; MOLECULAR LIBRARY; MOUSE; PHARMACOLOGY; PRECLINICAL STUDY; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION;

ACTIVINS; ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; COST-BENEFIT ANALYSIS; DRUG EVALUATION, PRECLINICAL; ENDODERM; HEPATOCYTES; HUMAN EMBRYONIC STEM CELLS; HUMANS; INHIBITORY CONCENTRATION 50; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PLURIPOTENT STEM CELLS; REAL-TIME POLYMERASE CHAIN REACTION; SMALL MOLECULE LIBRARIES; WNT3A PROTEIN;

EID: 84940869392     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.08.002     Document Type: Article

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