-
1
-
-
33644777646
-
Lab-on-a-chip: microfluidics in drug discovery
-
Dittrich P.S., Manz A. Lab-on-a-chip: microfluidics in drug discovery. Nat. Rev. Drug Discov. 2006, 5:210-218.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 210-218
-
-
Dittrich, P.S.1
Manz, A.2
-
2
-
-
84864539307
-
Revisiting lab-on-a-chip technology for drug discovery
-
Neuži P., Giselbrecht S., Länge K., Huang T.J., Manz A. Revisiting lab-on-a-chip technology for drug discovery. Nat. Rev. Drug Discov. 2012, 11:620-632.
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 620-632
-
-
Neuži, P.1
Giselbrecht, S.2
Länge, K.3
Huang, T.J.4
Manz, A.5
-
3
-
-
58849132813
-
Micro- and nanofluidic systems for high-throughput biological screening
-
Hong J., Edel J.B., deMello A.J. Micro- and nanofluidic systems for high-throughput biological screening. Drug Discov. Today 2009, 14:134-146.
-
(2009)
Drug Discov. Today
, vol.14
, pp. 134-146
-
-
Hong, J.1
Edel, J.B.2
deMello, A.J.3
-
4
-
-
79952395270
-
Cancer genomics: from discovery science to personalized medicine
-
Chin L., Andersen J.N., Futreal P.A. Cancer genomics: from discovery science to personalized medicine. Nat. Med. 2011, 17:297-303.
-
(2011)
Nat. Med.
, vol.17
, pp. 297-303
-
-
Chin, L.1
Andersen, J.N.2
Futreal, P.A.3
-
5
-
-
0033928586
-
Impact of genomics on drug discovery and clinical medicine
-
Emilien G., Ponchon M., Caldas C., Isacson O., Maloteaux J.M. Impact of genomics on drug discovery and clinical medicine. QJM 2000, 93:391-423.
-
(2000)
QJM
, vol.93
, pp. 391-423
-
-
Emilien, G.1
Ponchon, M.2
Caldas, C.3
Isacson, O.4
Maloteaux, J.M.5
-
6
-
-
77950438544
-
Microfluidic cell culture systems for drug research
-
Wu M.-H., Huang S.-B., Lee G.-B. Microfluidic cell culture systems for drug research. Lab. Chip 2010, 10:939-956.
-
(2010)
Lab. Chip
, vol.10
, pp. 939-956
-
-
Wu, M.-H.1
Huang, S.-B.2
Lee, G.-B.3
-
7
-
-
33745862756
-
HTS technologies in biopharmaceutical discovery
-
Wu G., Doberstein S.K. HTS technologies in biopharmaceutical discovery. Drug Discov. Today 2006, 11:718-724.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 718-724
-
-
Wu, G.1
Doberstein, S.K.2
-
8
-
-
77649234756
-
How to improve R&D productivity: the pharmaceutical industry's grand challenge
-
Paul S.M., Mytelka D.S., Dunwiddie C.T., Persinger C.C., Munos B.H., Lindborg S.R., Schacht A.L. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 2010, 9:203-214.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
Persinger, C.C.4
Munos, B.H.5
Lindborg, S.R.6
Schacht, A.L.7
-
10
-
-
0037947593
-
Assay development and high-throughput screening of caspases in microfluidic format
-
Wu G., Irvine J., Luft C., Pressley D., Nicholas H.C., Janzen B. Assay development and high-throughput screening of caspases in microfluidic format. Comb. Chem. High. Throughput Screen 2003, 6:303-312.
-
(2003)
Comb. Chem. High. Throughput Screen
, vol.6
, pp. 303-312
-
-
Wu, G.1
Irvine, J.2
Luft, C.3
Pressley, D.4
Nicholas, H.C.5
Janzen, B.6
-
11
-
-
37649010665
-
Microfluidics for drug discovery and development: from target selection to product lifecycle management
-
Kang L., Chung B.G., Langer R., Khademhosseini A. Microfluidics for drug discovery and development: from target selection to product lifecycle management. Drug Discov. Today 2008, 13:1-13.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 1-13
-
-
Kang, L.1
Chung, B.G.2
Langer, R.3
Khademhosseini, A.4
-
12
-
-
0036591838
-
Engineering cellular microenvironments to cell-based drug testing improve
-
Bhadriraju K., Chen C.S. Engineering cellular microenvironments to cell-based drug testing improve. Drug Discov. Today 2002, 7:612-620.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 612-620
-
-
Bhadriraju, K.1
Chen, C.S.2
-
13
-
-
77955984385
-
Cell-based assays: fuelling drug discovery
-
Michelini E., Cevenini L., Mezzanotte L., Coppa A., Roda A. Cell-based assays: fuelling drug discovery. Anal. Bioanal. Chem. 2010, 398:227-238.
-
(2010)
Anal. Bioanal. Chem.
, vol.398
, pp. 227-238
-
-
Michelini, E.1
Cevenini, L.2
Mezzanotte, L.3
Coppa, A.4
Roda, A.5
-
14
-
-
51349138269
-
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
-
Einav S., Gerber D., Bryson P.D., Sklan E.H., Elazar M., Maerkl S.J., Glenn J.S., Quake S.R. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat. Biotechnol. 2008, 26:1019-1027.
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 1019-1027
-
-
Einav, S.1
Gerber, D.2
Bryson, P.D.3
Sklan, E.H.4
Elazar, M.5
Maerkl, S.J.6
Glenn, J.S.7
Quake, S.R.8
-
15
-
-
33845864473
-
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins
-
Li L., Mustafi D., Fu Q., Tereshko V., Chen D.L., Tice J.D., Ismagilov R.F. Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:19243-19248.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 19243-19248
-
-
Li, L.1
Mustafi, D.2
Fu, Q.3
Tereshko, V.4
Chen, D.L.5
Tice, J.D.6
Ismagilov, R.F.7
-
17
-
-
84856441579
-
Biomimetic tissues on a chip for drug discovery
-
Ghaemmaghami A.M., Hancock M.J., Harrington H., Kaji H., Khademhosseini A. Biomimetic tissues on a chip for drug discovery. Drug Discov. Today 2012, 17:173-181.
-
(2012)
Drug Discov. Today
, vol.17
, pp. 173-181
-
-
Ghaemmaghami, A.M.1
Hancock, M.J.2
Harrington, H.3
Kaji, H.4
Khademhosseini, A.5
-
18
-
-
79960527448
-
The role of body-on-a-chip devices in drug and toxicity studies
-
Esch M.B., King T.L., Shuler M.L. The role of body-on-a-chip devices in drug and toxicity studies. Annu. Rev. Biomed. Eng. 2011, 13:55-72.
-
(2011)
Annu. Rev. Biomed. Eng.
, vol.13
, pp. 55-72
-
-
Esch, M.B.1
King, T.L.2
Shuler, M.L.3
-
19
-
-
0032703889
-
Patterning proteins and cells using soft lithography
-
Kane R.S., Takayama S., Ostuni E., Ingber D.E., Whitesides G.M. Patterning proteins and cells using soft lithography. Biomaterials 1999, 20:2363-2376.
-
(1999)
Biomaterials
, vol.20
, pp. 2363-2376
-
-
Kane, R.S.1
Takayama, S.2
Ostuni, E.3
Ingber, D.E.4
Whitesides, G.M.5
-
21
-
-
0037357723
-
Integration of cell culture and microfabrication technology
-
Park T.H., Shuler M.L. Integration of cell culture and microfabrication technology. Biotechnol. Prog. 2003, 19:243-253.
-
(2003)
Biotechnol. Prog.
, vol.19
, pp. 243-253
-
-
Park, T.H.1
Shuler, M.L.2
-
22
-
-
1642351161
-
Engineering flows in small devices: Microfluidics toward a lab-on-a-chip
-
Stone H.A., Stroock A.D., Ajdari A. Engineering flows in small devices: Microfluidics toward a lab-on-a-chip. Annu. Rev. Fluid Mech. 2004, 36:381-411.
-
(2004)
Annu. Rev. Fluid Mech.
, vol.36
, pp. 381-411
-
-
Stone, H.A.1
Stroock, A.D.2
Ajdari, A.3
-
23
-
-
34347256054
-
Microfluidic large-scale integration: the evolution of design rules for biological automation
-
Melin J., Quake S.R. Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu. Rev. Biophys. Biomol. Struct. 2007, 36:213-231.
-
(2007)
Annu. Rev. Biophys. Biomol. Struct.
, vol.36
, pp. 213-231
-
-
Melin, J.1
Quake, S.R.2
-
24
-
-
24944498780
-
Microfluidics: fluid physics at the nanoliter scale
-
Squires T.M., Quake S.R. Microfluidics: fluid physics at the nanoliter scale. Rev. Mod. Phys. 2005, 77:977-1026.
-
(2005)
Rev. Mod. Phys.
, vol.77
, pp. 977-1026
-
-
Squires, T.M.1
Quake, S.R.2
-
26
-
-
41149144716
-
Digital microfluidics for cell-based assays
-
Barbulovic-Nad I., Yang H., Park P.S., Wheeler A.R. Digital microfluidics for cell-based assays. Lab. Chip 2008, 8:519-526.
-
(2008)
Lab. Chip
, vol.8
, pp. 519-526
-
-
Barbulovic-Nad, I.1
Yang, H.2
Park, P.S.3
Wheeler, A.R.4
-
27
-
-
34249775501
-
High-density microfluidic arrays for cell cytotoxicity analysis
-
Wang Z.H., Kim M.C., Marquez M., Thorsen T. High-density microfluidic arrays for cell cytotoxicity analysis. Lab. Chip 2007, 7:740-745.
-
(2007)
Lab. Chip
, vol.7
, pp. 740-745
-
-
Wang, Z.H.1
Kim, M.C.2
Marquez, M.3
Thorsen, T.4
-
28
-
-
77955618032
-
Microfluidic platforms for single-cell analysis
-
Zare R.N., Kim S. Microfluidic platforms for single-cell analysis. Annu. Rev. Biomed. Eng. 2010, 12:187-201.
-
(2010)
Annu. Rev. Biomed. Eng.
, vol.12
, pp. 187-201
-
-
Zare, R.N.1
Kim, S.2
-
29
-
-
36448935709
-
Versatile, fully automated, microfluidic cell culture system
-
Gomez-Sjoeberg R., Leyrat A.A., Pirone D.M., Chen C.S., Quake S.R. Versatile, fully automated, microfluidic cell culture system. Anal. Chem. 2007, 79:8557-8563.
-
(2007)
Anal. Chem.
, vol.79
, pp. 8557-8563
-
-
Gomez-Sjoeberg, R.1
Leyrat, A.A.2
Pirone, D.M.3
Chen, C.S.4
Quake, S.R.5
-
30
-
-
84896753044
-
Droplet-based microfluidics enabling impact on drug discovery
-
Dressler O.J., Maceiczyk R.M., Chang S.-I., deMello A.J. Droplet-based microfluidics enabling impact on drug discovery. J. Biomol. Screen 2014, 19:483-496.
-
(2014)
J. Biomol. Screen
, vol.19
, pp. 483-496
-
-
Dressler, O.J.1
Maceiczyk, R.M.2
Chang, S.-I.3
deMello, A.J.4
-
31
-
-
28944445545
-
Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays
-
Khademhosseini A., Yeh J., Eng G., Karp J., Kaji H., Borenstein J., Farokhzad O.C., Langer R. Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays. Lab. Chip 2005, 5:1380-1386.
-
(2005)
Lab. Chip
, vol.5
, pp. 1380-1386
-
-
Khademhosseini, A.1
Yeh, J.2
Eng, G.3
Karp, J.4
Kaji, H.5
Borenstein, J.6
Farokhzad, O.C.7
Langer, R.8
-
32
-
-
84890558023
-
A microfluidic localized, multiple cell culture array using vacuum actuated cell seeding: integrated anticancer drug testing
-
Gao Y., Li P., Pappas D. A microfluidic localized, multiple cell culture array using vacuum actuated cell seeding: integrated anticancer drug testing. Biomed. Microdevices 2013, 15:907-915.
-
(2013)
Biomed. Microdevices
, vol.15
, pp. 907-915
-
-
Gao, Y.1
Li, P.2
Pappas, D.3
-
33
-
-
0034615958
-
Monolithic microfabricated valves and pumps by multilayer soft lithography
-
Unger M.A., Chou H.P., Thorsen T., Scherer A., Quake S.R. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 2000, 288:113-116.
-
(2000)
Science
, vol.288
, pp. 113-116
-
-
Unger, M.A.1
Chou, H.P.2
Thorsen, T.3
Scherer, A.4
Quake, S.R.5
-
34
-
-
76949100799
-
Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals
-
Park E.S., Brown A.C., DiFeo M.A., Barker T.H., Lu H. Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals. Lab. Chip 2010, 10:571-580.
-
(2010)
Lab. Chip
, vol.10
, pp. 571-580
-
-
Park, E.S.1
Brown, A.C.2
DiFeo, M.A.3
Barker, T.H.4
Lu, H.5
-
35
-
-
33745686447
-
Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes
-
Kane B.J., Zinner M.J., Yarmush M.L., Toner M. Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Anal. Chem. 2006, 78:4291-4298.
-
(2006)
Anal. Chem.
, vol.78
, pp. 4291-4298
-
-
Kane, B.J.1
Zinner, M.J.2
Yarmush, M.L.3
Toner, M.4
-
36
-
-
84860383201
-
A programmable microfluidic cell array for combinatorial drug screening
-
Kim J., Taylor D., Agrawal N., Wang H., Kim H., Han A., Rege K., Jayaraman A. A programmable microfluidic cell array for combinatorial drug screening. Lab. Chip 2012, 12:1813-1822.
-
(2012)
Lab. Chip
, vol.12
, pp. 1813-1822
-
-
Kim, J.1
Taylor, D.2
Agrawal, N.3
Wang, H.4
Kim, H.5
Han, A.6
Rege, K.7
Jayaraman, A.8
-
37
-
-
0034293766
-
Generation of solution and surface gradients using microfluidic systems
-
Jeon N.L., Dertinger S.K., Chiu D.T., Choi I.S., Stroock A.D., Whitesides G.M. Generation of solution and surface gradients using microfluidic systems. Langmuir 2000, 16:8311-8316.
-
(2000)
Langmuir
, vol.16
, pp. 8311-8316
-
-
Jeon, N.L.1
Dertinger, S.K.2
Chiu, D.T.3
Choi, I.S.4
Stroock, A.D.5
Whitesides, G.M.6
-
38
-
-
36349024270
-
Cell-based high content screening using an integrated microfluidic device
-
Ye N.N., Qin J.H., Shi W.W., Liu X., Lin B.C. Cell-based high content screening using an integrated microfluidic device. Lab. Chip 2007, 7:1696-1704.
-
(2007)
Lab. Chip
, vol.7
, pp. 1696-1704
-
-
Ye, N.N.1
Qin, J.H.2
Shi, W.W.3
Liu, X.4
Lin, B.C.5
-
39
-
-
27244441123
-
Microfluidic devices for the analysis of apoptosis
-
Qin J., Ye N., Liu X., Lin B. Microfluidic devices for the analysis of apoptosis. Electrophoresis 2005, 26:3780-3788.
-
(2005)
Electrophoresis
, vol.26
, pp. 3780-3788
-
-
Qin, J.1
Ye, N.2
Liu, X.3
Lin, B.4
-
40
-
-
84856754852
-
Controlled release of drugs from gradient hydrogels for high-throughput analysis of cell-drug interactions
-
Ostrovidov S., Annabi N., Seidi A., Ramalingam M., Dehghani F., Kaji H., Khademhosseini A. Controlled release of drugs from gradient hydrogels for high-throughput analysis of cell-drug interactions. Anal. Chem. 2012, 84:1302-1309.
-
(2012)
Anal. Chem.
, vol.84
, pp. 1302-1309
-
-
Ostrovidov, S.1
Annabi, N.2
Seidi, A.3
Ramalingam, M.4
Dehghani, F.5
Kaji, H.6
Khademhosseini, A.7
-
41
-
-
80052813897
-
Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array
-
Chung K., Rivet C.A., Kemp M.L., Lu H. Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array. Anal. Chem. 2011, 83:7044-7052.
-
(2011)
Anal. Chem.
, vol.83
, pp. 7044-7052
-
-
Chung, K.1
Rivet, C.A.2
Kemp, M.L.3
Lu, H.4
-
42
-
-
77957325589
-
Microfluidic serial dilution cell-based assay for analyzing drug dose response over a wide concentration range
-
Sugiura S., Hattori K., Kanamori T. Microfluidic serial dilution cell-based assay for analyzing drug dose response over a wide concentration range. Anal. Chem. 2010, 82:8278-8282.
-
(2010)
Anal. Chem.
, vol.82
, pp. 8278-8282
-
-
Sugiura, S.1
Hattori, K.2
Kanamori, T.3
-
43
-
-
79954576669
-
Generating nonlinear concentration gradients in microfluidic devices for cell studies
-
Selimović S.E., Sim W.Y., Kim S.B., Jang Y.H., Lee W.G., Khabiry M., Bae H., Jambovane S., Hong J.W., Khademhosseini A. Generating nonlinear concentration gradients in microfluidic devices for cell studies. Anal. Chem. 2011, 83:2020-2028.
-
(2011)
Anal. Chem.
, vol.83
, pp. 2020-2028
-
-
Selimović, S.E.1
Sim, W.Y.2
Kim, S.B.3
Jang, Y.H.4
Lee, W.G.5
Khabiry, M.6
Bae, H.7
Jambovane, S.8
Hong, J.W.9
Khademhosseini, A.10
-
44
-
-
80052549666
-
A radial microfluidic concentration gradient generator with high-density channels for cell apoptosis assay
-
Yang C.-G., Wu Y.-F., Xu Z.-R., Wang J.-H. A radial microfluidic concentration gradient generator with high-density channels for cell apoptosis assay. Lab. Chip 2011, 11:3305-3312.
-
(2011)
Lab. Chip
, vol.11
, pp. 3305-3312
-
-
Yang, C.-G.1
Wu, Y.-F.2
Xu, Z.-R.3
Wang, J.-H.4
-
45
-
-
8844266899
-
Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation
-
Zhu X.Y., Chu L.Y., Chueh B.H., Shen M.W., Hazarika B., Phadke N., Takayama S. Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation. Analyst 2004, 129:1026-1031.
-
(2004)
Analyst
, vol.129
, pp. 1026-1031
-
-
Zhu, X.Y.1
Chu, L.Y.2
Chueh, B.H.3
Shen, M.W.4
Hazarika, B.5
Phadke, N.6
Takayama, S.7
-
46
-
-
38149024155
-
Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing
-
Wu M.-H., Huang S.-B., Cui Z., Cui Z., Lee G.-B. Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing. Sens. Actuators B Chem. 2008, 129:231-240.
-
(2008)
Sens. Actuators B Chem.
, vol.129
, pp. 231-240
-
-
Wu, M.-H.1
Huang, S.-B.2
Cui, Z.3
Cui, Z.4
Lee, G.-B.5
-
47
-
-
40349113355
-
A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture
-
Wu M.-H., Huang S.-B., Cui Z., Cui Z., Lee G.-B. A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture. Biomedi. Microdevices 2008, 10:309-319.
-
(2008)
Biomedi. Microdevices
, vol.10
, pp. 309-319
-
-
Wu, M.-H.1
Huang, S.-B.2
Cui, Z.3
Cui, Z.4
Lee, G.-B.5
-
48
-
-
84863033996
-
Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip electrospray ionization mass spectrometry
-
Chen Q.S., Wu J., Zhang Y.D., Lin J.M. Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip electrospray ionization mass spectrometry. Anal. Chem. 2012, 84:1695-1701.
-
(2012)
Anal. Chem.
, vol.84
, pp. 1695-1701
-
-
Chen, Q.S.1
Wu, J.2
Zhang, Y.D.3
Lin, J.M.4
-
50
-
-
80051734317
-
Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening
-
Meissner R., Eker B., Kasi H., Bertsch A., Renaud P. Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening. Lab. Chip 2011, 11:2352-2361.
-
(2011)
Lab. Chip
, vol.11
, pp. 2352-2361
-
-
Meissner, R.1
Eker, B.2
Kasi, H.3
Bertsch, A.4
Renaud, P.5
-
51
-
-
80051771450
-
Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments
-
Hsiung L.C., Chiang C.L., Wang C.H., Huang Y.H., Kuo C.T., Cheng J.Y., Lin C.H., Wu V., Chou H.Y., Jong D.S., Lee H., Wo A.M. Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments. Lab. Chip 2011, 11:2333-2342.
-
(2011)
Lab. Chip
, vol.11
, pp. 2333-2342
-
-
Hsiung, L.C.1
Chiang, C.L.2
Wang, C.H.3
Huang, Y.H.4
Kuo, C.T.5
Cheng, J.Y.6
Lin, C.H.7
Wu, V.8
Chou, H.Y.9
Jong, D.S.10
Lee, H.11
Wo, A.M.12
-
52
-
-
39549120200
-
Compact microelectrode array system: tool for in situ monitoring of drug effects on neurotransmitter release from neural cells
-
Chen Y., Guo C., Lim L., Cheong S., Zhang Q., Tang K., Reboud J. Compact microelectrode array system: tool for in situ monitoring of drug effects on neurotransmitter release from neural cells. Anal. Chem. 2008, 80:1133-1140.
-
(2008)
Anal. Chem.
, vol.80
, pp. 1133-1140
-
-
Chen, Y.1
Guo, C.2
Lim, L.3
Cheong, S.4
Zhang, Q.5
Tang, K.6
Reboud, J.7
-
53
-
-
0042358985
-
Cell culture: biology's new dimension
-
Abbott A. Cell culture: biology's new dimension. Nature 2003, 424:870-872.
-
(2003)
Nature
, vol.424
, pp. 870-872
-
-
Abbott, A.1
-
54
-
-
33847356130
-
A novel 3D mammalian cell perfusion-culture system in microfluidic channels
-
Toh Y.-C., Zhang C., Zhang J., Khong Y.M., Chang S., Samper V.D., van Noort D., Hutmacher D.W., Yu H. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab. Chip 2007, 7:302-309.
-
(2007)
Lab. Chip
, vol.7
, pp. 302-309
-
-
Toh, Y.-C.1
Zhang, C.2
Zhang, J.3
Khong, Y.M.4
Chang, S.5
Samper, V.D.6
van Noort, D.7
Hutmacher, D.W.8
Yu, H.9
-
55
-
-
67650481611
-
A microfluidic 3D hepatocyte chip for drug toxicity testing
-
Toh Y.-C., Lim T.C., Tai D., Xiao G., van Noort D., Yu H. A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab. Chip 2009, 9:2026-2035.
-
(2009)
Lab. Chip
, vol.9
, pp. 2026-2035
-
-
Toh, Y.-C.1
Lim, T.C.2
Tai, D.3
Xiao, G.4
van Noort, D.5
Yu, H.6
-
56
-
-
84889074182
-
Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem
-
Weltin A., Slotwinski K., Kieninger J., Moser I., Jobst G., Wego M., Ehret R., Urban G.A. Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem. Lab. Chip 2014, 14:138-146.
-
(2014)
Lab. Chip
, vol.14
, pp. 138-146
-
-
Weltin, A.1
Slotwinski, K.2
Kieninger, J.3
Moser, I.4
Jobst, G.5
Wego, M.6
Ehret, R.7
Urban, G.A.8
-
57
-
-
43149111583
-
Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms
-
Clausell-Tormos J., Lieber D., Baret J.C., El-Harrak A., Miller O.J., Frenz L., Blouwolff J., Humphry K.J., Koster S., Duan H., Holtze C., Weitz D.A., Griffiths A.D., Merten C.A. Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms. Chem. Biol. 2008, 15:427-437.
-
(2008)
Chem. Biol.
, vol.15
, pp. 427-437
-
-
Clausell-Tormos, J.1
Lieber, D.2
Baret, J.C.3
El-Harrak, A.4
Miller, O.J.5
Frenz, L.6
Blouwolff, J.7
Humphry, K.J.8
Koster, S.9
Duan, H.10
Holtze, C.11
Weitz, D.A.12
Griffiths, A.D.13
Merten, C.A.14
-
58
-
-
70149096883
-
Droplet microfluidic technology for single-cell high-throughput screening
-
Brouzes E., Medkova M., Savenelli N., Marran D., Twardowski M., Hutchison J.B., Rothberg J.M., Link D.R., Perrimon N., Samuels M.L. Droplet microfluidic technology for single-cell high-throughput screening. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14195-14200.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 14195-14200
-
-
Brouzes, E.1
Medkova, M.2
Savenelli, N.3
Marran, D.4
Twardowski, M.5
Hutchison, J.B.6
Rothberg, J.M.7
Link, D.R.8
Perrimon, N.9
Samuels, M.L.10
-
59
-
-
77956102001
-
Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing
-
Yu L., Chen M.C., Cheung K.C. Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing. Lab. Chip 2010, 10:2424-2432.
-
(2010)
Lab. Chip
, vol.10
, pp. 2424-2432
-
-
Yu, L.1
Chen, M.C.2
Cheung, K.C.3
-
60
-
-
47949106623
-
Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics
-
Boedicker J.Q., Li L., Kline T.R., Ismagilov R.F. Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab. Chip 2008, 8:1265-1272.
-
(2008)
Lab. Chip
, vol.8
, pp. 1265-1272
-
-
Boedicker, J.Q.1
Li, L.2
Kline, T.R.3
Ismagilov, R.F.4
-
61
-
-
80755158911
-
Millifluidic droplet analyser for microbiology
-
Baraban L., Bertholle F., Salverda M.L., Bremond N., Panizza P., Baudry J., de Visser J.A.G., Bibette J. Millifluidic droplet analyser for microbiology. Lab. Chip 2011, 11:4057-4062.
-
(2011)
Lab. Chip
, vol.11
, pp. 4057-4062
-
-
Baraban, L.1
Bertholle, F.2
Salverda, M.L.3
Bremond, N.4
Panizza, P.5
Baudry, J.6
de Visser, J.A.G.7
Bibette, J.8
-
62
-
-
84882275569
-
Bacterial growth and adaptation in microdroplet chemostats
-
Jakiela S., Kaminski T.S., Cybulski O., Weibel D.B., Garstecki P. Bacterial growth and adaptation in microdroplet chemostats. Angew. Chem. Int. Ed. 2013, 52:8908-8911.
-
(2013)
Angew. Chem. Int. Ed.
, vol.52
, pp. 8908-8911
-
-
Jakiela, S.1
Kaminski, T.S.2
Cybulski, O.3
Weibel, D.B.4
Garstecki, P.5
-
63
-
-
77956115450
-
A modular approach for the generation, storage, mixing, and detection of droplet libraries for high throughput screening
-
Trivedi V., Doshi A., Kurup G., Ereifej E., Vandevord P., Basu A.S. A modular approach for the generation, storage, mixing, and detection of droplet libraries for high throughput screening. Lab. Chip 2010, 10:2433-2442.
-
(2010)
Lab. Chip
, vol.10
, pp. 2433-2442
-
-
Trivedi, V.1
Doshi, A.2
Kurup, G.3
Ereifej, E.4
Vandevord, P.5
Basu, A.S.6
-
64
-
-
84855696734
-
Uncovering toxicological complexity by multi-dimensional screenings in microsegmented flow: modulation of antibiotic interference by nanoparticles
-
Cao J., Kürsten D., Schneider S., Knauer A., Günther P.M., Köhler J.M. Uncovering toxicological complexity by multi-dimensional screenings in microsegmented flow: modulation of antibiotic interference by nanoparticles. Lab. Chip 2012, 12:474-484.
-
(2012)
Lab. Chip
, vol.12
, pp. 474-484
-
-
Cao, J.1
Kürsten, D.2
Schneider, S.3
Knauer, A.4
Günther, P.M.5
Köhler, J.M.6
-
65
-
-
84855647635
-
A digital microfluidic method for multiplexed cell-based apoptosis assays
-
Bogojevic D., Chamberlain M.D., Barbulovic-Nad I., Wheeler A.R. A digital microfluidic method for multiplexed cell-based apoptosis assays. Lab. Chip 2012, 12:627-634.
-
(2012)
Lab. Chip
, vol.12
, pp. 627-634
-
-
Bogojevic, D.1
Chamberlain, M.D.2
Barbulovic-Nad, I.3
Wheeler, A.R.4
-
66
-
-
38349104537
-
Three-dimensional cellular microarray for high-throughput toxicology assays
-
Lee M.-Y., Kumar R.A., Sukumaran S.M., Hogg M.G., Clark D.S., Dordick J.S. Three-dimensional cellular microarray for high-throughput toxicology assays. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:59-63.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 59-63
-
-
Lee, M.-Y.1
Kumar, R.A.2
Sukumaran, S.M.3
Hogg, M.G.4
Clark, D.S.5
Dordick, J.S.6
-
67
-
-
79957933734
-
Drug-eluting microarrays for cell-based screening of chemical-induced apoptosis
-
Kwon C.H., Wheeldon I., Kachouie N.N., Lee S.H., Bae H., Sant S., Fukuda J., Kang J.W., Khademhosseini A. Drug-eluting microarrays for cell-based screening of chemical-induced apoptosis. Anal. Chem. 2011, 83:4118-4125.
-
(2011)
Anal. Chem.
, vol.83
, pp. 4118-4125
-
-
Kwon, C.H.1
Wheeldon, I.2
Kachouie, N.N.3
Lee, S.H.4
Bae, H.5
Sant, S.6
Fukuda, J.7
Kang, J.W.8
Khademhosseini, A.9
-
68
-
-
78751560396
-
High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
-
Tung Y.-C., Hsiao A.Y., Allen S.G., Torisawa Y.-S., Ho M., Takayama S. High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 2011, 136:473-478.
-
(2011)
Analyst
, vol.136
, pp. 473-478
-
-
Tung, Y.-C.1
Hsiao, A.Y.2
Allen, S.G.3
Torisawa, Y.-S.4
Ho, M.5
Takayama, S.6
-
69
-
-
84863276263
-
Openly accessible microfluidic liquid handlers for automated high-throughput nanoliter cell culture
-
Zhou Y., Pang Y.H., Huang Y.Y. Openly accessible microfluidic liquid handlers for automated high-throughput nanoliter cell culture. Anal. Chem. 2012, 84:2576-2584.
-
(2012)
Anal. Chem.
, vol.84
, pp. 2576-2584
-
-
Zhou, Y.1
Pang, Y.H.2
Huang, Y.Y.3
-
70
-
-
4344668661
-
Drug repositioning: identifying and developing new uses for existing drugs
-
Ashburn T.T., Thor K.B. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov. 2004, 3:673-683.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
71
-
-
84880540809
-
Sequential operation droplet array: an automated microfluidic platform for picoliter-scale liquid handling, analysis, and screening
-
Zhu Y., Zhang Y.-X., Cai L.-F., Fang Q. Sequential operation droplet array: an automated microfluidic platform for picoliter-scale liquid handling, analysis, and screening. Anal. Chem. 2013, 85:6723-6731.
-
(2013)
Anal. Chem.
, vol.85
, pp. 6723-6731
-
-
Zhu, Y.1
Zhang, Y.-X.2
Cai, L.-F.3
Fang, Q.4
-
72
-
-
84880554705
-
Cell-based drug combination screening with a microfluidic droplet array system
-
Du G.-S., Pan J.-Z., Zhao S.-P., Zhu Y., den Toonder J.M., Fang Q. Cell-based drug combination screening with a microfluidic droplet array system. Anal. Chem. 2013, 85:6740-6747.
-
(2013)
Anal. Chem.
, vol.85
, pp. 6740-6747
-
-
Du, G.-S.1
Pan, J.-Z.2
Zhao, S.-P.3
Zhu, Y.4
den Toonder, J.M.5
Fang, Q.6
-
73
-
-
73449143825
-
Recent developments in PDMS surface modification for microfluidic devices
-
Zhou J., Ellis A.V., Voelcker N.H. Recent developments in PDMS surface modification for microfluidic devices. Electrophoresis 2010, 31:2-16.
-
(2010)
Electrophoresis
, vol.31
, pp. 2-16
-
-
Zhou, J.1
Ellis, A.V.2
Voelcker, N.H.3
-
74
-
-
1242333042
-
Nanoscale hydrophobic recovery: a chemical force microscopy study of UV/ozone-treated cross-linked poly(dimethylsiloxane)
-
Hillborg H., Tomczak N., Olah A., Schonherr H., Vancso G.J. Nanoscale hydrophobic recovery: a chemical force microscopy study of UV/ozone-treated cross-linked poly(dimethylsiloxane). Langmuir 2004, 20:785-794.
-
(2004)
Langmuir
, vol.20
, pp. 785-794
-
-
Hillborg, H.1
Tomczak, N.2
Olah, A.3
Schonherr, H.4
Vancso, G.J.5
-
75
-
-
77954632387
-
Convenient method for modifying poly(dimethylsiloxane) to be airtight and resistive against absorption of small molecules
-
Ren K., Zhao Y., Su J., Ryan D., Wu H. Convenient method for modifying poly(dimethylsiloxane) to be airtight and resistive against absorption of small molecules. Anal. Chem. 2010, 82:5965-5971.
-
(2010)
Anal. Chem.
, vol.82
, pp. 5965-5971
-
-
Ren, K.1
Zhao, Y.2
Su, J.3
Ryan, D.4
Wu, H.5
-
76
-
-
68849084893
-
Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics
-
Zhou J., Yan H., Ren K., Dai W., Wu H. Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics. Anal. Chem. 2009, 81:6627-6632.
-
(2009)
Anal. Chem.
, vol.81
, pp. 6627-6632
-
-
Zhou, J.1
Yan, H.2
Ren, K.3
Dai, W.4
Wu, H.5
-
77
-
-
0037131390
-
Microfluidic large-scale integration
-
Thorsen T., Maerkl S.J., Quake S.R. Microfluidic large-scale integration. Science 2002, 298:580-584.
-
(2002)
Science
, vol.298
, pp. 580-584
-
-
Thorsen, T.1
Maerkl, S.J.2
Quake, S.R.3
-
78
-
-
0141653940
-
Integrated nanoliter systems
-
Hong J.W., Quake S.R. Integrated nanoliter systems. Nat. Biotechnol. 2003, 21:1179-1183.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 1179-1183
-
-
Hong, J.W.1
Quake, S.R.2
-
79
-
-
84884255934
-
Human-on-chip for therapy development and fundamental science
-
Luni C., Serena E., Elvassore N. Human-on-chip for therapy development and fundamental science. Curr. Opin. Biotechnol. 2014, 25:45-50.
-
(2014)
Curr. Opin. Biotechnol.
, vol.25
, pp. 45-50
-
-
Luni, C.1
Serena, E.2
Elvassore, N.3
|