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Volumn 903, Issue , 2016, Pages 36-50

Microfluidics for cell-based high throughput screening platforms-A review

Author keywords

Cell based microfluidics; Drug discovery; High throughput screening

Indexed keywords

CELL CULTURE; CHEMICAL ANALYSIS; DIAGNOSIS; DRUG PRODUCTS; POLYMERASE CHAIN REACTION; STEM CELLS; THROUGHPUT;

EID: 84956889140     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2015.11.023     Document Type: Review
Times cited : (231)

References (80)
  • 1
    • 33644777646 scopus 로고    scopus 로고
    • Lab-on-a-chip: microfluidics in drug discovery
    • Dittrich P.S., Manz A. Lab-on-a-chip: microfluidics in drug discovery. Nat. Rev. Drug Discov. 2006, 5:210-218.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 210-218
    • Dittrich, P.S.1    Manz, A.2
  • 3
    • 58849132813 scopus 로고    scopus 로고
    • Micro- and nanofluidic systems for high-throughput biological screening
    • Hong J., Edel J.B., deMello A.J. Micro- and nanofluidic systems for high-throughput biological screening. Drug Discov. Today 2009, 14:134-146.
    • (2009) Drug Discov. Today , vol.14 , pp. 134-146
    • Hong, J.1    Edel, J.B.2    deMello, A.J.3
  • 4
    • 79952395270 scopus 로고    scopus 로고
    • Cancer genomics: from discovery science to personalized medicine
    • Chin L., Andersen J.N., Futreal P.A. Cancer genomics: from discovery science to personalized medicine. Nat. Med. 2011, 17:297-303.
    • (2011) Nat. Med. , vol.17 , pp. 297-303
    • Chin, L.1    Andersen, J.N.2    Futreal, P.A.3
  • 5
    • 0033928586 scopus 로고    scopus 로고
    • Impact of genomics on drug discovery and clinical medicine
    • Emilien G., Ponchon M., Caldas C., Isacson O., Maloteaux J.M. Impact of genomics on drug discovery and clinical medicine. QJM 2000, 93:391-423.
    • (2000) QJM , vol.93 , pp. 391-423
    • Emilien, G.1    Ponchon, M.2    Caldas, C.3    Isacson, O.4    Maloteaux, J.M.5
  • 6
    • 77950438544 scopus 로고    scopus 로고
    • Microfluidic cell culture systems for drug research
    • Wu M.-H., Huang S.-B., Lee G.-B. Microfluidic cell culture systems for drug research. Lab. Chip 2010, 10:939-956.
    • (2010) Lab. Chip , vol.10 , pp. 939-956
    • Wu, M.-H.1    Huang, S.-B.2    Lee, G.-B.3
  • 7
    • 33745862756 scopus 로고    scopus 로고
    • HTS technologies in biopharmaceutical discovery
    • Wu G., Doberstein S.K. HTS technologies in biopharmaceutical discovery. Drug Discov. Today 2006, 11:718-724.
    • (2006) Drug Discov. Today , vol.11 , pp. 718-724
    • Wu, G.1    Doberstein, S.K.2
  • 11
    • 37649010665 scopus 로고    scopus 로고
    • Microfluidics for drug discovery and development: from target selection to product lifecycle management
    • Kang L., Chung B.G., Langer R., Khademhosseini A. Microfluidics for drug discovery and development: from target selection to product lifecycle management. Drug Discov. Today 2008, 13:1-13.
    • (2008) Drug Discov. Today , vol.13 , pp. 1-13
    • Kang, L.1    Chung, B.G.2    Langer, R.3    Khademhosseini, A.4
  • 12
    • 0036591838 scopus 로고    scopus 로고
    • Engineering cellular microenvironments to cell-based drug testing improve
    • Bhadriraju K., Chen C.S. Engineering cellular microenvironments to cell-based drug testing improve. Drug Discov. Today 2002, 7:612-620.
    • (2002) Drug Discov. Today , vol.7 , pp. 612-620
    • Bhadriraju, K.1    Chen, C.S.2
  • 15
    • 33845864473 scopus 로고    scopus 로고
    • Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins
    • Li L., Mustafi D., Fu Q., Tereshko V., Chen D.L., Tice J.D., Ismagilov R.F. Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:19243-19248.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 19243-19248
    • Li, L.1    Mustafi, D.2    Fu, Q.3    Tereshko, V.4    Chen, D.L.5    Tice, J.D.6    Ismagilov, R.F.7
  • 18
    • 79960527448 scopus 로고    scopus 로고
    • The role of body-on-a-chip devices in drug and toxicity studies
    • Esch M.B., King T.L., Shuler M.L. The role of body-on-a-chip devices in drug and toxicity studies. Annu. Rev. Biomed. Eng. 2011, 13:55-72.
    • (2011) Annu. Rev. Biomed. Eng. , vol.13 , pp. 55-72
    • Esch, M.B.1    King, T.L.2    Shuler, M.L.3
  • 21
    • 0037357723 scopus 로고    scopus 로고
    • Integration of cell culture and microfabrication technology
    • Park T.H., Shuler M.L. Integration of cell culture and microfabrication technology. Biotechnol. Prog. 2003, 19:243-253.
    • (2003) Biotechnol. Prog. , vol.19 , pp. 243-253
    • Park, T.H.1    Shuler, M.L.2
  • 22
    • 1642351161 scopus 로고    scopus 로고
    • Engineering flows in small devices: Microfluidics toward a lab-on-a-chip
    • Stone H.A., Stroock A.D., Ajdari A. Engineering flows in small devices: Microfluidics toward a lab-on-a-chip. Annu. Rev. Fluid Mech. 2004, 36:381-411.
    • (2004) Annu. Rev. Fluid Mech. , vol.36 , pp. 381-411
    • Stone, H.A.1    Stroock, A.D.2    Ajdari, A.3
  • 23
    • 34347256054 scopus 로고    scopus 로고
    • Microfluidic large-scale integration: the evolution of design rules for biological automation
    • Melin J., Quake S.R. Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu. Rev. Biophys. Biomol. Struct. 2007, 36:213-231.
    • (2007) Annu. Rev. Biophys. Biomol. Struct. , vol.36 , pp. 213-231
    • Melin, J.1    Quake, S.R.2
  • 24
    • 24944498780 scopus 로고    scopus 로고
    • Microfluidics: fluid physics at the nanoliter scale
    • Squires T.M., Quake S.R. Microfluidics: fluid physics at the nanoliter scale. Rev. Mod. Phys. 2005, 77:977-1026.
    • (2005) Rev. Mod. Phys. , vol.77 , pp. 977-1026
    • Squires, T.M.1    Quake, S.R.2
  • 27
    • 34249775501 scopus 로고    scopus 로고
    • High-density microfluidic arrays for cell cytotoxicity analysis
    • Wang Z.H., Kim M.C., Marquez M., Thorsen T. High-density microfluidic arrays for cell cytotoxicity analysis. Lab. Chip 2007, 7:740-745.
    • (2007) Lab. Chip , vol.7 , pp. 740-745
    • Wang, Z.H.1    Kim, M.C.2    Marquez, M.3    Thorsen, T.4
  • 28
    • 77955618032 scopus 로고    scopus 로고
    • Microfluidic platforms for single-cell analysis
    • Zare R.N., Kim S. Microfluidic platforms for single-cell analysis. Annu. Rev. Biomed. Eng. 2010, 12:187-201.
    • (2010) Annu. Rev. Biomed. Eng. , vol.12 , pp. 187-201
    • Zare, R.N.1    Kim, S.2
  • 31
    • 28944445545 scopus 로고    scopus 로고
    • Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays
    • Khademhosseini A., Yeh J., Eng G., Karp J., Kaji H., Borenstein J., Farokhzad O.C., Langer R. Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays. Lab. Chip 2005, 5:1380-1386.
    • (2005) Lab. Chip , vol.5 , pp. 1380-1386
    • Khademhosseini, A.1    Yeh, J.2    Eng, G.3    Karp, J.4    Kaji, H.5    Borenstein, J.6    Farokhzad, O.C.7    Langer, R.8
  • 32
    • 84890558023 scopus 로고    scopus 로고
    • A microfluidic localized, multiple cell culture array using vacuum actuated cell seeding: integrated anticancer drug testing
    • Gao Y., Li P., Pappas D. A microfluidic localized, multiple cell culture array using vacuum actuated cell seeding: integrated anticancer drug testing. Biomed. Microdevices 2013, 15:907-915.
    • (2013) Biomed. Microdevices , vol.15 , pp. 907-915
    • Gao, Y.1    Li, P.2    Pappas, D.3
  • 33
    • 0034615958 scopus 로고    scopus 로고
    • Monolithic microfabricated valves and pumps by multilayer soft lithography
    • Unger M.A., Chou H.P., Thorsen T., Scherer A., Quake S.R. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 2000, 288:113-116.
    • (2000) Science , vol.288 , pp. 113-116
    • Unger, M.A.1    Chou, H.P.2    Thorsen, T.3    Scherer, A.4    Quake, S.R.5
  • 34
    • 76949100799 scopus 로고    scopus 로고
    • Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals
    • Park E.S., Brown A.C., DiFeo M.A., Barker T.H., Lu H. Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals. Lab. Chip 2010, 10:571-580.
    • (2010) Lab. Chip , vol.10 , pp. 571-580
    • Park, E.S.1    Brown, A.C.2    DiFeo, M.A.3    Barker, T.H.4    Lu, H.5
  • 35
    • 33745686447 scopus 로고    scopus 로고
    • Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes
    • Kane B.J., Zinner M.J., Yarmush M.L., Toner M. Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Anal. Chem. 2006, 78:4291-4298.
    • (2006) Anal. Chem. , vol.78 , pp. 4291-4298
    • Kane, B.J.1    Zinner, M.J.2    Yarmush, M.L.3    Toner, M.4
  • 38
    • 36349024270 scopus 로고    scopus 로고
    • Cell-based high content screening using an integrated microfluidic device
    • Ye N.N., Qin J.H., Shi W.W., Liu X., Lin B.C. Cell-based high content screening using an integrated microfluidic device. Lab. Chip 2007, 7:1696-1704.
    • (2007) Lab. Chip , vol.7 , pp. 1696-1704
    • Ye, N.N.1    Qin, J.H.2    Shi, W.W.3    Liu, X.4    Lin, B.C.5
  • 39
    • 27244441123 scopus 로고    scopus 로고
    • Microfluidic devices for the analysis of apoptosis
    • Qin J., Ye N., Liu X., Lin B. Microfluidic devices for the analysis of apoptosis. Electrophoresis 2005, 26:3780-3788.
    • (2005) Electrophoresis , vol.26 , pp. 3780-3788
    • Qin, J.1    Ye, N.2    Liu, X.3    Lin, B.4
  • 40
    • 84856754852 scopus 로고    scopus 로고
    • Controlled release of drugs from gradient hydrogels for high-throughput analysis of cell-drug interactions
    • Ostrovidov S., Annabi N., Seidi A., Ramalingam M., Dehghani F., Kaji H., Khademhosseini A. Controlled release of drugs from gradient hydrogels for high-throughput analysis of cell-drug interactions. Anal. Chem. 2012, 84:1302-1309.
    • (2012) Anal. Chem. , vol.84 , pp. 1302-1309
    • Ostrovidov, S.1    Annabi, N.2    Seidi, A.3    Ramalingam, M.4    Dehghani, F.5    Kaji, H.6    Khademhosseini, A.7
  • 41
    • 80052813897 scopus 로고    scopus 로고
    • Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array
    • Chung K., Rivet C.A., Kemp M.L., Lu H. Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array. Anal. Chem. 2011, 83:7044-7052.
    • (2011) Anal. Chem. , vol.83 , pp. 7044-7052
    • Chung, K.1    Rivet, C.A.2    Kemp, M.L.3    Lu, H.4
  • 42
    • 77957325589 scopus 로고    scopus 로고
    • Microfluidic serial dilution cell-based assay for analyzing drug dose response over a wide concentration range
    • Sugiura S., Hattori K., Kanamori T. Microfluidic serial dilution cell-based assay for analyzing drug dose response over a wide concentration range. Anal. Chem. 2010, 82:8278-8282.
    • (2010) Anal. Chem. , vol.82 , pp. 8278-8282
    • Sugiura, S.1    Hattori, K.2    Kanamori, T.3
  • 44
    • 80052549666 scopus 로고    scopus 로고
    • A radial microfluidic concentration gradient generator with high-density channels for cell apoptosis assay
    • Yang C.-G., Wu Y.-F., Xu Z.-R., Wang J.-H. A radial microfluidic concentration gradient generator with high-density channels for cell apoptosis assay. Lab. Chip 2011, 11:3305-3312.
    • (2011) Lab. Chip , vol.11 , pp. 3305-3312
    • Yang, C.-G.1    Wu, Y.-F.2    Xu, Z.-R.3    Wang, J.-H.4
  • 45
    • 8844266899 scopus 로고    scopus 로고
    • Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation
    • Zhu X.Y., Chu L.Y., Chueh B.H., Shen M.W., Hazarika B., Phadke N., Takayama S. Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation. Analyst 2004, 129:1026-1031.
    • (2004) Analyst , vol.129 , pp. 1026-1031
    • Zhu, X.Y.1    Chu, L.Y.2    Chueh, B.H.3    Shen, M.W.4    Hazarika, B.5    Phadke, N.6    Takayama, S.7
  • 46
    • 38149024155 scopus 로고    scopus 로고
    • Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing
    • Wu M.-H., Huang S.-B., Cui Z., Cui Z., Lee G.-B. Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing. Sens. Actuators B Chem. 2008, 129:231-240.
    • (2008) Sens. Actuators B Chem. , vol.129 , pp. 231-240
    • Wu, M.-H.1    Huang, S.-B.2    Cui, Z.3    Cui, Z.4    Lee, G.-B.5
  • 47
    • 40349113355 scopus 로고    scopus 로고
    • A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture
    • Wu M.-H., Huang S.-B., Cui Z., Cui Z., Lee G.-B. A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture. Biomedi. Microdevices 2008, 10:309-319.
    • (2008) Biomedi. Microdevices , vol.10 , pp. 309-319
    • Wu, M.-H.1    Huang, S.-B.2    Cui, Z.3    Cui, Z.4    Lee, G.-B.5
  • 48
    • 84863033996 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip electrospray ionization mass spectrometry
    • Chen Q.S., Wu J., Zhang Y.D., Lin J.M. Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip electrospray ionization mass spectrometry. Anal. Chem. 2012, 84:1695-1701.
    • (2012) Anal. Chem. , vol.84 , pp. 1695-1701
    • Chen, Q.S.1    Wu, J.2    Zhang, Y.D.3    Lin, J.M.4
  • 50
    • 80051734317 scopus 로고    scopus 로고
    • Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening
    • Meissner R., Eker B., Kasi H., Bertsch A., Renaud P. Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening. Lab. Chip 2011, 11:2352-2361.
    • (2011) Lab. Chip , vol.11 , pp. 2352-2361
    • Meissner, R.1    Eker, B.2    Kasi, H.3    Bertsch, A.4    Renaud, P.5
  • 52
    • 39549120200 scopus 로고    scopus 로고
    • Compact microelectrode array system: tool for in situ monitoring of drug effects on neurotransmitter release from neural cells
    • Chen Y., Guo C., Lim L., Cheong S., Zhang Q., Tang K., Reboud J. Compact microelectrode array system: tool for in situ monitoring of drug effects on neurotransmitter release from neural cells. Anal. Chem. 2008, 80:1133-1140.
    • (2008) Anal. Chem. , vol.80 , pp. 1133-1140
    • Chen, Y.1    Guo, C.2    Lim, L.3    Cheong, S.4    Zhang, Q.5    Tang, K.6    Reboud, J.7
  • 53
    • 0042358985 scopus 로고    scopus 로고
    • Cell culture: biology's new dimension
    • Abbott A. Cell culture: biology's new dimension. Nature 2003, 424:870-872.
    • (2003) Nature , vol.424 , pp. 870-872
    • Abbott, A.1
  • 55
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing
    • Toh Y.-C., Lim T.C., Tai D., Xiao G., van Noort D., Yu H. A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab. Chip 2009, 9:2026-2035.
    • (2009) Lab. Chip , vol.9 , pp. 2026-2035
    • Toh, Y.-C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4    van Noort, D.5    Yu, H.6
  • 56
    • 84889074182 scopus 로고    scopus 로고
    • Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem
    • Weltin A., Slotwinski K., Kieninger J., Moser I., Jobst G., Wego M., Ehret R., Urban G.A. Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem. Lab. Chip 2014, 14:138-146.
    • (2014) Lab. Chip , vol.14 , pp. 138-146
    • Weltin, A.1    Slotwinski, K.2    Kieninger, J.3    Moser, I.4    Jobst, G.5    Wego, M.6    Ehret, R.7    Urban, G.A.8
  • 59
    • 77956102001 scopus 로고    scopus 로고
    • Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing
    • Yu L., Chen M.C., Cheung K.C. Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing. Lab. Chip 2010, 10:2424-2432.
    • (2010) Lab. Chip , vol.10 , pp. 2424-2432
    • Yu, L.1    Chen, M.C.2    Cheung, K.C.3
  • 60
    • 47949106623 scopus 로고    scopus 로고
    • Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics
    • Boedicker J.Q., Li L., Kline T.R., Ismagilov R.F. Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab. Chip 2008, 8:1265-1272.
    • (2008) Lab. Chip , vol.8 , pp. 1265-1272
    • Boedicker, J.Q.1    Li, L.2    Kline, T.R.3    Ismagilov, R.F.4
  • 63
    • 77956115450 scopus 로고    scopus 로고
    • A modular approach for the generation, storage, mixing, and detection of droplet libraries for high throughput screening
    • Trivedi V., Doshi A., Kurup G., Ereifej E., Vandevord P., Basu A.S. A modular approach for the generation, storage, mixing, and detection of droplet libraries for high throughput screening. Lab. Chip 2010, 10:2433-2442.
    • (2010) Lab. Chip , vol.10 , pp. 2433-2442
    • Trivedi, V.1    Doshi, A.2    Kurup, G.3    Ereifej, E.4    Vandevord, P.5    Basu, A.S.6
  • 64
    • 84855696734 scopus 로고    scopus 로고
    • Uncovering toxicological complexity by multi-dimensional screenings in microsegmented flow: modulation of antibiotic interference by nanoparticles
    • Cao J., Kürsten D., Schneider S., Knauer A., Günther P.M., Köhler J.M. Uncovering toxicological complexity by multi-dimensional screenings in microsegmented flow: modulation of antibiotic interference by nanoparticles. Lab. Chip 2012, 12:474-484.
    • (2012) Lab. Chip , vol.12 , pp. 474-484
    • Cao, J.1    Kürsten, D.2    Schneider, S.3    Knauer, A.4    Günther, P.M.5    Köhler, J.M.6
  • 65
    • 84855647635 scopus 로고    scopus 로고
    • A digital microfluidic method for multiplexed cell-based apoptosis assays
    • Bogojevic D., Chamberlain M.D., Barbulovic-Nad I., Wheeler A.R. A digital microfluidic method for multiplexed cell-based apoptosis assays. Lab. Chip 2012, 12:627-634.
    • (2012) Lab. Chip , vol.12 , pp. 627-634
    • Bogojevic, D.1    Chamberlain, M.D.2    Barbulovic-Nad, I.3    Wheeler, A.R.4
  • 68
    • 78751560396 scopus 로고    scopus 로고
    • High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
    • Tung Y.-C., Hsiao A.Y., Allen S.G., Torisawa Y.-S., Ho M., Takayama S. High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 2011, 136:473-478.
    • (2011) Analyst , vol.136 , pp. 473-478
    • Tung, Y.-C.1    Hsiao, A.Y.2    Allen, S.G.3    Torisawa, Y.-S.4    Ho, M.5    Takayama, S.6
  • 69
    • 84863276263 scopus 로고    scopus 로고
    • Openly accessible microfluidic liquid handlers for automated high-throughput nanoliter cell culture
    • Zhou Y., Pang Y.H., Huang Y.Y. Openly accessible microfluidic liquid handlers for automated high-throughput nanoliter cell culture. Anal. Chem. 2012, 84:2576-2584.
    • (2012) Anal. Chem. , vol.84 , pp. 2576-2584
    • Zhou, Y.1    Pang, Y.H.2    Huang, Y.Y.3
  • 70
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: identifying and developing new uses for existing drugs
    • Ashburn T.T., Thor K.B. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov. 2004, 3:673-683.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 71
    • 84880540809 scopus 로고    scopus 로고
    • Sequential operation droplet array: an automated microfluidic platform for picoliter-scale liquid handling, analysis, and screening
    • Zhu Y., Zhang Y.-X., Cai L.-F., Fang Q. Sequential operation droplet array: an automated microfluidic platform for picoliter-scale liquid handling, analysis, and screening. Anal. Chem. 2013, 85:6723-6731.
    • (2013) Anal. Chem. , vol.85 , pp. 6723-6731
    • Zhu, Y.1    Zhang, Y.-X.2    Cai, L.-F.3    Fang, Q.4
  • 72
    • 84880554705 scopus 로고    scopus 로고
    • Cell-based drug combination screening with a microfluidic droplet array system
    • Du G.-S., Pan J.-Z., Zhao S.-P., Zhu Y., den Toonder J.M., Fang Q. Cell-based drug combination screening with a microfluidic droplet array system. Anal. Chem. 2013, 85:6740-6747.
    • (2013) Anal. Chem. , vol.85 , pp. 6740-6747
    • Du, G.-S.1    Pan, J.-Z.2    Zhao, S.-P.3    Zhu, Y.4    den Toonder, J.M.5    Fang, Q.6
  • 73
    • 73449143825 scopus 로고    scopus 로고
    • Recent developments in PDMS surface modification for microfluidic devices
    • Zhou J., Ellis A.V., Voelcker N.H. Recent developments in PDMS surface modification for microfluidic devices. Electrophoresis 2010, 31:2-16.
    • (2010) Electrophoresis , vol.31 , pp. 2-16
    • Zhou, J.1    Ellis, A.V.2    Voelcker, N.H.3
  • 74
    • 1242333042 scopus 로고    scopus 로고
    • Nanoscale hydrophobic recovery: a chemical force microscopy study of UV/ozone-treated cross-linked poly(dimethylsiloxane)
    • Hillborg H., Tomczak N., Olah A., Schonherr H., Vancso G.J. Nanoscale hydrophobic recovery: a chemical force microscopy study of UV/ozone-treated cross-linked poly(dimethylsiloxane). Langmuir 2004, 20:785-794.
    • (2004) Langmuir , vol.20 , pp. 785-794
    • Hillborg, H.1    Tomczak, N.2    Olah, A.3    Schonherr, H.4    Vancso, G.J.5
  • 75
    • 77954632387 scopus 로고    scopus 로고
    • Convenient method for modifying poly(dimethylsiloxane) to be airtight and resistive against absorption of small molecules
    • Ren K., Zhao Y., Su J., Ryan D., Wu H. Convenient method for modifying poly(dimethylsiloxane) to be airtight and resistive against absorption of small molecules. Anal. Chem. 2010, 82:5965-5971.
    • (2010) Anal. Chem. , vol.82 , pp. 5965-5971
    • Ren, K.1    Zhao, Y.2    Su, J.3    Ryan, D.4    Wu, H.5
  • 76
    • 68849084893 scopus 로고    scopus 로고
    • Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics
    • Zhou J., Yan H., Ren K., Dai W., Wu H. Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics. Anal. Chem. 2009, 81:6627-6632.
    • (2009) Anal. Chem. , vol.81 , pp. 6627-6632
    • Zhou, J.1    Yan, H.2    Ren, K.3    Dai, W.4    Wu, H.5
  • 77
    • 0037131390 scopus 로고    scopus 로고
    • Microfluidic large-scale integration
    • Thorsen T., Maerkl S.J., Quake S.R. Microfluidic large-scale integration. Science 2002, 298:580-584.
    • (2002) Science , vol.298 , pp. 580-584
    • Thorsen, T.1    Maerkl, S.J.2    Quake, S.R.3
  • 78
    • 0141653940 scopus 로고    scopus 로고
    • Integrated nanoliter systems
    • Hong J.W., Quake S.R. Integrated nanoliter systems. Nat. Biotechnol. 2003, 21:1179-1183.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 1179-1183
    • Hong, J.W.1    Quake, S.R.2
  • 79
    • 84884255934 scopus 로고    scopus 로고
    • Human-on-chip for therapy development and fundamental science
    • Luni C., Serena E., Elvassore N. Human-on-chip for therapy development and fundamental science. Curr. Opin. Biotechnol. 2014, 25:45-50.
    • (2014) Curr. Opin. Biotechnol. , vol.25 , pp. 45-50
    • Luni, C.1    Serena, E.2    Elvassore, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.