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Volumn 28, Issue 2-3 Special Issue, 2017, Pages 142-160

The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer's disease

Author keywords

Alzheimer's disease; cannabidiol; cannabinoid receptor; cannabinoids; cognition; dementia; endocannabinoid system; learning and memory; mouse model; therapy

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2 LINOLEOYL GLYCEROL; ACETYLCHOLINE; AMYLOID BETA PROTEIN; ANANDAMIDE; CANNABIDIOL; CANNABIMIMETIC; CANNABINOID; DRONABINOL; ENDOCANNABINOID; GLUTAMIC ACID; NABIXIMOLS; NEUROTRANSMITTER; PALMIDROL; PHYTOCANNABINOID; TAU PROTEIN; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; NEUROPROTECTIVE AGENT;

EID: 85016062573     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0000000000000247     Document Type: Review
Times cited : (41)

References (185)
  • 1
    • 37049202449 scopus 로고
    • Marihuana
    • Adams R (1940). Marihuana. Science 92:115-119.
    • (1940) Science , vol.92 , pp. 115-119
    • Adams, R.1
  • 3
    • 0041803006 scopus 로고    scopus 로고
    • Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
    • Andorfer C, Kress Y, Espinoza M, de Silva R, Tucker KL, Barde YA, et al. (2003). Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86:582-590.
    • (2003) J Neurochem , vol.86 , pp. 582-590
    • Andorfer, C.1    Kress, Y.2    Espinoza, M.3    De Silva, R.4    Tucker, K.L.5    Barde, Y.A.6
  • 4
    • 84885456781 scopus 로고    scopus 로고
    • What causes Alzheimers disease?
    • Armstrong RA (2013). What causes Alzheimers disease? Folia Neuropathol 51:169-188.
    • (2013) Folia Neuropathol , vol.51 , pp. 169-188
    • Armstrong, R.A.1
  • 5
    • 84867028653 scopus 로고    scopus 로고
    • The yin and yang of Cannabis-induced psychosis: The actions of (9)-tetrahydrocannabinol and cannabidiol in rodent models of schizophrenia
    • Arnold JC, Boucher AA, Karl T (2012). The yin and yang of Cannabis-induced psychosis: the actions of (9)-tetrahydrocannabinol and cannabidiol in rodent models of schizophrenia. Curr Pharm Des 18:5113-5130.
    • (2012) Curr Pharm des , vol.18 , pp. 5113-5130
    • Arnold, J.C.1    Boucher, A.A.2    Karl, T.3
  • 6
    • 84878863032 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in APP/PS1 mice
    • Aso E, Juves S, Maldonado R, Ferrer I (2013). CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in APP/PS1 mice. J Alzheimers Dis 35:847-858.
    • (2013) J Alzheimers Dis , vol.35 , pp. 847-858
    • Aso, E.1    Juves, S.2    Maldonado, R.3    Ferrer, I.4
  • 8
    • 84880934071 scopus 로고    scopus 로고
    • Role of the cannabinoid system in the transit of beta-amyloid across the blood-brain barrier
    • Bachmeier C, Beaulieu-Abdelahad D, Mullan M, Paris D (2013). Role of the cannabinoid system in the transit of beta-amyloid across the blood-brain barrier. Mol Cell Neurosci 56:255-262.
    • (2013) Mol Cell Neurosci , vol.56 , pp. 255-262
    • Bachmeier, C.1    Beaulieu-Abdelahad, D.2    Mullan, M.3    Paris, D.4
  • 9
    • 84861313192 scopus 로고    scopus 로고
    • Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027
    • Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, et al. (2012). Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci 32:7137-7145.
    • (2012) J Neurosci , vol.32 , pp. 7137-7145
    • Barten, D.M.1    Fanara, P.2    Andorfer, C.3    Hoque, N.4    Wong, P.Y.5    Husted, K.H.6
  • 10
    • 66149179229 scopus 로고    scopus 로고
    • Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems
    • Baruch-Suchodolsky R, Fischer B (2009). Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems. Biochemistry 48:4354-4370.
    • (2009) Biochemistry , vol.48 , pp. 4354-4370
    • Baruch-Suchodolsky, R.1    Fischer, B.2
  • 11
    • 84901935478 scopus 로고    scopus 로고
    • Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimers disease
    • Bedse G, Romano A, Cianci S, Lavecchia AM, Lorenzo P, Elphick MR, et al. (2014). Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimers disease. J Alzheimers Dis 40: 701-712.
    • (2014) J Alzheimers Dis , vol.40 , pp. 701-712
    • Bedse, G.1    Romano, A.2    Cianci, S.3    Lavecchia, A.M.4    Lorenzo, P.5    Elphick, M.R.6
  • 12
    • 79953752763 scopus 로고    scopus 로고
    • Investigation of 15 of the top candidate genes for late-onset Alzheimers disease
    • Belbin O, Carrasquillo MM, Crump M, Culley OJ, Hunter TA, Ma L, et al. (2011). Investigation of 15 of the top candidate genes for late-onset Alzheimers disease. Hum Genet 129:273-282.
    • (2011) Hum Genet , vol.129 , pp. 273-282
    • Belbin, O.1    Carrasquillo, M.M.2    Crump, M.3    Culley, O.J.4    Hunter, T.A.5    Ma, L.6
  • 14
    • 0031830516 scopus 로고    scopus 로고
    • An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
    • Ben-Shabat S, Fride E, Sheskin T, Tamiri T, Rhee MH, Vogel Z, et al. (1998). An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol 353:23-31.
    • (1998) Eur J Pharmacol , vol.353 , pp. 23-31
    • Ben-Shabat, S.1    Fride, E.2    Sheskin, T.3    Tamiri, T.4    Rhee, M.H.5    Vogel, Z.6
  • 15
    • 0348010292 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimers disease brains
    • Benito C, Nunez E, Tolon RM, Carrier EJ, Rabano A, Hillard CJ, Romero J (2003). Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimers disease brains. J Neurosci 23:11136-11141.
    • (2003) J Neurosci , vol.23 , pp. 11136-11141
    • Benito, C.1    Nunez, E.2    Tolon, R.M.3    Carrier, E.J.4    Rabano, A.5    Hillard, C.J.6    Romero, J.7
  • 17
  • 18
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T, Hanus L, de Petrocellis L, Tchilibon S, Ponde DE, Brandi I, et al. (2001). Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 134:845-852.
    • (2001) Br J Pharmacol , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6
  • 19
    • 10744229235 scopus 로고    scopus 로고
    • Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
    • Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, et al. (2003). Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol 163:463-468.
    • (2003) J Cell Biol , vol.163 , pp. 463-468
    • Bisogno, T.1    Howell, F.2    Williams, G.3    Minassi, A.4    Cascio, M.G.5    Ligresti, A.6
  • 20
    • 53649087673 scopus 로고    scopus 로고
    • Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats
    • Bitencourt RM, Pamplona FA, Takahashi RN (2008). Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats. Eur Neuropsychopharmacol 18:849-859.
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 849-859
    • Bitencourt, R.M.1    Pamplona, F.A.2    Takahashi, R.N.3
  • 22
    • 80051664599 scopus 로고    scopus 로고
    • Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
    • Booz GW (2011). Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med 51:1054-1061.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1054-1061
    • Booz, G.W.1
  • 23
    • 0033830240 scopus 로고    scopus 로고
    • Beta-amyloid peptides are cytotoxic to astrocytes in culture: A role for oxidative stress
    • Brera B, Serrano A, de Ceballos ML (2000). beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress. Neurobiol Dis 7:395-405.
    • (2000) Neurobiol Dis , vol.7 , pp. 395-405
    • Brera, B.1    Serrano, A.2    De Ceballos, M.L.3
  • 24
    • 35748973885 scopus 로고    scopus 로고
    • Novel cannabinoid receptors
    • Brown AJ (2007). Novel cannabinoid receptors. Br J Pharmacol 152:567-575.
    • (2007) Br J Pharmacol , vol.152 , pp. 567-575
    • Brown, A.J.1
  • 26
    • 10044225937 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide
    • Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, de Strooper B (2004). Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J Neurosci 24:10908-10917.
    • (2004) J Neurosci , vol.24 , pp. 10908-10917
    • Camacho, I.E.1    Serneels, L.2    Spittaels, K.3    Merchiers, P.4    Dominguez, D.5    De Strooper, B.6
  • 27
    • 35648944275 scopus 로고    scopus 로고
    • Alzheimers disease; Taking the edge off with cannabinoids?
    • Campbell VA, Gowran A (2007). Alzheimers disease; taking the edge off with cannabinoids? Br J Pharmacol 152:655-662.
    • (2007) Br J Pharmacol , vol.152 , pp. 655-662
    • Campbell, V.A.1    Gowran, A.2
  • 30
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
    • Carrier EJ, Auchampach JA, Hillard CJ (2006). Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA 103:7895-7900.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 31
    • 84880208269 scopus 로고    scopus 로고
    • Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy
    • Casarejos MJ, Perucho J, Gomez A, Munoz MP, Fernandez-Estevez M, Sagredo O, et al. (2013). Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. J Alzheimers Dis 35:525-539.
    • (2013) J Alzheimers Dis , vol.35 , pp. 525-539
    • Casarejos, M.J.1    Perucho, J.2    Gomez, A.3    Munoz, M.P.4    Fernandez-Estevez, M.5    Sagredo, O.6
  • 32
    • 77952476532 scopus 로고    scopus 로고
    • Effect of synthetic cannabinoid HU210 on memory deficits and neuropathology in Alzheimers disease mouse model
    • Chen B, Bromley-Brits K, He G, Cai F, Zhang X, Song W (2010). Effect of synthetic cannabinoid HU210 on memory deficits and neuropathology in Alzheimers disease mouse model. Curr Alzheimer Res 7:255-261.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 255-261
    • Chen, B.1    Bromley-Brits, K.2    He, G.3    Cai, F.4    Zhang, X.5    Song, W.6
  • 33
    • 84904430556 scopus 로고    scopus 로고
    • Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1?E9 mice
    • Cheng D, Low JK, Logge W, Garner B, Karl T (2014a). Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1?E9 mice. Psychopharmacology (Berl) 231:3009-3017.
    • (2014) Psychopharmacology (Berl) , vol.231 , pp. 3009-3017
    • Cheng, D.1    Low, J.K.2    Logge, W.3    Garner, B.4    Karl, T.5
  • 34
    • 84907972104 scopus 로고    scopus 로고
    • Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimers disease transgenic mice
    • Cheng D, Spiro AS, Jenner AM, Garner B, Karl T (2014b). Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimers disease transgenic mice. J Alzheimers Dis 42:1383-1396.
    • (2014) J Alzheimers Dis , vol.42 , pp. 1383-1396
    • Cheng, D.1    Spiro, A.S.2    Jenner, A.M.3    Garner, B.4    Karl, T.5
  • 35
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimers disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimers disease in late onset families. Science 261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 37
    • 27744510142 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death
    • DAbramo C, Massone S, Zingg JM, Pizzuti A, Marambaud P, Dalla Piccola B, et al. (2005). Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death. Biochem J 391 (Pt 3):693-698.
    • (2005) Biochem J , vol.391 , pp. 693-698
    • Dabramo, C.1    Massone, S.2    Zingg, J.M.3    Pizzuti, A.4    Marambaud, P.5    Dalla Piccola, B.6
  • 39
    • 46249121074 scopus 로고    scopus 로고
    • Effect of cannabidiol on sepsis-induced motility disturbances in mice: Involvement of CB receptors and fatty acid amide hydrolase
    • De Filippis D, Iuvone T, damico A, Esposito G, Steardo L, Herman AG, et al. (2008). Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. Neurogastroenterol Motil 20:919-927.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 919-927
    • De Filippis, D.1    Iuvone, T.2    Damico, A.3    Esposito, G.4    Steardo, L.5    Herman, A.G.6
  • 40
    • 20444470817 scopus 로고    scopus 로고
    • Recognition memory impairment and brain oxidative stress induced by postnatal iron administration
    • De Lima MN, Polydoro M, Laranja DC, Bonatto F, Bromberg E, Moreira JC, et al. (2005). Recognition memory impairment and brain oxidative stress induced by postnatal iron administration. Eur J Neurosci 21:2521-2528.
    • (2005) Eur J Neurosci , vol.21 , pp. 2521-2528
    • De Lima, M.N.1    Polydoro, M.2    Laranja, D.C.3    Bonatto, F.4    Bromberg, E.5    Moreira, J.C.6
  • 41
    • 84856628201 scopus 로고    scopus 로고
    • Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), ?9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour
    • Deiana S, Watanabe A, Yamasaki Y, Amada N, Arthur M, Fleming S, et al. (2012). Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), ?9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour. Psychopharmacology (Berl) 219:859-873.
    • (2012) Psychopharmacology (Berl) , vol.219 , pp. 859-873
    • Deiana, S.1    Watanabe, A.2    Yamasaki, Y.3    Amada, N.4    Arthur, M.5    Fleming, S.6
  • 42
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, et al. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 43
    • 84902304606 scopus 로고    scopus 로고
    • Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
    • Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, Hill C, et al. (2014). Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia 55:791-802.
    • (2014) Epilepsia , vol.55 , pp. 791-802
    • Devinsky, O.1    Cilio, M.R.2    Cross, H.3    Fernandez-Ruiz, J.4    French, J.5    Hill, C.6
  • 44
    • 65249141710 scopus 로고    scopus 로고
    • Correlation of iron in the hippocampus with MMSE in patients with Alzheimers disease
    • Ding B, Chen KM, Ling HW, Sun F, Li X, Wan T, et al. (2009). Correlation of iron in the hippocampus with MMSE in patients with Alzheimers disease. J Magn Reson Imaging 29:793-798.
    • (2009) J Magn Reson Imaging , vol.29 , pp. 793-798
    • Ding, B.1    Chen, K.M.2    Ling, H.W.3    Sun, F.4    Li, X.5    Wan, T.6
  • 47
    • 33847416960 scopus 로고    scopus 로고
    • Cannabinoids and psychosis
    • DSouza DC (2007). Cannabinoids and psychosis. Int Rev Neurobiol 78: 289-326.
    • (2007) Int Rev Neurobiol , vol.78 , pp. 289-326
    • Dsouza, D.C.1
  • 48
    • 29244478635 scopus 로고    scopus 로고
    • Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
    • Ehrhart J, Obregon D, Mori T, Hou H, Sun N, Bai Y, et al. (2005). Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2:29.
    • (2005) J Neuroinflammation , vol.2 , pp. 29
    • Ehrhart, J.1    Obregon, D.2    Mori, T.3    Hou, H.4    Sun, N.5    Bai, Y.6
  • 49
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    • Esposito G, de Filippis D, Carnuccio R, Izzo AA, Iuvone T (2006a). The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J Mol Med 84:253-258.
    • (2006) J Mol Med , vol.84 , pp. 253-258
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 50
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • Esposito G, de Filippis D, Maiuri MC, de Stefano D, Carnuccio R, Iuvone T (2006b). Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 399:91-95.
    • (2006) Neurosci Lett , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 51
    • 34547878297 scopus 로고    scopus 로고
    • Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
    • Esposito G, Scuderi C, Savani C, Steardo L Jr, de Filippis D, Cottone P, et al. (2007). Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151:1272-1279.
    • (2007) Br J Pharmacol , vol.151 , pp. 1272-1279
    • Esposito, G.1    Scuderi, C.2    Savani, C.3    Steardo, L.4    De Filippis, D.5    Cottone, P.6
  • 52
    • 82655189157 scopus 로고    scopus 로고
    • Cannabidiol reduces A-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR' involvement
    • Esposito G, Scuderi C, Valenza M, Togna GI, Latina V, de Filippis D, et al. (2011). Cannabidiol reduces A-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR? involvement. PLoS One 6:e28668.
    • (2011) PLoS One , vol.6 , pp. e28668
    • Esposito, G.1    Scuderi, C.2    Valenza, M.3    Togna, G.I.4    Latina, V.5    De Filippis, D.6
  • 54
    • 9644302602 scopus 로고    scopus 로고
    • Differential effects of THC-or CBD-rich Cannabis extracts on working memory in rats
    • Fadda P, Robinson L, Fratta W, Pertwee RG, Riedel G (2004). Differential effects of THC-or CBD-rich Cannabis extracts on working memory in rats. Neuropharmacology 47:1170-1179.
    • (2004) Neuropharmacology , vol.47 , pp. 1170-1179
    • Fadda, P.1    Robinson, L.2    Fratta, W.3    Pertwee, R.G.4    Riedel, G.5
  • 56
    • 0034825434 scopus 로고    scopus 로고
    • Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses
    • Fellermeier M, Eisenreich W, Bacher A, Zenk MH (2001). Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses. Eur J Biochem 268:1596-1604.
    • (2001) Eur J Biochem , vol.268 , pp. 1596-1604
    • Fellermeier, M.1    Eisenreich, W.2    Bacher, A.3    Zenk, M.H.4
  • 58
    • 0036884291 scopus 로고    scopus 로고
    • Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway
    • Garrido JL, Godoy JA, Alvarez A, Bronfman M, Inestrosa NC (2002). Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J 16:1982-1984.
    • (2002) FASEB J , vol.16 , pp. 1982-1984
    • Garrido, J.L.1    Godoy, J.A.2    Alvarez, A.3    Bronfman, M.4    Inestrosa, N.C.5
  • 60
    • 45749151056 scopus 로고    scopus 로고
    • Animal models of Alzheimers disease and frontotemporal dementia
    • Gotz J, Ittner LM (2008). Animal models of Alzheimers disease and frontotemporal dementia. Nat Rev Neurosci 9:532-544.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 532-544
    • Gotz, J.1    Ittner, L.M.2
  • 61
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    • Gotz J, Chen F, van Dorpe J, Nitsch RM (2001). Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293:1491-1495.
    • (2001) Science , vol.293 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.M.4
  • 62
    • 49149124192 scopus 로고    scopus 로고
    • Is tau aggregation toxic or protective: A sensible question in the absence of sensitive methods?
    • Gotz J, Ittner LM, Fndrich M, Schonrock N (2008). Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods? J Alzheimers Dis 14:423-429.
    • (2008) J Alzheimers Dis , vol.14 , pp. 423-429
    • Gotz, J.1    Ittner, L.M.2    Fndrich, M.3    Schonrock, N.4
  • 63
    • 0037255987 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of cannabinoids
    • Grotenhermen F (2003). Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 42:327-360.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 327-360
    • Grotenhermen, F.1
  • 64
    • 34548498839 scopus 로고    scopus 로고
    • The toxicology of Cannabis and Cannabis prohibition
    • Grotenhermen F (2007). The toxicology of Cannabis and Cannabis prohibition. Chem Biodivers 4:1744-1769.
    • (2007) Chem Biodivers , vol.4 , pp. 1744-1769
    • Grotenhermen, F.1
  • 65
    • 0029031348 scopus 로고
    • Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent
    • Gschwind M, Huber G (1995). Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent. J Neurochem 65:292-300.
    • (1995) J Neurochem , vol.65 , pp. 292-300
    • Gschwind, M.1    Huber, G.2
  • 66
    • 0037023277 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and argininosuccinate synthetase: Co-induction in brain tissue of patients with Alzheimers dementia and following stimulation with beta-amyloid 1-42 in vitro
    • Haas J, Storch-Hagenlocher B, Biessmann A, Wildemann B (2002). Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimers dementia and following stimulation with beta-amyloid 1-42 in vitro. Neurosci Lett 322:121-125.
    • (2002) Neurosci Lett , vol.322 , pp. 121-125
    • Haas, J.1    Storch-Hagenlocher, B.2    Biessmann, A.3    Wildemann, B.4
  • 67
    • 78650961973 scopus 로고    scopus 로고
    • The interplay of cannabinoid and NMDA glutamate receptor systems in humans: Preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects
    • Hallak JE, Dursun SM, Bosi DC, de Macedo LR, Machado-de-Sousa JP, Abro J, et al. (2011). The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Prog Neuropsychopharmacol Biol Psychiatry 35:198-202.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 198-202
    • Hallak, J.E.1    Dursun, S.M.2    Bosi, D.C.3    De Macedo, L.R.4    Machado-De-Sousa, J.P.5    Abro, J.6
  • 68
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D (1998). Cannabidiol and (-)delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 95:8268-8273.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 69
    • 0025787997 scopus 로고
    • Comparative metabolism of cannabidiol in dog, rat and man
    • Harvey DJ, Samara E, Mechoulam R (1991). Comparative metabolism of cannabidiol in dog, rat and man. Pharmacol Biochem Behav 40:523-532.
    • (1991) Pharmacol Biochem Behav , vol.40 , pp. 523-532
    • Harvey, D.J.1    Samara, E.2    Mechoulam, R.3
  • 70
    • 84855998880 scopus 로고    scopus 로고
    • Contrasting protective effects of cannabinoids against oxidative stress and amyloid-evoked neurotoxicity in vitro
    • Harvey BS, Ohlsson KS, Maag JL, Musgrave IF, Smid SD (2012). Contrasting protective effects of cannabinoids against oxidative stress and amyloid-evoked neurotoxicity in vitro. Neurotoxicology 33:138-146.
    • (2012) Neurotoxicology , vol.33 , pp. 138-146
    • Harvey, B.S.1    Ohlsson, K.S.2    Maag, J.L.3    Musgrave, I.F.4    Smid, S.D.5
  • 71
    • 84858331377 scopus 로고    scopus 로고
    • Off-target cannabinoid effects mediated by GPR55
    • Henstridge CM (2012). Off-target cannabinoid effects mediated by GPR55. Pharmacology 89:179-187.
    • (2012) Pharmacology , vol.89 , pp. 179-187
    • Henstridge, C.M.1
  • 72
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. (1998). Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4:97-100.
    • (1998) Nat Med , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6
  • 74
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. (1996). Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6
  • 75
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • Iuvone T, Esposito G, Esposito R, Santamaria R, di Rosa M, Izzo AA (2004). Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 89:134-141.
    • (2004) J Neurochem , vol.89 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 77
    • 70349189518 scopus 로고    scopus 로고
    • Nonpsychotropic plant cannabinoids: New therapeutic opportunities from an ancient herb
    • Izzo AA, Borrelli F, Capasso R, di Marzo V, Mechoulam R (2009). Nonpsychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 30:515-527.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3    Di Marzo, V.4    Mechoulam, R.5
  • 78
    • 84893798834 scopus 로고    scopus 로고
    • Cannabinoid effects on amyloid fibril and aggregate formation, neuronal and microglial-activated neurotoxicity in vitro
    • Janefjord E, Maag JL, Harvey BS, Smid SD (2014). Cannabinoid effects on amyloid fibril and aggregate formation, neuronal and microglial-activated neurotoxicity in vitro. Cell Mol Neurobiol 34:31-42.
    • (2014) Cell Mol Neurobiol , vol.34 , pp. 31-42
    • Janefjord, E.1    Maag, J.L.2    Harvey, B.S.3    Smid, S.D.4
  • 79
    • 0038845604 scopus 로고    scopus 로고
    • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    • Jarai Z, Wagner JA, Varga K, Lake KD, Compton DR, Martin BR, et al. (1999). Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA 96: 14136-14141.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14136-14141
    • Jarai, Z.1    Wagner, J.A.2    Varga, K.3    Lake, K.D.4    Compton, D.R.5    Martin, B.R.6
  • 80
    • 0036838392 scopus 로고    scopus 로고
    • Cardiovascular system effects of marijuana
    • Jones RT (2002). Cardiovascular system effects of marijuana. J Clin Pharmacol 42:58S-63S.
    • (2002) J Clin Pharmacol , vol.42 , pp. 58S-63S
    • Jones, R.T.1
  • 81
    • 84861859231 scopus 로고    scopus 로고
    • An amyloid 42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimers disease
    • Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, et al. (2012). An amyloid 42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimers disease. Neurobiol Aging 33 :1522-1532.
    • (2012) Neurobiol Aging , vol.33 , pp. 1522-1532
    • Jung, K.M.1    Astarita, G.2    Yasar, S.3    Vasilevko, V.4    Cribbs, D.H.5    Head, E.6
  • 82
    • 79851509826 scopus 로고    scopus 로고
    • Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1 E9 double transgenic mice
    • Kalifa S, Polston EK, Allard JS, Manaye KF (2011). Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1 E9 double transgenic mice. Brain Res 1376:94-100.
    • (2011) Brain Res , vol.1376 , pp. 94-100
    • Kalifa, S.1    Polston, E.K.2    Allard, J.S.3    Manaye, K.F.4
  • 83
    • 4444302117 scopus 로고    scopus 로고
    • Molecular genetics of late-onset Alzheimers disease
    • Kamboh MI (2004). Molecular genetics of late-onset Alzheimers disease. Ann Hum Genet 68 (Pt 4):381-404.
    • (2004) Ann Hum Genet , vol.68 , pp. 381-404
    • Kamboh, M.I.1
  • 84
    • 84859614049 scopus 로고    scopus 로고
    • The therapeutic potential of the endocannabinoid system for Alzheimers disease
    • Karl T, Cheng D, Garner B, Arnold JC (2012). The therapeutic potential of the endocannabinoid system for Alzheimers disease. Expert Opin Ther Targets 16:407-420.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 407-420
    • Karl, T.1    Cheng, D.2    Garner, B.3    Arnold, J.C.4
  • 87
    • 0033608169 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimers disease brains
    • Kitamura Y, Shimohama S, Koike H, Ji Kakimura, Matsuoka Y, Nomura Y, et al. (1999). Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimers disease brains. Biochem Biophys Res Commun 254:582-586.
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 582-586
    • Kitamura, Y.1    Shimohama, S.2    Koike, H.3    Kakimura, J.4    Matsuoka, Y.5    Nomura, Y.6
  • 88
    • 82955233174 scopus 로고    scopus 로고
    • Cannabidiol potentiates ?9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
    • Klein C, Karanges E, Spiro A, Wong A, Spencer J, Huynh T, et al. (2011). Cannabidiol potentiates ?9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology (Berl) 218:443-457.
    • (2011) Psychopharmacology (Berl) , vol.218 , pp. 443-457
    • Klein, C.1    Karanges, E.2    Spiro, A.3    Wong, A.4    Spencer, J.5    Huynh, T.6
  • 89
    • 60849123916 scopus 로고    scopus 로고
    • Endocannabinoids in Alzheimers disease and their impact on normative cognitive performance: A case-control and cohort study
    • Koppel J, Bradshaw H, Goldberg TE, Khalili H, Marambaud P, Walker MJ, et al. (2009). Endocannabinoids in Alzheimers disease and their impact on normative cognitive performance: a case-control and cohort study. Lipids Health Dis 8:2.
    • (2009) Lipids Health Dis , vol.8 , pp. 2
    • Koppel, J.1    Bradshaw, H.2    Goldberg, T.E.3    Khalili, H.4    Marambaud, P.5    Walker, M.J.6
  • 90
    • 77955973836 scopus 로고    scopus 로고
    • Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimers disease
    • Krause DL, Muller N (2010). Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimers disease. Int J Alzheimers Dis 2010. doi: 10.4061/2010/732806.
    • (2010) Int J Alzheimers Dis , vol.2010
    • Krause, D.L.1    Muller, N.2
  • 92
    • 23444432920 scopus 로고    scopus 로고
    • The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
    • Lambert DM, Fowler CJ (2005). The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 48: 5059-5087.
    • (2005) J Med Chem , vol.48 , pp. 5059-5087
    • Lambert, D.M.1    Fowler, C.J.2
  • 95
    • 84858391237 scopus 로고    scopus 로고
    • Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
    • Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, et al. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry 2:e94.
    • (2012) Transl Psychiatry , vol.2 , pp. e94
    • Leweke, F.M.1    Piomelli, D.2    Pahlisch, F.3    Muhl, D.4    Gerth, C.W.5    Hoyer, C.6
  • 96
    • 0029044095 scopus 로고
    • Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats
    • Lichtman AH, Dimen KR, Martin BR (1995). Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology (Berl) 119:282-290.
    • (1995) Psychopharmacology (Berl) , vol.119 , pp. 282-290
    • Lichtman, A.H.1    Dimen, K.R.2    Martin, B.R.3
  • 98
    • 11244328917 scopus 로고    scopus 로고
    • The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    • Lo Verme J, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D (2005). The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol 67:15-19.
    • (2005) Mol Pharmacol , vol.67 , pp. 15-19
    • Lo Verme, J.1    Fu, J.2    Astarita, G.3    La Rana, G.4    Russo, R.5    Calignano, A.6    Piomelli, D.7
  • 100
    • 77957228353 scopus 로고    scopus 로고
    • A behavioural comparison of acute and chronic delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice
    • Long LE, Chesworth R, Huang XF, McGregor IS, Arnold JC, Karl T (2010). A behavioural comparison of acute and chronic delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. Int J Neuropsychopharmacol 13: 861-876.
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 861-876
    • Long, L.E.1    Chesworth, R.2    Huang, X.F.3    McGregor, I.S.4    Arnold, J.C.5    Karl, T.6
  • 101
    • 31144468211 scopus 로고    scopus 로고
    • A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo
    • Lunn CA, Fine JS, Rojas-Triana A, Jackson JV, Fan X, Kung TT, et al. (2006). A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther 316:780-788.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 780-788
    • Lunn, C.A.1    Fine, J.S.2    Rojas-Triana, A.3    Jackson, J.V.4    Fan, X.5    Kung, T.T.6
  • 102
    • 68049129534 scopus 로고    scopus 로고
    • Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation
    • Magen I, Avraham Y, Ackerman Z, Vorobiev L, Mechoulam R, Berry EM (2009). Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. J Hepatol 51:528-534.
    • (2009) J Hepatol , vol.51 , pp. 528-534
    • Magen, I.1    Avraham, Y.2    Ackerman, Z.3    Vorobiev, L.4    Mechoulam, R.5    Berry, E.M.6
  • 103
    • 77249134168 scopus 로고    scopus 로고
    • Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
    • Magen I, Avraham Y, Ackerman Z, Vorobiev L, Mechoulam R, Berry EM (2010). Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation. Br J Pharmacol 159:950-957.
    • (2010) Br J Pharmacol , vol.159 , pp. 950-957
    • Magen, I.1    Avraham, Y.2    Ackerman, Z.3    Vorobiev, L.4    Mechoulam, R.5    Berry, E.M.6
  • 104
    • 35348864420 scopus 로고    scopus 로고
    • Endocannabinoid hedonic hotspot for sensory pleasure: Anandamide in nucleus accumbens shell enhances liking of a sweet reward
    • Mahler SV, Smith KS, Berridge KC (2007). Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances liking of a sweet reward. Neuropsychopharmacology 32:2267-2278.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2267-2278
    • Mahler, S.V.1    Smith, K.S.2    Berridge, K.C.3
  • 105
    • 25844440525 scopus 로고    scopus 로고
    • Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
    • Makara JK, Mor M, Fegley D, Szabo SI, Kathuria S, Astarita G, et al. (2005). Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci 8:1139-1141.
    • (2005) Nat Neurosci , vol.8 , pp. 1139-1141
    • Makara, J.K.1    Mor, M.2    Fegley, D.3    Szabo, S.I.4    Kathuria, S.5    Astarita, G.6
  • 106
    • 0029997920 scopus 로고    scopus 로고
    • The endogenous cannabinoid receptor agonist anandamide impairs memory in rats
    • Mallet P, Beninger R (1996). The endogenous cannabinoid receptor agonist anandamide impairs memory in rats. Behav Pharmacol 7:276-284.
    • (1996) Behav Pharmacol , vol.7 , pp. 276-284
    • Mallet, P.1    Beninger, R.2
  • 108
    • 79251544549 scopus 로고    scopus 로고
    • Alzheimers dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: Implications for early detection and therapy
    • Marchesi VT (2011). Alzheimers dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy. FASEB J 25:5-13.
    • (2011) FASEB J , vol.25 , pp. 5-13
    • Marchesi, V.T.1
  • 109
    • 77955053537 scopus 로고    scopus 로고
    • The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
    • Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, et al. (2010). The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci 13:951-957.
    • (2010) Nat Neurosci , vol.13 , pp. 951-957
    • Marrs, W.R.1    Blankman, J.L.2    Horne, E.A.3    Thomazeau, A.4    Lin, Y.H.5    Coy, J.6
  • 111
    • 84855812968 scopus 로고    scopus 로고
    • Prolonged oral cannabinoid administration prevents neuroinflammation, lowers-amyloid levels and improves cognitive performance in Tg APP 2576 mice
    • Martin-Moreno AM, Brera B, Spuch C, Carro E, Garcia-Garcia L, Delgado M, et al. (2012). Prolonged oral cannabinoid administration prevents neuroinflammation, lowers-amyloid levels and improves cognitive performance in Tg APP 2576 mice. J Neuroinflammation 9:8.
    • (2012) J Neuroinflammation , vol.9 , pp. 8
    • Martin-Moreno, A.M.1    Brera, B.2    Spuch, C.3    Carro, E.4    Garcia-Garcia, L.5    Delgado, M.6
  • 112
    • 0036954488 scopus 로고    scopus 로고
    • Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimers disease
    • Mattson MP (2002). Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimers disease. J Neurovirol 8:539-550.
    • (2002) J Neurovirol , vol.8 , pp. 539-550
    • Mattson, M.P.1
  • 113
    • 1642320366 scopus 로고    scopus 로고
    • Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade
    • Mazzola C, Micale V, Drago F (2003). Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade. Eur J Pharmacol 477:219-225.
    • (2003) Eur J Pharmacol , vol.477 , pp. 219-225
    • Mazzola, C.1    Micale, V.2    Drago, F.3
  • 114
    • 84924862476 scopus 로고    scopus 로고
    • Targeting microglia for the treatment of Alzheimers disease
    • McGeer PL, McGeer EG (2015). Targeting microglia for the treatment of Alzheimers disease. Expert Opin Ther Targets 19:497-506.
    • (2015) Expert Opin Ther Targets , vol.19 , pp. 497-506
    • McGeer, P.L.1    McGeer, E.G.2
  • 115
    • 84870575111 scopus 로고    scopus 로고
    • GPR18 in microglia: Implications for the CNS and endocannabinoid system signalling
    • McHugh D (2012). GPR18 in microglia: implications for the CNS and endocannabinoid system signalling. Br J Pharmacol 167:1575-1582.
    • (2012) Br J Pharmacol , vol.167 , pp. 1575-1582
    • McHugh, D.1
  • 116
    • 77952731052 scopus 로고    scopus 로고
    • N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
    • McHugh D, Hu SS, Rimmerman N, Juknat A, Vogel Z, Walker JM, Bradshaw HB (2010). N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci 11:44.
    • (2010) BMC Neurosci , vol.11 , pp. 44
    • McHugh, D.1    Hu, S.S.2    Rimmerman, N.3    Juknat, A.4    Vogel, Z.5    Walker, J.M.6    Bradshaw, H.B.7
  • 117
    • 84920829439 scopus 로고    scopus 로고
    • Are cannabidiol and (9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review
    • McPartland JM, Duncan M, di Marzo V, Pertwee RG (2015). Are cannabidiol and (9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol 172:737-753.
    • (2015) Br J Pharmacol , vol.172 , pp. 737-753
    • McPartland, J.M.1    Duncan, M.2    Di Marzo, V.3    Pertwee, R.G.4
  • 118
    • 0001123407 scopus 로고
    • A total synthesis of Dl-delta-1-tetrahydrocannabinol, the active constituent of hashish
    • Mechoulam R, Gaoni Y (1965). A total synthesis of Dl-delta-1-tetrahydrocannabinol, the active constituent of hashish. J Am Chem Soc 87:3273-3275.
    • (1965) J Am Chem Soc , vol.87 , pp. 3273-3275
    • Mechoulam, R.1    Gaoni, Y.2
  • 119
    • 0036838389 scopus 로고    scopus 로고
    • Cannabidiol: An overview of some pharmacological aspects
    • Mechoulam R, Parker LA, Gallily R (2002). Cannabidiol: an overview of some pharmacological aspects. J Clin Pharmacol 42:11s-19s.
    • (2002) J Clin Pharmacol , vol.42 , pp. 11s-19s
    • Mechoulam, R.1    Parker, L.A.2    Gallily, R.3
  • 120
    • 35648993493 scopus 로고    scopus 로고
    • Endocannabinoids and neurodegenerative diseases
    • Micale V, Mazzola C, Drago F (2007). Endocannabinoids and neurodegenerative diseases. Pharmacol Res 56:382-392.
    • (2007) Pharmacol Res , vol.56 , pp. 382-392
    • Micale, V.1    Mazzola, C.2    Drago, F.3
  • 122
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Nslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD (2000). Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283:1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Nslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6    Buxbaum, J.D.7
  • 124
    • 34748859154 scopus 로고    scopus 로고
    • Differential effects of the N-methyl-D-aspartate receptor antagonist MK-801 on different stages of object recognition memory in mice
    • Nilsson M, Hansson S, Carlsson A, Carlsson ML (2007). Differential effects of the N-methyl-D-aspartate receptor antagonist MK-801 on different stages of object recognition memory in mice. Neuroscience 149:123-130.
    • (2007) Neuroscience , vol.149 , pp. 123-130
    • Nilsson, M.1    Hansson, S.2    Carlsson, A.3    Carlsson, M.L.4
  • 125
    • 1242294480 scopus 로고    scopus 로고
    • Molecular characterization of a phospholipase D generating anandamide and its congeners
    • Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (2004). Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem 279:5298-5305.
    • (2004) J Biol Chem , vol.279 , pp. 5298-5305
    • Okamoto, Y.1    Morishita, J.2    Tsuboi, K.3    Tonai, T.4    Ueda, N.5
  • 126
    • 79952198989 scopus 로고    scopus 로고
    • Is lipid signaling through cannabinoid 2 receptors part of a protective system?
    • Pacher P, Mechoulam R (2011). Is lipid signaling through cannabinoid 2 receptors part of a protective system? Prog Lipid Res 50:193-211.
    • (2011) Prog Lipid Res , vol.50 , pp. 193-211
    • Pacher, P.1    Mechoulam, R.2
  • 127
    • 33750861867 scopus 로고    scopus 로고
    • The endocannabinoid system in ageing: A new target for drug development
    • Paradisi A, Oddi S, Maccarrone M (2006). The endocannabinoid system in ageing: a new target for drug development. Curr Drug Targets 7:1539-1552.
    • (2006) Curr Drug Targets , vol.7 , pp. 1539-1552
    • Paradisi, A.1    Oddi, S.2    Maccarrone, M.3
  • 128
    • 84883459353 scopus 로고    scopus 로고
    • Memantine and cholinesterase inhibitors: Complementary mechanisms in the treatment of Alzheimers disease
    • Parsons CG, Danysz W, Dekundy A, Pulte I (2013). Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimers disease. Neurotox Res 24:358-369.
    • (2013) Neurotox Res , vol.24 , pp. 358-369
    • Parsons, C.G.1    Danysz, W.2    Dekundy, A.3    Pulte, I.4
  • 129
    • 84908365360 scopus 로고    scopus 로고
    • Normal aging in rats and pathological aging in human Alzheimers disease decrease FAAH activity: Modulation by cannabinoid agonists
    • Pascual AC, Martin-Moreno AM, Giusto NM, de Ceballos ML, Pasquare SJ (2014). Normal aging in rats and pathological aging in human Alzheimers disease decrease FAAH activity: modulation by cannabinoid agonists. Exp Gerontol 60:92-99.
    • (2014) Exp Gerontol , vol.60 , pp. 92-99
    • Pascual, A.C.1    Martin-Moreno, A.M.2    Giusto, N.M.3    De Ceballos, M.L.4    Pasquare, S.J.5
  • 130
    • 38749148061 scopus 로고    scopus 로고
    • The cannabinoid receptor agonist nabilone for the treatment of dementia-related agitation
    • Passmore MJ (2008). The cannabinoid receptor agonist nabilone for the treatment of dementia-related agitation. Int J Geriatr Psychiatry 23:116-117.
    • (2008) Int J Geriatr Psychiatry , vol.23 , pp. 116-117
    • Passmore, M.J.1
  • 132
    • 1642417657 scopus 로고    scopus 로고
    • Di Marzo V, editor. Cannabinoids. New York, NY: Kluwer Academic/Plenum Publishers
    • Pertwee RG (2004). The pharmacology and therapeutic potential of cannabidiol. In: Di Marzo V, editor. Cannabinoids. New York, NY: Kluwer Academic/ Plenum Publishers. pp. 1-52.
    • (2004) The Pharmacology and Therapeutic Potential of Cannabidiol , pp. 1-52
    • Pertwee, R.G.1
  • 133
    • 12744258029 scopus 로고    scopus 로고
    • Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
    • Pertwee RG (2005). Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci 76:1307-1324.
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 134
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
    • Pertwee RG (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 153:199-215.
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 135
    • 0037027935 scopus 로고    scopus 로고
    • (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens
    • Pertwee RG, Ross RA, Craib SJ, Thomas A (2002). (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. Eur J Pharmacol 456:99-106.
    • (2002) Eur J Pharmacol , vol.456 , pp. 99-106
    • Pertwee, R.G.1    Ross, R.A.2    Craib, S.J.3    Thomas, A.4
  • 136
    • 0032577340 scopus 로고    scopus 로고
    • Complex pharmacology of natural cannabinoids: Evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
    • Petitet F, Jeantaud B, Reibaud M, Imperato A, Dubroeucq MC (1998). Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci 63:PL1-PL6.
    • (1998) Life Sci , vol.63 , pp. PL1-PL6
    • Petitet, F.1    Jeantaud, B.2    Reibaud, M.3    Imperato, A.4    Dubroeucq, M.C.5
  • 137
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides
    • Phiel CJ, Wilson CA, Lee VM, Klein PS (2003). GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides. Nature 423:435-439.
    • (2003) Nature , vol.423 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.3    Klein, P.S.4
  • 138
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • Piomelli D (2003). The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873-884.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 140
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimers disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • Ramirez BG, Blazquez C, Gomez del Pulgar T, Guzman M, de Ceballos ML (2005). Prevention of Alzheimers disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci 25:1904-1913.
    • (2005) J Neurosci , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez Del Pulgar, T.3    Guzman, M.4    De Ceballos, M.L.5
  • 141
    • 79960306559 scopus 로고    scopus 로고
    • Taming THC: Potential Cannabis synergy and phytocannabinoidterpenoid entourage effects
    • Russo EB (2011). Taming THC: potential Cannabis synergy and phytocannabinoidterpenoid entourage effects. Br J Pharmacol 163:1344-1364.
    • (2011) Br J Pharmacol , vol.163 , pp. 1344-1364
    • Russo, E.B.1
  • 142
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • Russo EB, Burnett A, Hall B, Parker KK (2005). Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 30:1037-1043.
    • (2005) Neurochem Res , vol.30 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 144
    • 0034495353 scopus 로고    scopus 로고
    • Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors
    • Satoh J, Kuroda Y (2000). Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors. Neuropathology 20:289-296.
    • (2000) Neuropathology , vol.20 , pp. 289-296
    • Satoh, J.1    Kuroda, Y.2
  • 145
    • 79955727727 scopus 로고    scopus 로고
    • The cholinergic system in aging and neuronal degeneration
    • Schliebs R, Arendt T (2011). The cholinergic system in aging and neuronal degeneration. Behav Brain Res 221:555-563.
    • (2011) Behav Brain Res , vol.221 , pp. 555-563
    • Schliebs, R.1    Arendt, T.2
  • 147
    • 57049085109 scopus 로고    scopus 로고
    • Memantine leads to behavioral improvement and amyloid reduction in Alzheimers-disease-model transgenic mice shown as by micromagnetic resonance imaging
    • Scholtzova H, Wadghiri YZ, Douadi M, Sigurdsson EM, Li YS, Quartermain D, et al. (2008). Memantine leads to behavioral improvement and amyloid reduction in Alzheimers-disease-model transgenic mice shown as by micromagnetic resonance imaging. J Neurosci Res 86:2784-2791.
    • (2008) J Neurosci Res , vol.86 , pp. 2784-2791
    • Scholtzova, H.1    Wadghiri, Y.Z.2    Douadi, M.3    Sigurdsson, E.M.4    Li, Y.S.5    Quartermain, D.6
  • 149
    • 84904262310 scopus 로고    scopus 로고
    • Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP + cells through PPAR' involvement
    • Scuderi C, Steardo L, Esposito G (2014). Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP + cells through PPAR? involvement. Phytother Res 28:1007-1013.
    • (2014) Phytother Res , vol.28 , pp. 1007-1013
    • Scuderi, C.1    Steardo, L.2    Esposito, G.3
  • 150
    • 84870574017 scopus 로고    scopus 로고
    • CB2 receptor and amyloid pathology in frontal cortex of Alzheimers disease patients
    • Solas M, Francis PT, Franco R, Ramirez MJ (2013). CB2 receptor and amyloid pathology in frontal cortex of Alzheimers disease patients. Neurobiol Aging 34:805-808.
    • (2013) Neurobiol Aging , vol.34 , pp. 805-808
    • Solas, M.1    Francis, P.T.2    Franco, R.3    Ramirez, M.J.4
  • 151
    • 84964315511 scopus 로고    scopus 로고
    • A protocol for the delivery of cannabidiol (CBD) and combined CBD and 9-tetrahydrocannabinol (THC) by vaporisation
    • Solowij N, Broyd SJ, van Hell HH, Hazekamp A (2014). A protocol for the delivery of cannabidiol (CBD) and combined CBD and 9-tetrahydrocannabinol (THC) by vaporisation. BMC Pharmacol Toxicol 15:58.
    • (2014) BMC Pharmacol Toxicol , vol.15 , pp. 58
    • Solowij, N.1    Broyd, S.J.2    Van Hell, H.H.3    Hazekamp, A.4
  • 153
    • 0028981873 scopus 로고
    • Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells
    • Sperber BR, Leight S, Goedert M, Lee VM (1995). Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells. Neurosci Lett 197:149-153.
    • (1995) Neurosci Lett , vol.197 , pp. 149-153
    • Sperber, B.R.1    Leight, S.2    Goedert, M.3    Lee, V.M.4
  • 154
    • 77954406421 scopus 로고    scopus 로고
    • Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
    • Stella N (2010). Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia 58:1017-1030.
    • (2010) Glia , vol.58 , pp. 1017-1030
    • Stella, N.1
  • 155
    • 0030870722 scopus 로고    scopus 로고
    • A second endogenous cannabinoid that modulates long-term potentiation
    • Stella N, Schweitzer P, Piomelli D (1997). A second endogenous cannabinoid that modulates long-term potentiation. Nature 388:773-778.
    • (1997) Nature , vol.388 , pp. 773-778
    • Stella, N.1    Schweitzer, P.2    Piomelli, D.3
  • 157
    • 3042845492 scopus 로고    scopus 로고
    • Microglia and Alzheimers disease pathogenesis
    • Streit WJ (2004). Microglia and Alzheimers disease pathogenesis. J Neurosci Res 77:1-8.
    • (2004) J Neurosci Res , vol.77 , pp. 1-8
    • Streit, W.J.1
  • 158
    • 84881542568 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 deficiency in a mouse model of Alzheimers disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
    • Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, et al. (2013). Cannabinoid receptor 1 deficiency in a mouse model of Alzheimers disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition. Neurobiol Aging 34:2574-2584.
    • (2013) Neurobiol Aging , vol.34 , pp. 2574-2584
    • Stumm, C.1    Hiebel, C.2    Hanstein, R.3    Purrio, M.4    Nagel, H.5    Conrad, A.6
  • 159
    • 77956322561 scopus 로고    scopus 로고
    • Neurotoxicity by microglia: Mechanisms and potential therapeutic strategy
    • Takeuchi H (2010). Neurotoxicity by microglia: Mechanisms and potential therapeutic strategy. Clin Exp Immunol 1:12-21.
    • (2010) Clin Exp Immunol , vol.1 , pp. 12-21
    • Takeuchi, H.1
  • 160
    • 77954177664 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: An overview
    • Tanasescu R, Constantinescu CS (2010). Cannabinoids and the immune system: an overview. Immunobiology 215:588-597.
    • (2010) Immunobiology , vol.215 , pp. 588-597
    • Tanasescu, R.1    Constantinescu, C.S.2
  • 161
    • 76449102392 scopus 로고    scopus 로고
    • A GPCR/secretase complex regulates beta-and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis
    • Teng L, Zhao J, Wang F, Ma L, Pei G (2010). A GPCR/secretase complex regulates beta-and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis. Cell Res 20:138-153.
    • (2010) Cell Res , vol.20 , pp. 138-153
    • Teng, L.1    Zhao, J.2    Wang, F.3    Ma, L.4    Pei, G.5
  • 163
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG (2007). Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol 150:613-623.
    • (2007) Br J Pharmacol , vol.150 , pp. 613-623
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3    Razdan, R.K.4    Ross, R.A.5    Pertwee, R.G.6
  • 164
    • 67651121672 scopus 로고    scopus 로고
    • The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
    • Tolon RM, Nunez E, Pazos MR, Benito C, Castillo AI, Martinez-Orgado JA, Romero J (2009). The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages. Brain Res 1283:148-154.
    • (2009) Brain Res , vol.1283 , pp. 148-154
    • Tolon, R.M.1    Nunez, E.2    Pazos, M.R.3    Benito, C.4    Castillo, A.I.5    Martinez-Orgado, J.A.6    Romero, J.7
  • 165
    • 77953530404 scopus 로고    scopus 로고
    • Regulation of cholesterol efflux by amyloid beta secretion
    • Umeda T, Mori H, Zheng H, Tomiyama T (2010). Regulation of cholesterol efflux by amyloid beta secretion. J Neurosci Res 88:1985-1994.
    • (2010) J Neurosci Res , vol.88 , pp. 1985-1994
    • Umeda, T.1    Mori, H.2    Zheng, H.3    Tomiyama, T.4
  • 166
    • 33745327044 scopus 로고    scopus 로고
    • Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: Effect of pharmacological elevation of endocannabinoid levels
    • Van der Stelt M, Mazzola C, Esposito G, Matias I, Petrosino S, de Filippis D, et al. (2006). Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. Cell Mol Life Sci 63:1410-1424.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1410-1424
    • Van Der Stelt, M.1    Mazzola, C.2    Esposito, G.3    Matias, I.4    Petrosino, S.5    De Filippis, D.6
  • 168
    • 0030886734 scopus 로고    scopus 로고
    • Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimers disease
    • Volicer L, Stelly M, Morris J, McLaughlin J, Volicer BJ (1997). Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimers disease. Int J Geriatr Psychiatry 12:913-919.
    • (1997) Int J Geriatr Psychiatry , vol.12 , pp. 913-919
    • Volicer, L.1    Stelly, M.2    Morris, J.3    McLaughlin, J.4    Volicer, B.J.5
  • 169
    • 77953796878 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis
    • Wade DT, Collin C, Stott C, Duncombe P (2010). Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Mult Scler 16:707-714.
    • (2010) Mult Scler , vol.16 , pp. 707-714
    • Wade, D.T.1    Collin, C.2    Stott, C.3    Duncombe, P.4
  • 170
    • 1842611884 scopus 로고    scopus 로고
    • Cannabinoids and neuroinflammation
    • Walter L, Stella N (2004). Cannabinoids and neuroinflammation. Br J Pharmacol 141:775-785.
    • (2004) Br J Pharmacol , vol.141 , pp. 775-785
    • Walter, L.1    Stella, N.2
  • 171
    • 0037442829 scopus 로고    scopus 로고
    • Nonpsychotropic cannabinoid receptors regulate microglial cell migration
    • Walter L, Franklin A, Witting A, Wade C, Xie Y, Kunos G, et al. (2003). Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci 23:1398-1405.
    • (2003) J Neurosci , vol.23 , pp. 1398-1405
    • Walter, L.1    Franklin, A.2    Witting, A.3    Wade, C.4    Xie, Y.5    Kunos, G.6
  • 172
    • 33645453054 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
    • Walther S, Mahlberg R, Eichmann U, Kunz D (2006). Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia. Psychopharmacology (Berl) 185:524-528.
    • (2006) Psychopharmacology (Berl) , vol.185 , pp. 524-528
    • Walther, S.1    Mahlberg, R.2    Eichmann, U.3    Kunz, D.4
  • 173
    • 79952390569 scopus 로고    scopus 로고
    • Randomized, controlled crossover trial of dronabinol, 2.5 mg, for agitation in 2 patients with dementia
    • Walther S, Schupbach B, Seifritz E, Homan P, Strik W (2011). Randomized, controlled crossover trial of dronabinol, 2.5 mg, for agitation in 2 patients with dementia. J Clin Psychopharmacol 31:256-258.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 256-258
    • Walther, S.1    Schupbach, B.2    Seifritz, E.3    Homan, P.4    Strik, W.5
  • 174
    • 0029745360 scopus 로고    scopus 로고
    • Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids
    • Watanabe K, Kayano Y, Matsunaga T, Yamamoto I, Yoshimura H (1996). Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids. Biol Pharm Bull 19:1109-1111.
    • (1996) Biol Pharm Bull , vol.19 , pp. 1109-1111
    • Watanabe, K.1    Kayano, Y.2    Matsunaga, T.3    Yamamoto, I.4    Yoshimura, H.5
  • 175
    • 0027948317 scopus 로고
    • Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimers brains
    • Westlake TM, Howlett AC, Bonner TI, Matsuda LA, Herkenham M (1994). Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimers brains. Neuroscience 63:637-652.
    • (1994) Neuroscience , vol.63 , pp. 637-652
    • Westlake, T.M.1    Howlett, A.C.2    Bonner, T.I.3    Matsuda, L.A.4    Herkenham, M.5
  • 176
    • 0032860394 scopus 로고    scopus 로고
    • Cannabinoid ligands and their effects on learning and performance in rhesus monkeys
    • Winsauer PJ, Lambert P, Moerschbaecher JM (1999). Cannabinoid ligands and their effects on learning and performance in rhesus monkeys. Behav Pharmacol 10:497-511.
    • (1999) Behav Pharmacol , vol.10 , pp. 497-511
    • Winsauer, P.J.1    Lambert, P.2    Moerschbaecher, J.M.3
  • 177
    • 77953565298 scopus 로고    scopus 로고
    • Cannabinoid receptor CB1 mediates baseline and activityinduced survival of new neurons in adult hippocampal neurogenesis
    • Wolf SA, Bick-Sander A, Fabel K, Leal-Galicia P, Tauber S, Ramirez-Rodriguez G, et al. (2010). Cannabinoid receptor CB1 mediates baseline and activityinduced survival of new neurons in adult hippocampal neurogenesis. Cell Commun Signal 8:12.
    • (2010) Cell Commun Signal , vol.8 , pp. 12
    • Wolf, S.A.1    Bick-Sander, A.2    Fabel, K.3    Leal-Galicia, P.4    Tauber, S.5    Ramirez-Rodriguez, G.6
  • 178
    • 65249116483 scopus 로고    scopus 로고
    • Tau mutations in neurodegenerative diseases
    • Wolfe MS (2009). Tau mutations in neurodegenerative diseases. J Biol Chem 284:6021-6025.
    • (2009) J Biol Chem , vol.284 , pp. 6021-6025
    • Wolfe, M.S.1
  • 179
    • 84870489074 scopus 로고    scopus 로고
    • Activation of the CB2 receptor system reverses amyloid-induced memory deficiency
    • Wu J, Bie B, Yang H, Xu JJ, Brown DL, Naguib M (2013). Activation of the CB2 receptor system reverses amyloid-induced memory deficiency. Neurobiol Aging 34:791-804.
    • (2013) Neurobiol Aging , vol.34 , pp. 791-804
    • Wu, J.1    Bie, B.2    Yang, H.3    Xu, J.J.4    Brown, D.L.5    Naguib, M.6
  • 180
    • 0035696257 scopus 로고    scopus 로고
    • Do NSAIDs prevent Alzheimers disease? And, if so, why? the epidemiological evidence
    • Zandi PP, Breitner JC (2001). Do NSAIDs prevent Alzheimers disease? And, if so, why? The epidemiological evidence. Neurobiol Aging 22: 811-817.
    • (2001) Neurobiol Aging , vol.22 , pp. 811-817
    • Zandi, P.P.1    Breitner, J.C.2
  • 182
    • 0020509686 scopus 로고
    • Effects on variable-interval performance in rats of delta 9-tetrahydrocannabinol and cannabidiol, separately and in combination
    • Zuardi AW, Karniol IG (1983). Effects on variable-interval performance in rats of delta 9-tetrahydrocannabinol and cannabidiol, separately and in combination. Braz J Med Biol Res 16:141-146.
    • (1983) Braz J Med Biol Res , vol.16 , pp. 141-146
    • Zuardi, A.W.1    Karniol, I.G.2
  • 183
    • 0019460907 scopus 로고
    • Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol
    • Zuardi AW, Finkelfarb E, Bueno OF, Musty RE, Karniol IG (1981). Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. Arch Int Pharmacodyn Ther 249:137-146.
    • (1981) Arch Int Pharmacodyn Ther , vol.249 , pp. 137-146
    • Zuardi, A.W.1    Finkelfarb, E.2    Bueno, O.F.3    Musty, R.E.4    Karniol, I.G.5
  • 184
    • 0025876938 scopus 로고
    • Effects of cannabidiol in animal models predictive of antipsychotic activity
    • Zuardi AW, Rodrigues JA, Cunha JM (1991). Effects of cannabidiol in animal models predictive of antipsychotic activity. Psychopharmacology (Berl) 104:260-264.
    • (1991) Psychopharmacology (Berl) , vol.104 , pp. 260-264
    • Zuardi, A.W.1    Rodrigues, J.A.2    Cunha, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.