Cannabidiol - Transdermal delivery and anti-inflammatory effect in a murine model

Journal of Controlled Release

Volumn 93, Issue 3, 2003, Pages 377-387

  Lodzki, M ^a   Godin, B ^a   Rakou, L ^a   Mechoulam, R ^a   Gallily, R ^a   Touitou, E ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Anti inflammatory; Cannabinoids; Delivery system; Ethosomes; Rheumatoid arthritis; Transdermal

Indexed keywords

DIFFERENTIAL SCANNING CALORIMETRY; DISEASES; EUTECTICS; MICROSCOPIC EXAMINATION; MIXTURES; TRANSMISSION ELECTRON MICROSCOPY;

ETHOSOMAL CARRIERS; RHEUMATIC DISEASES;

DRUG PRODUCTS;

ANTIINFLAMMATORY AGENT; CANNABIDIOL; CARRAGEENAN; DRUG CARRIER; PHOSPHATIDYLCHOLINE; PHOSPHOLIPON 90;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG MIXTURE; DRUG SCREENING; EDEMA; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; SKIN; SKIN PENETRATION; STEADY STATE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0344009662     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2003.09.001     Document Type: Article

References (27)

1. Malfait A.M., Gallily R., Sumariwalla P.F., Andreakos E., Mechoulam R., Feldmann M. The nonpsychoactive cannabis-constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. 97:2000;9561-9566.
2. Straus S.E. Immunoactive cannabinoids: therapeutic prospects for marijuana constituents. Proc. Natl. Acad. Sci. 97:2000;9363-9364.
3. Cunha J.M., Carlini E.A., Pereira A.E., Ramos O.L., Pimentel C., Gagliardi R., Santivo W.L., Lander N., Mechoulam R. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology. 21:1980;175-185.
4. Consore P., Kennedy K., Schram K. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacol. Biochem. Behav. 40:1991;517-522.
5. Samara E., Bialer M., Mechoulam R. Pharmacokinetics of cannabidiol in dogs. Drug. Metab. Dispos. 16:1987;469-472.
6. Interactive LogKow (KowWin) Demo (http://esc.syrres.com/interkow/kowdemo. htm).
7. Barry B.W. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur. J. Pharm. Sci. 14:2001;101-114.
8. Touitou E., Fabin B. Altered skin permeation of a highly lipophilic molecule. Int. J. Pharm. 43:1988;9-15.
9. Touitou E., Dayan N., Bergelson L., Godin B., Eliaz M. Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J. Control. Release. 65:2000;403-418.
10. Touitou E., Godin B., Weiss C. Enhanced delivery of drugs into and across the skin by ethosomal carriers. Drug Dev. Res. 50:2000;406-412.
11. Chiou W.L., Riegelman S. Pharmaceutical applications of solid dispersion systems. J. Pharm. Sci. 60:1971;1281-1302.
12. Kaplun-Frischoff Y., Touitou E. Testosterone skin permeation enhancement by menthol through formation of eutectic with drug and interaction with skin lipids. J. Pharm. Sci. 86:1997;1394-1399.
13. Samara E., Bialer M. Rapid HPLC assay with pharmacokinetic applications for monitoring cannabidiol in plasma. J. Chromatogr. Biomed. Appl. 416:1987;370-374.
14. 2. Br. J. Pharmacol. 126:1999;301-311.
15. Sammons M., Raval P., Davey P., Rogers D., Parsons A.A., Bingham S. Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway. Brain Res. 87:2000;48-54.
16. Blais C., Couture R., Drapeau G., Colman R.W., Adam A. Involvement of endogenous kinins in the pathogenesis of peptidoglycan-induced arthritis in the Lewis rat. Arthritis Rheum. 40:1997;1327-1333.
17. Windholz M. The Merck Index. 10th ed. 1983;Merck and Company, New Jersey, USA. (monograph 1723).
18. Bach D., Raz A., Goldman R. The effect of hashish compounds on phospholipid phase transition. Biochim. Biophys. Acta. 436:1976;889-894.
19. 2H-NMR. Biochim. Biophys. Acta. 1103:1992;25-36.
20. Bruggemann E.P., Melchior D.L. Alternations in the organization of phosphatidylcholine/cholesterol bilayers by tetrahydrocannabinol. J. Biol. Chem. 258:1983;8297-8303.
21. Touitou E., Fabin B., Dany S., Almog S. Transdermal delivery of tetrahydrocannabinol. Int. J. Pharm. 43:1988;17-22.
22. B. Fabin, PhD thesis, The Hebrew University of Jerusalem, Jerusalem, Israel, 1994.
23. Yoo S.D., Fincher T.K., Holladay J.W. Mammary excretion of cannabidiol in rabbits after intravenous administration. J. Pharm. Pharmacol. 46:1994;926-928.
24. Ivanovska N., Hristova M., Philipov S. Complement modulatory activity of bisbenzylisoquinoline alkaloids isolated from isopyrum thalictroides - II. Influence on C3-9 reactions in vitro and anti-inflammatory effect in vivo. Int. J. Immunopharmacol. 21:1999;337-347.
25. Sammons M., Raval P., Bingham S., Davey P., Parsons A.A. A method for determining thermal hyperalgesia and inflammation in the mouse hind paw. Br. J. Pharmacol. 122:1997;334.
26. Vinegar R., Truax J.F., Selph J.L., Johnston P.R., Venable A.L., McKenzie K.K. Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed. Proc. 46:1987;118-126.
27. Diaz S., Specter S., Vanderhoek J.Y., Coffey R.G. The effect of delta-9-tetrahydrocannabinol on arachidonic acid metabolism in human peripheral blood mononuclear cells. J. Pharmacol. Exp. Ther. 268:1991;1289-1296.