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Volumn 172, Issue 3, 2015, Pages 737-753

Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

Author keywords

[No Author keywords available]

Indexed keywords

CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; DELTA9 TETRAHYDROCANNABIVARIN; ENDOCANNABINOID; RIMONABANT; UNCLASSIFIED DRUG; CANNABINOID RECEPTOR AFFECTING AGENT; DRONABINOL; TETRAHYDROCANNABIVARIN 9;

EID: 84920829439     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12944     Document Type: Review
Times cited : (414)

References (123)
  • 7
    • 0029664402 scopus 로고    scopus 로고
    • (-)-delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase
    • Bayewitch M, Rhee MH, Avidor-Reiss T, Breuer A, Mechoulam R, Vogel Z (1996). (-)-delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase. J Biol Chem 271: 9902-9905.
    • (1996) J Biol Chem , vol.271 , pp. 9902-9905
    • Bayewitch, M.1    Rhee, M.H.2    Avidor-Reiss, T.3    Breuer, A.4    Mechoulam, R.5    Vogel, Z.6
  • 11
    • 69949093374 scopus 로고    scopus 로고
    • Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception
    • Booker L, Naidu PS, Razdan RK, Mahadevan A, Lichtman AH (2009). Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception. Drug Alcohol Depend 105: 42-47.
    • (2009) Drug Alcohol Depend , vol.105 , pp. 42-47
    • Booker, L.1    Naidu, P.S.2    Razdan, R.K.3    Mahadevan, A.4    Lichtman, A.H.5
  • 12
    • 0019604336 scopus 로고
    • Discriminative stimulus properties of delta 9-tetrahydrocannabinol: Mechanistic studies
    • Browne RG, Weissman A (1981). Discriminative stimulus properties of delta 9-tetrahydrocannabinol: mechanistic studies. J Clin Pharmacol 21: 227S-234S.
    • (1981) J Clin Pharmacol , vol.21 , pp. 227S-234S
    • Browne, R.G.1    Weissman, A.2
  • 13
    • 46649094780 scopus 로고    scopus 로고
    • Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
    • Campos AC, Guimaraes FS (2008). Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl) 199: 223-230.
    • (2008) Psychopharmacology (Berl) , vol.199 , pp. 223-230
    • Campos, A.C.1    Guimaraes, F.S.2
  • 14
    • 71549171421 scopus 로고    scopus 로고
    • Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids
    • Campos AC, Guimaraes FS (2009). Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. Prog Neuropsychopharmacol Biol Psychiatry 33: 1517-1521.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 1517-1521
    • Campos, A.C.1    Guimaraes, F.S.2
  • 15
    • 84877156654 scopus 로고    scopus 로고
    • Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats
    • Campos AC, de Paula Soares V, Carvalho MC, Ferreira FR, Vicente MA, Brandão ML et al. (2013). Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. Psychopharmacology (Berl) 226: 13-24.
    • (2013) Psychopharmacology (Berl) , vol.226 , pp. 13-24
    • Campos, A.C.1    De Paula Soares, V.2    Carvalho, M.C.3    Ferreira, F.R.4    Vicente, M.A.5    Brandão, M.L.6
  • 16
    • 84878644758 scopus 로고    scopus 로고
    • The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system
    • Campos AC, Ortega Z, Palazuelos J, Fogac¸a MV, Aguiar DC, Díaz-Alonso J et al. (2013). The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Int J Neuropsychopharmacol 16: 1407-1419.
    • (2013) Int J Neuropsychopharmacol , vol.16 , pp. 1407-1419
    • Campos, A.C.1    Ortega, Z.2    Palazuelos, J.3    Fogac¸a, M.V.4    Aguiar, D.C.5    Díaz-Alonso, J.6
  • 17
    • 72749107868 scopus 로고    scopus 로고
    • The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
    • Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J (2010). The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiol Dis 37: 434-440.
    • (2010) Neurobiol Dis , vol.37 , pp. 434-440
    • Castillo, A.1    Tolón, M.R.2    Fernández-Ruiz, J.3    Romero, J.4    Martinez-Orgado, J.5
  • 19
  • 20
    • 0019836219 scopus 로고
    • A critical review of the safety and antiemetic efficacy of delta-9-tetrahydrocannabinol
    • Cocchetto DM, Cook LF, Cato AE (1981). A critical review of the safety and antiemetic efficacy of delta-9-tetrahydrocannabinol. Drug Intell Clin Pharm 15: 867-875.
    • (1981) Drug Intell Clin Pharm , vol.15 , pp. 867-875
    • Cocchetto, D.M.1    Cook, L.F.2    Cato, A.E.3
  • 21
    • 50149114700 scopus 로고    scopus 로고
    • Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: Mechanisms involved
    • Comelli F, Giagnoni G, Bettoni I, Colleoni M, Costa B (2008). Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved. Phytother Res 22: 1017-1024.
    • (2008) Phytother Res , vol.22 , pp. 1017-1024
    • Comelli, F.1    Giagnoni, G.2    Bettoni, I.3    Colleoni, M.4    Costa, B.5
  • 22
    • 4744372178 scopus 로고    scopus 로고
    • Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
    • Costa B, Giagnoni G, Franke C, Trovato AE, Colleoni M (2004). Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. Br J Pharmacol 143: 247-250.
    • (2004) Br J Pharmacol , vol.143 , pp. 247-250
    • Costa, B.1    Giagnoni, G.2    Franke, C.3    Trovato, A.E.4    Colleoni, M.5
  • 23
    • 79960328574 scopus 로고    scopus 로고
    • Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
    • De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S et al. (2011). Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol 163: 1479-1494.
    • (2011) Br J Pharmacol , vol.163 , pp. 1479-1494
    • De Petrocellis, L.1    Ligresti, A.2    Moriello, A.S.3    Allarà, M.4    Bisogno, T.5    Petrosino, S.6
  • 24
    • 84856628201 scopus 로고    scopus 로고
    • 9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour
    • 9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour. Psychopharmacology (Berl) 219: 859-873.
    • (2012) Psychopharmacology (Berl) , vol.219 , pp. 859-873
    • Deiana, S.1    Watanabe, A.2    Yamasaki, Y.3    Amada, N.4    Arthur, M.5    Fleming, S.6
  • 25
    • 79952696792 scopus 로고    scopus 로고
    • Diminished gray matter in the hippocampus of cannabis users: Possible protective effects of cannabidiol
    • Demirakca T, Sartorius A, Ende G, Meyer N, Welzel H, Skopp G et al. (2011). Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol. Drug Alcohol Depend 114: 242-245.
    • (2011) Drug Alcohol Depend , vol.114 , pp. 242-245
    • Demirakca, T.1    Sartorius, A.2    Ende, G.3    Meyer, N.4    Welzel, H.5    Skopp, G.6
  • 27
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di Marzo V (2008). Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 7: 438-455.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 28
    • 78649387224 scopus 로고    scopus 로고
    • Anandamide serves two masters in the brain
    • Di Marzo V (2010). Anandamide serves two masters in the brain. Nat Neurosci 13: 1446-1448.
    • (2010) Nat Neurosci , vol.13 , pp. 1446-1448
    • Di Marzo, V.1
  • 29
    • 0032401036 scopus 로고    scopus 로고
    • Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action
    • Di Marzo V, Melck D, Bisogno T, De Petrocellis L (1998). Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci 21: 521-528.
    • (1998) Trends Neurosci , vol.21 , pp. 521-528
    • Di Marzo, V.1    Melck, D.2    Bisogno, T.3    De Petrocellis, L.4
  • 31
    • 0034023862 scopus 로고    scopus 로고
    • The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors
    • El Yacoubi M, Ledent C, Ménard JF, Parmentier M, Costentin J, Vaugeois JM (2000). The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors. Br J Pharmacol 129: 1465-1473.
    • (2000) Br J Pharmacol , vol.129 , pp. 1465-1473
    • El Yacoubi, M.1    Ledent, C.2    Ménard, J.F.3    Parmentier, M.4    Costentin, J.5    Vaugeois, J.M.6
  • 32
    • 84871534813 scopus 로고    scopus 로고
    • Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment
    • Englund A, Morrison PD, Nottage J, Hague D, Kane F, Bonaccorso S et al. (2013). Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol 27: 19-27.
    • (2013) J Psychopharmacol , vol.27 , pp. 19-27
    • Englund, A.1    Morrison, P.D.2    Nottage, J.3    Hague, D.4    Kane, F.5    Bonaccorso, S.6
  • 33
    • 9644302602 scopus 로고    scopus 로고
    • Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats
    • Fadda P, Robinson L, Fratta W, Pertwee RG, Riedel G (2004). Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. Neuropharmacology 47: 1170-1179.
    • (2004) Neuropharmacology , vol.47 , pp. 1170-1179
    • Fadda, P.1    Robinson, L.2    Fratta, W.3    Pertwee, R.G.4    Riedel, G.5
  • 35
    • 33947489961 scopus 로고
    • Isolation, structure, and partial synthesis of an active constituent of hashish
    • Gaoni Y, Mechoulam R (1964). Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc 86: 1646-1647.
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 37
    • 0014940443 scopus 로고
    • Preliminary experiments on the chemistry and pharmacology of Cannabis
    • Gill EW, Paton WDM, Pertwee RG (1970). Preliminary experiments on the chemistry and pharmacology of Cannabis. Nature 228: 134-136.
    • (1970) Nature , vol.228 , pp. 134-136
    • Gill, E.W.1    Paton, W.D.M.2    Pertwee, R.G.3
  • 39
    • 79952486586 scopus 로고    scopus 로고
    • The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors
    • Gomes FV, Resstel LB, Guimarães FS (2011). The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors. Psychopharmacology (Berl) 213: 465-473.
    • (2011) Psychopharmacology (Berl) , vol.213 , pp. 465-473
    • Gomes, F.V.1    Resstel, L.B.2    Guimarães, F.S.3
  • 40
    • 84880360557 scopus 로고    scopus 로고
    • Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice
    • Gomes FV, Del Bel EA, Guimarães FS (2013). Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice. Prog Neuropsychopharmacol Biol Psychiatry 46: 43-47.
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.46 , pp. 43-47
    • Gomes, F.V.1    Del Bel, E.A.2    Guimarães, F.S.3
  • 42
    • 33749242498 scopus 로고    scopus 로고
    • The development of Sativex - A natural cannabis-based medicine
    • Mechoulam R (ed.). Birkhäuser Verlag: Basel
    • Guy GW, Stott CG (2005) The development of Sativex - a natural cannabis-based medicine. In: Mechoulam R (ed.). Cannabinoids as Therapeutics. Birkhäuser Verlag: Basel, pp. 231-263.
    • (2005) Cannabinoids As Therapeutics , pp. 231-263
    • Guy, G.W.1    Stott, C.G.2
  • 43
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D (1998). Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A 95: 8268-8273.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 44
    • 62249219871 scopus 로고    scopus 로고
    • Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids
    • Hanuš L (2008). Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Med Res Rev 29: 213-271.
    • (2008) Med Res Rev , vol.29 , pp. 213-271
    • Hanuš, L.1
  • 45
    • 37349071370 scopus 로고    scopus 로고
    • Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism
    • Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K et al. (2008). Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain Res 1188: 157-164.
    • (2008) Brain Res , vol.1188 , pp. 157-164
    • Hayakawa, K.1    Mishima, K.2    Hazekawa, M.3    Sano, K.4    Irie, K.5    Orito, K.6
  • 48
    • 0015862930 scopus 로고
    • Cannabidiol and cannabinol in man
    • Hollister LE (1973). Cannabidiol and cannabinol in man. Experientia 29: 825-826.
    • (1973) Experientia , vol.29 , pp. 825-826
    • Hollister, L.E.1
  • 49
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • Hopkins AL (2008). Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4: 682-690.
    • (2008) Nat Chem Biol , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 50
    • 0024465469 scopus 로고
    • Regulation of adenylate cyclase by cannabinoid drugs. Insights based n thermodynamic studies
    • Howlett AC, Scott DK, Wilken GH (1989). Regulation of adenylate cyclase by cannabinoid drugs. Insights based n thermodynamic studies. Biochem Pharmacol 38: 3297-3304.
    • (1989) Biochem Pharmacol , vol.38 , pp. 3297-3304
    • Howlett, A.C.1    Scott, D.K.2    Wilken, G.H.3
  • 51
    • 26044436588 scopus 로고    scopus 로고
    • Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids
    • Ilan AB, Gevins A, Coleman M, ElSohly MA, de Wit H (2005). Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids. Behav Pharmacol 16: 487-496.
    • (2005) Behav Pharmacol , vol.16 , pp. 487-496
    • Ilan, A.B.1    Gevins, A.2    Coleman, M.3    ElSohly, M.A.4    De Wit, H.5
  • 52
    • 70349189518 scopus 로고    scopus 로고
    • Non-psychotropic plant cannabinoids: New therapeutic opportunities from an ancient herb
    • Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R (2009). Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 30: 515-527.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3    Di Marzo, V.4    Mechoulam, R.5
  • 54
    • 77952593814 scopus 로고    scopus 로고
    • The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
    • Jamontt JM, Molleman A, Pertwee RG, Parsons ME (2010). The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. Br J Pharmacol 160: 712-723.
    • (2010) Br J Pharmacol , vol.160 , pp. 712-723
    • Jamontt, J.M.1    Molleman, A.2    Pertwee, R.G.3    Parsons, M.E.4
  • 55
    • 0017623057 scopus 로고
    • Delta9-THC as a discriminative cue in pigeons: Effects of delta8-THC, CBD, and CBN
    • Järbe TU, Henriksson BG, Ohlin GC (1977). Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN. Arch Int Pharmacodyn Ther 228: 68-72.
    • (1977) Arch Int Pharmacodyn Ther , vol.228 , pp. 68-72
    • Järbe, T.U.1    Henriksson, B.G.2    Ohlin, G.C.3
  • 56
    • 0029790065 scopus 로고    scopus 로고
    • Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation
    • Jeon YJ, Yang KH, Pulaski JT, Kaminski NE (1996). Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation. Mol Pharmacol 50: 334-341.
    • (1996) Mol Pharmacol , vol.50 , pp. 334-341
    • Jeon, Y.J.1    Yang, K.H.2    Pulaski, J.T.3    Kaminski, N.E.4
  • 57
    • 75949093107 scopus 로고    scopus 로고
    • Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
    • Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT (2010). Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. J Pain Symptom Manage 39: 167-179.
    • (2010) J Pain Symptom Manage , vol.39 , pp. 167-179
    • Johnson, J.R.1    Burnell-Nugent, M.2    Lossignol, D.3    Ganae-Motan, E.D.4    Potts, R.5    Fallon, M.T.6
  • 58
    • 84860685529 scopus 로고    scopus 로고
    • Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
    • Jones NA, Glyn SE, Akiyama S, Hill TD, Hill AJ, Weston SE et al. (2012). Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure 21: 344-352.
    • (2012) Seizure , vol.21 , pp. 344-352
    • Jones, N.A.1    Glyn, S.E.2    Akiyama, S.3    Hill, T.D.4    Hill, A.J.5    Weston, S.E.6
  • 59
    • 78650968528 scopus 로고    scopus 로고
    • Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration
    • Karschner EL, Darwin WD, Goodwin RS, Wright S, Huestis MA (2011a). Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration. Clin Chem 57: 66-75.
    • (2011) Clin Chem , vol.57 , pp. 66-75
    • Karschner, E.L.1    Darwin, W.D.2    Goodwin, R.S.3    Wright, S.4    Huestis, M.A.5
  • 61
    • 82955233174 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
    • 9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology (Berl) 218: 443-457.
    • (2011) Psychopharmacology (Berl) , vol.218 , pp. 443-457
    • Klein, C.1    Karanges, E.2    Spiro, A.3    Wong, A.4    Spencer, J.5    Huynh, T.6
  • 62
    • 0037160078 scopus 로고    scopus 로고
    • Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    • Kozak KR, Crews BC, Morrow JD, Wang LH, Ma YH, Weinander R et al. (2002). Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277: 44877-44885.
    • (2002) J Biol Chem , vol.277 , pp. 44877-44885
    • Kozak, K.R.1    Crews, B.C.2    Morrow, J.D.3    Wang, L.H.4    Ma, Y.H.5    Weinander, R.6
  • 63
    • 76249095734 scopus 로고    scopus 로고
    • Cannabinoids delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells
    • Kozela E, Pietr M, Juknat A, Rimmerman N, Levy R, Vogel Z (2010). Cannabinoids delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells. J Biol Chem 285: 1616-1626.
    • (2010) J Biol Chem , vol.285 , pp. 1616-1626
    • Kozela, E.1    Pietr, M.2    Juknat, A.3    Rimmerman, N.4    Levy, R.5    Vogel, Z.6
  • 64
    • 76649127707 scopus 로고    scopus 로고
    • Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists
    • Lerner TN, Horne EA, Stella N, Kreitzer AC (2010). Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. J Neurosci 30: 2160-2164.
    • (2010) J Neurosci , vol.30 , pp. 2160-2164
    • Lerner, T.N.1    Horne, E.A.2    Stella, N.3    Kreitzer, A.C.4
  • 66
    • 84858391237 scopus 로고    scopus 로고
    • Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
    • Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C et al. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry 2: e94.
    • (2012) Transl Psychiatry , vol.2 , pp. e94
    • Leweke, F.M.1    Piomelli, D.2    Pahlisch, F.3    Muhl, D.4    Gerth, C.W.5    Hoyer, C.6
  • 67
    • 68049137869 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC et al. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6: e1000100.
    • (2009) PLoS Med , vol.6 , pp. e1000100
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3    Mulrow, C.4    Gotzsche, P.C.5
  • 69
    • 84898012521 scopus 로고
    • The action of chemical components of cannabis extracts
    • Loewe WS, Modell W (1941). The action of chemical components of cannabis extracts. J Pharmacol Exp Ther 72: 27.
    • (1941) J Pharmacol Exp Ther , vol.72 , pp. 27
    • Loewe, W.S.1    Modell, W.2
  • 71
    • 78651436142 scopus 로고    scopus 로고
    • Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
    • Maione S, Piscitelli F, Gatta L, Vita D, De Petrocellis L, Palazzo E et al. (2011). Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. Br J Pharmacol 162: 584-596.
    • (2011) Br J Pharmacol , vol.162 , pp. 584-596
    • Maione, S.1    Piscitelli, F.2    Gatta, L.3    Vita, D.4    De Petrocellis, L.5    Palazzo, E.6
  • 72
    • 67649274432 scopus 로고    scopus 로고
    • Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats
    • Malone DT, Jongejan D, Taylor DA (2009). Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. Pharmacol Biochem Behav 93: 91-96.
    • (2009) Pharmacol Biochem Behav , vol.93 , pp. 91-96
    • Malone, D.T.1    Jongejan, D.2    Taylor, D.A.3
  • 73
    • 73949139182 scopus 로고    scopus 로고
    • Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
    • Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, Lee J et al. (2010). Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer Ther 9: 180-189.
    • (2010) Mol Cancer Ther , vol.9 , pp. 180-189
    • Marcu, J.P.1    Christian, R.T.2    Lau, D.3    Zielinski, A.J.4    Horowitz, M.P.5    Lee, J.6
  • 74
    • 78650714744 scopus 로고    scopus 로고
    • Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission
    • Martire A, Tebano MT, Chiodi V, Ferreira SG, Cunha RA, Köfalvi A et al. (2011). Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission. J Neurochem 116: 273-280.
    • (2011) J Neurochem , vol.116 , pp. 273-280
    • Martire, A.1    Tebano, M.T.2    Chiodi, V.3    Ferreira, S.G.4    Cunha, R.A.5    Köfalvi, A.6
  • 76
    • 33644862386 scopus 로고    scopus 로고
    • The evolution of Cannabis and coevolution with the cannabinoid receptor - A hypothesis
    • Guy G, Robson R, Strong K, Whittle B (eds). Royal Society of Pharmacists: London
    • McPartland JM, Guy G (2004) The evolution of Cannabis and coevolution with the cannabinoid receptor - a hypothesis. In: Guy G, Robson R, Strong K, Whittle B (eds). The Medicinal Use of Cannabis. Royal Society of Pharmacists: London, pp. 71-102.
    • (2004) The Medicinal Use of Cannabis , pp. 71-102
    • McPartland, J.M.1    Guy, G.2
  • 77
    • 0033160865 scopus 로고    scopus 로고
    • Side effects of pharmaceuticals not elicited by comparable herbal medicines: The case of tetrahydrocannabinol and marijuana
    • McPartland JM, Pruitt PL (1999). Side effects of pharmaceuticals not elicited by comparable herbal medicines: the case of tetrahydrocannabinol and marijuana. Altern Ther Health Med 5: 57-62.
    • (1999) Altern Ther Health Med , vol.5 , pp. 57-62
    • McPartland, J.M.1    Pruitt, P.L.2
  • 78
    • 85071447718 scopus 로고    scopus 로고
    • Cannabis and cannabis extracts: Greater than the sum of their parts?
    • McPartland JM, Russo EB (2001). Cannabis and cannabis extracts: greater than the sum of their parts? J Cannabis Therapeutics 1: 103-132.
    • (2001) J Cannabis Therapeutics , vol.1 , pp. 103-132
    • McPartland, J.M.1    Russo, E.B.2
  • 79
    • 35648934575 scopus 로고    scopus 로고
    • Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: Interspecies differences
    • McPartland JM, Glass M, Pertwee RG (2007). Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences. Br J Pharmacol 152: 583-593.
    • (2007) Br J Pharmacol , vol.152 , pp. 583-593
    • McPartland, J.M.1    Glass, M.2    Pertwee, R.G.3
  • 83
    • 43749124214 scopus 로고    scopus 로고
    • Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
    • Morgan CJ, Curran HV (2008). Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis. Br J Psychiatry 192: 306-307.
    • (2008) Br J Psychiatry , vol.192 , pp. 306-307
    • Morgan, C.J.1    Curran, H.V.2
  • 84
    • 77954761129 scopus 로고    scopus 로고
    • Cannabidiol attenuates the appetitive effects of delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis
    • Morgan CJ, Freeman TP, Schafer GL, Curran HV (2010a). Cannabidiol attenuates the appetitive effects of delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. Neuropsychopharmacology 35: 1879-1885.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1879-1885
    • Morgan, C.J.1    Freeman, T.P.2    Schafer, G.L.3    Curran, H.V.4
  • 85
    • 77957687873 scopus 로고    scopus 로고
    • Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: Naturalistic study
    • Morgan CJ, Schafer G, Freeman TP, Curran HV (2010b). Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study. Br J Psychiatry 197: 285-290.
    • (2010) Br J Psychiatry , vol.197 , pp. 285-290
    • Morgan, C.J.1    Schafer, G.2    Freeman, T.P.3    Curran, H.V.4
  • 86
    • 2442640362 scopus 로고    scopus 로고
    • Effect of delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults
    • Nicholson AN, Turner C, Stone BM, Robson PJ (2004). Effect of delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol 24: 305-313.
    • (2004) J Clin Psychopharmacol , vol.24 , pp. 305-313
    • Nicholson, A.N.1    Turner, C.2    Stone, B.M.3    Robson, P.J.4
  • 87
    • 2342613658 scopus 로고    scopus 로고
    • Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 'N of 1' studies
    • Notcutt W, Price M, Miller R, Newport S, Phillips C, Simmons S et al. (2004). Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies. Anaesthesia 59: 440-452.
    • (2004) Anaesthesia , vol.59 , pp. 440-452
    • Notcutt, W.1    Price, M.2    Miller, R.3    Newport, S.4    Phillips, C.5    Simmons, S.6
  • 88
    • 84869121560 scopus 로고    scopus 로고
    • Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability
    • O'Brien LD, Wills KL, Segsworth B, Dashney B, Rock EM, Limebeer CL et al. (2013). Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability. Pharmacol Biochem Behav 103: 597-602.
    • (2013) Pharmacol Biochem Behav , vol.103 , pp. 597-602
    • O'Brien, L.D.1    Wills, K.L.2    Segsworth, B.3    Dashney, B.4    Rock, E.M.5    Limebeer, C.L.6
  • 89
    • 33750050803 scopus 로고    scopus 로고
    • Neuropathic pain and the endocannabinoid system in the dorsal raphe: Pharmacological treatment and interactions with the serotonergic system
    • Palazzo E, de Novellis V, Petrosino S, Marabese I, Vita D, Giordano C et al. (2006). Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system. Eur J Neurosci 24: 2011-2020.
    • (2006) Eur J Neurosci , vol.24 , pp. 2011-2020
    • Palazzo, E.1    De Novellis, V.2    Petrosino, S.3    Marabese, I.4    Vita, D.5    Giordano, C.6
  • 90
    • 84891791940 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY: An expert-driven knowledge base of drug targets and their ligands
    • Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP et al.; NC-IUPHAR (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucl. Acids Res. 42 (Database Issue): D1098-1106.
    • (2014) Nucl. Acids Res. , vol.42 , Issue.DATABASE ISSUE , pp. D1098-D1106
    • Pawson, A.J.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Alexander, S.P.5    Buneman, O.P.6    NC-IUPHAR7
  • 91
    • 1642417657 scopus 로고    scopus 로고
    • The pharmacology and therapeutic potential of cannabidiol
    • Di Marzo V (ed.). Kluwer Academic/Plenum Publishers: New York
    • Pertwee RG (2004) The pharmacology and therapeutic potential of cannabidiol. In: Di Marzo V (ed.). Cannabinoids. Kluwer Academic/Plenum Publishers: New York, pp. 32-83.
    • (2004) Cannabinoids , pp. 32-83
    • Pertwee, R.G.1
  • 92
    • 33644804271 scopus 로고    scopus 로고
    • The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
    • Pertwee RG (2005). The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J 7: E625-E654.
    • (2005) AAPS J , vol.7 , pp. E625-E654
    • Pertwee, R.G.1
  • 93
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
    • Pertwee RG (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 153: 199-215.
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 95
    • 78650120798 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB1 and CB2
    • Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2. Pharmacol Rev 62: 588-631.
    • (2010) Pharmacol Rev , vol.62 , pp. 588-631
    • Pertwee, R.G.1    Howlett, A.C.2    Abood, M.E.3    Alexander, S.P.4    Di Marzo, V.5    Elphick, M.R.6
  • 96
    • 0032577340 scopus 로고    scopus 로고
    • Complex pharmacology of natural cannabinoids: Evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
    • Petitet F, Jeantaud B, Reibaud M, Imperato A, Dubroeucq MC (1998). Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci 63: PL1-PL6.
    • (1998) Life Sci , vol.63 , pp. PL1-PL6
    • Petitet, F.1    Jeantaud, B.2    Reibaud, M.3    Imperato, A.4    Dubroeucq, M.C.5
  • 97
    • 46749129338 scopus 로고    scopus 로고
    • TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons
    • Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (2008). TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neuroscience 28: 6231-6238.
    • (2008) J Neuroscience , vol.28 , pp. 6231-6238
    • Qin, N.1    Neeper, M.P.2    Liu, Y.3    Hutchinson, T.L.4    Lubin, M.L.5    Flores, C.M.6
  • 98
    • 0036844185 scopus 로고    scopus 로고
    • Use of coefficient of variation in assessing variability of quantitative assays
    • Reed GF, Lynn F, Meade BD (2002). Use of coefficient of variation in assessing variability of quantitative assays. Clin Diagn Lab Immunol 9: 1235-1239.
    • (2002) Clin Diagn Lab Immunol , vol.9 , pp. 1235-1239
    • Reed, G.F.1    Lynn, F.2    Meade, B.D.3
  • 99
    • 0030756533 scopus 로고    scopus 로고
    • Cannabinol derivatives: Binding to cannabinoid receptors and inhibition of adenylylcyclase
    • Rhee MH, Vogel Z, Barg J, Bayewitch M, Levy R, Hanus L et al. (1997). Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. J Med Chem 40: 3228-3233.
    • (1997) J Med Chem , vol.40 , pp. 3228-3233
    • Rhee, M.H.1    Vogel, Z.2    Barg, J.3    Bayewitch, M.4    Levy, R.5    Hanus, L.6
  • 100
    • 67649856310 scopus 로고    scopus 로고
    • Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
    • Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L (2009). Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. Br J Pharmacol 156: 1154-1166.
    • (2009) Br J Pharmacol , vol.156 , pp. 1154-1166
    • Riedel, G.1    Fadda, P.2    McKillop-Smith, S.3    Pertwee, R.G.4    Platt, B.5    Robinson, L.6
  • 101
    • 84884554661 scopus 로고    scopus 로고
    • 9-tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats
    • 9-tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats. Br J Pharmacol 170: 671-678.
    • (2013) Br J Pharmacol , vol.170 , pp. 671-678
    • Rock, E.M.1    Sticht, M.A.2    Duncan, M.3    Stott, C.4    Parker, L.A.5
  • 102
    • 67349135787 scopus 로고    scopus 로고
    • Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects
    • Roser P, Gallinat J, Weinberg G, Juckel G, Gorynia I, Stadelmann AM (2009). Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects. Eur Arch Psychiatry Clin Neurosci 259: 284-292.
    • (2009) Eur Arch Psychiatry Clin Neurosci , vol.259 , pp. 284-292
    • Roser, P.1    Gallinat, J.2    Weinberg, G.3    Juckel, G.4    Gorynia, I.5    Stadelmann, A.M.6
  • 103
    • 28844489930 scopus 로고    scopus 로고
    • A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
    • Russo E, Guy GW (2006). A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Med Hypotheses 66: 234-246.
    • (2006) Med Hypotheses , vol.66 , pp. 234-246
    • Russo, E.1    Guy, G.W.2
  • 104
    • 3242768538 scopus 로고    scopus 로고
    • Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
    • Russo EB (2004). Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro Endocrinol Lett 25: 31-39.
    • (2004) Neuro Endocrinol Lett , vol.25 , pp. 31-39
    • Russo, E.B.1
  • 105
    • 79960306559 scopus 로고    scopus 로고
    • Taming THC: Potential cannabis synergy and phytocannabinoid-pterpenoid entourage effects
    • Russo EB (2011). Taming THC: potential cannabis synergy and phytocannabinoid-pterpenoid entourage effects. Br J Pharmacol 163: 1344-1364.
    • (2011) Br J Pharmacol , vol.163 , pp. 1344-1364
    • Russo, E.B.1
  • 106
    • 79960062773 scopus 로고    scopus 로고
    • Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease
    • Sagredo O, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernández-Ruiz J (2011). Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease. J Neurosci Res 89: 1509-1518.
    • (2011) J Neurosci Res , vol.89 , pp. 1509-1518
    • Sagredo, O.1    Pazos, M.R.2    Satta, V.3    Ramos, J.A.4    Pertwee, R.G.5    Fernández-Ruiz, J.6
  • 107
    • 0346057814 scopus 로고    scopus 로고
    • An optimized approach to study endocannabinoid signaling: Evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors
    • Savinainen JR, Saario SM, Niemi R, Järvinen T, Laitinen JT (2003). An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors. Br J Pharmacol 140: 1451-1459.
    • (2003) Br J Pharmacol , vol.140 , pp. 1451-1459
    • Savinainen, J.R.1    Saario, S.M.2    Niemi, R.3    Järvinen, T.4    Laitinen, J.T.5
  • 109
    • 3242687074 scopus 로고    scopus 로고
    • The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice
    • Shafaroodi H, Samini M, Moezi L, Homayoun H, Sadeghipour H, Tavakoli S et al. (2004). The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice. Neuropharmacology 47: 390-400.
    • (2004) Neuropharmacology , vol.47 , pp. 390-400
    • Shafaroodi, H.1    Samini, M.2    Moezi, L.3    Homayoun, H.4    Sadeghipour, H.5    Tavakoli, S.6
  • 110
    • 84879459582 scopus 로고    scopus 로고
    • A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray
    • Stott CG, White L, Wright S, Wilbraham D, Guy GW (2013). A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray. Eur J Clin Pharmacol 69: 1135-1147.
    • (2013) Eur J Clin Pharmacol , vol.69 , pp. 1135-1147
    • Stott, C.G.1    White, L.2    Wright, S.3    Wilbraham, D.4    Guy, G.W.5
  • 111
    • 33746793870 scopus 로고    scopus 로고
    • Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: A multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group
    • Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W et al. (2006). Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group. J Clin Oncol 24: 3394-3400.
    • (2006) J Clin Oncol , vol.24 , pp. 3394-3400
    • Strasser, F.1    Luftner, D.2    Possinger, K.3    Ernst, G.4    Ruhstaller, T.5    Meissner, W.6
  • 112
    • 39149092685 scopus 로고    scopus 로고
    • Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol
    • Vann RE, Gamage TF, Warner JA, Marshall EM, Taylor NL, Martin BR et al. (2008). Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol. Drug Alcohol Depend 94: 191-198.
    • (2008) Drug Alcohol Depend , vol.94 , pp. 191-198
    • Vann, R.E.1    Gamage, T.F.2    Warner, J.A.3    Marshall, E.M.4    Taylor, N.L.5    Martin, B.R.6
  • 114
    • 0345669751 scopus 로고    scopus 로고
    • A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms
    • Wade DT, Robson P, House H, Makela P, Aram J (2003). A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clin Rehabil 17: 21-29.
    • (2003) Clin Rehabil , vol.17 , pp. 21-29
    • Wade, D.T.1    Robson, P.2    House, H.3    Makela, P.4    Aram, J.5
  • 115
    • 0141742514 scopus 로고    scopus 로고
    • The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy
    • Wallace MJ, Blair RE, Falenski KW, Martin BR, DeLorenzo RJ (2003). The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J Pharmacol Exp Ther 307: 129-137.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 129-137
    • Wallace, M.J.1    Blair, R.E.2    Falenski, K.W.3    Martin, B.R.4    DeLorenzo, R.J.5
  • 116
    • 84880536518 scopus 로고    scopus 로고
    • The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
    • Wargent ET, Zaibi MS, Silvestri C, Hislop DC, Stocker CJ, Stott CG et al. (2013). The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. Nutr Diabetes 3: e68.
    • (2013) Nutr Diabetes , vol.3 , pp. e68
    • Wargent, E.T.1    Zaibi, M.S.2    Silvestri, C.3    Hislop, D.C.4    Stocker, C.J.5    Stott, C.G.6
  • 118
    • 0034775480 scopus 로고    scopus 로고
    • Synergy and other interactions in phytomedicines
    • Williamson EM (2001). Synergy and other interactions in phytomedicines. Phytomedicine 8: 401-409.
    • (2001) Phytomedicine , vol.8 , pp. 401-409
    • Williamson, E.M.1
  • 119
    • 77953565298 scopus 로고    scopus 로고
    • Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
    • Wolf SA, Bick-Sander A, Fabel K, Leal-Galicia P, Tauber S, Ramirez-Rodriguez G et al. (2010). Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis. Cell Commun Signal 8: 12.
    • (2010) Cell Commun Signal , vol.8 , pp. 12
    • Wolf, S.A.1    Bick-Sander, A.2    Fabel, K.3    Leal-Galicia, P.4    Tauber, S.5    Ramirez-Rodriguez, G.6
  • 120
    • 79955072836 scopus 로고    scopus 로고
    • Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia
    • Xiong W, Cheng K, Cui T, Godlewski G, Rice KC, Xu Y et al. (2011). Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nat Chem Biol 7: 296-303.
    • (2011) Nat Chem Biol , vol.7 , pp. 296-303
    • Xiong, W.1    Cheng, K.2    Cui, T.3    Godlewski, G.4    Rice, K.C.5    Xu, Y.6
  • 121
    • 0242654882 scopus 로고    scopus 로고
    • Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): Multicentre randomised placebo-controlled trial
    • Zijicek J, Fox P, Sanders H, Wright D, Vickery J, Nunn A et al. (2003). Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial. Lancet 362: 1517-1526.
    • (2003) Lancet , vol.362 , pp. 1517-1526
    • Zijicek, J.1    Fox, P.2    Sanders, H.3    Wright, D.4    Vickery, J.5    Nunn, A.6
  • 122
    • 54249156391 scopus 로고    scopus 로고
    • Cannabidiol: From an inactive cannabinoid to a drug with wide spectrum of action
    • Zuardi AW (2008). Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Rev Bras Psiquiatr 30: 271-280.
    • (2008) Rev Bras Psiquiatr , vol.30 , pp. 271-280
    • Zuardi, A.W.1
  • 123
    • 0019460907 scopus 로고
    • Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol
    • Zuardi AW, Finkelfarb E, Bueno OF, Musty RE, Karniol IG (1981). Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. Arch Int Pharmacodyn Ther 249: 137-146.
    • (1981) Arch Int Pharmacodyn Ther , vol.249 , pp. 137-146
    • Zuardi, A.W.1    Finkelfarb, E.2    Bueno, O.F.3    Musty, R.E.4    Karniol, I.G.5


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