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Volumn 20, Issue 8, 2008, Pages 919-927

Effect of cannabidiol on sepsis-induced motility disturbances in mice: Involvement of CB1 receptors and fatty acid amide hydrolase

Author keywords

Cannabidiol; Endocannabinoid system; Fatty acid amide hydrolase; Septic ileus

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; ENDOCANNABINOID; FATTY ACID AMIDASE; LIPOPOLYSACCHARIDE;

EID: 46249121074     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01114.x     Document Type: Article
Times cited : (72)

References (54)
  • 1
    • 0018947105 scopus 로고
    • Chronic administration of cannabidiol to healthy volunteers and epileptic patients
    • Cunha JM, Carlini EA, Pereira AE et al. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 1980 21 : 175 85.
    • (1980) Pharmacology , vol.21 , pp. 175-85
    • Cunha, J.M.1    Carlini, E.A.2    Pereira, A.E.3
  • 2
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait AM, Gallily R, Sumariwalla PF et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 2000 97 : 9561 6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9561-6
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3
  • 3
    • 0036838389 scopus 로고    scopus 로고
    • Cannabidiol: An overview of some pharmacological aspects
    • Mechoulam R, Parker LA, Gallily R. Cannabidiol: an overview of some pharmacological aspects. J Clin Pharmacol 2002 42 : 11S 9S.
    • (2002) J Clin Pharmacol , vol.42
    • Mechoulam, R.1    Parker, L.A.2    Gallily, R.3
  • 4
    • 8444238592 scopus 로고    scopus 로고
    • Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
    • Hayakawa K, Mishima K, Abe K et al. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport 2004 15 : 2381 5.
    • (2004) Neuroreport , vol.15 , pp. 2381-5
    • Hayakawa, K.1    Mishima, K.2    Abe, K.3
  • 5
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 2004 89 : 134 41.
    • (2004) J Neurochem , vol.89 , pp. 134-41
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 6
    • 12344250051 scopus 로고    scopus 로고
    • The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro
    • Sacerdote P, Martucci C, Vaccani A et al. The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J Neuroimmunol 2005 159 : 97 105.
    • (2005) J Neuroimmunol , vol.159 , pp. 97-105
    • Sacerdote, P.1    Martucci, C.2    Vaccani, A.3
  • 7
    • 33846070616 scopus 로고    scopus 로고
    • The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
    • Costa B, Trovato AE, Comelli F, Giagnoni G, Colleoni M. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain. Eur J Pharmacol 2007 556 : 75 83.
    • (2007) Eur J Pharmacol , vol.556 , pp. 75-83
    • Costa, B.1    Trovato, A.E.2    Comelli, F.3    Giagnoni, G.4    Colleoni, M.5
  • 8
    • 34547100965 scopus 로고    scopus 로고
    • Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
    • Rajesh M, Mukhopadhyay P, Batkai S et al. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am J Physiol 2007 293 : H610 9.
    • (2007) Am J Physiol , vol.293
    • Rajesh, M.1    Mukhopadhyay, P.2    Batkai, S.3
  • 9
    • 36849091565 scopus 로고    scopus 로고
    • Cannabidiol, a non-psychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
    • Durst R, Danenberg H, Gallily R et al. Cannabidiol, a non-psychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury. Am J Physiol 2007 293 : H3602 7.
    • (2007) Am J Physiol , vol.293
    • Durst, R.1    Danenberg, H.2    Gallily, R.3
  • 11
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T, Hanus L, De Petrocellis L et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 2001 134 : 845 52.
    • (2001) Br J Pharmacol , vol.134 , pp. 845-52
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3
  • 12
    • 17844388088 scopus 로고    scopus 로고
    • Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
    • Vaccani A, Massi P, Colombo A, Rubino T, Parolaro D. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 2005 144 : 1032 6.
    • (2005) Br J Pharmacol , vol.144 , pp. 1032-6
    • Vaccani, A.1    Massi, P.2    Colombo, A.3    Rubino, T.4    Parolaro, D.5
  • 13
    • 34547984234 scopus 로고    scopus 로고
    • Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors
    • Sagredo O, Ramos JA, Decio A, Mechoulam R, Fernández-Ruiz J. Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors. Eur J Neurosci 2007 26 : 843 51.
    • (2007) Eur J Neurosci , vol.26 , pp. 843-51
    • Sagredo, O.1    Ramos, J.A.2    Decio, A.3    Mechoulam, R.4    Fernández-Ruiz, J.5
  • 14
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006 58 : 389 462.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 15
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 1998 95 : 8268 73.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8268-73
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 16
    • 34147213422 scopus 로고    scopus 로고
    • Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue
    • Ryan D, Drysdale AJ, Pertwee RG, Platt B. Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. Eur J Neurosci 2007 25 : 2093 102.
    • (2007) Eur J Neurosci , vol.25 , pp. 2093-102
    • Ryan, D.1    Drysdale, A.J.2    Pertwee, R.G.3    Platt, B.4
  • 17
    • 0036011159 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications
    • Bisogno T, De Petrocellis L, Di Marzo V. Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. Curr Pharm Des 2002 8 : 533 47.
    • (2002) Curr Pharm des , vol.8 , pp. 533-47
    • Bisogno, T.1    De Petrocellis, L.2    Di Marzo, V.3
  • 18
    • 0029745360 scopus 로고    scopus 로고
    • Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids
    • Watanabe K, Kayano Y, Matsunaga T, Yamamoto I, Yoshimura H. Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids. Biol Pharm Bull 1996 19 : 1109 11.
    • (1996) Biol Pharm Bull , vol.19 , pp. 1109-11
    • Watanabe, K.1    Kayano, Y.2    Matsunaga, T.3    Yamamoto, I.4    Yoshimura, H.5
  • 19
    • 38449109178 scopus 로고    scopus 로고
    • 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
    • Massi P, Valenti M, Vaccani A et al. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 2008 104 : 1091 100.
    • (2008) J Neurochem , vol.104 , pp. 1091-100
    • Massi, P.1    Valenti, M.2    Vaccani, A.3
  • 20
    • 11144355734 scopus 로고    scopus 로고
    • The endogenous cannabinoid system protects against colonic inflammation
    • Massa F, Marsicano G, Hermann H et al. The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest 2004 113 : 1202 9.
    • (2004) J Clin Invest , vol.113 , pp. 1202-9
    • Massa, F.1    Marsicano, G.2    Hermann, H.3
  • 21
    • 33645832524 scopus 로고    scopus 로고
    • Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
    • D'Argenio G, Valenti M, Scaglione G, Cosenza V, Sorrentini I, Di Marzo V. Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. FASEB J 2006 20 : 568 70.
    • (2006) FASEB J , vol.20 , pp. 568-70
    • D'Argenio, G.1    Valenti, M.2    Scaglione, G.3    Cosenza, V.4    Sorrentini, I.5    Di Marzo, V.6
  • 22
    • 33745783119 scopus 로고    scopus 로고
    • Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium
    • Kimball ES, Schneider CR, Wallace NH, Hornby PJ. Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. Am J Physiol 2006 291 : G364 71.
    • (2006) Am J Physiol , vol.291
    • Kimball, E.S.1    Schneider, C.R.2    Wallace, N.H.3    Hornby, P.J.4
  • 23
    • 34247859056 scopus 로고    scopus 로고
    • Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats
    • D'Argenio G, Petrosino S, Gianfrani C et al. Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. J Mol Med 2007 85 : 523 30.
    • (2007) J Mol Med , vol.85 , pp. 523-30
    • D'Argenio, G.1    Petrosino, S.2    Gianfrani, C.3
  • 24
    • 0033381432 scopus 로고    scopus 로고
    • The role of the gastrointestinal tract in postinjury multiple organ failure
    • Moore FA. The role of the gastrointestinal tract in postinjury multiple organ failure. Am J Surg 1999 17 : 449 53.
    • (1999) Am J Surg , vol.17 , pp. 449-53
    • Moore, F.A.1
  • 25
    • 16444384543 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of septic ileus in mice
    • De Winter BY, van Nassauw L, De Man JG et al. Role of oxidative stress in the pathogenesis of septic ileus in mice. Neurogastroenterol Motil 2005 17 : 251 61.
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 251-61
    • De Winter, B.Y.1    Van Nassauw, L.2    De Man, J.G.3
  • 26
    • 36849020501 scopus 로고    scopus 로고
    • Melatonin reverses LPS-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress
    • De Filippis D, Iuvone T, Esposito G et al. Melatonin reverses LPS-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress. J Pineal Res 2008 44 : 45 51.
    • (2008) J Pineal Res , vol.44 , pp. 45-51
    • De Filippis, D.1    Iuvone, T.2    Esposito, G.3
  • 27
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    • Esposito G, De Filippis D, Carnuccio R, Izzo AA, Iuvone T. The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J Mol Med 2006 84 : 253 8.
    • (2006) J Mol Med , vol.84 , pp. 253-8
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 28
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 2006 399 : 91 5.
    • (2006) Neurosci Lett , vol.399 , pp. 91-5
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 29
    • 34547878297 scopus 로고    scopus 로고
    • Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
    • Esposito G, Scuderi C, Savani C et al. Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 2007 151 : 1272 9.
    • (2007) Br J Pharmacol , vol.151 , pp. 1272-9
    • Esposito, G.1    Scuderi, C.2    Savani, C.3
  • 30
    • 0031823187 scopus 로고    scopus 로고
    • Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension
    • Varga K, Wagner JA, Bridgen DT, Kunos G. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J 1998 12 : 1035 44.
    • (1998) FASEB J , vol.12 , pp. 1035-44
    • Varga, K.1    Wagner, J.A.2    Bridgen, D.T.3    Kunos, G.4
  • 31
    • 0031773354 scopus 로고    scopus 로고
    • Cardiovascular actions of cannabinoids and their generation during shock
    • Wagner JA, Varga K, Kunos G. Cardiovascular actions of cannabinoids and their generation during shock. J Mol Med 1998 76 : 824 36.
    • (1998) J Mol Med , vol.76 , pp. 824-36
    • Wagner, J.A.1    Varga, K.2    Kunos, G.3
  • 32
    • 0035883892 scopus 로고    scopus 로고
    • Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
    • Maccarrone M, De Petrocellis L, Bari M et al. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Arch Biochem Biophys 2001 393 : 321 8.
    • (2001) Arch Biochem Biophys , vol.393 , pp. 321-8
    • MacCarrone, M.1    De Petrocellis, L.2    Bari, M.3
  • 33
    • 0033567190 scopus 로고    scopus 로고
    • Biosynthesis and inactivation of the endocannabinoid 2- arachidonoylglycerol in circulating and tumoral macrophages
    • Di Marzo V, Bisogno T, De Petrocellis L et al. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur J Biochem 1999 264 : 258 67.
    • (1999) Eur J Biochem , vol.264 , pp. 258-67
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3
  • 34
    • 34648846246 scopus 로고    scopus 로고
    • Experimental pancreatitis disturbs gastrointestinal and colonic motility in mice: Effect of the prokinetic agent tegaserod
    • Seerden TC, De Man JG, Holzer P et al. Experimental pancreatitis disturbs gastrointestinal and colonic motility in mice: effect of the prokinetic agent tegaserod. Neurogastroenterol Motil 2007 19 : 856 64.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 856-64
    • Seerden, T.C.1    De Man, J.G.2    Holzer, P.3
  • 35
    • 42249110372 scopus 로고    scopus 로고
    • Functional study on TRPV1-mediated signalling in the mouse small intestine: Involvement of tachykinin receptors
    • doi
    • De Man JG, Boeckx S, Anguille S et al. Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors. Neurogastroenterol Motil doi
    • Neurogastroenterol Motil
    • De Man, J.G.1    Boeckx, S.2    Anguille, S.3
  • 36
    • 0036688880 scopus 로고    scopus 로고
    • Effect of inhibition of inducible nitric oxide synthase and guanylyl cyclase on endotoxin-induced delay in gastric emptying and intestinal transit in mice
    • De Winter BY, Bredenoord AJ, De Man JG, Moreels TG, Herman AG, Pelckmans PA. Effect of inhibition of inducible nitric oxide synthase and guanylyl cyclase on endotoxin-induced delay in gastric emptying and intestinal transit in mice. Shock 2002 18 : 125 31.
    • (2002) Shock , vol.18 , pp. 125-31
    • De Winter, B.Y.1    Bredenoord, A.J.2    De Man, J.G.3    Moreels, T.G.4    Herman, A.G.5    Pelckmans, P.A.6
  • 37
    • 0024370916 scopus 로고
    • Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents
    • Shook JE, Burks TF. Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. J Pharmacol Exp Ther 1989 249 : 444 9.
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 444-9
    • Shook, J.E.1    Burks, T.F.2
  • 38
    • 19444387559 scopus 로고    scopus 로고
    • Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB(1) and unidentified receptors
    • Fride E, Ponde D, Breuer A, Hanus L. Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors. Neuropharmacology 2005 48 : 1117 29.
    • (2005) Neuropharmacology , vol.48 , pp. 1117-29
    • Fride, E.1    Ponde, D.2    Breuer, A.3    Hanus, L.4
  • 39
    • 0032803098 scopus 로고    scopus 로고
    • The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats
    • Izzo AA, Mascolo N, Pinto L, Capasso R, Capasso F. The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats. Eur J Pharmacol 1999 384 : 37 42.
    • (1999) Eur J Pharmacol , vol.384 , pp. 37-42
    • Izzo, A.A.1    Mascolo, N.2    Pinto, L.3    Capasso, R.4    Capasso, F.5
  • 41
    • 0034740564 scopus 로고    scopus 로고
    • Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
    • Izzo AA, Fezza F, Capasso R et al. Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation. Br J Pharmacol 2001 134 : 563 70.
    • (2001) Br J Pharmacol , vol.134 , pp. 563-70
    • Izzo, A.A.1    Fezza, F.2    Capasso, R.3
  • 42
    • 0036885056 scopus 로고    scopus 로고
    • The endocannabinoid system and the molecular basis of paralytic ileus in mice
    • Mascolo N, Izzo AA, Ligresti A et al. The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB J 2002 16 : 1973 5.
    • (2002) FASEB J , vol.16 , pp. 1973-5
    • Mascolo, N.1    Izzo, A.A.2    Ligresti, A.3
  • 43
    • 4444319561 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats
    • Mathison R, Ho W, Pittman QJ, Davison JS, Sharkey KA. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 2004 142 : 1247 54.
    • (2004) Br J Pharmacol , vol.142 , pp. 1247-54
    • Mathison, R.1    Ho, W.2    Pittman, Q.J.3    Davison, J.S.4    Sharkey, K.A.5
  • 44
    • 34548149517 scopus 로고    scopus 로고
    • Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex
    • Yuece B, Sibaev A, Broedl UC et al. Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex. Neurogastroenterol Motil 2007 19 : 744 53.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 744-53
    • Yuece, B.1    Sibaev, A.2    Broedl, U.C.3
  • 45
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol 2007 150 : 613 23.
    • (2007) Br J Pharmacol , vol.150 , pp. 613-23
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3    Razdan, R.K.4    Ross, R.A.5    Pertwee, R.G.6
  • 46
    • 39449083008 scopus 로고    scopus 로고
    • The diverse CB(1) and CB(2) receptor pharmacology of three plant cannabinoids: Delta(9)-tetrahydrocannabinol, cannabidiol and Delta(9)-tetrahydrocannabivarin
    • Pertwee RG. The diverse CB(1) and CB(2) receptor pharmacology of three plant cannabinoids: Delta(9)-tetrahydrocannabinol, cannabidiol and Delta(9)-tetrahydrocannabivarin. Br J Pharmacol 2007 152 : 583 93.
    • (2007) Br J Pharmacol , vol.152 , pp. 583-93
    • Pertwee, R.G.1
  • 47
    • 0033961214 scopus 로고    scopus 로고
    • Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase and do not express cannabinoid receptors
    • Maccarrone M, Fiorucci L, Erba F, Bari M, Finazzi-Agrò A, Ascoli F. Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase and do not express cannabinoid receptors. FEBS Lett 2000 468 : 176 80.
    • (2000) FEBS Lett , vol.468 , pp. 176-80
    • MacCarrone, M.1    Fiorucci, L.2    Erba, F.3    Bari, M.4    Finazzi-Agrò, A.5    Ascoli, F.6
  • 48
    • 24144466887 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase controls mouse intestinal motility in vivo
    • Capasso R, Matias I, Lutz B et al. Fatty acid amide hydrolase controls mouse intestinal motility in vivo. Gastroenterology 2005 129 : 941 51.
    • (2005) Gastroenterology , vol.129 , pp. 941-51
    • Capasso, R.1    Matias, I.2    Lutz, B.3
  • 50
    • 0242497230 scopus 로고    scopus 로고
    • Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor
    • Liu J, Batkai S, Pacher P et al. Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. J Biol Chem 2003 278 : 45034 9.
    • (2003) J Biol Chem , vol.278 , pp. 45034-9
    • Liu, J.1    Batkai, S.2    Pacher, P.3
  • 51
    • 33749165439 scopus 로고    scopus 로고
    • Endocannabinoid overactivity and intestinal inflammation
    • Di Marzo V, Izzo AA. Endocannabinoid overactivity and intestinal inflammation. Gut 2006 55 : 1373 6.
    • (2006) Gut , vol.55 , pp. 1373-6
    • Di Marzo, V.1    Izzo, A.A.2
  • 52
    • 35748980586 scopus 로고    scopus 로고
    • Endocannabinoids and the gastrointestinal tract: What are the key questions?
    • Sanger GJ. Endocannabinoids and the gastrointestinal tract: what are the key questions? Br J Pharmacol 2007 152 : 663 70.
    • (2007) Br J Pharmacol , vol.152 , pp. 663-70
    • Sanger, G.J.1
  • 53
    • 31144434923 scopus 로고    scopus 로고
    • Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis
    • Kohro S, Imaizumi H, Yamakage M et al. Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. J Anesth 2006 20 : 11 6.
    • (2006) J Anesth , vol.20 , pp. 11-6
    • Kohro, S.1    Imaizumi, H.2    Yamakage, M.3
  • 54
    • 4744372178 scopus 로고    scopus 로고
    • Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
    • Costa B, Giagnoni G, Franke C, Trovato AE, Colleoni M. Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. Br J Pharmacol 2004 143 : 247 50.
    • (2004) Br J Pharmacol , vol.143 , pp. 247-50
    • Costa, B.1    Giagnoni, G.2    Franke, C.3    Trovato, A.E.4    Colleoni, M.5


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