메뉴 건너뛰기




Volumn 45, Issue , 2017, Pages 85-91

Systems biology solutions for biochemical production challenges

Author keywords

[No Author keywords available]

Indexed keywords

METABOLISM;

EID: 85015323705     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2016.11.018     Document Type: Review
Times cited : (27)

References (64)
  • 1
    • 85015320169 scopus 로고    scopus 로고
    • Industrialization of Biology: A Roadmap to Accelerate the Advanced Manufacturing of Chemicals
    • 1 Industrialization of Biology: A Roadmap to Accelerate the Advanced Manufacturing of Chemicals. The National Academies Press; 2015.
    • (2015) The National Academies Press
  • 2
    • 0142027026 scopus 로고    scopus 로고
    • Metabolic engineering for the microbial production of 1,3-propanediol
    • 2 Nakamura, C.E., Whited, G.M., Metabolic engineering for the microbial production of 1,3-propanediol. Curr Opin Biotechnol 14 (2003), 454–459.
    • (2003) Curr Opin Biotechnol , vol.14 , pp. 454-459
    • Nakamura, C.E.1    Whited, G.M.2
  • 3
    • 84901340681 scopus 로고    scopus 로고
    • Metabolic evolution of two reducing equivalent-conserving pathways for high-yield succinate production in Escherichia coli
    • 3 Zhu, X., Tan, Z., Xu, H., Chen, J., Tang, J., Zhang, X., Metabolic evolution of two reducing equivalent-conserving pathways for high-yield succinate production in Escherichia coli. Metab Eng 24 (2014), 87–96.
    • (2014) Metab Eng , vol.24 , pp. 87-96
    • Zhu, X.1    Tan, Z.2    Xu, H.3    Chen, J.4    Tang, J.5    Zhang, X.6
  • 5
    • 84887622083 scopus 로고    scopus 로고
    • From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals
    • 5 Van Dien, S., From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals. Curr Opin Biotechnol 24 (2013), 1061–1068.
    • (2013) Curr Opin Biotechnol , vol.24 , pp. 1061-1068
    • Van Dien, S.1
  • 6
    • 84943604629 scopus 로고    scopus 로고
    • Systems strategies for developing industrial microbial strains
    • 6 Lee, S.Y., Kim, H.U., Systems strategies for developing industrial microbial strains. Nat Biotechnol 33 (2015), 1061–1072.
    • (2015) Nat Biotechnol , vol.33 , pp. 1061-1072
    • Lee, S.Y.1    Kim, H.U.2
  • 8
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • 8 Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., Charpentier, E., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337 (2012), 816–821.
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3    Hauer, M.4    Doudna, J.A.5    Charpentier, E.6
  • 10
    • 68949161807 scopus 로고    scopus 로고
    • Programming cells by multiplex genome engineering and accelerated evolution
    • 10 Wang, H.H., Isaacs, F.J., Carr, P.A., Sun, Z.Z., Xu, G., Forest, C.R., Church, G.M., Programming cells by multiplex genome engineering and accelerated evolution. Nature 460 (2009), 894–898.
    • (2009) Nature , vol.460 , pp. 894-898
    • Wang, H.H.1    Isaacs, F.J.2    Carr, P.A.3    Sun, Z.Z.4    Xu, G.5    Forest, C.R.6    Church, G.M.7
  • 11
    • 84952682854 scopus 로고    scopus 로고
    • CRISPR/Cas9 advances engineering of microbial cell factories
    • 11 Jakočiūnas, T., Jensen, M.K., Keasling, J.D., CRISPR/Cas9 advances engineering of microbial cell factories. Metab Eng 34 (2016), 44–59.
    • (2016) Metab Eng , vol.34 , pp. 44-59
    • Jakočiūnas, T.1    Jensen, M.K.2    Keasling, J.D.3
  • 12
    • 84949524121 scopus 로고    scopus 로고
    • Seven gene deletions in seven days: fast generation of Escherichia coli strains tolerant to acetate and osmotic stress
    • 12 Jensen, S.I., Lennen, R.M., Herrgård, M.J., Nielsen, A.T., Seven gene deletions in seven days: fast generation of Escherichia coli strains tolerant to acetate and osmotic stress. Sci Rep, 5, 2015, 17874.
    • (2015) Sci Rep , vol.5 , pp. 17874
    • Jensen, S.I.1    Lennen, R.M.2    Herrgård, M.J.3    Nielsen, A.T.4
  • 13
    • 84951061481 scopus 로고    scopus 로고
    • Pseudo-transition analysis identifies the key regulators of dynamic metabolic adaptations from steady-state data
    • Comprehensive multi-omic (transcriptomics, proteomics, metabolomics and fluxomics) characterization of  E. coli wild-type strains and examples on how this can be used to understand engineered strains.
    • 13• Gerosa, L., Haverkorn Van Rijsewijk, B.R.B., Christodoulou, D., Kochanowski, K., Schmidt, T.S.B., Noor, E., Sauer, U., Pseudo-transition analysis identifies the key regulators of dynamic metabolic adaptations from steady-state data. Cell Syst 1 (2015), 270–282 Comprehensive multi-omic (transcriptomics, proteomics, metabolomics and fluxomics) characterization of  E. coli wild-type strains and examples on how this can be used to understand engineered strains.
    • (2015) Cell Syst , vol.1 , pp. 270-282
    • Gerosa, L.1    Haverkorn Van Rijsewijk, B.R.B.2    Christodoulou, D.3    Kochanowski, K.4    Schmidt, T.S.B.5    Noor, E.6    Sauer, U.7
  • 15
    • 82255186724 scopus 로고    scopus 로고
    • Predicting phenotypic variation in yeast from individual genome sequences
    • 15 Jelier, R., Semple, J.I., Garcia-Verdugo, R., Lehner, B., Predicting phenotypic variation in yeast from individual genome sequences. Nat Genet 43 (2011), 1270–1274.
    • (2011) Nat Genet , vol.43 , pp. 1270-1274
    • Jelier, R.1    Semple, J.I.2    Garcia-Verdugo, R.3    Lehner, B.4
  • 16
  • 17
    • 84905668376 scopus 로고    scopus 로고
    • Improving fatty acids production by engineering dynamic pathway regulation and metabolic control
    • 17 Xu, P., Li, L., Zhang, F., Stephanopoulos, G., Koffas, M., Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proc Natl Acad Sci U S A 111 (2014), 11299–11304.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 11299-11304
    • Xu, P.1    Li, L.2    Zhang, F.3    Stephanopoulos, G.4    Koffas, M.5
  • 19
    • 34249934691 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation
    • 19 Park, J.H., Lee, K.H., Kim, T.Y., Lee, S.Y., Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation. Proc Natl Acad Sci U S A 104 (2007), 7797–7802.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7797-7802
    • Park, J.H.1    Lee, K.H.2    Kim, T.Y.3    Lee, S.Y.4
  • 20
    • 84969752776 scopus 로고    scopus 로고
    • Characterizing strain variation in engineered E. coli using a multi-omics-based workflow
    • Description of a systematic workflow for the analysis of targeted proteomics and metabolomics data on production strains incorporating the use of GEMs.
    • 20•• Brunk, E., George, K.W., Alonso-Gutierrez, J., Thompson, M., Baidoo, E., Wang, G., Petzold, C.J., McCloskey, D., Monk, J., Yang, L., et al. Characterizing strain variation in engineered E. coli using a multi-omics-based workflow. Cell Syst 2 (2016), 335–346 Description of a systematic workflow for the analysis of targeted proteomics and metabolomics data on production strains incorporating the use of GEMs.
    • (2016) Cell Syst , vol.2 , pp. 335-346
    • Brunk, E.1    George, K.W.2    Alonso-Gutierrez, J.3    Thompson, M.4    Baidoo, E.5    Wang, G.6    Petzold, C.J.7    McCloskey, D.8    Monk, J.9    Yang, L.10
  • 22
    • 84872409095 scopus 로고    scopus 로고
    • Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway—metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum
    • 22 Kind, S., Becker, J., Wittmann, C., Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway—metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum. Metab Eng 15 (2013), 184–195.
    • (2013) Metab Eng , vol.15 , pp. 184-195
    • Kind, S.1    Becker, J.2    Wittmann, C.3
  • 23
    • 84991740197 scopus 로고    scopus 로고
    • Multi-omics quantification of species variation of Escherichia coli links molecular features with strain phenotypes
    • Genomic, transcriptomic, physiological and GEM-based characterization of seven different  E. coli wild type strains that are commonly used in metabolic engineering.
    • 23•• Monk, J.M., Koza, A., Campodonico, M.A., Machado, D., Seoane, J.M., Palsson, B.O., Herrgård, M.J., Feist, A.M., Multi-omics quantification of species variation of Escherichia coli links molecular features with strain phenotypes. Cell Syst 3 (2016), 1–14 Genomic, transcriptomic, physiological and GEM-based characterization of seven different  E. coli wild type strains that are commonly used in metabolic engineering.
    • (2016) Cell Syst , vol.3 , pp. 1-14
    • Monk, J.M.1    Koza, A.2    Campodonico, M.A.3    Machado, D.4    Seoane, J.M.5    Palsson, B.O.6    Herrgård, M.J.7    Feist, A.M.8
  • 24
    • 84952802569 scopus 로고    scopus 로고
    • A quantitative system-scale characterization of the metabolism of Clostridium acetobutylicum
    • 24 Yoo, M., Bestel-Corre, G., Croux, C., Riviere, A., Meynial-Salles, I., Soucaille, P., A quantitative system-scale characterization of the metabolism of Clostridium acetobutylicum. MBio 6 (2015), e01808–e01815.
    • (2015) MBio , vol.6 , pp. e01808-e01815
    • Yoo, M.1    Bestel-Corre, G.2    Croux, C.3    Riviere, A.4    Meynial-Salles, I.5    Soucaille, P.6
  • 25
    • 84896932547 scopus 로고    scopus 로고
    • Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis
    • 25 Kozak, B.U., van Rossum, H.M., Benjamin, K.R., Wu, L., Daran, J.M.G., Pronk, J.T., Van Maris, A.J.A., Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis. Metab Eng 21 (2014), 46–59.
    • (2014) Metab Eng , vol.21 , pp. 46-59
    • Kozak, B.U.1    van Rossum, H.M.2    Benjamin, K.R.3    Wu, L.4    Daran, J.M.G.5    Pronk, J.T.6    Van Maris, A.J.A.7
  • 26
    • 84907483760 scopus 로고    scopus 로고
    • Altered sterol composition renders yeast thermotolerant
    • Genomic, transcriptomic, and physiological analysis of evolved thermotolerant  S. cerevisiae strains revealed a thermotolerance mechanism of altered membrane sterol composition.
    • 26•• Caspeta, L., Chen, Y., Ghiaci, P., Feizi, A., Buskov, S., Hallström, B.M., Petranovic, D., Nielsen, J., Altered sterol composition renders yeast thermotolerant. Science 944 (2014), 75–78 Genomic, transcriptomic, and physiological analysis of evolved thermotolerant  S. cerevisiae strains revealed a thermotolerance mechanism of altered membrane sterol composition.
    • (2014) Science , vol.944 , pp. 75-78
    • Caspeta, L.1    Chen, Y.2    Ghiaci, P.3    Feizi, A.4    Buskov, S.5    Hallström, B.M.6    Petranovic, D.7    Nielsen, J.8
  • 27
    • 84907862283 scopus 로고    scopus 로고
    • Evolution reveals a glutathione-dependent mechanism of 3-hydroxypropionic acid tolerance
    • Elucidation of the mechanism of 3-hydroxypropionic acid tolerance in evolved  S. cerevisiae isolates through transcriptomic analysis and genetic reconstructions.
    • 27•• Kildegaard, K.R., Hallström, B.M., Blicher, T.H., Sonnenschein, N., Jensen, N.B., Sherstyk, S., Harrison, S.J., Maury, J., Herrgård, M.J., Juncker, A.S., et al. Evolution reveals a glutathione-dependent mechanism of 3-hydroxypropionic acid tolerance. Metab Eng 26 (2014), 57–66 Elucidation of the mechanism of 3-hydroxypropionic acid tolerance in evolved  S. cerevisiae isolates through transcriptomic analysis and genetic reconstructions.
    • (2014) Metab Eng , vol.26 , pp. 57-66
    • Kildegaard, K.R.1    Hallström, B.M.2    Blicher, T.H.3    Sonnenschein, N.4    Jensen, N.B.5    Sherstyk, S.6    Harrison, S.J.7    Maury, J.8    Herrgård, M.J.9    Juncker, A.S.10
  • 28
    • 84907020111 scopus 로고    scopus 로고
    • Combinatorial strategies for improving multiple-stress resistance in industrially relevant Escherichia coli strains
    • 28 Lennen, R.M., Herrgård, M.J., Combinatorial strategies for improving multiple-stress resistance in industrially relevant Escherichia coli strains. Appl Environ Microbiol 80 (2014), 6223–6242.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 6223-6242
    • Lennen, R.M.1    Herrgård, M.J.2
  • 31
    • 84989852376 scopus 로고    scopus 로고
    • Rewriting yeast central carbon metabolism for industrial isoprenoid production
    • GEMs are effectively used for determining heterologous pathways leading to improved farnesene production.
    • 31•• Meadows, A.L., Hawkins, K.M., Tsegaye, Y., Antipov, E., Kim, Y., Raetz, L., Dahl, R.H., Tai, A., Mahatdejkul-Meadows, T., Xu, L., et al. Rewriting yeast central carbon metabolism for industrial isoprenoid production. Nature 537 (2016), 694–697 GEMs are effectively used for determining heterologous pathways leading to improved farnesene production.
    • (2016) Nature , vol.537 , pp. 694-697
    • Meadows, A.L.1    Hawkins, K.M.2    Tsegaye, Y.3    Antipov, E.4    Kim, Y.5    Raetz, L.6    Dahl, R.H.7    Tai, A.8    Mahatdejkul-Meadows, T.9    Xu, L.10
  • 32
    • 85006511727 scopus 로고    scopus 로고
    • Engineering an NADPH/NADP+ redox biosensor in yeast
    • For the purpose of testing redox biosensor  in vivo, the authors use a GEM of  S. cerevisiae to predict single gene deletions that are likely to have an impact on the NAPH/NADP+ redox charge.
    • 32• Zhang, J., Sonnenschein, N., Pihl, T.P.B., Pedersen, K.R., Jensen, M.K., Keasling, J.D., Engineering an NADPH/NADP+ redox biosensor in yeast. ACS Synth Biol 5 (2016), 1546–1556 For the purpose of testing redox biosensor  in vivo, the authors use a GEM of  S. cerevisiae to predict single gene deletions that are likely to have an impact on the NAPH/NADP+ redox charge.
    • (2016) ACS Synth Biol , vol.5 , pp. 1546-1556
    • Zhang, J.1    Sonnenschein, N.2    Pihl, T.P.B.3    Pedersen, K.R.4    Jensen, M.K.5    Keasling, J.D.6
  • 33
    • 84938074954 scopus 로고    scopus 로고
    • Co-evolution of strain design methods based on flux balance and elementary mode analysis
    • 33 Machado, D., Herrgård, M., Co-evolution of strain design methods based on flux balance and elementary mode analysis. Metab Eng Commun 2 (2015), 85–92.
    • (2015) Metab Eng Commun , vol.2 , pp. 85-92
    • Machado, D.1    Herrgård, M.2
  • 34
  • 35
    • 0242487787 scopus 로고    scopus 로고
    • Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
    • 35 Burgard, A.P., Pharkya, P., Maranas, C.D., Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnol Bioeng 84 (2003), 647–657.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 647-657
    • Burgard, A.P.1    Pharkya, P.2    Maranas, C.D.3
  • 36
    • 30044437327 scopus 로고    scopus 로고
    • Evolutionary programming as a platform for in silico metabolic engineering
    • 36 Patil, K.R., Rocha, I., Forster, J., Nielsen, J., Evolutionary programming as a platform for in silico metabolic engineering. BMC Bioinf, 6, 2005, 308.
    • (2005) BMC Bioinf , vol.6 , pp. 308
    • Patil, K.R.1    Rocha, I.2    Forster, J.3    Nielsen, J.4
  • 37
    • 77949495880 scopus 로고    scopus 로고
    • Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways
    • 37 Tepper, N., Shlomi, T., Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways. Bioinformatics 26 (2009), 536–543.
    • (2009) Bioinformatics , vol.26 , pp. 536-543
    • Tepper, N.1    Shlomi, T.2
  • 38
    • 84896731390 scopus 로고    scopus 로고
    • Enumeration of smallest intervention strategies in genome-scale metabolic networks
    • 38 von Kamp, A., Klamt, S., Enumeration of smallest intervention strategies in genome-scale metabolic networks. PLoS Comput Biol, 10, 2014, e1003378.
    • (2014) PLoS Comput Biol , vol.10 , pp. e1003378
    • von Kamp, A.1    Klamt, S.2
  • 39
    • 84974657997 scopus 로고    scopus 로고
    • Model-based metabolic engineering enables high yield itaconic acid production by Escherichia coli
    • Iterative design and implementation of a high yield  E. coli production strain for itaconic acid using minimal cut sets.
    • 39•• Harder, B.-J., Bettenbrock, K., Klamt, S., Model-based metabolic engineering enables high yield itaconic acid production by Escherichia coli. Metab Eng 38 (2016), 29–37 Iterative design and implementation of a high yield  E. coli production strain for itaconic acid using minimal cut sets.
    • (2016) Metab Eng , vol.38 , pp. 29-37
    • Harder, B.-J.1    Bettenbrock, K.2    Klamt, S.3
  • 40
    • 84901306814 scopus 로고    scopus 로고
    • Systematic evaluation of methods for integration of transcriptomic data into constraint-based models of metabolism
    • Systematic evaluation of methods for integration of transcriptome data with GEMs revealing that all methods do not surpass parsimonious flux balance analysis in predicting metabolic fluxes quantitatively.
    • 40• Machado, D., Herrgård, M., Systematic evaluation of methods for integration of transcriptomic data into constraint-based models of metabolism. PLoS Comput Biol, 10, 2014, e1003580 Systematic evaluation of methods for integration of transcriptome data with GEMs revealing that all methods do not surpass parsimonious flux balance analysis in predicting metabolic fluxes quantitatively.
    • (2014) PLoS Comput Biol , vol.10 , pp. e1003580
    • Machado, D.1    Herrgård, M.2
  • 43
    • 84930227327 scopus 로고    scopus 로고
    • Using genome-scale models to predict biological capabilities
    • 43 O'Brien, E.J., Monk, J.M., Palsson, B.O., Using genome-scale models to predict biological capabilities. Cell 161 (2015), 971–987.
    • (2015) Cell , vol.161 , pp. 971-987
    • O'Brien, E.J.1    Monk, J.M.2    Palsson, B.O.3
  • 44
    • 84990177186 scopus 로고    scopus 로고
    • Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli
    • 44 Kim, M., Rai, N., Zorraquino, V., Tagkopoulos, I., Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli. Nat Commun, 7, 2016, 13090.
    • (2016) Nat Commun , vol.7 , pp. 13090
    • Kim, M.1    Rai, N.2    Zorraquino, V.3    Tagkopoulos, I.4
  • 45
    • 84901321053 scopus 로고    scopus 로고
    • Contribution of network donnectivity in determining the relationship between gene expression and metabolite concentration changes
    • At the reaction level, metabolite concentration and gene expression changes do not correlate. The authors find that only after taking the network and kinetic context into account they are able to predict changes in metabolite levels from gene expression data.
    • 45• Zelezniak, A., Sheridan, S., Patil, K.R., Contribution of network donnectivity in determining the relationship between gene expression and metabolite concentration changes. PLoS Comput Biol, 10, 2014, e1003572 At the reaction level, metabolite concentration and gene expression changes do not correlate. The authors find that only after taking the network and kinetic context into account they are able to predict changes in metabolite levels from gene expression data.
    • (2014) PLoS Comput Biol , vol.10 , pp. e1003572
    • Zelezniak, A.1    Sheridan, S.2    Patil, K.R.3
  • 47
    • 84963796141 scopus 로고    scopus 로고
    • Modeling method for increased precision and scope of directly measurable fluxes at a genome-scale
    • 47 McCloskey, D., Young, J.D., Xu, S., Palsson, B.O., Feist, A.M., Modeling method for increased precision and scope of directly measurable fluxes at a genome-scale. Anal Chem 88 (2016), 3844–3852.
    • (2016) Anal Chem , vol.88 , pp. 3844-3852
    • McCloskey, D.1    Young, J.D.2    Xu, S.3    Palsson, B.O.4    Feist, A.M.5
  • 48
    • 84917705874 scopus 로고    scopus 로고
    • Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium
    • Foundational study using a robotic ALE system to obtain high-resolution fitness trajectories of  E. coli evolved on minimal glucose medium.
    • 48• LaCroix, R.A., Sandberg, T.E., O'Brien, E.J., Utrilla, J., Ebrahim, A., Guzman, G.I., Szubin, R., Palsson, B.O., Feist, A.M., Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium. Appl Environ Microbiol 81 (2015), 17–30 Foundational study using a robotic ALE system to obtain high-resolution fitness trajectories of  E. coli evolved on minimal glucose medium.
    • (2015) Appl Environ Microbiol , vol.81 , pp. 17-30
    • LaCroix, R.A.1    Sandberg, T.E.2    O'Brien, E.J.3    Utrilla, J.4    Ebrahim, A.5    Guzman, G.I.6    Szubin, R.7    Palsson, B.O.8    Feist, A.M.9
  • 49
    • 84928889593 scopus 로고    scopus 로고
    • Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol
    • 49 Cheng, K.-K., Lee, B.-S., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., et al. Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol. Nat Commun, 5, 2014, 3233.
    • (2014) Nat Commun , vol.5 , pp. 3233
    • Cheng, K.-K.1    Lee, B.-S.2    Masuda, T.3    Ito, T.4    Ikeda, K.5    Hirayama, A.6    Deng, L.7    Dong, J.8    Shimizu, K.9    Soga, T.10
  • 50
    • 84967180536 scopus 로고    scopus 로고
    • Global rebalancing of cellular resources by pleiotropic point mutations illustrates a multi-scale mechanism of adaptive evolution
    • 50 Utrilla, J., O'Brien, E.J., Chen, K., McCloskey, D., Cheung, J., Wang, H., Armenta-Medina, D., Feist, A.M., Palsson, B.O., Global rebalancing of cellular resources by pleiotropic point mutations illustrates a multi-scale mechanism of adaptive evolution. Cell Syst 2 (2016), 260–271.
    • (2016) Cell Syst , vol.2 , pp. 260-271
    • Utrilla, J.1    O'Brien, E.J.2    Chen, K.3    McCloskey, D.4    Cheung, J.5    Wang, H.6    Armenta-Medina, D.7    Feist, A.M.8    Palsson, B.O.9
  • 53
    • 84901358601 scopus 로고    scopus 로고
    • Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB
    • 53 Winkler, J.D., Garcia, C., Olson, M., Callaway, E., Kao, K.C., Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB. Appl Environ Microbiol 80 (2014), 3729–3740.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 3729-3740
    • Winkler, J.D.1    Garcia, C.2    Olson, M.3    Callaway, E.4    Kao, K.C.5
  • 54
    • 84898637077 scopus 로고    scopus 로고
    • Adaptation of Escherichia coli to elevated sodium concentrations increases cation tolerance and enables greater lactic acid production
    • 54 Wu, X., Altman, R., Eiteman, M.A., Altman, E., Adaptation of Escherichia coli to elevated sodium concentrations increases cation tolerance and enables greater lactic acid production. Appl Environ Microbiol 80 (2014), 2880–2888.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 2880-2888
    • Wu, X.1    Altman, R.2    Eiteman, M.A.3    Altman, E.4
  • 56
    • 84927514444 scopus 로고    scopus 로고
    • Evolution for exogenous octanoic acid tolerance improves carboxylic acid production and membrane integrity
    • 56 Royce, L.A., Yoon, J.M., Chen, Y., Rickenbach, E., Shanks, J.V., Jarboe, L.R., Evolution for exogenous octanoic acid tolerance improves carboxylic acid production and membrane integrity. Metab Eng 29 (2015), 180–188.
    • (2015) Metab Eng , vol.29 , pp. 180-188
    • Royce, L.A.1    Yoon, J.M.2    Chen, Y.3    Rickenbach, E.4    Shanks, J.V.5    Jarboe, L.R.6
  • 58
    • 59949093124 scopus 로고    scopus 로고
    • Novel evolutionary engineering approach for accelerated utilization of glucose, xylose, and arabinose mixtures by engineered Saccharomyces cerevisiae strains
    • 58 Wouter Wisselink, H., Toirkens, M.J., Wu, Q., Pronk, J.T., Van Maris, A.J.A., Novel evolutionary engineering approach for accelerated utilization of glucose, xylose, and arabinose mixtures by engineered Saccharomyces cerevisiae strains. Appl Environ Microbiol 75 (2009), 907–914.
    • (2009) Appl Environ Microbiol , vol.75 , pp. 907-914
    • Wouter Wisselink, H.1    Toirkens, M.J.2    Wu, Q.3    Pronk, J.T.4    Van Maris, A.J.A.5
  • 59
    • 84955276048 scopus 로고    scopus 로고
    • Evolved hexose transporter enhances xylose uptake and glucose/xylose co-utilization in Saccharomyces cerevisiae
    • 59 Reider Apel, A., Ouellet, M., Szmidt-Middleton, H., Keasling, J.D., Mukhopadhyay, A., Evolved hexose transporter enhances xylose uptake and glucose/xylose co-utilization in Saccharomyces cerevisiae. Sci Rep, 6, 2016, 19512.
    • (2016) Sci Rep , vol.6 , pp. 19512
    • Reider Apel, A.1    Ouellet, M.2    Szmidt-Middleton, H.3    Keasling, J.D.4    Mukhopadhyay, A.5
  • 61
    • 84982801326 scopus 로고    scopus 로고
    • Metabolic engineering of microbial competitive advantage for industrial fermentation processes
    • ALE was used to complement heterologous pathway expression to enable three microorganisms to utilise xenobiotic nitrogen and phosphorous sources as selective agents.
    • 61• Shaw, A.J., Lam, F.H., Hamilton, M., Consiglio, A., MacEwen, K., Brevnova, E.E., Greenhagen, E., LaTouf, W.G., South, C.R., van Dijken, H., et al. Metabolic engineering of microbial competitive advantage for industrial fermentation processes. Science 353 (2016), 583–586 ALE was used to complement heterologous pathway expression to enable three microorganisms to utilise xenobiotic nitrogen and phosphorous sources as selective agents.
    • (2016) Science , vol.353 , pp. 583-586
    • Shaw, A.J.1    Lam, F.H.2    Hamilton, M.3    Consiglio, A.4    MacEwen, K.5    Brevnova, E.E.6    Greenhagen, E.7    LaTouf, W.G.8    South, C.R.9    van Dijken, H.10
  • 62
    • 84945388093 scopus 로고    scopus 로고
    • Biosensor-driven adaptive laboratory evolution of L-valine production in Corynebacterium glutamicum
    • 62 Mahr, R., Gätgens, C., Gätgens, J., Polen, T., Kalinowski, J., Frunzke, J., Biosensor-driven adaptive laboratory evolution of L-valine production in Corynebacterium glutamicum. Metab Eng 32 (2015), 184–194.
    • (2015) Metab Eng , vol.32 , pp. 184-194
    • Mahr, R.1    Gätgens, C.2    Gätgens, J.3    Polen, T.4    Kalinowski, J.5    Frunzke, J.6
  • 63
    • 84921476371 scopus 로고    scopus 로고
    • A synthetic suicide riboswitch for the high-throughput screening of metabolite production in Saccharomyces cerevisiae
    • 63 Lee, S.W., Oh, M.K., A synthetic suicide riboswitch for the high-throughput screening of metabolite production in Saccharomyces cerevisiae. Metab Eng 28 (2015), 143–150.
    • (2015) Metab Eng , vol.28 , pp. 143-150
    • Lee, S.W.1    Oh, M.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.