Systematic Evaluation of Methods for Integration of Transcriptomic Data into Constraint-Based Models of Metabolism

PLoS Computational Biology

Volumn 10, Issue 4, 2014, Pages

  Machado, Daniel ^a   Herrgård, Markus ^a  

^a Chalmers University of Technology   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DATA INTEGRATION; ENZYME ACTIVITY; ESCHERICHIA COLI; FORECASTING; PHYSIOLOGY;

BIOCHEMICAL NETWORK; CONSTRAINT-BASED MODELING; CONSTRAINTS-BASED MODELING; EVALUATION OF METHODS; FLUX DISTRIBUTIONS; METABOLIC FLUX; PREDICTIVE CAPABILITIES; SYSTEMATIC EVALUATION; TRANSCRIPT LEVEL; TRANSCRIPTOMICS;

METABOLISM;

ADAPTATION OF METABOLISM METHOD; AKESSON METHOD; ANALYTIC METHOD; ARTICLE; CONSTRAINT BASED MODEL; DATA PROCESSING; E FLUX METHOD; ESCHERICHIA COLI; EVALUATION STUDY; EXPLORATION OF ALTERNATIVE METABOLIC OPTIMA METHOD; FANG METHOD; FLUX COUPLED GENE METHOD; GENE EXPRESSION; GENE EXPRESSION FBA METHOD; GENE INACTIVITY MODERATED BY METABOLISM AND EXPRESSION METHOD; INFORMATION MODEL; INTEGRATIVE METABOLIC ANALYSIS TOOL METHOD; INTEGRATIVE NETWORK INFERENCE METHOD; INTERMETHOD COMPARISON; LEE METHOD; METABOLIC ADJUSTMENT BY DIFFERENTIAL EXPRESSION METHOD; METABOLIC CONTEXT SPECIFICITY ASSESSED BY DETERMINISTIC REACTION EVALUATION METHOD; METHODOLOGY; MOXLEY METHOD; NONHUMAN; PARSIMONY ANALYSIS; PHENOTYPE; PROBABILISTIC REGULATION OF METABOLISM METHOD; RELATIVE CHANGE METHOD; SACCHAROMYCES CEREVISIAE; SENSITIVITY ANALYSIS; TEMPORAL EXPRESSION BASED ANALYSIS OF METABOLISM METHOD; TRANSCRIPTIONALLY CONTROLLED FBA METHOD; TRANSCRIPTOMICS; BIOLOGICAL MODEL; METABOLISM;

TRANSCRIPTOME;

ESCHERICHIA COLI; METABOLISM; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE; TRANSCRIPTOME;

EID: 84901306814     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003580     Document Type: Article

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