A Method to Constrain Genome-Scale Models with 13C Labeling Data

PLoS Computational Biology

Volumn 11, Issue 9, 2015, Pages

  García Martín, Héctor ^a,b   Kumar, Vinay Satish ^a,b   Weaver, Daniel ^a,b   Ghosh, Amit ^a,b   Chubukov, Victor ^a,b   Mukhopadhyay, Aindrila ^a,b   Arkin, Adam ^a,c   Keasling, Jay D ^a,b,c,d  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b JOINT BIOENERGY INSTITUTE   (United States)

^c University of California   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL SYSTEMS; FORECASTING; GENES; METABOLIC ENGINEERING; OPTIMIZATION; PHYSIOLOGY;

13-C LABELING; BIOLOGICAL BEHAVIOR; CURRENT LIMITATION; EVOLUTIONARY OPTIMIZATIONS; FLUX BALANCE ANALYSIS; GENOME-SCALE MODEL; METABOLIC FLUX; OPTIMIZATION PRINCIPLE; RATE OPTIMIZATIONS; SIMPLE++;

METABOLISM;

CARBON 13; CARBON;

ANALYTIC METHOD; ARTICLE; CARBON METABOLISM; COMPUTER PREDICTION; EXTERNAL LABELING VARIABILITY ANALYSIS; FLUX BALANCE ANALYSIS; GENETIC ALGORITHM; GENETIC MODEL; INTERMETHOD COMPARISON; ISOTOPE LABELING; MATHEMATICAL MODEL; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; PROCESS OPTIMIZATION; VALIDATION STUDY; ALGORITHM; BACTERIAL GENOME; BIOLOGICAL MODEL; ESCHERICHIA COLI; GENE INACTIVATION; GENETICS; METABOLISM; PROCEDURES; SYSTEMS BIOLOGY;

ALGORITHMS; CARBON ISOTOPES; ESCHERICHIA COLI; GENE KNOCKOUT TECHNIQUES; GENOME, BACTERIAL; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; MODELS, BIOLOGICAL; SYSTEMS BIOLOGY;

EID: 84943573409     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004363     Document Type: Article

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