Model-based metabolic engineering enables high yield itaconic acid production by Escherichia coli

Metabolic Engineering

Volumn 38, Issue , 2016, Pages 29-37

  Harder, Björn Johannes ^a   Bettenbrock, Katja ^a   Klamt, Steffen ^a  

^a MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

Author keywords

Biotechnology; Computational strain design; Constraint based and stoichiometric modeling; Escherichia coli; Itaconate production; Metabolic engineering; Microbial cell factories

Indexed keywords

AMINO ACIDS; ASPERGILLUS; BIOTECHNOLOGY; CELL ENGINEERING; ESCHERICHIA COLI; GENES; GLUCOSE; ITERATIVE METHODS; METABOLIC ENGINEERING; METABOLISM; OXYGEN SUPPLY;

BY-PRODUCT FORMATION; FED-BATCH CULTIVATION; GENETIC MODIFICATIONS; HETEROLOGOUS PRODUCTION; INTERVENTION STRATEGY; MICROBIAL CELL FACTORIES; REALISTIC APPLICATIONS; STOICHIOMETRIC MODELS;

SUBSTRATES;

GLUCOSE; GLUTAMIC ACID; ITACONIC ACID; ESCHERICHIA COLI PROTEIN; SUCCINIC ACID DERIVATIVE;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOMASS; ESCHERICHIA COLI; FED BATCH CULTURE; GROWTH RATE; METABOLIC ENGINEERING; NONHUMAN; PLASMID; PRIORITY JOURNAL; BIOLOGICAL MODEL; BIOSYNTHESIS; COMPUTER SIMULATION; GENE EXPRESSION REGULATION; GENETIC ENHANCEMENT; GENETICS; ISOLATION AND PURIFICATION; METABOLIC FLUX ANALYSIS; METABOLISM; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION;

BIOSYNTHETIC PATHWAYS; COMPUTER SIMULATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENHANCEMENT; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SUCCINATES;

EID: 84974657997     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.05.008     Document Type: Article

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