Evolution reveals a glutathione-dependent mechanism of 3-hydroxypropionic acid tolerance

Metabolic Engineering

Volumn 26, Issue , 2014, Pages 57-66

  Kildegaard, Kanchana R ^a   Hallström, Björn M ^b   Blicher, Thomas H ^c   Sonnenschein, Nikolaus ^a   Jensen, Niels B ^a   Sherstyk, Svetlana ^a   Harrison, Scott J ^a   Maury, Jérôme ^a   Herrgård, Markus J ^a   Juncker, Agnieszka S ^a   Forster, Jochen ^a   Nielsen, Jens ^a,d   Borodina, Irina ^a  

^a Chalmers University of Technology   (Denmark)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^c University of Copenhagen   (Denmark)

^d CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

3 hydroxypropionic acid; 3 hydroxypropionic aldehyde (reuterin); Adaptive laboratory evolution; Saccharomyces cerevisiae; Tolerance

Indexed keywords

FITS AND TOLERANCES;

3-HYDROXYPROPIONIC ACID; ADAPTIVE LABORATORY EVOLUTION; REUTERIN;

YEAST;

(HYDROXYMETHYL)GLUTATHIONE DEHYDROGENASE; ALCOHOL DEHYDROGENASE; ALDEHYDE; CARBOXYLIC ACID; COENZYME A TRANSFERASE; GLUTATHIONE; HYDRACRYLIC ACID; TRANSCRIPTOME; UNCLASSIFIED DRUG; LACTIC ACID;

ARTICLE; BACTERIAL STRAIN; DETOXIFICATION; ENZYME ACTIVITY; ENZYME MECHANISM; GENE; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GENOME; METABOLIC ENGINEERING; NONHUMAN; PH; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; YEAST; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; DIRECTED MOLECULAR EVOLUTION; DOSE RESPONSE; DRUG EFFECTS; DRUG TOLERANCE; ESCHERICHIA COLI; GENETIC ENHANCEMENT; GENETICS; METABOLISM; PROCEDURES;

CELL PROLIFERATION; DIRECTED MOLECULAR EVOLUTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ESCHERICHIA COLI; GENETIC ENHANCEMENT; GLUTATHIONE; LACTIC ACID; SACCHAROMYCES CEREVISIAE;

EID: 84907862283     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.09.004     Document Type: Article

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