Biosensor-driven adaptive laboratory evolution of l-valine production in Corynebacterium glutamicum

Metabolic Engineering

Volumn 32, Issue , 2015, Pages 184-194

  Mahr, Regina ^a   Gätgens, Cornelia ^a   Gätgens, Jochem ^a   Polen, Tino ^a   Kalinowski, Jörn ^b   Frunzke, Julia ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

Adaptive laboratory evolution; Biosensor; Corynebacterium glutamicum; L valine; Metabolic engineering; Transcription factor

Indexed keywords

BIOSENSORS; FLOW CYTOMETRY; FLUORESCENCE; METABOLIC ENGINEERING; METABOLISM; METABOLITES; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ADAPTIVE LABORATORY EVOLUTION; CORYNEBACTERIUM GLUTAMICUM; EXPERIMENTAL EVOLUTION; FLUORESCENCE ACTIVATED CELL SORTING; L-VALINE; MICROBIAL METABOLITES; MICROBIAL PRODUCTION; TRANSCRIPTIONAL REGULATOR;

AMINO ACIDS;

ALANINE; VALINE; BACTERIAL DNA; FLUORESCENT DYE; RECOMBINANT DNA;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOSENSOR; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; FLUORESCENCE ACTIVATED CELL SORTING; GENE SEQUENCE; GROWTH RATE; LOSS OF FUNCTION MUTATION; METABOLIC ENGINEERING; METABOLITE; NONHUMAN; PRIORITY JOURNAL; URED GENE; BIOSYNTHESIS; CORYNEBACTERIUM; DIRECTED MOLECULAR EVOLUTION; GENETIC PROCEDURES; GENETICS; METABOLISM; MUTATION;

BIOSENSING TECHNIQUES; CORYNEBACTERIUM; CORYNEBACTERIUM GLUTAMICUM; DIRECTED MOLECULAR EVOLUTION; DNA, BACTERIAL; DNA, RECOMBINANT; FLUORESCENT DYES; METABOLIC ENGINEERING; MUTATION; VALINE;

EID: 84945388093     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2015.09.017     Document Type: Article

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