-
1
-
-
84864186953
-
Metabolic engineering of Saccharomyces cerevisiae: A key cell factory platform for future biorefineries
-
Hong, K.K. and Nielsen, J. Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries. Cell. Mol. Life Sci. 69, 2671-2690 (2012).
-
(2012)
Cell. Mol. Life Sci.
, vol.69
, pp. 2671-2690
-
-
Hong, K.K.1
Nielsen, J.2
-
2
-
-
84924363983
-
How to set up collaborations between academia and industrial biotech companies
-
Pronk, J.T. et al. How to set up collaborations between academia and industrial biotech companies. Nat. Biotechnol. 33, 237-240 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 237-240
-
-
Pronk, J.T.1
-
3
-
-
0025895183
-
Toward a science of metabolic engineering
-
Bailey, J.E. Toward a science of metabolic engineering. Science 252, 1668-1675 (1991).
-
(1991)
Science
, vol.252
, pp. 1668-1675
-
-
Bailey, J.E.1
-
4
-
-
84861440312
-
Systems metabolic engineering of microorganisms for natural and non-natural chemicals
-
Lee, J.W. et al. Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Nat. Chem. Biol. 8, 536-546 (2012).
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 536-546
-
-
Lee, J.W.1
-
5
-
-
84878836229
-
Systems metabolic engineering in an industrial setting
-
Sagt, C.M. Systems metabolic engineering in an industrial setting. Appl. Microbiol. Biotechnol. 97, 2319-2326 (2013).
-
(2013)
Appl. Microbiol. Biotechnol.
, vol.97
, pp. 2319-2326
-
-
Sagt, C.M.1
-
6
-
-
34249934691
-
Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation
-
Park, J.H., Lee, K.H., Kim, T.Y. and Lee, S.Y. Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation. Proc. Natl. Acad. Sci. USA 104, 7797-7802 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 7797-7802
-
-
Park, J.H.1
Lee, K.H.2
Kim, T.Y.3
Lee, S.Y.4
-
7
-
-
79952578981
-
Fed-batch culture of Escherichia coli for L-valine production based on in silico flux response analysis
-
Park, J.H., Kim, T.Y., Lee, K.H. and Lee, S.Y. Fed-batch culture of Escherichia coli for L-valine production based on in silico flux response analysis. Biotechnol. Bioeng. 108, 934-946 (2011).
-
(2011)
Biotechnol. Bioeng.
, vol.108
, pp. 934-946
-
-
Park, J.H.1
Kim, T.Y.2
Lee, K.H.3
Lee, S.Y.4
-
8
-
-
79953162662
-
Escherichia coli W as a new platform strain for the enhanced production of L-valine by systems metabolic engineering
-
Park, J.H., Jang, Y.S., Lee, J.W. and Lee, S.Y. Escherichia coli W as a new platform strain for the enhanced production of L-valine by systems metabolic engineering. Biotechnol. Bioeng. 108, 1140-1147 (2011).
-
(2011)
Biotechnol. Bioeng.
, vol.108
, pp. 1140-1147
-
-
Park, J.H.1
Jang, Y.S.2
Lee, J.W.3
Lee, S.Y.4
-
9
-
-
36849002434
-
Systems metabolic engineering of Escherichia coli for L-threonine production
-
Lee, K.H., Park, J.H., Kim, T.Y., Kim, H.U. and Lee, S.Y. Systems metabolic engineering of Escherichia coli for L-threonine production. Mol. Syst. Biol. 3, 149 (2007).
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 149
-
-
Lee, K.H.1
Park, J.H.2
Kim, T.Y.3
Kim, H.U.4
Lee, S.Y.5
-
10
-
-
79952109824
-
Development of sucrose-utilizing Escherichia coli K-12 strain by cloning b-fructofuranosidases and its application for L-threonine production
-
Lee, J.W. et al. Development of sucrose-utilizing Escherichia coli K-12 strain by cloning b-fructofuranosidases and its application for L-threonine production. Appl. Microbiol. Biotechnol. 88, 905-913 (2010).
-
(2010)
Appl. Microbiol. Biotechnol.
, vol.88
, pp. 905-913
-
-
Lee, J.W.1
-
11
-
-
79959374585
-
Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol
-
Yim, H. et al. Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol. Nat. Chem. Biol. 7, 445-452 (2011).
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 445-452
-
-
Yim, H.1
-
12
-
-
84876784070
-
High-level semi-synthetic production of the potent antimalarial artemisinin
-
Paddon, C.J. et al. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 496, 528-532 (2013).
-
(2013)
Nature
, vol.496
, pp. 528-532
-
-
Paddon, C.J.1
-
13
-
-
33645029734
-
Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production
-
Lee, S.J., Song, H. and Lee, S.Y. Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production. Appl. Environ. Microbiol. 72, 1939-1948 (2006).
-
(2006)
Appl. Environ. Microbiol.
, vol.72
, pp. 1939-1948
-
-
Lee, S.J.1
Song, H.2
Lee, S.Y.3
-
14
-
-
84884531356
-
Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing Basfia succiniciproducens
-
Becker, J. et al. Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing Basfia succiniciproducens. Biotechnol. Bioeng. 110, 3013-3023 (2013).
-
(2013)
Biotechnol. Bioeng.
, vol.110
, pp. 3013-3023
-
-
Becker, J.1
-
15
-
-
84907362164
-
Metabolic engineering of Corynebacterium glutamicum for L-arginine production
-
Park, S.H. et al. Metabolic engineering of Corynebacterium glutamicum for L-arginine production. Nat. Commun. 5, 4618 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 4618
-
-
Park, S.H.1
-
16
-
-
79952106791
-
From zero to hero- design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production
-
Becker, J., Zelder, O., Häfner, S., Schröder, H. and Wittmann, C. From zero to hero- design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production. Metab. Eng. 13, 159-168 (2011).
-
(2011)
Metab. Eng.
, vol.13
, pp. 159-168
-
-
Becker, J.1
Zelder, O.2
Häfner, S.3
Schröder, H.4
Wittmann, C.5
-
17
-
-
84905366023
-
From zero to hero-production of bio-based nylon from renewable resources using engineered Corynebacterium glutamicum
-
Kind, S. et al. From zero to hero-production of bio-based nylon from renewable resources using engineered Corynebacterium glutamicum. Metab. Eng. 25, 113-123 (2014).
-
(2014)
Metab. Eng.
, vol.25
, pp. 113-123
-
-
Kind, S.1
-
18
-
-
20644467467
-
Systems biotechnology for strain improvement
-
Lee, S.Y., Lee, D.Y. and Kim, T.Y. Systems biotechnology for strain improvement. Trends Biotechnol. 23, 349-358 (2005).
-
(2005)
Trends Biotechnol.
, vol.23
, pp. 349-358
-
-
Lee, S.Y.1
Lee, D.Y.2
Kim, T.Y.3
-
19
-
-
84857192122
-
Computational tools for the synthetic design of biochemical pathways
-
Medema, M.H., van Raaphorst, R., Takano, E. and Breitling, R. Computational tools for the synthetic design of biochemical pathways. Nat. Rev. Microbiol. 10, 191-202 (2012).
-
(2012)
Nat. Rev. Microbiol.
, vol.10
, pp. 191-202
-
-
Medema, M.H.1
Van Raaphorst, R.2
Takano, E.3
Breitling, R.4
-
20
-
-
84899051891
-
Semi-synthetic artemisinin: A model for the use of synthetic biology in pharmaceutical development
-
Paddon, C.J. and Keasling, J.D. Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development. Nat. Rev. Microbiol. 12, 355-367 (2014).
-
(2014)
Nat. Rev. Microbiol.
, vol.12
, pp. 355-367
-
-
Paddon, C.J.1
Keasling, J.D.2
-
21
-
-
84873800970
-
Genome-scale engineering for systems and synthetic biology
-
Esvelt, K.M. and Wang, H.H. Genome-scale engineering for systems and synthetic biology. Mol. Syst. Biol. 9, 641 (2013).
-
(2013)
Mol. Syst. Biol.
, vol.9
, pp. 641
-
-
Esvelt, K.M.1
Wang, H.H.2
-
22
-
-
84859776222
-
The future of metabolic engineering and synthetic biology: Towards a systematic practice
-
Yadav, V.G., De Mey, M., Lim, C.G., Ajikumar, P.K. and Stephanopoulos, G. The future of metabolic engineering and synthetic biology: towards a systematic practice. Metab. Eng. 14, 233-241 (2012).
-
(2012)
Metab. Eng.
, vol.14
, pp. 233-241
-
-
Yadav, V.G.1
De Mey, M.2
Lim, C.G.3
Ajikumar, P.K.4
Stephanopoulos, G.5
-
23
-
-
84865279828
-
Directed evolution: An evolving and enabling synthetic biology tool
-
Cobb, R.E., Si, T. and Zhao, H. Directed evolution: an evolving and enabling synthetic biology tool. Curr. Opin. Chem. Biol. 16, 285-291 (2012).
-
(2012)
Curr. Opin. Chem. Biol.
, vol.16
, pp. 285-291
-
-
Cobb, R.E.1
Si, T.2
Zhao, H.3
-
24
-
-
0029874193
-
High cell-density culture of Escherichia coli
-
Lee, S.Y. High cell-density culture of Escherichia coli. Trends Biotechnol. 14, 98-105 (1996).
-
(1996)
Trends Biotechnol.
, vol.14
, pp. 98-105
-
-
Lee, S.Y.1
-
25
-
-
84879074498
-
Emerging tools for synthetic genome design
-
Lee, B.R., Cho, S., Song, Y., Kim, S.C. and Cho, B.K. Emerging tools for synthetic genome design. Mol. Cells 35, 359-370 (2013).
-
(2013)
Mol. Cells
, vol.35
, pp. 359-370
-
-
Lee, B.R.1
Cho, S.2
Song, Y.3
Kim, S.C.4
Cho, B.K.5
-
26
-
-
84921508419
-
Genome engineering and gene expression control for bacterial strain development
-
Song, C.W., Lee, J. and Lee, S.Y. Genome engineering and gene expression control for bacterial strain development. Biotechnol. J. 10, 56-68 (2015).
-
(2015)
Biotechnol. J.
, vol.10
, pp. 56-68
-
-
Song, C.W.1
Lee, J.2
Lee, S.Y.3
-
27
-
-
84937573954
-
Multi-scale exploration of the technical, economic, and environmental dimensions of bio-based chemical production
-
Zhuang, K.H. and Herrgård, M.J. Multi-scale exploration of the technical, economic, and environmental dimensions of bio-based chemical production. Metab. Eng. 31, 1-12 (2015).
-
(2015)
Metab. Eng.
, vol.31
, pp. 1-12
-
-
Zhuang, K.H.1
Herrgård, M.J.2
-
28
-
-
84924060551
-
The future of industrial bioprocessing: Batch or continuous?
-
Croughan, M.S., Konstantinov, K.B. and Cooney, C. The future of industrial bioprocessing: batch or continuous? Biotechnol. Bioeng. 112, 648-651 (2015).
-
(2015)
Biotechnol. Bioeng.
, vol.112
, pp. 648-651
-
-
Croughan, M.S.1
Konstantinov, K.B.2
Cooney, C.3
-
29
-
-
84887622083
-
From the first drop to the first truckload: Commercialization of microbial processes for renewable chemicals
-
Van Dien, S. From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals. Curr. Opin. Biotechnol. 24, 1061-1068 (2013).
-
(2013)
Curr. Opin. Biotechnol.
, vol.24
, pp. 1061-1068
-
-
Van Dien, S.1
-
30
-
-
84884918887
-
Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to g-butyrolactone by acid treatment
-
Choi, S. et al. Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to g-butyrolactone by acid treatment. Metab. Eng. 20, 73-83 (2013).
-
(2013)
Metab. Eng.
, vol.20
, pp. 73-83
-
-
Choi, S.1
-
31
-
-
84868610929
-
Integration of chemical catalysis with extractive fermentation to produce fuels
-
Anbarasan, P. et al. Integration of chemical catalysis with extractive fermentation to produce fuels. Nature 491, 235-239 (2012).
-
(2012)
Nature
, vol.491
, pp. 235-239
-
-
Anbarasan, P.1
-
32
-
-
77950850438
-
Systematic planning of genome-scale experiments in poorly studied species
-
Guan, Y., Dunham, M., Caudy, A. and Troyanskaya, O. Systematic planning of genome-scale experiments in poorly studied species. PLOS Comput. Biol. 6, e1000698 (2010).
-
(2010)
PLOS Comput. Biol.
, vol.6
, pp. e1000698
-
-
Guan, Y.1
Dunham, M.2
Caudy, A.3
Troyanskaya, O.4
-
33
-
-
84934947770
-
High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system
-
Cobb, R.E., Wang, Y. and Zhao, H. High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system. ACS Synth. Biol. 4, 723-728 (2015).
-
(2015)
ACS Synth. Biol.
, vol.4
, pp. 723-728
-
-
Cobb, R.E.1
Wang, Y.2
Zhao, H.3
-
34
-
-
84940106526
-
CRISPR-Cas9 based engineering of actinomycetal genomes
-
Tong, Y., Charusanti, P., Zhang, L., Weber, T. and Lee, S.Y. CRISPR-Cas9 based engineering of actinomycetal genomes. ACS Synth. Biol. doi:10.1021/acssynbio.5b00038 (25 March 2015).
-
(2015)
ACS Synth. Biol.
-
-
Tong, Y.1
Charusanti, P.2
Zhang, L.3
Weber, T.4
Lee, S.Y.5
-
35
-
-
84883001788
-
Production of bulk chemicals via novel metabolic pathways in microorganisms
-
Shin, J.H., Kim, H.U., Kim, D.I. and Lee, S.Y. Production of bulk chemicals via novel metabolic pathways in microorganisms. Biotechnol. Adv. 31, 925-935 (2013).
-
(2013)
Biotechnol. Adv.
, vol.31
, pp. 925-935
-
-
Shin, J.H.1
Kim, H.U.2
Kim, D.I.3
Lee, S.Y.4
-
36
-
-
79960414910
-
Systems metabolic engineering for chemicals and materials
-
Lee, J.W., Kim, T.Y., Jang, Y.S., Choi, S. and Lee, S.Y. Systems metabolic engineering for chemicals and materials. Trends Biotechnol. 29, 370-378 (2011).
-
(2011)
Trends Biotechnol.
, vol.29
, pp. 370-378
-
-
Lee, J.W.1
Kim, T.Y.2
Jang, Y.S.3
Choi, S.4
Lee, S.Y.5
-
37
-
-
82755189684
-
Microbial production of building block chemicals and polymers
-
Lee, J.W., Kim, H.U., Choi, S., Yi, J. and Lee, S.Y. Microbial production of building block chemicals and polymers. Curr. Opin. Biotechnol. 22, 758-767 (2011).
-
(2011)
Curr. Opin. Biotechnol.
, vol.22
, pp. 758-767
-
-
Lee, J.W.1
Kim, H.U.2
Choi, S.3
Yi, J.4
Lee, S.Y.5
-
38
-
-
84886948663
-
Microbial production of short-chain alkanes
-
Choi, Y.J. and Lee, S.Y. Microbial production of short-chain alkanes. Nature 502, 571-574 (2013).
-
(2013)
Nature
, vol.502
, pp. 571-574
-
-
Choi, Y.J.1
Lee, S.Y.2
-
39
-
-
80051941601
-
Engineered reversal of the b-oxidation cycle for the synthesis of fuels and chemicals
-
Dellomonaco, C., Clomburg, J.M., Miller, E.N. and Gonzalez, R. Engineered reversal of the b-oxidation cycle for the synthesis of fuels and chemicals. Nature 476, 355-359 (2011).
-
(2011)
Nature
, vol.476
, pp. 355-359
-
-
Dellomonaco, C.1
Clomburg, J.M.2
Miller, E.N.3
Gonzalez, R.4
-
40
-
-
84931420611
-
Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli
-
Yu, J.L., Xia, X.X., Zhong, J.J. and Qian, Z.G. Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli. Biotechnol. Bioeng. 111, 2580-2586 (2014).
-
(2014)
Biotechnol. Bioeng.
, vol.111
, pp. 2580-2586
-
-
Yu, J.L.1
Xia, X.X.2
Zhong, J.J.3
Qian, Z.G.4
-
41
-
-
84909594451
-
Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via b-alanine
-
Borodina, I. et al. Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via b-alanine. Metab. Eng. 27, 57-64 (2015).
-
(2015)
Metab. Eng.
, vol.27
, pp. 57-64
-
-
Borodina, I.1
-
42
-
-
84879825498
-
Metabolic and pathway engineering to influence native and altered erythromycin production through E. Coli
-
Jiang, M. and Pfeifer, B.A. Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli. Metab. Eng. 19, 42-49 (2013).
-
(2013)
Metab. Eng.
, vol.19
, pp. 42-49
-
-
Jiang, M.1
Pfeifer, B.A.2
-
43
-
-
77950899704
-
Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine
-
Zhang, K., Li, H., Cho, K.M. and Liao, J.C. Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine. Proc. Natl. Acad. Sci. USA 107, 6234-6239 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 6234-6239
-
-
Zhang, K.1
Li, H.2
Cho, K.M.3
Liao, J.C.4
-
44
-
-
84921517479
-
Functional optimization of gene clusters by combinatorial design and assembly
-
Smanski, M.J. et al. Functional optimization of gene clusters by combinatorial design and assembly. Nat. Biotechnol. 32, 1241-1249 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1241-1249
-
-
Smanski, M.J.1
-
45
-
-
84905757148
-
Microbial tolerance engineering toward biochemical production: From lignocellulose to products
-
Ling, H., Teo, W., Chen, B., Leong, S.S. and Chang, M.W. Microbial tolerance engineering toward biochemical production: from lignocellulose to products. Curr. Opin. Biotechnol. 29, 99-106 (2014).
-
(2014)
Curr. Opin. Biotechnol.
, vol.29
, pp. 99-106
-
-
Ling, H.1
Teo, W.2
Chen, B.3
Leong, S.S.4
Chang, M.W.5
-
46
-
-
84865590210
-
Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter
-
Utrilla, J. et al. Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter. Metab. Eng. 14, 469-476 (2012).
-
(2012)
Metab. Eng.
, vol.14
, pp. 469-476
-
-
Utrilla, J.1
-
47
-
-
79955806186
-
Engineering microbial biofuel tolerance and export using efflux pumps
-
Dunlop, M.J. et al. Engineering microbial biofuel tolerance and export using efflux pumps. Mol. Syst. Biol. 7, 487 (2011).
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 487
-
-
Dunlop, M.J.1
-
48
-
-
84907518524
-
Biofuels. Engineering alcohol tolerance in yeast
-
Lam, F.H., Ghaderi, A., Fink, G.R. and Stephanopoulos, G. Biofuels. Engineering alcohol tolerance in yeast. Science 346, 71-75 (2014).
-
(2014)
Science
, vol.346
, pp. 71-75
-
-
Lam, F.H.1
Ghaderi, A.2
Fink, G.R.3
Stephanopoulos, G.4
-
49
-
-
84873596341
-
Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs
-
Na, D. et al. Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs. Nat. Biotechnol. 31, 170-174 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 170-174
-
-
Na, D.1
-
50
-
-
84883419083
-
Design and use of synthetic regulatory small RNAs to control gene expression in Escherichia coli
-
Yoo, S.M., Na, D. and Lee, S.Y. Design and use of synthetic regulatory small RNAs to control gene expression in Escherichia coli. Nat. Protoc. 8, 1694-1707 (2013).
-
(2013)
Nat. Protoc.
, vol.8
, pp. 1694-1707
-
-
Yoo, S.M.1
Na, D.2
Lee, S.Y.3
-
51
-
-
84901623994
-
Optimal cofactor swapping can increase the theoretical yield for chemical production in Escherichia coli and Saccharomyces cerevisiae
-
King, Z.A. and Feist, A.M. Optimal cofactor swapping can increase the theoretical yield for chemical production in Escherichia coli and Saccharomyces cerevisiae. Metab. Eng. 24, 117-128 (2014).
-
(2014)
Metab. Eng.
, vol.24
, pp. 117-128
-
-
King, Z.A.1
Feist, A.M.2
-
52
-
-
0031077787
-
Alteration of substrate specificity of Zymomonas mobilis alcohol dehydrogenase-2 using in vitro
-
random mutagenesis
-
Rellos, P., Ma, J. and Scopes, R.K. Alteration of substrate specificity of Zymomonas mobilis alcohol dehydrogenase-2 using in vitro random mutagenesis. Protein Expr. Purif. 9, 83-90 (1997).
-
(1997)
Protein Expr. Purif.
, vol.9
, pp. 83-90
-
-
Rellos, P.1
Ma, J.2
Scopes, R.K.3
-
53
-
-
84867660750
-
Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network
-
Kim, J. and Copley, S.D. Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network. Proc. Natl. Acad. Sci. USA 109, E2856-E2864 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E2856-E2864
-
-
Kim, J.1
Copley, S.D.2
-
54
-
-
56449105588
-
Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli
-
Jantama, K. et al. Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C. Biotechnol. Bioeng. 101, 881-893 (2008).
-
(2008)
C. Biotechnol. Bioeng.
, vol.101
, pp. 881-893
-
-
Jantama, K.1
-
55
-
-
84920748206
-
Design of homo-organic acid producing strains using multi-objective optimization
-
Kim, T.Y., Park, J.M., Kim, H.U., Cho, K.M. and Lee, S.Y. Design of homo-organic acid producing strains using multi-objective optimization. Metab. Eng. 28, 63-73 (2015).
-
(2015)
Metab. Eng.
, vol.28
, pp. 63-73
-
-
Kim, T.Y.1
Park, J.M.2
Kim, H.U.3
Cho, K.M.4
Lee, S.Y.5
-
56
-
-
84858439602
-
Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods
-
Lewis, N.E., Nagarajan, H. and Palsson, B.O. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nat. Rev. Microbiol. 10, 291-305 (2012).
-
(2012)
Nat. Rev. Microbiol.
, vol.10
, pp. 291-305
-
-
Lewis, N.E.1
Nagarajan, H.2
Palsson, B.O.3
-
57
-
-
68949161807
-
Programming cells by multiplex genome engineering and accelerated evolution
-
Wang, H.H. et al. Programming cells by multiplex genome engineering and accelerated evolution. Nature 460, 894-898 (2009).
-
(2009)
Nature
, vol.460
, pp. 894-898
-
-
Wang, H.H.1
-
58
-
-
84861963767
-
Genome-scale promoter engineering by coselection MAGE
-
Wang, H.H. et al. Genome-scale promoter engineering by coselection MAGE. Nat. Methods 9, 591-593 (2012).
-
(2012)
Nat. Methods
, vol.9
, pp. 591-593
-
-
Wang, H.H.1
-
59
-
-
77955459156
-
Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides
-
Warner, J.R., Reeder, P.J., Karimpour-Fard, A., Woodruff, L.B. and Gill, R.T. Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides. Nat. Biotechnol. 28, 856-862 (2010).
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 856-862
-
-
Warner, J.R.1
Reeder, P.J.2
Karimpour-Fard, A.3
Woodruff, L.B.4
Gill, R.T.5
-
60
-
-
84905408748
-
Biofuel production: An odyssey from metabolic engineering to fermentation scale-up
-
Hollinshead, W., He, L. and Tang, Y.J. Biofuel production: an odyssey from metabolic engineering to fermentation scale-up. Front. Microbiol. 5, 344 (2014).
-
(2014)
Front. Microbiol.
, vol.5
, pp. 344
-
-
Hollinshead, W.1
He, L.2
Tang, Y.J.3
-
61
-
-
84887422015
-
Engineering dynamic pathway regulation using stress-response promoters
-
Dahl, R.H. et al. Engineering dynamic pathway regulation using stress-response promoters. Nat. Biotechnol. 31, 1039-1046 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 1039-1046
-
-
Dahl, R.H.1
-
62
-
-
84941346066
-
Complete biosynthesis of opioids in yeast
-
Galanie, S., Thodey, K., Trenchard, I.J., Filsinger, I.M. and Smolke, C.D. Complete biosynthesis of opioids in yeast. Science 349, 1095-1100 (2015).
-
(2015)
Science
, vol.349
, pp. 1095-1100
-
-
Galanie, S.1
Thodey, K.2
Trenchard, I.J.3
Filsinger, I.M.4
Smolke, C.D.5
-
63
-
-
84864258618
-
A whole-cell computational model predicts phenotype from genotype
-
Karr, J.R. et al. A whole-cell computational model predicts phenotype from genotype. Cell 150, 389-401 (2012).
-
(2012)
Cell
, vol.150
, pp. 389-401
-
-
Karr, J.R.1
-
64
-
-
0028532887
-
Broth recycle in a yeast fermentation
-
Hsiao, T.Y., Glatz, C.E. and Glatz, B.A. Broth recycle in a yeast fermentation. Biotechnol. Bioeng. 44, 1228-1234 (1994).
-
(1994)
Biotechnol. Bioeng.
, vol.44
, pp. 1228-1234
-
-
Hsiao, T.Y.1
Glatz, C.E.2
Glatz, B.A.3
-
65
-
-
84920257993
-
Development of an enhanced chromosomal expression system based on porin synthesis operon for halophile Halomonas sp
-
Yin, J., Fu, X.Z., Wu, Q., Chen, J.C. and Chen, G.Q. Development of an enhanced chromosomal expression system based on porin synthesis operon for halophile Halomonas sp. Appl. Microbiol. Biotechnol. 98, 8987-8997 (2014).
-
(2014)
Appl. Microbiol. Biotechnol.
, vol.98
, pp. 8987-8997
-
-
Yin, J.1
Fu, X.Z.2
Wu, Q.3
Chen, J.C.4
Chen, G.Q.5
-
66
-
-
84907483760
-
Biofuels. Altered sterol composition renders yeast thermotolerant
-
Caspeta, L. et al. Biofuels. Altered sterol composition renders yeast thermotolerant. Science 346, 75-78 (2014).
-
(2014)
Science
, vol.346
, pp. 75-78
-
-
Caspeta, L.1
-
67
-
-
37349099750
-
A predictive model for transcriptional control of physiology in a free living cell
-
Bonneau, R. et al. A predictive model for transcriptional control of physiology in a free living cell. Cell 131, 1354-1365 (2007).
-
(2007)
Cell
, vol.131
, pp. 1354-1365
-
-
Bonneau, R.1
-
68
-
-
84899157254
-
An appropriate concentration of arginine is required for normal root growth in rice
-
Xia, J., Yamaji, N. and Ma, J.F. An appropriate concentration of arginine is required for normal root growth in rice. Plant Signal. Behav. 9, e28717 (2014).
-
(2014)
Plant Signal. Behav.
, vol.9
, pp. e28717
-
-
Xia, J.1
Yamaji, N.2
Ma, J.F.3
-
69
-
-
0242487787
-
Optknock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
-
Burgard, A.P., Pharkya, P. and Maranas, C.D. Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnol. Bioeng. 84, 647-657 (2003).
-
(2003)
Biotechnol. Bioeng.
, vol.84
, pp. 647-657
-
-
Burgard, A.P.1
Pharkya, P.2
Maranas, C.D.3
-
70
-
-
84887628469
-
13C metabolic flux analysis: Optimal design of isotopic labeling experiments
-
Antoniewicz, M.R. 13C metabolic flux analysis: optimal design of isotopic labeling experiments. Curr. Opin. Biotechnol. 24, 1116-1121 (2013).
-
(2013)
Curr. Opin. Biotechnol.
, vol.24
, pp. 1116-1121
-
-
Antoniewicz, M.R.1
-
71
-
-
58149154663
-
Elementary mode analysis: A useful metabolic pathway analysis tool for characterizing cellular metabolism
-
Trinh, C.T., Wlaschin, A. and Srienc, F. Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism. Appl. Microbiol. Biotechnol. 81, 813-826 (2009).
-
(2009)
Appl. Microbiol. Biotechnol.
, vol.81
, pp. 813-826
-
-
Trinh, C.T.1
Wlaschin, A.2
Srienc, F.3
-
72
-
-
38349151554
-
Metabolic flux analysis and metabolic engineering of microorganisms
-
Kim, H.U., Kim, T.Y. and Lee, S.Y. Metabolic flux analysis and metabolic engineering of microorganisms. Mol. Biosyst. 4, 113-120 (2008).
-
(2008)
Mol. Biosyst.
, vol.4
, pp. 113-120
-
-
Kim, H.U.1
Kim, T.Y.2
Lee, S.Y.3
|