A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination

Genes and Development

Volumn 30, Issue 23, 2016, Pages 2581-2595

  Luo, Kuntian ^a,b   Li, Lei ^a   Li, Yunhui ^a   Wu, Chenming ^a   Yin, Yujiao ^a   Chen, Yuping ^a   Deng, Min ^b   Nowsheen, Somaira ^c   Yuan, Jian ^a,b   Lou, Zhenkun ^b,d  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b MAYO CLINIC   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

BRCA2; Deubiquitination; DNA damage response; Homologous recombination; Rad51; UCHL3

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; BETA ACTIN; BRCA1 PROTEIN; BRCA2 PROTEIN; DEUBIQUITINASE; HISTONE H2AX; MYC PROTEIN; OLAPARIB; PROTEINASE; RAD51 PROTEIN; SHORT HAIRPIN RNA; UBIQUITIN; UCHL3 PROTEIN; UNCLASSIFIED DRUG; BRCA2 PROTEIN, HUMAN; CYSTEINE PROTEINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN BINDING; UCHL3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RESISTANCE; DEUBIQUITINATION; DNA DAMAGE RESPONSE; ENZYME ACTIVE SITE; HOMOLOGOUS RECOMBINATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; WILD TYPE; BREAST TUMOR; DNA REPAIR; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; HEK293 CELL LINE; HUMAN; MCF-7 CELL LINE; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TUMOR CELL LINE;

BRCA2 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; DNA REPAIR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HOMOLOGOUS RECOMBINATION; HUMANS; MCF-7 CELLS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; PROTEIN BINDING; RAD51 RECOMBINASE; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; UBIQUITINATION;

EID: 85007374794     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.289439.116     Document Type: Article

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