Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: Modeling and experimental validation of a chimera peptide

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5782-5791

  Nomme, Julian ^a   Renodon Cornière, Axelle ^a   Asanomi, Yuya ^b   Sakaguchi, Kazuyasu ^b   Stasiak, Alicja Z ^c   Stasiak, Andrzej ^c   Norden, Bengt ^d   Tran, Vinh ^a   Takahashi, Masayuki ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b HOKKAIDO UNIVERSITY   (Japan)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; CHIMERIC PROTEIN; NUCLEOTIDYLTRANSFERASE INHIBITOR; RAD51 PROTEIN; RAD51 PROTEIN INHIBITOR; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; DRUG DESIGN; DRUG SYNTHESIS; ELECTRON MICROSCOPY; ENZYME INHIBITOR INTERACTION; MOLECULAR MODEL; PROTEIN DNA BINDING; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; BINDING SITES; BRCA2 PROTEIN; CALORIMETRY; DNA; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; RAD51 RECOMBINASE; THERMODYNAMICS;

EID: 77955356550     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1002974     Document Type: Article

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