메뉴 건너뛰기




Volumn 108, Issue 26, 2011, Pages 10448-10453

Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms

Author keywords

Breast cancer; Cancer; Chromosome stability; DNA break repair; Recombination

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BRCA2 PROTEIN; DOUBLE STRANDED DNA; NUCLEOPROTEIN; RAD51 PROTEIN; SINGLE STRANDED DNA;

EID: 79960597176     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106971108     Document Type: Article
Times cited : (126)

References (38)
  • 4
    • 0033179235 scopus 로고    scopus 로고
    • BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo
    • Yuan SS, et al. (1999) BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res 59:3547-3551.
    • (1999) Cancer Res , vol.59 , pp. 3547-3551
    • Yuan, S.S.1
  • 5
    • 77956325620 scopus 로고    scopus 로고
    • DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
    • Cejka P, et al. (2010) DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2. Nature 467:112-116.
    • (2010) Nature , vol.467 , pp. 112-116
    • Cejka, P.1
  • 6
    • 77956302112 scopus 로고    scopus 로고
    • Mechanism of the ATP-dependent DNA end resection machinery from Saccharomyces cerevisiae
    • Niu H, et al. (2010) Mechanism of the ATP-dependent DNA end resection machinery from Saccharomyces cerevisiae. Nature 467:108-111.
    • (2010) Nature , vol.467 , pp. 108-111
    • Niu, H.1
  • 7
    • 79951688343 scopus 로고    scopus 로고
    • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
    • Nimonkar AV, et al. (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev 25:350-362.
    • (2011) Genes Dev , vol.25 , pp. 350-362
    • Nimonkar, A.V.1
  • 8
    • 77957975815 scopus 로고    scopus 로고
    • Purified human BRCA2 stimulates RAD51-mediated recombination
    • Jensen RB, Carreira A, Kowalczykowski SC (2010) Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 467:678-683.
    • (2010) Nature , vol.467 , pp. 678-683
    • Jensen, R.B.1    Carreira, A.2    Kowalczykowski, S.C.3
  • 9
    • 77957804215 scopus 로고    scopus 로고
    • Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
    • Liu J, Doty T, Gibson B, Heyer WD (2010) Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol 17:1260-1262.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1260-1262
    • Liu, J.1    Doty, T.2    Gibson, B.3    Heyer, W.D.4
  • 10
    • 0030140414 scopus 로고    scopus 로고
    • Internal repeats in the BRCA2 protein sequence
    • Bork P, Blomberg N, Nilges M (1996) Internal repeats in the BRCA2 protein sequence. Nat Genet 13:22-23.
    • (1996) Nat Genet , vol.13 , pp. 22-23
    • Bork, P.1    Blomberg, N.2    Nilges, M.3
  • 12
    • 0041378027 scopus 로고    scopus 로고
    • Sequence fingerprints in BRCA2 and RAD51: Implications for DNA repair and cancer
    • DOI 10.1016/S1568-7864(03)00097-1
    • Lo T, Pellegrini L, Venkitaraman AR, Blundell TL (2003) Sequence fingerprints in BRCA2 and RAD51: Implications for DNA repair and cancer. DNA Repair (Amst) 2:1015-1028. (Pubitemid 37088163)
    • (2003) DNA Repair , vol.2 , Issue.9 , pp. 1015-1028
    • Lo, T.1    Pellegrini, L.2    Venkitaraman, A.R.3    Blundell, T.L.4
  • 13
    • 34249878748 scopus 로고    scopus 로고
    • Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2
    • DOI 10.1038/nsmb1245, PII NSMB1245
    • Esashi F, Galkin VE, Yu X, Egelman EH, West SC (2007) Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol 14:468-474. (Pubitemid 46871809)
    • (2007) Nature Structural and Molecular Biology , vol.14 , Issue.6 , pp. 468-474
    • Esashi, F.1    Galkin, V.E.2    Yu, X.3    Egelman, E.H.4    West, S.C.5
  • 14
    • 34249887673 scopus 로고    scopus 로고
    • Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats
    • DOI 10.1038/nsmb1251, PII NSMB1251
    • Davies OR, Pellegrini L (2007) Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Nat Struct Mol Biol 14:475-483. (Pubitemid 46871813)
    • (2007) Nature Structural and Molecular Biology , vol.14 , Issue.6 , pp. 475-483
    • Davies, O.R.1    Pellegrini, L.2
  • 15
    • 34250879021 scopus 로고    scopus 로고
    • Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
    • DOI 10.1038/sj.emboj.7601739, PII 7601739
    • Thorslund T, Esashi F, West SC (2007) Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J 26:2915-2922. (Pubitemid 46975788)
    • (2007) EMBO Journal , vol.26 , Issue.12 , pp. 2915-2922
    • Thorslund, T.1    Esashi, F.2    West, S.C.3
  • 18
    • 3242749855 scopus 로고    scopus 로고
    • Emerging functions of BRCA2 in DNA recombination
    • DOI 10.1016/j.tibs.2004.04.009, PII S0968000404001021
    • Pellegrini L, Venkitaraman A (2004) Emerging functions of BRCA2 in DNA recombination. Trends Biochem Sci 29:310-316. (Pubitemid 38968763)
    • (2004) Trends in Biochemical Sciences , vol.29 , Issue.6 , pp. 310-316
    • Pellegrini, L.1    Venkitaraman, A.2
  • 20
    • 0031466027 scopus 로고    scopus 로고
    • RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2
    • DOI 10.1074/jbc.272.51.31941
    • Wong AKC, Pero R, Ormonde PA, Tavtigian SV, Bartel PL (1997) RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J Biol Chem 272:31941-31944. (Pubitemid 28011857)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.51 , pp. 31941-31944
    • Wong, A.K.C.1    Pero, R.2    Ormonde, P.A.3    Tavtigian, S.V.4    Bartel, P.L.5
  • 21
    • 0032574733 scopus 로고    scopus 로고
    • The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
    • Chen PL, et al. (1998) The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci USA 95:5287-5292.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5287-5292
    • Chen, P.L.1
  • 22
    • 15844373362 scopus 로고    scopus 로고
    • CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
    • DOI 10.1038/nature03404
    • Esashi F, et al. (2005) CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434:598-604. (Pubitemid 40488546)
    • (2005) Nature , vol.434 , Issue.7033 , pp. 598-604
    • Esashi, F.1    Christ, N.2    Cannon, J.3    Liu, Y.4    Hunt, T.5    Jasin, M.6    West, S.C.7
  • 23
    • 0032702679 scopus 로고    scopus 로고
    • 2/M checkpoint control
    • Chen CF, Chen PL, Zhong Q, Sharp ZD, Lee WH (1999) Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control. J Biol Chem 274:32931-32935. (Pubitemid 129535331)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.46 , pp. 32931-32935
    • Chen, C.-F.1    Chen, P.-L.2    Zhong, Q.3    Sharp, Z.D.4    Lee, W.-H.5
  • 24
    • 62149104415 scopus 로고    scopus 로고
    • The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51
    • Carreira A, et al. (2009) The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51. Cell 136:1032-1043.
    • (2009) Cell , vol.136 , pp. 1032-1043
    • Carreira, A.1
  • 25
    • 0029112483 scopus 로고
    • DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA
    • Sung P, Robberson DL (1995) DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA. Cell 82:453-461.
    • (1995) Cell , vol.82 , pp. 453-461
    • Sung, P.1    Robberson, D.L.2
  • 26
    • 0030584084 scopus 로고    scopus 로고
    • Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro
    • DOI 10.1016/S0092-8674(00)81394-X
    • Baumann P, Benson FE, West SC (1996) Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87:757-766. (Pubitemid 26386948)
    • (1996) Cell , vol.87 , Issue.4 , pp. 757-766
    • Baumann, P.1    Benson, F.E.2    West, S.C.3
  • 27
    • 0034161571 scopus 로고    scopus 로고
    • Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing
    • Mazin AV, Zaitseva E, Sung P, Kowalczykowski SC (2000) Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing. EMBO J 19:1148-1156. (Pubitemid 30119839)
    • (2000) EMBO Journal , vol.19 , Issue.5 , pp. 1148-1156
    • Mazin, A.V.1    Zaitseva, E.2    Sung, P.3    Kowalczykowski, S.C.4
  • 28
    • 0028072098 scopus 로고
    • Purification and characterization of the human Rad51 protein, an analogue of E.coli RecA
    • Benson FE, Stasiak A, West SC (1994) Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. EMBO J 13:5764-5771. (Pubitemid 24363044)
    • (1994) EMBO Journal , vol.13 , Issue.23 , pp. 5764-5771
    • Benson, F.E.1    Stasiak, A.2    West, S.C.3
  • 29
    • 33750296934 scopus 로고    scopus 로고
    • Direct observation of individual RecA filaments assembling on single DNA molecules
    • DOI 10.1038/nature05197, PII NATURE05197
    • Galletto R, Amitani I, Baskin RJ, Kowalczykowski SC (2006) Direct observation of individual RecA filaments assembling on single DNA molecules. Nature 443:875-878. (Pubitemid 44622700)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 875-878
    • Galletto, R.1    Amitani, I.2    Baskin, R.J.3    Kowalczykowski, S.C.4
  • 30
    • 0034635469 scopus 로고    scopus 로고
    • Rad51 uses one mechanism to drive DNA strand exchange in both directions
    • DOI 10.1074/jbc.275.6.3970
    • Namsaraev EA, Berg P (2000) Rad51 uses one mechanism to drive DNA strand exchange in both directions. J Biol Chem 275:3970-3976. (Pubitemid 30094624)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.6 , pp. 3970-3976
    • Namsaraev, E.A.1    Berg, P.2
  • 32
    • 0030766963 scopus 로고    scopus 로고
    • The human Rad51 protein: Polarity of strand transfer and stimulation by hRP-A
    • DOI 10.1093/emboj/16.17.5198
    • Baumann P, West SC (1997) The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A. EMBO J 16:5198-5206. (Pubitemid 27380128)
    • (1997) EMBO Journal , vol.16 , Issue.17 , pp. 5198-5206
    • Baumann, P.1    West, S.C.2
  • 33
    • 75649090767 scopus 로고    scopus 로고
    • Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase
    • Rajendra E, Venkitaraman AR (2010) Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase. Nucleic Acids Res 38:82-96.
    • (2010) Nucleic Acids Res , vol.38 , pp. 82-96
    • Rajendra, E.1    Venkitaraman, A.R.2
  • 34
    • 16244407723 scopus 로고    scopus 로고
    • RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair
    • DOI 10.1128/MCB.25.8.3127-3139.2005
    • Martin JS, Winkelmann N, Petalcorin MI, McIlwraith MJ, Boulton SJ (2005) RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Mol Cell Biol 25:3127-3139. (Pubitemid 40464315)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.8 , pp. 3127-3139
    • Martin, J.S.1    Winkelmann, N.2    Petalcorin, M.I.R.3    McIlwraith, M.J.4    Boulton, S.J.5
  • 35
    • 14144253224 scopus 로고    scopus 로고
    • The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
    • DOI 10.1038/nature03234
    • Yang H, Li Q, Fan J, Holloman WK, Pavletich NP (2005) The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature 433:653-657. (Pubitemid 40283000)
    • (2005) Nature , vol.433 , Issue.7026 , pp. 653-657
    • Yang, H.1    Li, Q.2    Fan, J.3    Holloman, W.K.4    Pavletich, H.P.5
  • 37
    • 0038392868 scopus 로고    scopus 로고
    • RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: A universal step of recombinational repair
    • DOI 10.1016/S1097-2765(03)00188-6
    • Morimatsu K, Kowalczykowski SC (2003) RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: A universal step of recombinational repair. Mol Cell 11:1337-1347. (Pubitemid 36645151)
    • (2003) Molecular Cell , vol.11 , Issue.5 , pp. 1337-1347
    • Morimatsu, K.1    Kowalczykowski, S.C.2
  • 38
    • 32444451553 scopus 로고    scopus 로고
    • The RecA binding locus of RecBCD is a general domain for recruitment of DNA strand exchange proteins
    • DOI 10.1016/j.molcel.2006.01.007, PII S1097276506000086
    • Spies M, Kowalczykowski SC (2006) The RecA binding locus of RecBCD is a general domain for recruitment of DNA strand exchange proteins. Mol Cell 21:573-580. (Pubitemid 43228012)
    • (2006) Molecular Cell , vol.21 , Issue.4 , pp. 573-580
    • Spies, M.1    Kowalczykowski, S.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.