The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 9, 1998, Pages 5287-5292

  Chen, Phang Lang ^a   Chen, Chi Fen ^a   Chen, Yumay ^a   Xiao, Jun ^a   Sharp, Z Dave ^a   Lee, Wen Hwa ^a,b  

^a Univ of Texas Health Science Center ^*  (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Breast cancer; DNA repair

Indexed keywords

BRCA2 PROTEIN; GENE PRODUCT; MESYLIC ACID METHYL ESTER; RAD51 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CHROMOSOME 13Q; CONTROLLED STUDY; DNA REPAIR; FAMILIAL CANCER; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

BRCA2 PROTEIN; BREAST NEOPLASMS; DNA DAMAGE; DNA REPAIR; DNA, COMPLEMENTARY; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOLOGIC TECHNIQUES; METHYL METHANESULFONATE; MOLECULAR WEIGHT; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; RAD51 RECOMBINASE; REPETITIVE SEQUENCES, NUCLEIC ACID; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0032574733     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.9.5287     Document Type: Article

References (36)

1. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., Micklem, G., et al. (1995) Nature (London) 378, 789-792.
2. Tavtigian, S. V., Simard, J., Rommens, J., Couch, F., Shattuckeidens, D., Neuhausen, S., Merajver, S., Thorlacius, S., Offit, K., Stoppalyonnet, D., et al. (1996) Nat. Genet. 12, 333-337.
3. Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S., Tran, T., Averill, D., et al. (1994) Science 265, 2088-2090.
4. Gudmundsson, J., Johannesdottir, G., Arason, A., Bergthorsson, J. T., Ingvarsson, S., Egilsson, V. & Barkardottir, R. B. (1996) Am. J. Hum. Genet. 58, 749-756.
5. Thorlacius, S., Olafsdottir, G., Tryggvadottir, L., Neuhausen, S., Jonasson, J. G., Tavtigian, S. V., Tulinius, H., Ogmundsdottir, H. M. & Eyfjörd, J. E. (1996) Nat. Genet. 13, 117-119.
6. Katagiri, T., Nakamura, Y. & Miki, Y. (1996) Cancer Res. 56, 4575-4577.
7. Goggins, M., Schutte, M., Lu, J., Moskaluk, C. A., Weinstein, C. L., Petersen, G. M., Yeo, C. J., Jackson, C. E., Lynch, H. T., Hruban, R. H. & Kern, S. E. (1996) Cancer Res. 56, 5360-5364.
8. Futreal, P. A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L. M., Haugen-Strano, A., Swensen, J., Miki, Y., et al. (1994) Science 266, 120-122.
9. Miki, Y., Katagiri, T., Kasumi, F., Yoshimoto, T. & Nakamura, Y. (1996) Nat. Genet. 13, 245-247.
10. Rajan, J. V., Marquis, S. T., Gardner, H. P. & Chodosh, L. A. (1997) Dev. Biol. 184, 385-401.
11. Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D. S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P. & Bradley, A. (1997) Nature (London) 386, 804-810.
12. Vaughn, J. P., Cirisano, F. D., Huper, G., Berchuck, A., Futreal, P. A., Marks, J. R. & Iglehart, J. D. (1996) Cancer Res. 56, 4590-4594.
13. Ludwig, T., Chapman, D. L., Papaioannou, V. E. & Efstratiadis, A. (1997) Genes Dev. 11, 1226-1241.
14. Suzuki, A., de la Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A., Itie, A., Koo, W., Billia, P., Ho, A., Fukumoto, M., Hui, C. C. & Mak, T. W. (1997) Genes Dev. 11, 1242-1252.
15. Chen, Y., Riley, D. J., Chen, P.-L. & Lee, W.-H. (1997) Mol. Cell. Biol. 17, 6049-6056.
16. Chen, Y., Sharp, Z. D. & Lee, W.-H. (1997) J. Biol. Chem. 272, 24081-24087.
17. Durfee, T., Becherer, K., Chen, P.-L., Yeh, S.-H., Yang, Y., Kilburn, A. E., Lee, W.-H. & Elledge, S. J. (1993) Genes Dev. 7, 555-569.
18. Shinohara, A., Ogawa, H., Matsuda, Y., Ushio, N., Ikeo, K. & Ogawa, T. (1993) Nat. Genet. 4, 239-243.
19. Bork, P., Blomberg, N. & Nilges, M. (1996) Nat. Genet. 13, 22-23.
20. Bignell, G., Micklem, G., Stratton, M. R., Ashworth, A. & Wooster, R. (1997) Hum. Mol. Genet. 6, 53-58.
21. Benson, F. E., Stasiak, A. & West, S. C. (1994) EMBO J. 13, 5764-5771.
22. Donovan, J. W., Milne, G. T. & Weaver, D. T. (1994) Genes Dev. 8, 2552-2562.
23. Hays, S. L., Firmenich, A. A. & Berg, P. (1995) Proc. Natl. Acad. Sci. USA 92, 6925-6929.
24. Haaf, T., Golub, E. I., Reddy, G., Radding, C. M. & Ward, D. C. (1995) Proc. Natl. Acad. Sci. USA 92, 2298-2302.
25. Shinohara, A., Ogawa, H. & Ogawa, T. (1992) Cell 69, 457-470.
26. Morita, T., Yoshimura, Y., Yamamoto, A., Murata, K., Mori, M. & Yamamoto, H. (1993) Proc. Natl. Acad. Sci. USA 90, 6577-6580.
27. Mizuta, R., LaSalle, J. M., Cheng, H.-L., Shinohara, A., Ogawa, H., Copeland, N., Jenkins, N. A., Lalande, M. & Alt, F. W. (1997) Proc. Natl. Acad. Sci. USA 94, 6927-6932.
28. Pati, D., Keller, C., Groudine, M. & Plon, S. E. (1997) Mol. Cell. Biol. 17, 3037-3046.
29. Bezzubova, O., Silbergleit, A., Yamaguchi-Iwai, Y., Takeda, S. & Buerstedde, J. M. (1997) Cell 89, 185-193.
30. Scully, R., Chen, J. J., Plug, A., Xiao, Y. H., Weaver, D., Feunteun, J., Ashley, T. & Livingston, D. M. (1997) Cell 88, 265-275.
31. Wu, L. J. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M. C. W., Hwang, L. Y., Bowcock, A. M. & Baer, R. (1996) Nat. Genet. 14, 430-440.
32. Koonin, E. V., Altschul, S. F. & Bork, P. (1996) Nat. Genet. 13, 266-267.
33. Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F. & Koonin, E. V. (1997) FASEB J. 11, 68-76.
34. Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R., Peltomaki, P., Sistonen, P., Aaltonen, L. A., Nystrom-Lahti, M., et al. (1993) Cell 75, 1215-1225.
35. Fishel, R., Lescoe, M. K., Rao, M. R., Copeland, N. G., Jenkins, N. A., Garber, J., Kane, M. & Kolodner, R. (1993) Cell 75, 1027-1038.
36. Durfee, T., Mancini, M., Jones, D., Elledge, S. J. & Lee, W.-H. (1994) J. Cell Biol. 127, 609-622.