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Volumn 5, Issue 4, 2015, Pages 1281-1294

L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia

Author keywords

Cancer; L type amino acid; mtorc1 pathway; Transport

Indexed keywords

2 AMINO 3 [4 [(5 AMINO 2 PHENYLBENZO[D]OXAZOL 7 YL)METHOXY] 3,5 DICHLOROPHENYL]PROPANOIC ACID; ACIVICIN; AMINO ACID TRANSPORTER; ANTINEOPLASTIC AGENT; ESK 242; ESK 246; GLYCOSIDE; IODOTYROSINE; L TYPE AMINO ACID TRANSPORT 1; L TYPE AMINO ACID TRANSPORT 2; L TYPE AMINO ACID TRANSPORT 3; L TYPE AMINO ACID TRANSPORT 4; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; UNCLASSIFIED DRUG;

EID: 85006216312     PISSN: None     EISSN: 21566976     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (249)

References (118)
  • 1
    • 84885175489 scopus 로고    scopus 로고
    • A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naive castration-resistant prostate cancer
    • Kruczek K, Ratterman M, Tolzien K, Sulo S, Lestingi TM and Nabhan C. A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naive castration-resistant prostate cancer. Br J Cancer 2013; 109: 1711-1716.
    • (2013) Br J Cancer , vol.109 , pp. 1711-1716
    • Kruczek, K.1    Ratterman, M.2    Tolzien, K.3    Sulo, S.4    Lestingi, T.M.5    Nabhan, C.6
  • 3
    • 84875190864 scopus 로고    scopus 로고
    • The SLC3 and SLC7 families of amino acid transporters
    • Fotiadis D, Kanai Y and Palacin M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med 2013; 34: 139-158.
    • (2013) Mol Aspects Med , vol.34 , pp. 139-158
    • Fotiadis, D.1    Kanai, Y.2    Palacin, M.3
  • 4
    • 84875142410 scopus 로고    scopus 로고
    • The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1
    • Bodoy S, Fotiadis D, Stoeger C, Kanai Y and Palacin M. The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1. Mol Aspects Med 2013; 34: 638-645.
    • (2013) Mol Aspects Med , vol.34 , pp. 638-645
    • Bodoy, S.1    Fotiadis, D.2    Stoeger, C.3    Kanai, Y.4    Palacin, M.5
  • 5
    • 0032508585 scopus 로고    scopus 로고
    • Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
    • Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E and Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 1998; 273: 23629-23632.
    • (1998) J Biol Chem , vol.273 , pp. 23629-23632
    • Kanai, Y.1    Segawa, H.2    Miyamoto, K.3    Uchino, H.4    Takeda, E.5    Endou, H.6
  • 7
    • 0040610689 scopus 로고    scopus 로고
    • Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
    • Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A and Palacin M. Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 1999; 274: 19738-19744.
    • (1999) J Biol Chem , vol.274 , pp. 19738-19744
    • Pineda, M.1    Fernandez, E.2    Torrents, D.3    Estevez, R.4    Lopez, C.5    Camps, M.6    Lloberas, J.7    Zorzano, A.8    Palacin, M.9
  • 8
    • 0033520913 scopus 로고    scopus 로고
    • LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine
    • Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F and Kuhn LC. LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 1999; 274: 34948-34954.
    • (1999) J Biol Chem , vol.274 , pp. 34948-34954
    • Rossier, G.1    Meier, C.2    Bauch, C.3    Summa, V.4    Sordat, B.5    Verrey, F.6    Kuhn, L.C.7
  • 9
    • 0033538560 scopus 로고    scopus 로고
    • Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity
    • Segawa H, Fukasawa Y, Miyamoto K, Takeda E, Endou H and Kanai Y. Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 1999; 274: 19745-19751.
    • (1999) J Biol Chem , vol.274 , pp. 19745-19751
    • Segawa, H.1    Fukasawa, Y.2    Miyamoto, K.3    Takeda, E.4    Endou, H.5    Kanai, Y.6
  • 11
    • 15744398433 scopus 로고    scopus 로고
    • Identification of LAT4, a novel amino acid transporter with system L activity
    • Bodoy S, Martin L, Zorzano A, Palacin M, Estevez R and Bertran J. Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem 2005; 280: 12002-12011.
    • (2005) J Biol Chem , vol.280 , pp. 12002-12011
    • Bodoy, S.1    Martin, L.2    Zorzano, A.3    Palacin, M.4    Estevez, R.5    Bertran, J.6
  • 19
    • 34247892541 scopus 로고    scopus 로고
    • Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation
    • Fukuhara D, Kanai Y, Chairoungdua A, Babu E, Bessho F, Kawano T, Akimoto Y, Endou H and Yan K. Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation. Am J Pathol 2007; 170: 888-898.
    • (2007) Am J Pathol , vol.170 , pp. 888-898
    • Fukuhara, D.1    Kanai, Y.2    Chairoungdua, A.3    Babu, E.4    Bessho, F.5    Kawano, T.6    Akimoto, Y.7    Endou, H.8    Yan, K.9
  • 30
    • 41749089533 scopus 로고    scopus 로고
    • Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells
    • discussion 503-494
    • Kobayashi K, Ohnishi A, Promsuk J, Shimizu S, Kanai Y, Shiokawa Y and Nagane M. Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. Neurosurgery 2008; 62: 493-503; discussion 503-494.
    • (2008) Neurosurgery , vol.62 , pp. 493-503
    • Kobayashi, K.1    Ohnishi, A.2    Promsuk, J.3    Shimizu, S.4    Kanai, Y.5    Shiokawa, Y.6    Nagane, M.7
  • 35
    • 66949138193 scopus 로고    scopus 로고
    • L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer
    • Imai H, Kaira K, Oriuchi N, Yanagitani N, Sunaga N, Ishizuka T, Kanai Y, Endou H, Nakajima T and Mori M. L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer. Histopathology 2009; 54: 804-813.
    • (2009) Histopathology , vol.54 , pp. 804-813
    • Imai, H.1    Kaira, K.2    Oriuchi, N.3    Yanagitani, N.4    Sunaga, N.5    Ishizuka, T.6    Kanai, Y.7    Endou, H.8    Nakajima, T.9    Mori, M.10
  • 42
    • 45749107547 scopus 로고    scopus 로고
    • BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells
    • Kim CS, Cho SH, Chun HS, Lee SY, Endou H, Kanai Y and Kim do K. BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol Pharm Bull 2008; 31: 1096-1100.
    • (2008) Biol Pharm Bull , vol.31 , pp. 1096-1100
    • Kim, C.S.1    Cho, S.H.2    Chun, H.S.3    Lee, S.Y.4    Endou, H.5    Kanai, Y.6    Kim do, K.7
  • 43
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
    • Chung J, Kuo CJ, Crabtree GR and Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 1992; 69: 1227-1236.
    • (1992) Cell , vol.69 , pp. 1227-1236
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 45
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P and Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14: 1296-1302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 46
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM and Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 47
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J and Su B. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006; 127: 125-137.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6    Huang, Q.7    Qin, J.8    Su, B.9
  • 50
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee AR, Manning BD, Roux PP, Cantley LC and Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003; 13: 1259-1268.
    • (2003) Curr Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 51
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA and Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 2003; 5: 578-581.
    • (2003) Nat Cell Biol , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 52
    • 84894212463 scopus 로고    scopus 로고
    • Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
    • Demetriades C, Doumpas N and Teleman AA. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 2014; 156: 786-799.
    • (2014) Cell , vol.156 , pp. 786-799
    • Demetriades, C.1    Doumpas, N.2    Teleman, A.A.3
  • 54
    • 84862777407 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    • Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH and Kim S. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012; 149: 410-424.
    • (2012) Cell , vol.149 , pp. 410-424
    • Han, J.M.1    Jeong, S.J.2    Park, M.C.3    Kim, G.4    Kwon, N.H.5    Kim, H.K.6    Ha, S.H.7    Ryu, S.H.8    Kim, S.9
  • 59
    • 0019133275 scopus 로고
    • L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
    • Sener A and Malaisse WJ. L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature 1980; 288: 187-189.
    • (1980) Nature , vol.288 , pp. 187-189
    • Sener, A.1    Malaisse, W.J.2
  • 60
    • 80555143078 scopus 로고    scopus 로고
    • mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
    • Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y and Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 2011; 334: 678-683.
    • (2011) Science , vol.334 , pp. 678-683
    • Zoncu, R.1    Bar-Peled, L.2    Efeyan, A.3    Wang, S.4    Sancak, Y.5    Sabatini, D.M.6
  • 64
    • 84907525131 scopus 로고    scopus 로고
    • Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
    • Peng M, Yin N and Li MO. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell 2014; 159: 122-133.
    • (2014) Cell , vol.159 , pp. 122-133
    • Peng, M.1    Yin, N.2    Li, M.O.3
  • 68
    • 0030710958 scopus 로고    scopus 로고
    • Complementation of dominant suppression implicates CD98 in integrin activation
    • Fenczik CA, Sethi T, Ramos JW, Hughes PE and Ginsberg MH. Complementation of dominant suppression implicates CD98 in integrin activation. Nature 1997; 390: 81-85.
    • (1997) Nature , vol.390 , pp. 81-85
    • Fenczik, C.A.1    Sethi, T.2    Ramos, J.W.3    Hughes, P.E.4    Ginsberg, M.H.5
  • 69
    • 46449090587 scopus 로고    scopus 로고
    • CD98 activation increases surface expression and clusteringof beta1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms
    • Kim SM and Hahn JH. CD98 activation increases surface expression and clusteringof beta1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms. Exp Mol Med 2008; 40: 261-270.
    • (2008) Exp Mol Med , vol.40 , pp. 261-270
    • Kim, S.M.1    Hahn, J.H.2
  • 70
    • 0034681366 scopus 로고    scopus 로고
    • Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains
    • Zent R, Fenczik CA, Calderwood DA, Liu S, Dellos M and Ginsberg MH. Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains. J Biol Chem 2000; 275: 5059-5064.
    • (2000) J Biol Chem , vol.275 , pp. 5059-5064
    • Zent, R.1    Fenczik, C.A.2    Calderwood, D.A.3    Liu, S.4    Dellos, M.5    Ginsberg, M.H.6
  • 71
    • 3042777493 scopus 로고    scopus 로고
    • Beta1 integrins show specific association with CD98 protein in low density membranes
    • Kolesnikova TV, Mannion BA, Berditchevski F and Hemler ME. Beta1 integrins show specific association with CD98 protein in low density membranes. BMC Biochem 2001; 2: 10.
    • (2001) BMC Biochem , vol.2 , pp. 10
    • Kolesnikova, T.V.1    Mannion, B.A.2    Berditchevski, F.3    Hemler, M.E.4
  • 72
    • 34548229492 scopus 로고    scopus 로고
    • CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling
    • Prager GW, Feral CC, Kim C, Han J and Ginsberg MH. CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J Biol Chem 2007; 282: 24477-24484.
    • (2007) J Biol Chem , vol.282 , pp. 24477-24484
    • Prager, G.W.1    Feral, C.C.2    Kim, C.3    Han, J.4    Ginsberg, M.H.5
  • 73
    • 0026556814 scopus 로고
    • Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
    • Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF and Hinnebusch AG. Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 1992; 68: 585-596.
    • (1992) Cell , vol.68 , pp. 585-596
    • Dever, T.E.1    Feng, L.2    Wek, R.C.3    Cigan, A.M.4    Donahue, T.F.5    Hinnebusch, A.G.6
  • 75
    • 84916638478 scopus 로고    scopus 로고
    • ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation
    • Ren P, Yue M, Xiao D, Xiu R, Gan L, Liu H and Qing G. ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation. J Pathol 2015; 235: 90-100.
    • (2015) J Pathol , vol.235 , pp. 90-100
    • Ren, P.1    Yue, M.2    Xiao, D.3    Xiu, R.4    Gan, L.5    Liu, H.6    Qing, G.7
  • 76
    • 7444229809 scopus 로고    scopus 로고
    • Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation
    • Sato H, Nomura S, Maebara K, Sato K, Tamba M and Bannai S. Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation. Biochem Biophys Res Commun 2004; 325: 109-116.
    • (2004) Biochem Biophys Res Commun , vol.325 , pp. 109-116
    • Sato, H.1    Nomura, S.2    Maebara, K.3    Sato, K.4    Tamba, M.5    Bannai, S.6
  • 77
    • 4344597633 scopus 로고    scopus 로고
    • L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter
    • Shennan DB, Thomson J, Gow IF, Travers MT and Barber MC. L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter. Biochim Biophys Acta 2004; 1664: 206-16.
    • (2004) Biochim Biophys Acta , vol.1664 , pp. 206-216
    • Shennan, D.B.1    Thomson, J.2    Gow, I.F.3    Travers, M.T.4    Barber, M.C.5
  • 78
    • 79960353171 scopus 로고    scopus 로고
    • Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechan-ism
    • Hamdi MM and Mutungi G. Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechan-ism. J Physiol 2011; 589: 3623-3640.
    • (2011) J Physiol , vol.589 , pp. 3623-3640
    • Hamdi, M.M.1    Mutungi, G.2
  • 79
    • 70449090348 scopus 로고    scopus 로고
    • Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells
    • Luo X, Yin P, Reierstad S, Ishikawa H, Lin Z, Pavone ME, Zhao H, Marsh EE and Bulun SE. Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells. J Clin Endocrinol Metab 2009; 94: 4533-4539.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4533-4539
    • Luo, X.1    Yin, P.2    Reierstad, S.3    Ishikawa, H.4    Lin, Z.5    Pavone, M.E.6    Zhao, H.7    Marsh, E.E.8    Bulun, S.E.9
  • 81
    • 84876514626 scopus 로고    scopus 로고
    • Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
    • Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM and Cantrell DA. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 2013; 14: 500-508.
    • (2013) Nat Immunol , vol.14 , pp. 500-508
    • Sinclair, L.V.1    Rolf, J.2    Emslie, E.3    Shi, Y.B.4    Taylor, P.M.5    Cantrell, D.A.6
  • 83
    • 0021688655 scopus 로고
    • Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells
    • Hann SR and Eisenman RN. Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells. Mol Cell Biol 1984; 4: 2486-2497.
    • (1984) Mol Cell Biol , vol.4 , pp. 2486-2497
    • Hann, S.R.1    Eisenman, R.N.2
  • 84
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. MYC on the path to cancer. Cell 2012; 149: 22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 89
    • 84881614360 scopus 로고    scopus 로고
    • Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203
    • Toyoshima J, Kusuhara H, Wempe MF, Endou H and Sugiyama Y. Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203. J Pharm Sci. 2013; 102: 3228-38.
    • (2013) J Pharm Sci , vol.102 , pp. 3228-3238
    • Toyoshima, J.1    Kusuhara, H.2    Wempe, M.F.3    Endou, H.4    Sugiyama, Y.5
  • 92
    • 48749132702 scopus 로고    scopus 로고
    • Molecular and histological markers in urothelial carcinomas of the upper urinary tract
    • Eltz S, Comperat E, Cussenot O and Roupret M. Molecular and histological markers in urothelial carcinomas of the upper urinary tract. BJU Int 2008; 102: 532-535.
    • (2008) BJU Int , vol.102 , pp. 532-535
    • Eltz, S.1    Comperat, E.2    Cussenot, O.3    Roupret, M.4
  • 94
    • 34248199317 scopus 로고    scopus 로고
    • Gene expression profiles in T24 human bladder carcinoma cells by inhibiting an L-type amino acid transporter LAT1
    • Baniasadi S, Chairoungdua A, Iribe Y, Kanai Y, Endou H, Aisaki K, Igarashi K and Kanno J. Gene expression profiles in T24 human bladder carcinoma cells by inhibiting an L-type amino acid transporter, LAT1. Arch Pharm Res 2007; 30: 444-452.
    • (2007) Arch Pharm Res , vol.30 , pp. 444-452
    • Baniasadi, S.1    Chairoungdua, A.2    Iribe, Y.3    Kanai, Y.4    Endou, H.5    Aisaki, K.6    Igarashi, K.7    Kanno, J.8
  • 95
    • 84856492407 scopus 로고    scopus 로고
    • Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis
    • Furuya M, Horiguchi J, Nakajima H, Kanai Y and Oyama T. Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis. Cancer Sci 2012; 103: 382-389.
    • (2012) Cancer Sci , vol.103 , pp. 382-389
    • Furuya, M.1    Horiguchi, J.2    Nakajima, H.3    Kanai, Y.4    Oyama, T.5
  • 96
    • 55249114168 scopus 로고    scopus 로고
    • Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells
    • Shennan DB and Thomson J. Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. Oncol Rep 2008; 20: 885-889.
    • (2008) Oncol Rep , vol.20 , pp. 885-889
    • Shennan, D.B.1    Thomson, J.2
  • 97
    • 0037376259 scopus 로고    scopus 로고
    • Functional and molecular characteristics of system L in human breast cancer cells
    • Shennan DB, Thomson J, Barber MC and Travers MT. Functional and molecular characteristics of system L in human breast cancer cells. Biochim Biophys Acta 2003; 1611: 81-90.
    • (2003) Biochim Biophys Acta , vol.1611 , pp. 81-90
    • Shennan, D.B.1    Thomson, J.2    Barber, M.C.3    Travers, M.T.4
  • 99
    • 36849055449 scopus 로고    scopus 로고
    • L-type amino acid transporters LAT1 and LAT4 in cancer: uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo
    • Haase C, Bergmann R, Fuechtner F, Hoepping A and Pietzsch J. L-type amino acid transporters LAT1 and LAT4 in cancer: uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo. J Nucl Med 2007; 48: 2063-2071.
    • (2007) J Nucl Med , vol.48 , pp. 2063-2071
    • Haase, C.1    Bergmann, R.2    Fuechtner, F.3    Hoepping, A.4    Pietzsch, J.5
  • 100
    • 20044374008 scopus 로고    scopus 로고
    • Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma
    • Kobayashi H, Ishii Y and Takayama T. Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma. J Surg Oncol 2005; 90: 233-238.
    • (2005) J Surg Oncol , vol.90 , pp. 233-238
    • Kobayashi, H.1    Ishii, Y.2    Takayama, T.3
  • 101
    • 60249083430 scopus 로고    scopus 로고
    • System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line
    • Yamauchi K, Sakurai H, Kimura T, Wiriyasermkul P, Nagamori S, Kanai Y and Kohno N. System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line. Cancer Lett 2009; 276: 95-101.
    • (2009) Cancer Lett , vol.276 , pp. 95-101
    • Yamauchi, K.1    Sakurai, H.2    Kimura, T.3    Wiriyasermkul, P.4    Nagamori, S.5    Kanai, Y.6    Kohno, N.7
  • 103
    • 84886299079 scopus 로고    scopus 로고
    • Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells
    • Xu SM, Tang K, Meng L and Tang Y. Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells. J Huazhong Univ Sci Technolog Med Sci 2013; 33: 632-635.
    • (2013) J Huazhong Univ Sci Technolog Med Sci , vol.33 , pp. 632-635
    • Xu, S.M.1    Tang, K.2    Meng, L.3    Tang, Y.4
  • 104
    • 0035184543 scopus 로고    scopus 로고
    • Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models
    • discussion 271-262
    • Ohkame H, Masuda H, Ishii Y and Kanai Y. Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models. J Surg Oncol 2001; 78: 265-271; discussion 271-262.
    • (2001) J Surg Oncol , vol.78 , pp. 265-271
    • Ohkame, H.1    Masuda, H.2    Ishii, Y.3    Kanai, Y.4
  • 105
    • 0035225115 scopus 로고    scopus 로고
    • Expression of L-type amino acid transporter 1 in a rat model of liver metastasis: positive correlation with tumor size
    • Tamai S, Masuda H, Ishii Y, Suzuki S, Kanai Y and Endou H. Expression of L-type amino acid transporter 1 in a rat model of liver metastasis: positive correlation with tumor size. Cancer Detect Prev 2001; 25: 439-445.
    • (2001) Cancer Detect Prev , vol.25 , pp. 439-445
    • Tamai, S.1    Masuda, H.2    Ishii, Y.3    Suzuki, S.4    Kanai, Y.5    Endou, H.6
  • 106
    • 26444462089 scopus 로고    scopus 로고
    • Adenoviral modulation of the tumor-associated system L amino acid transporter, LAT1, alters amino acid transport, cell growth and 4F2/CD98 expressionwith cell-type specific effects in cultured hepatic cells
    • Storey BT, Fugere C, Lesieur-Brooks A, Vaslet C and Thompson NL. Adenoviral modulation of the tumor-associated system L amino acid transporter, LAT1, alters amino acid transport, cell growth and 4F2/CD98 expressionwith cell-type specific effects in cultured hepatic cells. Int J Cancer 2005; 117: 387-397.
    • (2005) Int J Cancer , vol.117 , pp. 387-397
    • Storey, B.T.1    Fugere, C.2    Lesieur-Brooks, A.3    Vaslet, C.4    Thompson, N.L.5
  • 107
    • 34548571952 scopus 로고    scopus 로고
    • Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues
    • Kondoh N, Imazeki N, Arai M, Hada A, Hatsuse K, Matsuo H, Matsubara O, Ohkura S and Yamamoto M. Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues. Int J Oncol 2007; 31: 81-87.
    • (2007) Int J Oncol , vol.31 , pp. 81-87
    • Kondoh, N.1    Imazeki, N.2    Arai, M.3    Hada, A.4    Hatsuse, K.5    Matsuo, H.6    Matsubara, O.7    Ohkura, S.8    Yamamoto, M.9
  • 108
    • 77955890344 scopus 로고    scopus 로고
    • Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells
    • Ritchie JW and Taylor PM. Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells. Amino Acids 2010; 38: 1361-1367.
    • (2010) Amino Acids , vol.38 , pp. 1361-1367
    • Ritchie, J.W.1    Taylor, P.M.2
  • 109
    • 84864821436 scopus 로고    scopus 로고
    • Canine Lat1: molecular structure, distribution and its expression in cancer samples
    • Ochiai H, Morishita T, Onda K, Sugiyama H and Maruo T. Canine Lat1: molecular structure, distribution and its expression in cancer samples. J Vet Med Sci 2012; 74: 917-922.
    • (2012) J Vet Med Sci , vol.74 , pp. 917-922
    • Ochiai, H.1    Morishita, T.2    Onda, K.3    Sugiyama, H.4    Maruo, T.5
  • 111
    • 65549121941 scopus 로고    scopus 로고
    • Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines
    • Kuhne A, Tzvetkov MV, Hagos Y, Lage H, Burckhardt G and Brockmoller J. Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines. Biochemical Pharmacology 2009; 78: 45-53.
    • (2009) Biochemical Pharmacology , vol.78 , pp. 45-53
    • Kuhne, A.1    Tzvetkov, M.V.2    Hagos, Y.3    Lage, H.4    Burckhardt, G.5    Brockmoller, J.6
  • 113
    • 77954757238 scopus 로고    scopus 로고
    • Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors
    • Fan X, Ross DD, Arakawa H, Ganapathy V, Tamai I and Nakanishi T. Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors. Biochem Pharmacol 2010; 80: 811-818.
    • (2010) Biochem Pharmacol , vol.80 , pp. 811-818
    • Fan, X.1    Ross, D.D.2    Arakawa, H.3    Ganapathy, V.4    Tamai, I.5    Nakanishi, T.6
  • 115
    • 84867904232 scopus 로고    scopus 로고
    • High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas
    • Yanagisawa N, Ichinoe M, Mikami T, Nakada N, Hana K, Koizumi W, Endou H and Okayasu I. High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas. J Clin Pathol 2012; 65: 1019-1023.
    • (2012) J Clin Pathol , vol.65 , pp. 1019-1023
    • Yanagisawa, N.1    Ichinoe, M.2    Mikami, T.3    Nakada, N.4    Hana, K.5    Koizumi, W.6    Endou, H.7    Okayasu, I.8
  • 116
    • 84865346124 scopus 로고    scopus 로고
    • c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells
    • Hayashi K, Jutabha P, Endou H and Anzai N. c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells. Oncology Reports 2012; 28: 862-866.
    • (2012) Oncology Reports , vol.28 , pp. 862-866
    • Hayashi, K.1    Jutabha, P.2    Endou, H.3    Anzai, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.