L-Leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): Kinetics, regulation by estrogen and molecular identity of the transporter

Biochimica et Biophysica Acta - Biomembranes

Volumn 1664, Issue 2, 2004, Pages 206-216

  Shennan, D B ^a   Thomson, J ^a   Gow, I F ^a   Travers, M T ^a   Barber, M C ^a  

^a HANNAH RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Cancer cell; Estrogen; L Leucine

Indexed keywords

ALANINE; CARRIER PROTEIN; ESTROGEN; LEUCINE; LYSINE; MELPHALAN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; HORMONAL REGULATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; TEMPERATURE DEPENDENCE; TRANSPORT KINETICS;

AMINO ACID TRANSPORT SYSTEM Y+; ANTIGENS, CD98; ANTIGENS, CD98 LIGHT CHAINS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL LINE, TUMOR; ESTROGENS; HUMANS; KINETICS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEUCINE; MELPHALAN;

MINK CELL FOCUS-FORMING VIRUS;

EID: 4344597633     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2004.05.008     Document Type: Article

References (35)

1. Deves R., Boyd C.A.R. Surface antigen CD98(4F2): not a single membrane protein, but a family of proteins with multiple functions. J. Membr. Biol. 173:2000;165-177
2. Wagner C.A., Lang F., Broer S. Function and structure of heterodimeric amino acid transporters. Am. J. Physiol. 281:2001;C1077-C1093
3. Ritchie J.W., Taylor P.M. Role of the system L permease LAT1 in amino acid and iodothyronine transport in placenta. Biochem. J. 356:2001;719-725
4. Friesema E.C., Docter R., Moerings E.P., Verrey F., Krenning E.P., Hennemann G., Visser T.J. Thyroid hormone transport by the heterodimeric human system L amino acid transporter. Endocrinology. 142:2001;4339-4348
5. Kim D.K., Kanai Y., Choi H.W., Tangtrongsup S., Chairoungdua A., Babu E., Tachampa K., Anzai N., Iribe Y., Endou H. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim. Biophys. Acta. 1565:2002;112-122
6. Kanai Y., Endou H.H. Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr. Drug Metab. 2:2001;339-354
7. Uchino H., Kanai Y., Kim do K., Wempe M.F., Chairoungdua A., Morim E., Anders M.W., Endou H. Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanism of substrate recognition. Mol. Pharmacol. 61:2002;729-737
8. Simmons-Willis T.A., Koh A.S., Clarkson T.W., Ballatori N. Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human LAT1 and LAT2 amino acid carriers. Biochem. J. 367:2002;239-246
9. Kanai Y., Segawa H., Miyamoto K., Uchino H., Takeda E., Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 273:1998;23629-23632
10. Mastroberardino L., Spindler B., Pfeiffer R., Skelly P.J., Loffing J., Shoemaker C.B., Verrey F. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature. 395:1998;288-291
11. Prasad P.D., Wang H., Huang W., Kekuda R., Rajan D.P., Leibach F.H., Ganapathy V. Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem. Biophys. Res. Commun. 255:1999;283-288
12. Pineda M., Fernandez E., Torrents D., Estavez R., Lopez C., Camps M., Lloberas J., Zorzano A., Palacin M. Identification of a membrane protein, LAT-2 that co-expresses with 4F2 heavy chain, an L-type amino transport activity with broad substrate specificity for small and large zwitterionic amino acids. J. Biol. Chem. 274:1999;19738-19744
13. +-independent neutral amino acid transporter with broad substrate specificity. J. Biol. Chem. 274:1999;19745-19751
14. +- independent, broad-specific neutral amino acid transporter from mammalian intestine. Biochim. Biophys. Acta. 1463:2000;6-14
15. Rossier G., Meiers C., Bauch C., Summa V., Sordat B., Verrey F., Kuhn L.C. LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J. Biol. Chem. 274:1999;34948-34954
16. Babu E., Kanai Y., Chairoungdua A., Kim D.K., Tribe Y., Tangtrongsup S., Jutabha P., Li Y., Ahmed N., Sakamoto S., Anzai N., Nagamori S., Endou H. Indentification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J. Biol. Chem. 278:2003;43838-43845
17. Wolf D.A., Wang S., Panzica M.A., Bassily N.H., Thompson N.L. Expression of a highly conserved oncofetal gene, TA1/E16, in human colon carcinoma and other primary cancers: homology to Schistosoma mansoni amino acid permease and Caenorhabditis elegans gene product. Cancer Res. 56:1996;5012-5022
18. Tamai S., Masuda H., Ishii Y., Susuki S., Kanai Y., Endou H. Expression of L-type amino acid transporter 1 in a rat model of liver metastasis: positive correlation with tumor size. Cancer Detec. Prev. 25:2001;439-445
19. Ohkame H., Masuda H., Ishii Y., Kanai Y. Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models. J. Surg. Oncol. 78:2001;265-272
20. Yanagida O., Kanai Y., Chairoungdua A., Kim D.K., Segawa H., Nii T., Cha S.H., Matsuo H., Fukushima J., Fukasawa Y., Tani Y., Taketani Y., Uchino H., Kim J.Y., Inatomi J., Okayasu I., Miyamoto K., Takeda E., Goya T., Endou H. Human L-type amino acid transporter 1 (LAT1): characterization of a function and expression in tumor cell lines. Biochim. Biophys. Acta. 1514:2001;291-302
21. Shennan D.B., Thomson J., Barber M.C., Travers M.T. Functional and molecular characteristics of system L in human breast cancer cells. Biochim. Biophys. Acta. 1611:2003;81-90
22. Moscow J.A., Swanson C.A., Cowan K.H. Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan. Br. J. Cancer. 68:1993;732-737
23. Verrey F. System L: heteromeric exchangers of large, neutral amino acids involved in directional transport. Pflugers Arch. 445:2003;529-533
24. Davis L.G., Dibner M.D., Battey J.F. Davis L.G., Bibner M.D., Battey J.F. Basic Methods in Molecular Biology. 1986;143-146 Elsevier, Amsterdam
25. Deves R., Krupka R.M. A simple experimental approach to the determination of carrier transport parameters for unlabeled substrate analogs. Biochim. Biophys. Acta. 556:1979;524-532
26. Travers M.T., Gow I.F., Barber M.C., Thomson J., Shennan D.B. Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells. Biochim. Biophys. Acta. 1661:2004;106-112
27. Soulez M., Parker M.G. Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling. J. Mol. Endocrinol. 27:2001;259-274
28. Bhat H.K., Vadgama J.V. Role of estrogen receptor in the regulation of estrogen induced amino acid transport of system A in breast cancer and other receptor positive tumor cells. Int. J. Mol. Med. 9:2002;271-279
29. Meier C., Ristic Z., Klauser S., Verrey F. Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J. 21:2002;580-589
30. Liu X., Charrier L., Gewirtz A., Sitaraman S., Merlin D. CD98 and ICAM-1 regulate the activity of amino acid transporter LAT-2 in polarised intestinal epithelia. J. Biol. Chem. 278:2003;23672-23677
31. Segel G.B., Woodlock T.J., Lichtman M.A. Trans-stimulation of L-system amino acid transport in normal and chronic leukemic human lymphocytes: phorbol ester restores function in CLL. J. Cell. Physiol. 134:1988;503-508
32. Shennan D.B., Calvert D.T., Travers M.T., Kudo Y., Boyd C.A.R. A study of L-leucine, L-phenylalanine and L-alanine transport in the perfused rat mammary gland: possible involvement of LAT1 and LAT2. Biochim. Biophys. Acta. 1564:2002;133-139
33. Shennan D.B., Peaker M. Transport of milk constituents by the mammary gland. Physiol. Rev. 80:2000;925-951
34. Shennan D.B., Thomson J., Travers M.T., Kudo Y., Boyd C.A.R. Properties and regulation of system L in lactating mammary tissue. Poujeol P., Petersen O. Proceedings 3rd Federation of European Physiological Societies Congress. 2003;247-251 Monduzzi Editore Int. Proc. Division, Italy
35. Kudo Y., Boyd C.A.R. Heterodimeric amino acid transporters: expression of heavy chains of CD98 correlates with induction of amino acid transport systems in human placental trophoblasts. J. Physiol. 523.1:2000;13-18