LAT1 regulates growth of uterine leiomyoma smooth muscle cells

Reproductive Sciences

Volumn 17, Issue 9, 2010, Pages 791-797

  Luo, Xia ^a,b   Coon, John S V ^a   Su, Emily ^a   Kerry Pearson, Elizabeth ^a   Yin, Ping ^a   Ishikawa, Hiroshi ^a   Bulun, Serdar E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b SHANDONG UNIVERSITY   (China)

Author keywords

fibroid; LAT1; leiomyoma; mifepristone; proliferation; Uterine

Indexed keywords

AMINO ACID TRANSPORTER; MIFEPRISTONE; PROTEIN LAT1; PROTEIN LAT2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; GROWTH REGULATION; HUMAN; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; TUMOR GROWTH; UTERUS MYOMA;

ADULT; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HORMONE ANTAGONISTS; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEIOMYOMA; MIDDLE AGED; MIFEPRISTONE; MYOCYTES, SMOOTH MUSCLE; MYOMETRIUM; PROGESTERONE; RNA INTERFERENCE; RNA, MESSENGER; UTERINE NEOPLASMS;

EID: 77955672097     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719110372419     Document Type: Article

References (28)

1. Vollenhoven BJ, Lawrence AS, Healy DL Uterine fibroids: a clinical review. Br J Obstet Gynaecol. 1990 ; 97 (4). 285-298.
2. Moller C., Hoffmann J., Kirkland TA, Schwede W. Investigational developments for the treatment of progesterone-dependent diseases. Expert Opin Investig Drugs. 2008 ; 17 (4). 469-479.
3. Kurachi O., Matsuo H., Samoto T., Maruo T. Tumor necrosis factor-alpha expression in human uterine leiomyoma and its down-regulation by progesterone. J Clin Endocrinol Metab. 2001 ; 86 (5). 2275-2280.
4. Maruo T., Ohara N., Wang J., Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update. 2004 ; 10 (3). 207-220.
5. Matsuo H., Maruo T., Samoto T. Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone. J Clin Endocrinol Metab. 1997 ; 82 (1). 293-299.
6. Shimomura Y., Matsuo H., Samoto T., Maruo T. Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J Clin Endocrinol Metab. 1998 ; 83 (6). 2192-2198.
7. Yin P., Lin Z., Cheng YH, et al. Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. J Clin Endocrinol Metab. 2007 ; 92 (11). 4459-4466.
8. Yin P., Lin Z., Reierstad S., et al. Krüppel-like transcription factor 11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells. Cancer Res. 2010 ; 70 (4). 1722-1730.
9. Luo X., Yin P., Reierstad S., et al. Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells. J Clin Endocrinol Metab. 2009 ; 94 (11). 4533-4539.
10. Kaira K., Oriuchi N., Imai H., et al. L-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms. Cancer Sci. 2008 ; 99 (12). 2380-2386.
11. Kim CH, Park KJ, Park JR, et al. The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells. Anticancer Res. 2006 ; 26 (4B). 2943-2948.
12. Kobayashi H., Ishii Y., Takayama T. Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma. J Surg Oncol. 2005 ; 90 (4). 233-238.
13. Yanagida O., Kanai Y., Chairoungdua A., et al. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta. 2001 ; 1514 (2). 291-302.
14. Rossi MJ, Chegini N., Masterson BJ Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro. Endocrinology. 1992 ; 130 (3). 1716-1727.
15. Kim DK, Kanai Y., Choi HW, et al. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim Biophys Acta. 2002 ; 1565 (1). 112-121.
16. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001 ; 25 (4). 402-408.
17. Steinauer J., Pritts EA, Jackson R., Jacoby AF Systematic review of mifepristone for the treatment of uterine leiomyomata. Obstet Gynecol. 2004 ; 103 (6). 1331-1336.
18. Kanai Y., Segawa H., Miyamoto K., Uchino H., Takeda E., Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem. 1998 ; 273 (37). 23629-23632.
19. Kim DK, Kim IJ, Hwang S., et al. System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells. Neurosci Res. 2004 ; 50 (4). 437-446.
20. Shennan DB, Thomson J., Gow IF, Travers MT, Barber MC Lleucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter. Biochim Biophys Acta. 2004 ; 1664 (2). 206-216.
21. Yoon JH, Kim IJ, Kim H., et al. Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. Cancer Lett. 2005 ; 222 (2). 237-245.
22. Meier C., Ristic Z., Klauser S., Verrey F. Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J. 2002 ; 21 (4). 580-589.
23. Graham JD, Clarke CL Physiological action of progesterone in target tissues. Endocr Rev. 1997 ; 18 (4). 502-519.
24. Jacobsen BM, Richer JK, Schittone SA, Horwitz KB New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation. J Biol Chem. 2002 ; 277 (31). 27793-27800.
25. Leo JC, Lin VC The activities of progesterone receptor isoform A and B are differentially modulated by their ligands in a gene-selective manner. Int J Cancer. 2008 ; 122 (1). 230-243.
26. Busso N., Collart M., Vassalli JD, Belin D. Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes. Exp Cell Res. 1987 ; 173 (2). 425-430.
27. Gagne D., Pons M., Crastes de Paulet A. Analysis of the relation between receptor binding affinity and antagonist efficacy of anti-glucocorticoids. J Steroid Biochem. 1986 ; 25 (3). 315-322.
28. Neef G., Beier S., Elger W., Henderson D., Wiechert R. New steroids with antiprogestational and antiglucocorticoid activities. Steroids. 1984 ; 44 (4). 349-372.