Sestrins function as guanine nucleotide dissociation inhibitors for rag GTPases to control mTORC1 signaling

Cell

Volumn 159, Issue 1, 2014, Pages 122-133

  Peng, Min ^a   Yin, Na ^a   Li, Ming O ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LYSINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAGA GUANOSINE TRIPHOSPHATASE; RAGB GUANOSINE TRIPHOSPHATASE; RAGC GUANOSINE TRIPHOSPHATASE; SESTRIN; UNCLASSIFIED DRUG; AMINO ACID; CELL CYCLE PROTEIN; HEAT SHOCK PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; RAGA PROTEIN, MOUSE; RAGB PROTEIN, MOUSE; SESN3 PROTEIN, MOUSE; SESTRIN 1 PROTEIN, MOUSE; SESTRIN 2 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TUBERIN; TUMOR SUPPRESSOR PROTEIN;

ALLELE; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL SIZE; CONTROLLED STUDY; DIET RESTRICTION; EMBRYO DEVELOPMENT; ENZYME BINDING; GENE ACTIVATION; GENE CONTROL; GENE DOSAGE; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HELA CELL LINE; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; KWASHIORKOR; LYSOSOME; MOUSE; NONHUMAN; NULL ALLELE; NUTRIENT; PHENOTYPE; PHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; ANIMAL EMBRYO; CYTOLOGY; FEMALE; FIBROBLAST; GENE TARGETING; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOLECULAR GENETICS; NEWBORN; PREGNANCY; STARVATION;

AMINO ACID SEQUENCE; AMINO ACIDS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANIMALS, NEWBORN; CELL CYCLE PROTEINS; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; GENE KNOCK-IN TECHNIQUES; HEAT-SHOCK PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PREGNANCY; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STARVATION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84907525131     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.08.038     Document Type: Article

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