High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non-cancerous lesions

Pathology International

Volumn 61, Issue 5, 2011, Pages 281-289

  Ichinoe, Masaaki ^a,b   Mikami, Tetuo ^a,b   Yoshida, Tsutomu ^a,b   Igawa, Ikuyo ^c   Tsuruta, Tomoko ^a   Nakada, Norihiro ^a,b   Anzai, Naohiko ^d   Suzuki, Yoshiyuki ^e   Endou, Hitoshi ^c,d   Okayasu, Isao ^a,b  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c J Pharma Co   (Japan)

^d KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Sugi Institute of Biological Science   (Japan)

Author keywords

Amino acid transporter; Gastric carcinoma; L type amino acid transporter 1 (LAT1)

Indexed keywords

AMINO ACID TRANSPORTER;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER STAGING; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CARCINOMA;

ADENOCARCINOMA; ADENOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CELL PROLIFERATION; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PRECANCEROUS CONDITIONS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79955017462     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2011.02650.x     Document Type: Article

References (19)

1. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 1998; 273: 23629-32.
2. Rajan DP, Kekuda R, Huang W etal. Cloning and expression of a b(0, +)-like amino acid transporter functioning as a heterodimer with 4F2hc instead of rBAT. A new candidate gene for cystinuria. J Biol Chem 1999; 274: 29005-10.
3. Sakata T, Ferdous G, Tsuruta T etal. L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol Int 2009; 59: 7-18.
4. Kobayashi H, Ishii Y, Takayama T. Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma. J Surg Oncol 2005; 90: 233-38.
5. Kaira K, Oriuchi N, Imai H etal. Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma. Lung Cancer 2009; 66: 120-26.
6. Yanagida O, Kanai Y, Chairoungdua A etal. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 2001; 1514: 291-302.
7. Japanese gastric cancer association. Japanese classification of gastric carcinoma-2nd English Edition. Gastric Cancer 1998; 1: 10-24.
8. Sinicrope FA, Ruan SB, Cleary KR, Stephens LC, Lee JJ, Levin B. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 1995; 55: 237-41.
9. Ueyama H, Yao T, Nakashima Y etal. Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma. Am J Surg Pathol 2010; 34: 609-19.
10. Nakamura T, Yao T, Kabashima A, Nishiyama K, Maehara Y, Tsuneyoshi M. Loss of phenotypic expression is related to tumour progression in early gastric differentiated adenocarcinoma. Histopathology 2005; 4: 357-67.
11. Sobin LH, Gospodarowicz MK, Wittekind C. UICC. TNM Classification of Malignant Tumours 7th ed. 2009; 73-7.
12. Nawashiro H, Otani N, Uozumi Y etal. High expression of L-type amino acid transporter 1 in infiltrating glioma cells. Brain Tumor Pathol 2005; 22: 89-91.
13. Kim DK, Ahn SG, Park JC, Kanai Y, Endou H, Yoon JH. Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions. Anticancer Res 2004; 24: 1671-5.
14. Nakanishi K, Matsuo H, Kanai Y etal. LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Virchows Arch 2006; 448: 142-50.
15. Fraga S, Pinho MJ, Soares-da-Silva P. Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells. Amino Acids 2005; 29: 229-33.
16. Kaira K, Oriuchi N, Imai H etal. Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer. Br J Cancer 2008; 98: 742-8.
17. Nakanishi K, Ogata S, Kanai Y etal. Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract. Virchows Arch 2007; 451: 681-90.
18. Shennan DB, Thomson J. Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. Oncol Rep 2008; 20: 885-9.
19. Oda K, Hosoda N, Endou H etal. l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci 2010; 101: 173-9.