Protein characterization of Na+-independent system L amino acid transporter 3 in mice: A potential role in supply of branched-chain amino acids under nutrient starvation

American Journal of Pathology

Volumn 170, Issue 3, 2007, Pages 888-898

  Fukuhara, Daisuke ^a   Kanai, Yoshikatsu ^a   Chairoungdua, Arthit ^a   Babu, Ellappan ^a   Bessho, Fumio ^a   Kawano, Toshio ^a   Akimoto, Yoshihiro ^a   Endou, Hitoshi ^a   Yan, Kunimasa ^a  

^a KYORIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; AMINO ACID TRANSPORTER 3; SODIUM ION; UNCLASSIFIED DRUG; BRANCHED CHAIN AMINO ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STARVATION; UPREGULATION; ANIMAL; CELL CULTURE; CONFOCAL MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; IMMUNOELECTRON MICROSCOPY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

AMINO ACID TRANSPORT SYSTEMS, BASIC; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELLS, CULTURED; CLONING, MOLECULAR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED ICR; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, NUCLEIC ACID; STARVATION;

EID: 34247892541     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.060428     Document Type: Article

References (47)

1. Christensen HN: Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 1990, 70:43-77
2. Palacín M, Estevez R, Bertran J, Zorzano A: Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 1998, 78:969-1054
3. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H: Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 1998, 273:23629-23632
4. Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M: Identification of a membrane protein, LAT2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 1999, 274:19738-19744
5. Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kuhn LC: LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 1999, 274:34948-34954
6. +-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 1999, 274:19745-19751
7. Verrey F: System L: heteromeric exchangers of large, neutral amino acids involved in directional transport. Pflugers Arch 2003, 445:529-533
8. Babu E, Kanai Y, Chairoungdua A, Kim do K, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S, Anzai N, Nagamori S, Endou H: Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem 2003, 278:43838-43845
9. Martinet W, De Meyer GR, Andries L, Herman AG, Kockx MM: In situ detection of starvation-induced autophagy. J Histochem Cytochem 2006, 54:85-96
10. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y: In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004, 15:1101-1111
11. Kanai Y, Nussberger S, Romero MF, Boron WF, Hebert SC, Hediger MA: Electrogenic properties of the epithelial and neuronal high affinity glutamate transporter. J Biol Chem 1995, 270:16561-16568
12. +-dependent neutral amino acid transporter. J Biol Chem 1996, 271:14883-14890
13. Fujii Y, Khoshnoodi J, Takenaka H, Hosoyamada M, Nakajo A, Bessho F, Kudo A, Takahashi S, Arimura Y, Yamada A, Nagasawa T, Ruotsalainen V, Tryggvason K, Lee AS, Yan K: The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action glucocorticoids in the acquired glomerular diseases. Kidney Int 2006, 69:1350-1359
14. Nishibori Y, Liu L, Hosoyamada M, Endou H, Kudo A, Takenaka H, Higashihara E, Bessho F, Takahashi S, Kershaw D, Ruotsalainen V, Tryggvason K, Khoshnoodi J, Yan K: Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane. Kidney Int 2004, 66:1755-1765
15. Yan K, Kudo A, Hirano H, Watanabe T, Tasaka T, Kataoka S, Nakajima N, Nishibori Y, Shibata T, Kohsaka T, Higashihara E, Tanaka H, Watanabe H, Nagasawa T, Awa S: Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus. Kidney Int 1999, 56:65-73
16. Akimoto Y, Yamamoto K, Munemoto E, Wells L, Vosseller K, Hart GW, Kawakami H, Hirano H: Elevated post-translational modification of proteins by O-linked N-acetylglucosamine in various tissues of diabetic Goto-Kakizaki rats accompanied by diabetic complications. Acta Histochem Cytochem 2005, 38:131-142
17. Akimoto Y, Kreppel LK, Hirano H, Hart GW: Localization of the O-linked N-acetylglucosamine transferase in rat pancreas. Diabetes 1999, 48:2407-2413
18. Ohara-Imaizumi M, Ohtsuka T, Matsushima S, Akimoto Y, Nishiwaki C, Nakamichi Y, Kikuta T, Nagai S, Kawakami H, Watanabe T, Nagamatsu S: ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy. Mol Biol Cell 2005, 16:3289-3300
19. Bodoy S, Martin L, Zorzano A, Palacin M, Estevez R, Bertran J: Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem 2005, 280:12002-12011
20. Wagner CA, Lang F, Broer S: Function and structure of heterodimeric amino acid transporters. Am J Physiol Cell Physiol 2001, 281:C1077-C1093
21. Nakanishi K, Matsuo H, Kanai Y, Endou H, Hiroi S, Tominaga S, Mukai M, Ikeda E, Ozeki Y, Aida S, Kawai T: LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Virchows Arch 2005, 21:1-9
22. Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, Cha SH, Matsuo H, Fukushima J, Fukasawa Y, Tani Y, Taketani Y, Uchino H, Kim JY, Inatomi J, Okayasu I, Miyamoto K, Takeda E, Goya T, Endou H: Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 2001, 1514:291-302
23. Matsuo H, Tsukada S, Nakata T, Chairoungdua A, Kim DK, Cha SH, Inatomi J, Yorifuji H, Fukuda J, Endou H, Kanai Y: Expression of a system L neutral amino acid transporter at the blood-brain barrier. Neuroreport 2000, 11:3507-3511
24. Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM: Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc Natl Acad Sci USA 1999, 96:12079-12084
25. Ritchie JW, Taylor PM: Role of the system L permease LAT1 in amino acid and iodothyronine transport in placenta. Biochem J 2001, 356:719-725
26. Dave MH, Schulz N, Zecevic M, Wagner CA, Verrey F: Expression of heteromeric amino acid transporters along the murine intestine. J Physiol 2004, 558:597-610
27. Ghadially FN: Ultrastructural Pathology of the Cell and Matrix. Edited by FN Ghadially. Newton, Butterworth-Heinemann, 1997, pp 1038-1045
28. Papadimitriou JM, Walters MN, Archer JM: Cytoplasmic crystalline aggregates in murine pancreatic acinocytes. Pathology 1969, 1:289-293
29. Machino M, Hoshino K: Membrane unbound crystals in pancreatic acinar cells of the mouse. Virchows Arch B Cell Pathol 1975, 17:261-267
30. Adibi SA, Krzysik BA, Morse EL, Amin PM, Allen ER: Oxidative energy metabolism in the skeletal muscle: biochemical and ultrastructural evidence for adaptive changes. J Lab Clin Med 1974, 83:548-562
31. Goldberg AL, Odessey R: Oxidation of amino acids by diaphragms from fed and fasted rats. Am J Physiol 1972, 223:1384-1391
32. Ahlborg G, Felig P, Hagenfeldt L, Hendler R, Wahren J: Substrate turnover during prolonged exercise in man: splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest 1974, 53:1080-1090
33. Harper AE, Miller RH, Block KP: Branched-chain amino acid metabolism. Annu Rev Nutr 1984, 4:409-454
34. Livesey G, Lund P: Enzymic determination of branched-chain amino acids and 2-oxoacids in rat tissues: transfer of 2-oxoacids from skeletal muscle to liver in vivo. Biochem J 1980, 188:705-713
35. Abumrad NN, Robinson RP, Gooch BR, Lacy WW: The effect of leucine infusion on substrate flux across the human forearm. J Surg Res 1982, 32:453-463
36. Holecek M: Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition 2002, 18:130-133
37. Adibi SA, Drash AL: Hormone and amino acid levels in altered nutritional states. J Lab Clin Med 1970, 76:722-732
38. Adibi SA: Influence of dietary deprivations on plasma concentration of free amino acids of man. J Appl Physiol 1968, 25:52-57
39. Felig P, Owen OE, Wahren J, Cahill Jr GF: Amino acid metabolism during prolonged starvation. J Clin Invest 1969, 48:584-594
40. Swendseid ME, Umezawa CY, Drenick E: Plasma amino acid levels in obese subjects before, during, and after starvation. Am J Clin Nutr 1969, 22:740-743
41. Ahlman B, Andersson K, Leijonmarck CE, Ljungqvist O, Hedenborg L, Wernerman J: Short-term starvation alters the free amino acid content of the human intestinal mucosa. Clin Sci (Lond) 1994, 86:653-662
42. Holecek M, Sprongl L, Tilser I: Metabolism of branched-chain amino acids in starved rats: the role of hepatic tissue. Physiol Res 2001, 50:25-33
43. Bloxam DL: Nutritional aspects of amino acid metabolism. Br J Nutr 1972, 27:233-247
44. Pozefsky T, Tancredi RG, Moxley RT, Dupre J, Tobin JD: Effects of brief starvation on muscle amino acid metabolism in nonobese man. J Clin Invest 1976, 57:444-449
45. Prasad PD, Wang H, Huang W, Kekuda R, Rajan DP, Leibach FH, Ganapathy V: Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem Biophys Res Commun 1999, 255:283-288
46. Weiss MD, Donnelly WH, Rossignol C, Varoqui H, Erickson JD, Anderson KJ: Ontogeny of the neutral amino acid transporter SNAT1 in the developing rat. J Mol Histol 2005, 36:301-309
47. Hashimoto Y, Sadamoto Y, Konno A, Kon Y, Iwanaga T: Distribution of neutral amino acid transporter ASCT1 in the non-neuronal tissues of mice. Jpn J Vet Res 2004, 52:113-122