Adenoviral modulation of the tumor-associated system L amino acid transporter, LAT1, alters amino acid transport, cell growth and 4F2/CD98 expression with cell-type specific effects in cultured hepatic cells

International Journal of Cancer

Volumn 117, Issue 3, 2005, Pages 387-397

  Storey, Bill T ^b   Fugere, Celine ^a   Lesleur Brooks, Anne ^a   Vaslet, Charles ^b   Thompson, Nancy L ^a,b  

^a RHODE ISLAND HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

4F2; Adenovirus; CD98; LAT1; Leucine

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; ANTISENSE OLIGONUCLEOTIDE; CD98 ANTIGEN; PROTEIN 4F2; PROTEIN LAT1; UNCLASSIFIED DRUG;

ADENOVIRUS; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER MODEL; CELL COUNT; CELL CYCLE S PHASE; CELL VIABILITY; CONTROLLED STUDY; LIVER CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ADENOVIRIDAE; AMINO ACID TRANSPORT SYSTEM L; AMINO ACIDS; ANIMALS; ANTIGENS, CD98; APOPTOSIS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL CYCLE; CELL DIVISION; DNA PRIMERS; HEPATOCYTES; POLYMERASE CHAIN REACTION; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 26444462089     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.21169     Document Type: Article

References (31)

1. Sang J, Lim YP, Panzica M, Finch P, Thompson NL. TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation. Cancer Res 1995;55:1152-9.
2. Tamai S, Musada H, Ishii Y, Suzuki S, Kanai Y, Endou H. Expression of L-type amino acid transporter 1 in a rat model of liver metastasis: positive correlation with tumor size. Cancer Detect Prev 2001;25:439-45.
3. Ohkame H, Musada H, Ishii Y, Kanai Y. Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models. J Surg Oncol 2001;78:265-72.
4. Yoon JH, Kim YB, Kim MS, Park JC, Kook JK, Jung HM, Kim SG, Yoo H, Ko YM, Lee SH, Kim BY, Chun HS, et al. Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells. Cancer Lett 2004;205:215-26.
5. Travers MT, Gow IF, Barber MC, Thompson J, Shennan DB. Indoleamine 2, 3-dioxygenase activity and L-tryptophan transport in human breast cancer cells. Biochem Biophys Acta 2004;1661:106-12.
6. Kim DK, Kanai Y, Choi HW, Tangtrongsup S, Chairoungdua A, Babu E, Tachampa K, Anzai N, Iribe Y, Endou H. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochem Biophys Acta 2002;1565:112-22.
7. Wolf DA, Panzica MA, Wang S, Bassily NH, Thompson NL. Expression of a highly conserved oncofetal gene, TA1/E16, in human colon carcinoma and other primary cancers: homology to Schistosoma mansoni amino acid permease and Caenorhabditis elegans gene products. Cancer Res 1996;56:5012-22.
8. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Eur J Physiol 2004;447:532-42.
9. Verrey F, Jack DL, Paulsen IT, Saier MH Jr, Pfeiffer R. New glycoprotein-associated amino acid transporters. J Membrane Biol 1999;172:181-92.
10. Mannion BA, Kolesnikova TV, Lin SH, Wang S, Thompson NL, Hemler ME. The light chain of CD98 is identified as E16/TA1 protein. J Biol Chem 1998;273:33127-9.
11. Meier C, Ristic Z, Klauser S, Verrey F. Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J 2002;21:580-9.
12. Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nu T, Cha SH, Matsuo H, Fukushima J, Fukasawa J, Tani Y, Taktani Y, et al. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochem Biophys Acta 2001;1514:291-302.
13. Broer A, Wagner CA, Lang F, Broer S. The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine. Biochem J 2000;349:787-95.
14. Cho JY, Skubitz KM, Katz DR, Chain BM. CD98-dependent homotypic aggregation is associated with translocation of protein kinase C delta and activation of mitogen-activated protein kinases. Exp Cell Res 2002;286:1-11.
15. Kudo Y, Boyd CAR, Millo J, Sargent IL, Redman CWG. Manipulation of CD98 expression affects both trophoblast cell fusion and amino acid transport activity during syncytialization of human placental BeWo cells. J Physiol 2003;550:3-9.
16. Rintoul RC, Buttery RC, Mackinnon AC, Wong WS, Mosher D, Haslett C, Sethi T. Cross-linking CD98 promotes integrin-like signaling and anchorage- independent growth. Mol Biol Cell 2002;13:2841-52.
17. Hara K, Kudoh H, Enomoto T, Hashimoto Y, Masuko T. Enhanced tumorigenicity caused by truncation of the extracellular domain of GP125/CD98 heavy chain. Oncogene 2000;19:6209-15.
18. Campbell WA, Sah DE, Medina MM, Albina JE, Coleman WB, Thompson NL. TA1/LAT-1/CD98 light chain and system L activity, but not 4F2/CD98 heavy chain, respond to arginine availability in rat hepatic cells. Loss of response in tumor cells. J Biol Chem 2000;275:5347-54.
19. Campbell WA, Thompson NL. Overexpression of LAT1/CD98 light chain is sufficient to increase system L-amino acid transport activity in mouse hepatocytes but not fibroblasts. J Biol Chem 2001;276:16877-84.
20. Shishido T, Uno S, Kamohara M, Tsuneoka-Suzuki T, Hashimoto Y, Enomoto T, Masuko T. Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity. Int J Cancer 2000;87:311-6.
21. Papetti M, Herman IM. Controlling tumor-derived and vascular endothelial cell growth: role of the 4F2 cell surface antigen. Am J Pathol 2001;159:165-77.
22. Yagita H, Masuko T, Hashimoto Y. Inhibition of tumor cell growth in vitro by murine monoclonal antibodies that recognize a proliferation-associated cell surface antigen system in rats and humans. Cancer Res 1986;46:1478-84.
23. Tsao MS, Smith JD, Nelson KG, Grisham JW. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. Exp Cell Res 1984;154:38-52.
24. Gazzola GC, Dall Asta V, Franchi-Gazzola R, White MF. The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells. Anal Biochem 1981;115:368-74.
25. Kilberg MS. Measurement of amino acid transport by hepatocytes in suspension or monolayer culture. Methods Enzymol 1989;173:564-75.
26. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
27. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253-62.
28. Bauch C, Forster N, Loffing-Cueini D, Summa V, Verrey F. Functional cooperation of epithelial heteromeric amino acid transporters expressed in madin-darby canine kidney cells. J Biol Chem 2003;278:1316-22.
29. Feral CC, Nishiya N, Fenczik CA, Stuhlmann H, Siepak M, Ginsberg MH. CD98hc (SLC3A2) mediates integrin signaling. PNAS 2005;102:355-60.
30. Fuchs BC, Perez C, Suetterlin JE, Chaudhry SB, Bode BP. Inducible antisense RNA targeting amino acid transporter ATBO/ASCT2 elicits apoptosis in human hepatoma cells. Am J Physiol 2004;286:G467-8.
31. Noguchi Y, Saito A, Miyagi Y, Yamanaka S, Marat D, Doi C, Yoshikawa T, Tsuburaya A, Ito T, Satoh S. Suppression of facilitative glucose transporter 1 mRNA can suppress tumor growth. Cancer Lett. 2000;154:175-82.