Monoterpene glycoside ESK246 from pittosporum targets LAT3 amino acid transport and prostate cancer cell growth

ACS Chemical Biology

Volumn 9, Issue 6, 2014, Pages 1369-1376

  Wang, Qian ^a,b   Grkovic, Tanja ^c   Font, Josep ^a,b   Bonham, Sarah ^c   Pouwer, Rebecca H ^c   Bailey, Charles G ^a,b   Moran, Anne M ^a,b   Ryan, Renae M ^b,d   Rasko, John E J ^a,b,e   Jormakka, Mika ^a,b   Quinn, Ronald J ^c   Holst, Jeff ^a,b  

^a CENTENARY INSTITUTE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c GRIFFITH UNIVERSITY   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; ESK 242; ESK 246; GLYCOSIDE; L TYPE AMINO ACID TRANSPORTER 1; L TYPE AMINO ACID TRANSPORTER 3; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; AMINO ACID TRANSPORT SYSTEMS, BASIC; ANTINEOPLASTIC AGENTS; ESK242; ESK246; GLYCOSIDES; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOTERPENES; MULTIPROTEIN COMPLEXES; SLC7A6 PROTEIN, HUMAN; TOR SERINE-THREONINE KINASES;

AMINO ACID TRANSPORT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; AUSTRALIA; CANCER GROWTH; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CELL VIABILITY; CELL VIABILITY ASSAY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG PURIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; LNCAP CELL LINE; MALE; MEDICINAL PLANT; MTT ASSAY; NONHUMAN; OOCYTE; PITTOSPORUM VENULOSUM; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; XENOPUS LAEVIS; ANIMALS; ANTAGONISTS AND INHIBITORS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; GROWTH AND DEVELOPMENT; HUMANS; METABOLISM; OOCYTES; PATHOLOGY; PROSTATIC NEOPLASMS; ROSALES; TUMOR CELLS, CULTURED;

AMINO ACID TRANSPORT SYSTEMS, BASIC; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL PROLIFERATION; FEMALE; GLYCOSIDES; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEUCINE; MALE; MONOTERPENES; MULTIPROTEIN COMPLEXES; OOCYTES; PROSTATIC NEOPLASMS; ROSALES; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; XENOPUS LAEVIS;

EID: 84903130701     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500120x     Document Type: Article

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