JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells

Journal of Pharmacological Sciences

Volumn 124, Issue 2, 2014, Pages 208-217

  Yun, Dae Woong ^a   Lee, Seul Ah ^a   Park, Min Gyeong ^a   Kim, Jae Sung ^a   Yu, Sun Kyoung ^a   Park, Mi Ra ^a   Kim, Su Gwan ^a   Oh, Ji Su ^a   Kim, Chun Sung ^a   Kim, Heung Joong ^a   Kim, Jin Soo ^a   Chun, Hong Sung ^a   Kanai, Yoshikatsu ^b   Endou, Hitoshi ^c,d   Wempe, Michael F ^e   Kim, Do Kyung ^a  

^a Chosun University   (South Korea)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d J Pharma Co   (Japan)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

Anti cancer therapy; Apoptosis; JPH203; L type amino acid transporter 1; Oral cancer cell

Indexed keywords

AMINO ACID TRANSPORTER; ANTINEOPLASTIC AGENT; CASPASE; JPH 203; LEUCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL GROWTH; CELL PROLIFERATION; DRUG ACTIVITY; DRUG STRUCTURE; HEAVY CHAIN; HUMAN; MOUTH CANCER; UPREGULATION;

AMINO ACID TRANSPORT SYSTEM L; ANTIGENS, CD98 HEAVY CHAIN; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOXAZOLES; CASPASES; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEUCINE; MOUTH NEOPLASMS; TUMOR CELLS, CULTURED; TYROSINE; UP-REGULATION;

EID: 84895515780     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13154FP     Document Type: Article

References (36)

1. Notani PN. Epidemiology and prevention of head and neck cancer: a global view. In: Saranath D, ed. Contemporary Issues in Oral Cancer. New Delhi: Oxford University Press; 2000. p. 1-29.
2. Moreno-Lopez LA, Esparza-Gomez GC, Gonzalez-Navarro A, Cerero-Lapiedra R, Gonzalez-Hernandez MJ, Dominguez-Rojas V. Risk of oral cancer associated with tobacco smoking, alcohol consumption and oral hygiene: a case-control study in Madrid, Spain. Oral Oncol. 2000;36: 170-174.
3. Ellis GL, Auclair PL, Gnepp DR. Surgical pathology of the salivary glands. In: Auclair PL, Ellis GL, editors. Primary squamous cell carcinoma. Philadelphia: W. B. Saunders Company; 1991. p. 369-378.
4. Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev. 1990;70: 43-77.
5. McGivan JD, Pastor-Anglada M. Regulatory and molecular aspects of mammalian amino acid transport. Biochem J. 1994;299: 321-334.
6. Morimoto E, Kanai Y, Kim DK, Chairoungdua A, Choi HW, Wempe MF, et al. Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters. J Pharmacol Sci. 2008;108: 505-516.
7. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem. 1998;273: 23629-23632.
8. Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, et al. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta. 2001;1514: 291-302.
9. Segawa H, Fukasawa Y, Miyamoto K, Takeda E, Endou H, Kanai Y. Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem. 1999;274: 19745-19751.
10. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, et al. Transport ofamino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002;61: 729-737.
11. Nakamura E, Sato M, Yang H, Miyagawa F, Harasaki M, Tomita K, et al. 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem. 1999;274: 3009-3016.
12. Prasad PD, Wang H, Huang H, Kekuda R, Rajan DP, Leibach FH, et al. Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem Biophys Res Commun. 1999;255: 283-288.
13. Sang J, Lim YP, Panzia MA, Finch P, Thompson NL. TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation. Cancer Res. 1995;55: 1152-1159.
14. Wolf DA, Wang S, Panzia MA, Bassily NH, Thompson NL. Expression of a highly conserved oncofetal gene, TA1/E16, in human colon carcinoma and other primary cancers: homology to Schistosoma mansoni amino acid permease and Caenorhabditis elegans gene products. Cancer Res. 1996;56: 5012-5022.
15. Pineda M, Fernández E, Torrents D, Estévez R, López C, Camps M, et al. Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem. 1999;274: 19738-19744.
16. Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, et al. LAT2, a new basolateral 4F2hc/CD98- associated amino acid transporter of kidney and intestine. J Biol Chem. 1999;274: 34948-34954.
17. Rajan DP, Kekuda R, Huang W, Devoe LD, Leibach FH, Prasad PD, et al. Cloning and functional characterization of a Na+-independent, broad-specific neutral amino acid transporter from mammalian intestine. Biochim Biophys Acta. 2000;1463: 6-14.
18. Kim CS, Moon IS, Park JH, Shin WC, Chun HS, Lee SY, et al. Inhibition of L-type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells. Biol Pharm Bull. 2010;33: 1117-1121.
19. Sloan JL, Mager S. Cloning and functional expression of a human Na+- and Cl - dependent neutral and cationic amino acid transporter B0, +. J Biol Chem. 1999;274: 23740-23745.
20. Kim DK, Kanai Y, Choi HW, Tangtrongsup S, Chairoungdua A, Babu E, et al. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim Biophys Acta. 2002;1565: 112-121.
21. Kim CS, Cho SH, Chun HS, Lee SY, Endou H, Kanai Y, et al. BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol Pharm Bull. 2008;31: 1096-1100.
22. Oda K, Hosoda N, Endo H, Saito K, Tsujihara K, Yamamura M, et al. L-Type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci. 2010;101: 173-179.
23. Wempe MF, Rice PJ, Lightner JW, Jutabha P, Hayashi M, Anzai N, et al. Metabolism and pharmacokinetic studies of JPH203, an L-amino acid transporter 1 (LAT1) selective compound. Drug Metab Pharmacokinet. 2012;27: 155-161.
24. Yoon JH, Kim YB, Kim MS, Park JC, Kook JK, Jung HM, et al. Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells. Cancer Lett. 2004;205: 215-226.
25. Jingushi K, Nakamura T, Takahashi-Yanaga F, Matsuzaki E, Watanabe Y, Yoshihara T, et al. Differentiation-inducing factor-1 suppresses the expression of c-Myc in the human cancer cell lines. J Pharmacol Sci. 2013;121: 103-109.
26. Kikuchi T, Pan X, Ishii K, Nakamura Y, Ogihara E, Koike K, et al. Cytotoxic and apoptosis-inducing activities of 12-O-Acetylazedarachin B from the fruits of Melia azedarach in human cancer cell lines. Biol Pharm Bull. 2013;36: 135-139.
27. Cohen GM. Caspases: the executioners of apoptosis. Biochem J. 1997;326: 1-16.
28. Herrnring C, Reimer T, Jeschke U, Makovitzky J, Krüger K, Gerber B, et al. Expression of the apoptosis-inducing ligands FasL and TRAIL in malignant and benign human breast tumors. Histochem Cell Biol. 2000;113: 189-194.
29. Kim DK, Kim IJ, Hwang S, Kook JH, Lee MC, Shin BA, et al. System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells. Neurosci Res. 2004;50: 437-446.
30. Kim SG, Kim HH, Kim HK, Kim CH, Chun HS, Kanai Y, et al. Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells. Anticancer Res. 2006;26: 1989-1996.
31. Yoon JH, Kim IJ, Kim H, Kim HJ, Jeong MJ, Ahn SG, et al. Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. Cancer Lett. 2005;222: 237-245.
32. Kim DK, Ahn SG, Park JC, Kanai Y, Endou H, Yoon JH. Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions. Anticancer Res. 2004;24: 1671-1675.
33. Sakata T, Ferdous G, Tsuruta T, Satoh T, Baba S, Muto T, et al. L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol Int. 2009;59: 7-18.
34. Lu J, Kunimoto S, Yamazaki Y, Kaminishi M, Esumi H. Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation. Cancer Sci. 2004;95: 547-552.
35. Datta R, Kojima H, Yoshida K, Kufe D. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. J Biol Chem. 1997;272: 20317-20320.
36. Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 1997;89: 175-184.