Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 11, 2009, Pages 4533-4539

  Luo, Xia ^a,b   Yin, Ping ^a   Reierstad, Scott ^a   Ishikawa, Hiroshi ^a   Lin, Zhihong ^a   Pavone, Mary Ellen ^a   Zhao, Hong ^a   Marsh, Erica E ^a   Bulun, Serdar E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; AMINO ACID TRANSPORTER 2; AMINO ACID TRANSPORTER 4F2; LAT PROTEIN; MESSENGER RNA; MIFEPRISTONE; PROGESTERONE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HEAVY CHAIN; HUMAN; HUMAN CELL CULTURE; HUMAN TISSUE; IN VIVO STUDY; MUSCLE TISSUE; MYOMETRIUM; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; TUMOR CELL; UTERUS MYOMA;

EID: 70449090348     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1286     Document Type: Article

References (38)

1. Vollenhoven BJ, Lawrence AS, Healy DL 1990 Uterine fibroids: a clinical review. Br J Obstet Gynaecol 97:285-298
2. Wilcox LS, Koonin LM, Pokras R, Strauss LT, Xia Z, Peterson HB 1994 Hysterectomy in the United States, 1988-1990. Obstet Gynecol 83:549-555
3. Möller C, Hoffmann J, Kirkland TA, Schwede W 2008 Investigational developments for the treatment of progesterone-dependent diseases. Expert Opin Investig Drugs 17:469-479 (Pubitemid 351578166)
4. Marsh EE, Bulun SE 2006 Steroid hormones and leiomyomas. Obstet Gynecol Clin North Am 33:59-67
5. Yin P, Lin Z, Cheng YH, Marsh EE, Utsunomiya H, Ishikawa H, Xue Q, Reierstad S, Innes J, Thung S, Kim JJ, Xu E, Bulun SE 2007 Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. J Clin Endocrinol Metab 92:4459-4466 (Pubitemid 350074770)
6. Brandon DD, Bethea CL, Strawn EY, Novy MJ, Burry KA, Harrington MS, Erickson TE, Warner C, Keenan EJ, Clinton GM 1993 Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas. Am J Obstet Gynecol 169: 78-85 (Pubitemid 23223932)
7. Englund K, Blanck A, Gustavsson I, Lundkvist U, Sjöblom P, Norgren A, Lindblom B 1998 Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment. J Clin Endocrinol Metab 83:4092-4096 (Pubitemid 28513601)
8. Ichimura T, Kawamura N, Ito F, Shibata S, Minakuchi K, Tsujimura A, Umesaki N, Ogita S 1998 Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens. Fertil Steril 70:967-971 (Pubitemid 28499098)
9. Carr BR, Marshburn PB, Weatherall PT, Bradshaw KD, Breslau NA, Byrd W, Roark M, Steinkampf MP 1993 An evaluation of the effect of gonadotropin- releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trial. J Clin Endocrinol Metab 76:1217-1223 (Pubitemid 23155439)
10. Friedman AJ, Barbieri RL, Doubilet PM, Fine C, Schiff I 1988 A randomized, double-blind trial of a gonadotropin releasing-hormone agonist (leuprolide) with or without medroxyprogesterone acetate in the treatment of leiomyomata uteri. Fertil Steril 49:404-409 (Pubitemid 18063993)
11. Rosati P, Exacoustòs C, Mancuso S 1992 Longitudinal evaluation of uterine myoma growth during pregnancy. A sonographic study. J Ultrasound Med 11:511-515 (Pubitemid 23047026)
12. Aharoni A, Reiter A, Golan D, Paltiely Y, Sharf M 1988 Patterns of growth of uterine leiomyomas during pregnancy. A prospective longitudinal study. Br J Obstet Gynaecol 95:510-513 (Pubitemid 18221043)
13. Hammoud AO, Asaad R, Berman J, Treadwell MC, Blackwell S, Diamond MP 2006 Volume change of uterine myomas during pregnancy: do myomas really grow? J Minim Invasive Gynecol 13:386-390
14. Neiger R, Sonek JD, Croom CS, Ventolini G 2006 Pregnancy-related changes in the size of uterine leiomyomas. J Reprod Med 51:671-674 (Pubitemid 44469900)
15. Maruo T, Matsuo H, Shimomura Y, Kurachi O, Gao Z, Nakago S, Yamada T, Chen W, Wang J 2003 Effects of progesterone on growth factor expression in human uterine leiomyoma. Steroids 68:817-824 (Pubitemid 37532405)
16. Maruo T, Ohara N, Wang J, Matsuo H 2004 Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update 10:207-220 (Pubitemid 38750141)
17. Kim DK, Kim IJ, Hwang S, Kook JH, Lee MC, Shin BA, Bae CS, Yoon JH, Ahn SG, Kim SA, Kanai Y, Endou H, Kim JK 2004 System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells. Neurosci Res 50:437-446 (Pubitemid 39572990)
18. Segawa H, Fukasawa Y, Miyamoto K, Takeda E, Endou H, Kanai Y 1999 Identification and functional characterization of a Na+- independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274:19745-19751 (Pubitemid 129519422)
19. Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kühn LC 1999 LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 274:34948-34954 (Pubitemid 129509543)
20. del Amo EM, Urtti A, Yliperttula M 2008 Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur J Pharm Sci 35:161-174
21. Rossi MJ, Chegini N, Masterson BJ 1992 Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro. Endocrinology 130:1716-1727
22. Kim DK, Kanai Y, Choi HW, Tangtrongsup S, Chairoungdua A, Babu E, Tachampa K, Anzai N, Iribe Y, Endou H 2002 Characterization of the system Lamino acid transporter in T24 human bladder carcinoma cells. Biochim Biophys Acta 1565:112-121 (Pubitemid 35239839)
23. Ishikawa H, Reierstad S, Demura M, Rademaker AW, Kasai T, Inoue M, Usui H, Shozu M, Bulun SE 2009 High aromatase expression in uterine leiomyoma tissues of African-American women. J Clin Endocrinol Metab 94:1752-1756
24. Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25:402-408 (Pubitemid 34164012)
25. Pineda M, Fernández E, Torrents D, Estévez R, Ló pez C, Camps M, Lloberas J, Zorzano A, Palacín M 1999 Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 274:19738-19744
26. Liu X, Charrier L, Gewirtz A, Sitaraman S, Merlin D 2003 CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. J Biol Chem 278:23672-23677 (Pubitemid 36830189)
27. Meier C, Ristic Z, Klauser S, Verrey F 2002 Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J 21:580-589 (Pubitemid 34174039)
28. Yagita H, Masuko T, Hashimoto Y 1986 Inhibition of tumor cell growth in vitro by murine monoclonal antibodies that recognize a proliferation-associated cell surface antigen system in rats and humans. Cancer Res 46:1478-1484 (Pubitemid 16048299)
29. Murphy AA, Kettel LM, Morales AJ, Roberts VJ, Yen SS 1993 Regression of uterine leiomyomata in response to the antiprogesterone RU 486. J Clin Endocrinol Metab 76:513-517 (Pubitemid 23073084)
30. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P 1990 Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9:1603-1614 (Pubitemid 20137018)
31. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP 1993 Human progesterone receptor A form is a celland promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 7:1244-1255 (Pubitemid 23319107)
32. Wen DX, Xu YF, Mais DE, Goldman ME, McDonnell DP 1994 The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol 14:8356-8364
33. Laverty G, Elbrønd VS, Arnason SS, Skadhauge E 2006 Endocrine regulation of ion transport in the avian lower intestine. Gen Comp Endocrinol 147:70-77
34. Mate A, Barfull A, Hermosa AM, Gómez-Amores L, Vázquez CM, Planas JM 2006 Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats. Am J Physiol Regul Integr Comp Physiol 291:R760-R767 (Pubitemid 44352360)
35. Moretó M, Cristià E, Pérez-Bosque A, Afzal-Ahmed I, Amat C, Naftalin RJ 2005 Aldosterone reduces crypt colon permeability during low-sodium adaptation. J Membr Biol 206:43-51 (Pubitemid 43163348)
36. Boldyreff B, Wehling M 2004 Aldosterone: refreshing a slow hormone by swift action. News Physiol Sci 19:97-100 (Pubitemid 38925479)
37. Boldyreff B, Wehling M 2003 Rapid aldosterone actions: from the membrane to signaling cascades to gene transcription and physiological effects. J Steroid Biochem Mol Biol 85:375-381 (Pubitemid 37011113)
38. Lerner J 1985 Effectors of amino acid transport processes in animal cell membranes. Comp Biochem Physiol A Comp Physiol 81:713-739