Mechanism and Regulation of NLRP3 Inflammasome Activation

Trends in Biochemical Sciences

Volumn 41, Issue 12, 2016, Pages 1012-1021

  He, Yuan ^a   Hara, Hideki ^a   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

alternative inflammasome; K+ efflux; Nek7; NLRP3 inflammasome; noncanonical inflammasome

Indexed keywords

CALCIUM ION; CASPASE 11; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; REACTIVE OXYGEN METABOLITE; IL1B PROTEIN, HUMAN; INTERLEUKIN 18; INTERLEUKIN 18 PROTEIN, HUMAN; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; NEK7 PROTEIN, HUMAN; NIMA RELATED KINASE; NLRP3 PROTEIN, HUMAN; POTASSIUM;

CALCIUM SIGNALING; CELL DAMAGE; ENZYME ACTIVATION; HUMAN; IMMUNE RESPONSE; INFECTION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LYSOSOME; MACROPHAGE; MITOCHONDRION; NONHUMAN; POTASSIUM TRANSPORT; PROTEIN EXPRESSION; REVIEW; AGONISTS; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; ION TRANSPORT; METABOLISM; MONOCYTE; MOUSE; PYROPTOSIS; SIGNAL TRANSDUCTION;

ANIMALS; CASPASE 1; GENE EXPRESSION REGULATION; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; ION TRANSPORT; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MONOCYTES; NIMA-RELATED KINASES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; POTASSIUM; PYROPTOSIS; SIGNAL TRANSDUCTION;

EID: 84995751273     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2016.09.002     Document Type: Review

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