Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Nature

Volumn 535, Issue 7610, 2016, Pages 153-158

  Liu, Xing ^a,b   Zhang, Zhibin ^a,b   Ruan, Jianbin ^a,b   Pan, Youdong ^c   Magupalli, Venkat Giri ^a,b   Wu, Hao ^a,b   Lieberman, Judy ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN; CASPASE 11; CASPASE 4; CASPASE 5; GASDERMIN D; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; PERFORIN; PHOSPHATIDYLSERINE; POLYPHOSPHOINOSITIDE; PROTEIN; UNCLASSIFIED DRUG; GSDMA PROTEIN, HUMAN; GSDMD PROTEIN, HUMAN; LIPOSOME; MEMBRANE PROTEIN; TUMOR PROTEIN;

BACTERIAL DISEASE; BACTERIUM; CELLS AND CELL COMPONENTS; CYTOGENETICS; EXPERIMENTAL STUDY; MEMBRANE; MICROBIAL ACTIVITY; MUTATION; PROTEIN; RODENT;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BACTERIUM COLONY; CELL MEMBRANE; COLONY FORMING UNIT; CONTROLLED STUDY; ELECTRON MICROSCOPY; ESCHERICHIA COLI; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; MEMBRANE BINDING; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PYROPTOSIS; STAPHYLOCOCCUS AUREUS; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL LINE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CONSERVED SEQUENCE; CYTOLOGY; DRUG EFFECTS; GENETICS; LISTERIA MONOCYTOGENES; METABOLISM; MICROBIAL VIABILITY; MOLECULAR GENETICS; MUTATION; POROSITY; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; ULTRASTRUCTURE;

BACTERIA (MICROORGANISMS); MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; CARDIOLIPINS; CELL LINE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CONSERVED SEQUENCE; ESCHERICHIA COLI; HUMANS; INFLAMMASOMES; LIPOSOMES; LISTERIA MONOCYTOGENES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROBIAL VIABILITY; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLSERINES; POROSITY; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PYROPTOSIS; STAPHYLOCOCCUS AUREUS;

EID: 84978374487     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18629     Document Type: Article

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