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Volumn 244, Issue , 2016, Pages 167-183

Therapeutic and diagnostic applications of extracellular vesicles

Author keywords

Biomarker; Diagnostics; Drug delivery; Exosomes; Extracellular vesicles; Vaccination

Indexed keywords

CONTROLLED DRUG DELIVERY; DIAGNOSIS; DRUG DELIVERY; PHYSIOLOGY; PLASMA DIAGNOSTICS; TARGETED DRUG DELIVERY; VACCINES;

EID: 84995608724     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.07.054     Document Type: Article
Times cited : (163)

References (259)
  • 1
    • 0014082202 scopus 로고
    • The nature and significance of platelet products in human plasma
    • [1] Wolf, P., The nature and significance of platelet products in human plasma. Br. J. Haematol. 13 (1967), 269–288.
    • (1967) Br. J. Haematol. , vol.13 , pp. 269-288
    • Wolf, P.1
  • 2
    • 0014132665 scopus 로고
    • Fine structure of early cartilage calcification
    • [2] Bonucci, E., Fine structure of early cartilage calcification. J. Ultrastruct. Res. 20 (1967), 33–50.
    • (1967) J. Ultrastruct. Res. , vol.20 , pp. 33-50
    • Bonucci, E.1
  • 3
    • 0016761866 scopus 로고
    • Microvesicles and vesicles of multivesicular bodies versus “virus-like” particles
    • [3] Dalton, A.J., Microvesicles and vesicles of multivesicular bodies versus “virus-like” particles. J. Natl. Cancer Inst. 54 (1975), 1137–1148.
    • (1975) J. Natl. Cancer Inst. , vol.54 , pp. 1137-1148
    • Dalton, A.J.1
  • 5
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • [5] Pan, B.T., Johnstone, R.M., Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33 (1983), 967–978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 6
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
    • [6] Johnstone, R.M., Adam, M., Hammond, J.R., Orr, L., Turbide, C., Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem. 262 (1987), 9412–9420.
    • (1987) J. Biol. Chem. , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 7
    • 0026826746 scopus 로고
    • Maturation of reticulocytes: formation of exosomes as a mechanism for shedding membrane proteins
    • [7] Johnstone, R.M., The Jeanne Manery-Fisher Memorial Lecture, Maturation of reticulocytes: formation of exosomes as a mechanism for shedding membrane proteins. Biochem. Cell Biol. 70:1992 (1991), 179–190.
    • (1991) Biochem. Cell Biol. , vol.70 , Issue.1992 , pp. 179-190
    • Johnstone, R.M.1    The Jeanne Manery-Fisher Memorial Lecture2
  • 8
    • 0025890156 scopus 로고
    • Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins
    • [8] Johnstone, R.M., Mathew, A., Mason, A.B., Teng, K., Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins. J. Cell. Physiol. 147 (1991), 27–36.
    • (1991) J. Cell. Physiol. , vol.147 , pp. 27-36
    • Johnstone, R.M.1    Mathew, A.2    Mason, A.B.3    Teng, K.4
  • 11
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • [11] Pisitkun, T., Shen, R.F., Knepper, M.A., Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 13368–13373.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 13368-13373
    • Pisitkun, T.1    Shen, R.F.2    Knepper, M.A.3
  • 14
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • [14] Valadi, H., Ekstrom, K., Bossios, A., Sjostrand, M., Lee, J.J., Lotvall, J.O., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9 (2007), 654–U672.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-U672
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 15
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    • [15] Ratajczak, J., Miekus, K., Kucia, M., Zhang, J., Reca, R., Dvorak, P., Ratajczak, M.Z., Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20 (2006), 847–856.
    • (2006) Leukemia , vol.20 , pp. 847-856
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3    Zhang, J.4    Reca, R.5    Dvorak, P.6    Ratajczak, M.Z.7
  • 16
    • 84929506373 scopus 로고    scopus 로고
    • Ectosomes and exosomes: shedding the confusion between extracellular vesicles
    • [16] Cocucci, E., Meldolesi, J., Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol. 25 (2015), 364–372.
    • (2015) Trends Cell Biol. , vol.25 , pp. 364-372
    • Cocucci, E.1    Meldolesi, J.2
  • 17
    • 0033957359 scopus 로고    scopus 로고
    • Morphologic and biochemical hallmarks of apoptosis
    • [17] Saraste, A., Pulkki, K., Morphologic and biochemical hallmarks of apoptosis. Cardiovasc. Res. 45 (2000), 528–537.
    • (2000) Cardiovasc. Res. , vol.45 , pp. 528-537
    • Saraste, A.1    Pulkki, K.2
  • 21
    • 84862618600 scopus 로고    scopus 로고
    • Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers
    • [21] D'Souza-Schorey, C., Clancy, J.W., Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev. 26 (2012), 1287–1299.
    • (2012) Genes Dev. , vol.26 , pp. 1287-1299
    • D'Souza-Schorey, C.1    Clancy, J.W.2
  • 22
    • 80052233389 scopus 로고    scopus 로고
    • Endosome maturation
    • [22] Huotari, J., Helenius, A., Endosome maturation. EMBO J. 30 (2011), 3481–3500.
    • (2011) EMBO J. , vol.30 , pp. 3481-3500
    • Huotari, J.1    Helenius, A.2
  • 23
    • 0037096162 scopus 로고    scopus 로고
    • The exosome pathway in K562 cells is regulated by Rab11
    • [23] Savina, A., Vidal, M., Colombo, M.I., The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. 115 (2002), 2505–2515.
    • (2002) J. Cell Sci. , vol.115 , pp. 2505-2515
    • Savina, A.1    Vidal, M.2    Colombo, M.I.3
  • 25
    • 58849151841 scopus 로고    scopus 로고
    • Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen
    • [25] Poliakov, A., Spilman, M., Dokland, T., Amling, C.L., Mobley, J.A., Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen. Prostate 69 (2009), 159–167.
    • (2009) Prostate , vol.69 , pp. 159-167
    • Poliakov, A.1    Spilman, M.2    Dokland, T.3    Amling, C.L.4    Mobley, J.A.5
  • 27
  • 29
    • 84858444838 scopus 로고    scopus 로고
    • ExoCarta 2012: database of exosomal proteins, RNA and lipids
    • [29] Mathivanan, S., Fahner, C.J., Reid, G.E., Simpson, R.J., ExoCarta 2012: database of exosomal proteins, RNA and lipids. Nucleic Acids Res. 40 (2012), D1241–D1244.
    • (2012) Nucleic Acids Res. , vol.40 , pp. D1241-D1244
    • Mathivanan, S.1    Fahner, C.J.2    Reid, G.E.3    Simpson, R.J.4
  • 31
    • 84875069590 scopus 로고    scopus 로고
    • Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands
    • [31] Munich, S., Sobo-Vujanovic, A., Buchser, W.J., Beer-Stolz, D., Vujanovic, N.L., Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology 1 (2012), 1074–1083.
    • (2012) Oncoimmunology , vol.1 , pp. 1074-1083
    • Munich, S.1    Sobo-Vujanovic, A.2    Buchser, W.J.3    Beer-Stolz, D.4    Vujanovic, N.L.5
  • 35
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • [35] Escola, J.M., Kleijmeer, M.J., Stoorvogel, W., Griffith, J.M., Yoshie, O., Geuze, H.J., Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273 (1998), 20121–20127.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20121-20127
    • Escola, J.M.1    Kleijmeer, M.J.2    Stoorvogel, W.3    Griffith, J.M.4    Yoshie, O.5    Geuze, H.J.6
  • 36
    • 84867546396 scopus 로고    scopus 로고
    • Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions
    • [36] Nolte-'t Hoen, E.N., Buermans, H.P., Waasdorp, M., Stoorvogel, W., Wauben, M.H., t'Hoen, P.A., Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions. Nucleic Acids Res. 40 (2012), 9272–9285.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 9272-9285
    • Nolte-'t Hoen, E.N.1    Buermans, H.P.2    Waasdorp, M.3    Stoorvogel, W.4    Wauben, M.H.5    t'Hoen, P.A.6
  • 40
    • 84864411871 scopus 로고    scopus 로고
    • Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types
    • [40] Guduric-Fuchs, J., O'Connor, A., Camp, B., O'Neill, C.L., Medina, R.J., Simpson, D.A., Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genomics, 13, 2012, 357.
    • (2012) BMC Genomics , vol.13 , pp. 357
    • Guduric-Fuchs, J.1    O'Connor, A.2    Camp, B.3    O'Neill, C.L.4    Medina, R.J.5    Simpson, D.A.6
  • 41
    • 77955643809 scopus 로고    scopus 로고
    • Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    • e11803
    • [41] Collino, F., Deregibus, M.C., Bruno, S., Sterpone, L., Aghemo, G., Viltono, L., Tetta, C., Camussi, G., Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One, 5, 2010, e11803.
    • (2010) PLoS One , vol.5
    • Collino, F.1    Deregibus, M.C.2    Bruno, S.3    Sterpone, L.4    Aghemo, G.5    Viltono, L.6    Tetta, C.7    Camussi, G.8
  • 43
    • 84890458696 scopus 로고    scopus 로고
    • Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
    • [43] Colombo, M., Moita, C., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L.F., Thery, C., Raposo, G., Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J. Cell Sci. 126 (2013), 5553–5565.
    • (2013) J. Cell Sci. , vol.126 , pp. 5553-5565
    • Colombo, M.1    Moita, C.2    van Niel, G.3    Kowal, J.4    Vigneron, J.5    Benaroch, P.6    Manel, N.7    Moita, L.F.8    Thery, C.9    Raposo, G.10
  • 46
    • 84936869846 scopus 로고    scopus 로고
    • Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines
    • [46] Tosar, J.P., Gambaro, F., Sanguinetti, J., Bonilla, B., Witwer, K.W., Cayota, A., Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Res. 43 (2015), 5601–5616.
    • (2015) Nucleic Acids Res. , vol.43 , pp. 5601-5616
    • Tosar, J.P.1    Gambaro, F.2    Sanguinetti, J.3    Bonilla, B.4    Witwer, K.W.5    Cayota, A.6
  • 49
    • 84866502787 scopus 로고    scopus 로고
    • Hypoxic enhancement of exosome release by breast cancer cells
    • [49] King, H.W., Michael, M.Z., Gleadle, J.M., Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer, 12, 2012, 421.
    • (2012) BMC Cancer , vol.12 , pp. 421
    • King, H.W.1    Michael, M.Z.2    Gleadle, J.M.3
  • 53
    • 24644485206 scopus 로고    scopus 로고
    • Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
    • [53] Segura, E., Amigorena, S., Thery, C., Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol. Dis. 35 (2005), 89–93.
    • (2005) Blood Cells Mol. Dis. , vol.35 , pp. 89-93
    • Segura, E.1    Amigorena, S.2    Thery, C.3
  • 56
    • 84929177606 scopus 로고    scopus 로고
    • Liposome-protein corona in a physiological environment: challenges and opportunities for targeted delivery of nanomedicines
    • [56] Caracciolo, G., Liposome-protein corona in a physiological environment: challenges and opportunities for targeted delivery of nanomedicines. Nanomedicine 11 (2015), 543–557.
    • (2015) Nanomedicine , vol.11 , pp. 543-557
    • Caracciolo, G.1
  • 57
    • 84892928740 scopus 로고    scopus 로고
    • The effects of lipoplex formulation variables on the protein corona and comparisons with in vitro transfection efficiency
    • [57] Betker, J.L., Gomez, J., Anchordoquy, T.J., The effects of lipoplex formulation variables on the protein corona and comparisons with in vitro transfection efficiency. J. Control. Release 171 (2013), 261–268.
    • (2013) J. Control. Release , vol.171 , pp. 261-268
    • Betker, J.L.1    Gomez, J.2    Anchordoquy, T.J.3
  • 59
    • 85008708017 scopus 로고    scopus 로고
    • Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation
    • [59] Bobrie, A., Colombo, M., Krumeich, S., Raposo, G., Thery, C., Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation. J. Extracell Vesicles, 1, 2012.
    • (2012) J. Extracell Vesicles , vol.1
    • Bobrie, A.1    Colombo, M.2    Krumeich, S.3    Raposo, G.4    Thery, C.5
  • 63
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Chapter 3. (Unit 3 22)
    • [63] Thery, C., Amigorena, S., Raposo, G., Clayton, A., Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol., 2006 Chapter 3. (Unit 3 22).
    • (2006) Curr. Protoc. Cell Biol.
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 68
    • 84928958602 scopus 로고    scopus 로고
    • Analysis of exosome purification methods using a model liposome system and tunable-resistive pulse sensing
    • [68] Lane, R.E., Korbie, D., Anderson, W., Vaidyanathan, R., Trau, M., Analysis of exosome purification methods using a model liposome system and tunable-resistive pulse sensing. Sci. Rep., 5, 2015, 7639.
    • (2015) Sci. Rep. , vol.5 , pp. 7639
    • Lane, R.E.1    Korbie, D.2    Anderson, W.3    Vaidyanathan, R.4    Trau, M.5
  • 71
    • 84983549222 scopus 로고    scopus 로고
    • High-speed centrifugation induces aggregation of extracellular vesicles
    • [71] Linares, R., Tan, S., Gounou, C., Arraud, N., Brisson, A.R., High-speed centrifugation induces aggregation of extracellular vesicles. J. Extracell Vesicles, 4, 2015, 29509.
    • (2015) J. Extracell Vesicles , vol.4 , pp. 29509
    • Linares, R.1    Tan, S.2    Gounou, C.3    Arraud, N.4    Brisson, A.R.5
  • 72
    • 84928309389 scopus 로고    scopus 로고
    • Colorimetric nanoplasmonic assay to determine purity and titrate extracellular vesicles
    • [72] Maiolo, D., Paolini, L., Di Noto, G., Zendrini, A., Berti, D., Bergese, P., Ricotta, D., Colorimetric nanoplasmonic assay to determine purity and titrate extracellular vesicles. Anal. Chem. 87 (2015), 4168–4176.
    • (2015) Anal. Chem. , vol.87 , pp. 4168-4176
    • Maiolo, D.1    Paolini, L.2    Di Noto, G.3    Zendrini, A.4    Berti, D.5    Bergese, P.6    Ricotta, D.7
  • 73
    • 50949128891 scopus 로고    scopus 로고
    • Discrimination between exosomes and HIV-1: purification of both vesicles from cell-free supernatants
    • [73] Cantin, R., Diou, J., Belanger, D., Tremblay, A.M., Gilbert, C., Discrimination between exosomes and HIV-1: purification of both vesicles from cell-free supernatants. J. Immunol. Methods 338 (2008), 21–30.
    • (2008) J. Immunol. Methods , vol.338 , pp. 21-30
    • Cantin, R.1    Diou, J.2    Belanger, D.3    Tremblay, A.M.4    Gilbert, C.5
  • 74
    • 85016457286 scopus 로고    scopus 로고
    • Ready-made chromatography columns for extracellular vesicle isolation from plasma
    • [74] Welton, J.L., Webber, J.P., Botos, L.-A., Jones, M., Clayton, A., Ready-made chromatography columns for extracellular vesicle isolation from plasma. J. Extracell Vesicles, 4, 2015, 27269.
    • (2015) J. Extracell Vesicles , vol.4 , pp. 27269
    • Welton, J.L.1    Webber, J.P.2    Botos, L.-A.3    Jones, M.4    Clayton, A.5
  • 75
    • 0025280469 scopus 로고
    • Comparison of polyethylene glycol precipitation and ultracentrifugation for recovery of cytomegalovirus from urine prior to detection of DNA by dot-blot hybridisation
    • [75] Kimpton, C.P., Corbitt, G., Morris, D.J., Comparison of polyethylene glycol precipitation and ultracentrifugation for recovery of cytomegalovirus from urine prior to detection of DNA by dot-blot hybridisation. J. Virol. Methods 28 (1990), 141–145.
    • (1990) J. Virol. Methods , vol.28 , pp. 141-145
    • Kimpton, C.P.1    Corbitt, G.2    Morris, D.J.3
  • 77
    • 84867590084 scopus 로고    scopus 로고
    • A direct extraction method for microRNAs from exosomes captured by immunoaffinity beads
    • [77] Yoo, C.E., Kim, G., Kim, M., Park, D., Kang, H.J., Lee, M., Huh, N., A direct extraction method for microRNAs from exosomes captured by immunoaffinity beads. Anal. Biochem. 431 (2012), 96–98.
    • (2012) Anal. Biochem. , vol.431 , pp. 96-98
    • Yoo, C.E.1    Kim, G.2    Kim, M.3    Park, D.4    Kang, H.J.5    Lee, M.6    Huh, N.7
  • 78
    • 84867558562 scopus 로고    scopus 로고
    • Noble polymeric surface conjugated with zwitterionic moieties and antibodies for the isolation of exosomes from human serum
    • [78] Kim, G., Yoo, C.E., Kim, M., Kang, H.J., Park, D., Lee, M., Huh, N., Noble polymeric surface conjugated with zwitterionic moieties and antibodies for the isolation of exosomes from human serum. Bioconjug. Chem. 23 (2012), 2114–2120.
    • (2012) Bioconjug. Chem. , vol.23 , pp. 2114-2120
    • Kim, G.1    Yoo, C.E.2    Kim, M.3    Kang, H.J.4    Park, D.5    Lee, M.6    Huh, N.7
  • 81
    • 84900307606 scopus 로고    scopus 로고
    • Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
    • [81] Im, H., Shao, H., Park, Y.I., Peterson, V.M., Castro, C.M., Weissleder, R., Lee, H., Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat. Biotechnol. 32 (2014), 490–495.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 490-495
    • Im, H.1    Shao, H.2    Park, Y.I.3    Peterson, V.M.4    Castro, C.M.5    Weissleder, R.6    Lee, H.7
  • 85
    • 85006075858 scopus 로고    scopus 로고
    • Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer
    • [85] Hong, C.S., Funk, S., Muller, L., Boyiadzis, M., Whiteside, T.L., Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer. J. Extracell Vesicles, 5, 2016, 29289.
    • (2016) J. Extracell Vesicles , vol.5 , pp. 29289
    • Hong, C.S.1    Funk, S.2    Muller, L.3    Boyiadzis, M.4    Whiteside, T.L.5
  • 89
    • 84957599052 scopus 로고    scopus 로고
    • Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets
    • [89] Muller, L., Mitsuhashi, M., Simms, P., Gooding, W.E., Whiteside, T.L., Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets. Sci. Rep., 6, 2016, 20254.
    • (2016) Sci. Rep. , vol.6 , pp. 20254
    • Muller, L.1    Mitsuhashi, M.2    Simms, P.3    Gooding, W.E.4    Whiteside, T.L.5
  • 94
    • 84870807127 scopus 로고    scopus 로고
    • Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo
    • [94] Zhang, H.C., Liu, X.B., Huang, S., Bi, X.Y., Wang, H.X., Xie, L.X., Wang, Y.Q., Cao, X.F., Lv, J., Xiao, F.J., Yang, Y., Guo, Z.K., Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo. Stem Cells Dev. 21 (2012), 3289–3297.
    • (2012) Stem Cells Dev. , vol.21 , pp. 3289-3297
    • Zhang, H.C.1    Liu, X.B.2    Huang, S.3    Bi, X.Y.4    Wang, H.X.5    Xie, L.X.6    Wang, Y.Q.7    Cao, X.F.8    Lv, J.9    Xiao, F.J.10    Yang, Y.11    Guo, Z.K.12
  • 95
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • [95] Arslan, F., Lai, R.C., Smeets, M.B., Akeroyd, L., Choo, A., Aguor, E.N., Timmers, L., van Rijen, H.V., Doevendans, P.A., Pasterkamp, G., Lim, S.K., de Kleijn, D.P., Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res. 10 (2013), 301–312.
    • (2013) Stem Cell Res. , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3    Akeroyd, L.4    Choo, A.5    Aguor, E.N.6    Timmers, L.7    van Rijen, H.V.8    Doevendans, P.A.9    Pasterkamp, G.10    Lim, S.K.11    de Kleijn, D.P.12
  • 97
    • 84862867271 scopus 로고    scopus 로고
    • Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth
    • [97] Xin, H., Li, Y., Buller, B., Katakowski, M., Zhang, Y., Wang, X., Shang, X., Zhang, Z.G., Chopp, M., Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 30 (2012), 1556–1564.
    • (2012) Stem Cells , vol.30 , pp. 1556-1564
    • Xin, H.1    Li, Y.2    Buller, B.3    Katakowski, M.4    Zhang, Y.5    Wang, X.6    Shang, X.7    Zhang, Z.G.8    Chopp, M.9
  • 101
    • 84960842751 scopus 로고    scopus 로고
    • Exosomes as therapeutics: the implications of molecular composition and exosomal heterogeneity
    • [101] Ferguson, S., Nguyen, J., Exosomes as therapeutics: the implications of molecular composition and exosomal heterogeneity. J. Control. Release 228 (2016), 179–190.
    • (2016) J. Control. Release , vol.228 , pp. 179-190
    • Ferguson, S.1    Nguyen, J.2
  • 102
    • 84929050359 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
    • [102] Rani, S., Ryan, A.E., Griffin, M.D., Ritter, T., Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications. Mol. Ther. 23 (2015), 812–823.
    • (2015) Mol. Ther. , vol.23 , pp. 812-823
    • Rani, S.1    Ryan, A.E.2    Griffin, M.D.3    Ritter, T.4
  • 103
    • 84939893615 scopus 로고    scopus 로고
    • A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles
    • [103] Akyurekli, C., Le, Y., Richardson, R.B., Fergusson, D., Tay, J., Allan, D.S., A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles. Stem Cell Rev. 11 (2015), 150–160.
    • (2015) Stem Cell Rev. , vol.11 , pp. 150-160
    • Akyurekli, C.1    Le, Y.2    Richardson, R.B.3    Fergusson, D.4    Tay, J.5    Allan, D.S.6
  • 106
    • 84859608013 scopus 로고    scopus 로고
    • Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells
    • e34653
    • [106] Waldenstrom, A., Genneback, N., Hellman, U., Ronquist, G., Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS One, 7, 2012, e34653.
    • (2012) PLoS One , vol.7
    • Waldenstrom, A.1    Genneback, N.2    Hellman, U.3    Ronquist, G.4
  • 107
    • 84943605767 scopus 로고    scopus 로고
    • Lessons in simplicity that should shape the future of drug delivery
    • [107] Raemdonck, K., De Smedt, S.C., Lessons in simplicity that should shape the future of drug delivery. Nat. Biotechnol. 33 (2015), 1026–1027.
    • (2015) Nat. Biotechnol. , vol.33 , pp. 1026-1027
    • Raemdonck, K.1    De Smedt, S.C.2
  • 108
    • 84875341955 scopus 로고    scopus 로고
    • Viral and nonviral delivery systems for gene delivery
    • [108] Nayerossadat, N., Maedeh, T., Ali, P.A., Viral and nonviral delivery systems for gene delivery. Adv. Biomed. Res., 1, 2012, 27.
    • (2012) Adv. Biomed. Res. , vol.1 , pp. 27
    • Nayerossadat, N.1    Maedeh, T.2    Ali, P.A.3
  • 110
    • 0026054526 scopus 로고
    • Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size
    • [110] Allen, T.M., Austin, G.A., Chonn, A., Lin, L., Lee, K.C., Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size. Biochim. Biophys. Acta 1061 (1991), 56–64.
    • (1991) Biochim. Biophys. Acta , vol.1061 , pp. 56-64
    • Allen, T.M.1    Austin, G.A.2    Chonn, A.3    Lin, L.4    Lee, K.C.5
  • 111
    • 35748931458 scopus 로고    scopus 로고
    • Lipids as modulators of membrane fusion mediated by viral fusion proteins
    • [111] Teissier, E., Pecheur, E.I., Lipids as modulators of membrane fusion mediated by viral fusion proteins. Eur. Biophys. J. 36 (2007), 887–899.
    • (2007) Eur. Biophys. J. , vol.36 , pp. 887-899
    • Teissier, E.1    Pecheur, E.I.2
  • 115
    • 84876729225 scopus 로고    scopus 로고
    • Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection
    • [115] Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., Takakura, Y., Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. J. Biotechnol. 165 (2013), 77–84.
    • (2013) J. Biotechnol. , vol.165 , pp. 77-84
    • Takahashi, Y.1    Nishikawa, M.2    Shinotsuka, H.3    Matsui, Y.4    Ohara, S.5    Imai, T.6    Takakura, Y.7
  • 116
    • 84892653021 scopus 로고    scopus 로고
    • CD169 mediates the capture of exosomes in spleen and lymph node
    • [116] Saunderson, S.C., Dunn, A.C., Crocker, P.R., McLellan, A.D., CD169 mediates the capture of exosomes in spleen and lymph node. Blood 123 (2014), 208–216.
    • (2014) Blood , vol.123 , pp. 208-216
    • Saunderson, S.C.1    Dunn, A.C.2    Crocker, P.R.3    McLellan, A.D.4
  • 121
    • 0242333900 scopus 로고    scopus 로고
    • Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells
    • [121] Fomina, A.F., Deerinck, T.J., Ellisman, M.H., Cahalan, M.D., Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells. Exp. Cell Res. 291 (2003), 150–166.
    • (2003) Exp. Cell Res. , vol.291 , pp. 150-166
    • Fomina, A.F.1    Deerinck, T.J.2    Ellisman, M.H.3    Cahalan, M.D.4
  • 122
    • 0345701525 scopus 로고    scopus 로고
    • Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59
    • [122] Clayton, A., Harris, C.L., Court, J., Mason, M.D., Morgan, B.P., Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur. J. Immunol. 33 (2003), 522–531.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 522-531
    • Clayton, A.1    Harris, C.L.2    Court, J.3    Mason, M.D.4    Morgan, B.P.5
  • 123
    • 84963709613 scopus 로고    scopus 로고
    • Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness
    • [123] Whitehead, B., Wu, L., Hvam, M.L., Aslan, H., Dong, M., Dyrskjot, L., Ostenfeld, M.S., Moghimi, S.M., Howard, K.A., Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness. J. Extracell Vesicles, 4, 2015, 29685.
    • (2015) J. Extracell Vesicles , vol.4 , pp. 29685
    • Whitehead, B.1    Wu, L.2    Hvam, M.L.3    Aslan, H.4    Dong, M.5    Dyrskjot, L.6    Ostenfeld, M.S.7    Moghimi, S.M.8    Howard, K.A.9
  • 124
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • [124] Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., Wood, M.J., Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29 (2011), 341–345.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 125
    • 84862201678 scopus 로고    scopus 로고
    • Brain-targeting gene delivery using a rabies virus glycoprotein peptide modulated hollow liposome: bio-behavioral study
    • [125] Tao, Y., Han, J., Dou, H., Brain-targeting gene delivery using a rabies virus glycoprotein peptide modulated hollow liposome: bio-behavioral study. J. Math. Chem. 22 (2012), 11808–11815.
    • (2012) J. Math. Chem. , vol.22 , pp. 11808-11815
    • Tao, Y.1    Han, J.2    Dou, H.3
  • 126
    • 84925728665 scopus 로고    scopus 로고
    • Stabilization of exosome-targeting peptides via engineered glycosylation
    • [126] Hung, M.E., Leonard, J.N., Stabilization of exosome-targeting peptides via engineered glycosylation. J. Biol. Chem. 290 (2015), 8166–8172.
    • (2015) J. Biol. Chem. , vol.290 , pp. 8166-8172
    • Hung, M.E.1    Leonard, J.N.2
  • 131
    • 84935026792 scopus 로고    scopus 로고
    • Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio rerio
    • [131] Yang, T., Martin, P., Fogarty, B., Brown, A., Schurman, K., Phipps, R., Yin, V.P., Lockman, P., Bai, S., Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio rerio. Pharm. Res. 32 (2015), 2003–2014.
    • (2015) Pharm. Res. , vol.32 , pp. 2003-2014
    • Yang, T.1    Martin, P.2    Fogarty, B.3    Brown, A.4    Schurman, K.5    Phipps, R.6    Yin, V.P.7    Lockman, P.8    Bai, S.9
  • 133
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • [133] Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G.J., Wei, J., Nie, G., A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 35 (2014), 2383–2390.
    • (2014) Biomaterials , vol.35 , pp. 2383-2390
    • Tian, Y.1    Li, S.2    Song, J.3    Ji, T.4    Zhu, M.5    Anderson, G.J.6    Wei, J.7    Nie, G.8
  • 134
    • 80053894454 scopus 로고    scopus 로고
    • EBV-gp350 confers B-cell tropism to tailored exosomes and is a neo-antigen in normal and malignant B cells-a new option for the treatment of B-CLL
    • [134] Ruiss, R., Jochum, S., Mocikat, R., Hammerschmidt, W., Zeidler, R., EBV-gp350 confers B-cell tropism to tailored exosomes and is a neo-antigen in normal and malignant B cells-a new option for the treatment of B-CLL. PLoS One, 6, 2011.
    • (2011) PLoS One , vol.6
    • Ruiss, R.1    Jochum, S.2    Mocikat, R.3    Hammerschmidt, W.4    Zeidler, R.5
  • 135
    • 79957879331 scopus 로고    scopus 로고
    • Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    • [135] Hood, J.L., San, R.S., Wickline, S.A., Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 71 (2011), 3792–3801.
    • (2011) Cancer Res. , vol.71 , pp. 3792-3801
    • Hood, J.L.1    San, R.S.2    Wickline, S.A.3
  • 136
    • 84932197182 scopus 로고    scopus 로고
    • Magnetic resonance imaging of melanoma exosomes in lymph nodes
    • [136] Hu, L., Wickline, S.A., Hood, J.L., Magnetic resonance imaging of melanoma exosomes in lymph nodes. Magn. Reson. Med. 74 (2015), 266–271.
    • (2015) Magn. Reson. Med. , vol.74 , pp. 266-271
    • Hu, L.1    Wickline, S.A.2    Hood, J.L.3
  • 137
    • 80053574021 scopus 로고    scopus 로고
    • Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
    • [137] Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R.C., Ju, S., Mu, J., Zhang, L., Steinman, L., Miller, D., Zhang, H.G., Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol. Ther. 19 (2011), 1769–1779.
    • (2011) Mol. Ther. , vol.19 , pp. 1769-1779
    • Zhuang, X.1    Xiang, X.2    Grizzle, W.3    Sun, D.4    Zhang, S.5    Axtell, R.C.6    Ju, S.7    Mu, J.8    Zhang, L.9    Steinman, L.10    Miller, D.11    Zhang, H.G.12
  • 139
    • 85013654823 scopus 로고    scopus 로고
    • Routes and mechanisms of extracellular vesicle uptake
    • [139] Mulcahy, L.A., Pink, R.C., Carter, D.R., Routes and mechanisms of extracellular vesicle uptake. J. Extracell Vesicles, 3, 2014, 24641.
    • (2014) J. Extracell Vesicles , vol.3 , pp. 24641
    • Mulcahy, L.A.1    Pink, R.C.2    Carter, D.R.3
  • 141
    • 84905898424 scopus 로고    scopus 로고
    • Intracellular delivery of nanomaterials: how to catch endosomal escape in the act
    • [141] Martens, T.F., Remaut, K., Demeester, J., De Smedt, S.C., Braeckmans, K., Intracellular delivery of nanomaterials: how to catch endosomal escape in the act. Nano Today 9 (2014), 344–364.
    • (2014) Nano Today , vol.9 , pp. 344-364
    • Martens, T.F.1    Remaut, K.2    Demeester, J.3    De Smedt, S.C.4    Braeckmans, K.5
  • 142
    • 45049087024 scopus 로고    scopus 로고
    • Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus
    • [142] Temchura, V.V., Tenbusch, M., Nchinda, G., Nabi, G., Tippler, B., Zelenyuk, M., Wildner, O., Uberla, K., Kuate, S., Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus. Vaccine 26 (2008), 3662–3672.
    • (2008) Vaccine , vol.26 , pp. 3662-3672
    • Temchura, V.V.1    Tenbusch, M.2    Nchinda, G.3    Nabi, G.4    Tippler, B.5    Zelenyuk, M.6    Wildner, O.7    Uberla, K.8    Kuate, S.9
  • 143
    • 0019976569 scopus 로고
    • Pathway of vesicular stomatitis virus entry leading to infection
    • [143] Matlin, K.S., Reggio, H., Helenius, A., Simons, K., Pathway of vesicular stomatitis virus entry leading to infection. J. Mol. Biol. 156 (1982), 609–631.
    • (1982) J. Mol. Biol. , vol.156 , pp. 609-631
    • Matlin, K.S.1    Reggio, H.2    Helenius, A.3    Simons, K.4
  • 145
    • 84876728629 scopus 로고    scopus 로고
    • Cell-penetrating peptide-mediated therapeutic molecule delivery into the central nervous system
    • [145] Zou, L.L., Ma, J.L., Wang, T., Yang, T.B., Liu, C.B., Cell-penetrating peptide-mediated therapeutic molecule delivery into the central nervous system. Curr. Neuropharmacol. 11 (2013), 197–208.
    • (2013) Curr. Neuropharmacol. , vol.11 , pp. 197-208
    • Zou, L.L.1    Ma, J.L.2    Wang, T.3    Yang, T.B.4    Liu, C.B.5
  • 147
    • 80052577736 scopus 로고    scopus 로고
    • Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1beta production by macrophages
    • [147] Atay, S., Gercel-Taylor, C., Taylor, D.D., Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1beta production by macrophages. Am. J. Reprod. Immunol. 66 (2011), 259–269.
    • (2011) Am. J. Reprod. Immunol. , vol.66 , pp. 259-269
    • Atay, S.1    Gercel-Taylor, C.2    Taylor, D.D.3
  • 149
    • 79952159254 scopus 로고    scopus 로고
    • Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
    • e16899
    • [149] Hedlund, M., Nagaeva, O., Kargl, D., Baranov, V., Mincheva-Nilsson, L., Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells. PLoS One, 6, 2011, e16899.
    • (2011) PLoS One , vol.6
    • Hedlund, M.1    Nagaeva, O.2    Kargl, D.3    Baranov, V.4    Mincheva-Nilsson, L.5
  • 150
    • 79960516623 scopus 로고    scopus 로고
    • Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production
    • [150] Clayton, A., Al-Taei, S., Webber, J., Mason, M.D., Tabi, Z., Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. J. Immunol. 187 (2011), 676–683.
    • (2011) J. Immunol. , vol.187 , pp. 676-683
    • Clayton, A.1    Al-Taei, S.2    Webber, J.3    Mason, M.D.4    Tabi, Z.5
  • 151
    • 84893232712 scopus 로고    scopus 로고
    • New considerations in the preparation of nucleic acid-loaded extracellular vesicles
    • [151] Vader, P., Kooijmans, S.A., Stremersch, S., Raemdonck, K., New considerations in the preparation of nucleic acid-loaded extracellular vesicles. Ther. Deliv. 5 (2014), 105–107.
    • (2014) Ther. Deliv. , vol.5 , pp. 105-107
    • Vader, P.1    Kooijmans, S.A.2    Stremersch, S.3    Raemdonck, K.4
  • 153
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • [153] Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., Ochiya, T., Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem. 285 (2010), 17442–17452.
    • (2010) J. Biol. Chem. , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Takeshita, F.4    Matsuki, Y.5    Ochiya, T.6
  • 156
    • 79954568598 scopus 로고    scopus 로고
    • Protein targeting to exosomes/microvesicles by plasma membrane anchors
    • [156] Shen, B., Wu, N., Yang, J.M., Gould, S.J., Protein targeting to exosomes/microvesicles by plasma membrane anchors. J. Biol. Chem. 286 (2011), 14383–14395.
    • (2011) J. Biol. Chem. , vol.286 , pp. 14383-14395
    • Shen, B.1    Wu, N.2    Yang, J.M.3    Gould, S.J.4
  • 161
    • 84902544740 scopus 로고    scopus 로고
    • Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo
    • [161] Gyorgy, B., Fitzpatrick, Z., Crommentuijn, M.H., Mu, D., Maguire, C.A., Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo. Biomaterials 35 (2014), 7598–7609.
    • (2014) Biomaterials , vol.35 , pp. 7598-7609
    • Gyorgy, B.1    Fitzpatrick, Z.2    Crommentuijn, M.H.3    Mu, D.4    Maguire, C.A.5
  • 163
    • 40649113147 scopus 로고    scopus 로고
    • Transfection by electroporation
    • Chapter 9. (Unit 9 3)
    • [163] Potter, H., Transfection by electroporation. Curr. Protoc. Mol. Biol., 2003 Chapter 9. (Unit 9 3).
    • (2003) Curr. Protoc. Mol. Biol.
    • Potter, H.1
  • 166
    • 84960907941 scopus 로고    scopus 로고
    • Exogenous DNA loading into extracellular vesicles via electroporation is size-dependent and enables limited gene delivery
    • [166] Lamichhane, T.N., Raiker, R.S., Jay, S.M., Exogenous DNA loading into extracellular vesicles via electroporation is size-dependent and enables limited gene delivery. Mol. Pharm. 12 (2015), 3650–3657.
    • (2015) Mol. Pharm. , vol.12 , pp. 3650-3657
    • Lamichhane, T.N.1    Raiker, R.S.2    Jay, S.M.3
  • 170
    • 84891542333 scopus 로고    scopus 로고
    • Maximizing exosome colloidal stability following electroporation
    • [170] Hood, J.L., Scott, M.J., Wickline, S.A., Maximizing exosome colloidal stability following electroporation. Anal. Biochem. 448 (2014), 41–49.
    • (2014) Anal. Biochem. , vol.448 , pp. 41-49
    • Hood, J.L.1    Scott, M.J.2    Wickline, S.A.3
  • 172
    • 84936886409 scopus 로고    scopus 로고
    • Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins
    • [172] Fuhrmann, G., Serio, A., Mazo, M., Nair, R., Stevens, M.M., Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. J. Control. Release 205 (2015), 35–44.
    • (2015) J. Control. Release , vol.205 , pp. 35-44
    • Fuhrmann, G.1    Serio, A.2    Mazo, M.3    Nair, R.4    Stevens, M.M.5
  • 173
    • 84928818473 scopus 로고    scopus 로고
    • Free extracellular miRNA functionally targets cells by transfecting exosomes from their companion cells
    • e0122991
    • [173] Bryniarski, K., Ptak, W., Martin, E., Nazimek, K., Szczepanik, M., Sanak, M., Askenase, P.W., Free extracellular miRNA functionally targets cells by transfecting exosomes from their companion cells. PLoS One, 10, 2015, e0122991.
    • (2015) PLoS One , vol.10
    • Bryniarski, K.1    Ptak, W.2    Martin, E.3    Nazimek, K.4    Szczepanik, M.5    Sanak, M.6    Askenase, P.W.7
  • 174
    • 77956264919 scopus 로고    scopus 로고
    • A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    • [174] Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., Zhang, H.G., A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol. Ther. 18 (2010), 1606–1614.
    • (2010) Mol. Ther. , vol.18 , pp. 1606-1614
    • Sun, D.1    Zhuang, X.2    Xiang, X.3    Liu, Y.4    Zhang, S.5    Liu, C.6    Barnes, S.7    Grizzle, W.8    Miller, D.9    Zhang, H.G.10
  • 175
    • 84949564767 scopus 로고    scopus 로고
    • Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells
    • [175] Saari, H., Lazaro-Ibanez, E., Viitala, T., Vuorimaa-Laukkanen, E., Siljander, P., Yliperttula, M., Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells. J. Control. Release 220 (2015), 727–737.
    • (2015) J. Control. Release , vol.220 , pp. 727-737
    • Saari, H.1    Lazaro-Ibanez, E.2    Viitala, T.3    Vuorimaa-Laukkanen, E.4    Siljander, P.5    Yliperttula, M.6
  • 178
    • 85005990374 scopus 로고    scopus 로고
    • A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery
    • [178] Hung, M.E., Leonard, J.N., A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery. J. Extracell Vesicles, 5, 2016, 31027.
    • (2016) J. Extracell Vesicles , vol.5 , pp. 31027
    • Hung, M.E.1    Leonard, J.N.2
  • 179
    • 84874988827 scopus 로고    scopus 로고
    • Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery
    • [179] Yeo, R.W., Lai, R.C., Zhang, B., Tan, S.S., Yin, Y., Teh, B.J., Lim, S.K., Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery. Adv. Drug Deliv. Rev. 65 (2012), 336–341.
    • (2012) Adv. Drug Deliv. Rev. , vol.65 , pp. 336-341
    • Yeo, R.W.1    Lai, R.C.2    Zhang, B.3    Tan, S.S.4    Yin, Y.5    Teh, B.J.6    Lim, S.K.7
  • 180
    • 81955167406 scopus 로고    scopus 로고
    • Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
    • [180] Zhu, W., Huang, L., Li, Y., Zhang, X., Gu, J., Yan, Y., Xu, X., Wang, M., Qian, H., Xu, W., Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett. 315 (2012), 28–37.
    • (2012) Cancer Lett. , vol.315 , pp. 28-37
    • Zhu, W.1    Huang, L.2    Li, Y.3    Zhang, X.4    Gu, J.5    Yan, Y.6    Xu, X.7    Wang, M.8    Qian, H.9    Xu, W.10
  • 181
    • 84872909274 scopus 로고    scopus 로고
    • Immature dendritic cell-derived exosomes: a promise subcellular vaccine for autoimmunity
    • [181] Yin, W., Ouyang, S., Li, Y., Xiao, B., Yang, H., Immature dendritic cell-derived exosomes: a promise subcellular vaccine for autoimmunity. Inflammation 36 (2013), 232–240.
    • (2013) Inflammation , vol.36 , pp. 232-240
    • Yin, W.1    Ouyang, S.2    Li, Y.3    Xiao, B.4    Yang, H.5
  • 182
    • 84929807408 scopus 로고    scopus 로고
    • Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites
    • [182] Wang, Q., Ren, Y., Mu, J., Egilmez, N.K., Zhuang, X., Deng, Z., Zhang, L., Yan, J., Miller, D., Zhang, H.G., Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites. Cancer Res. 75 (2015), 2520–2529.
    • (2015) Cancer Res. , vol.75 , pp. 2520-2529
    • Wang, Q.1    Ren, Y.2    Mu, J.3    Egilmez, N.K.4    Zhuang, X.5    Deng, Z.6    Zhang, L.7    Yan, J.8    Miller, D.9    Zhang, H.G.10
  • 183
    • 84951831545 scopus 로고    scopus 로고
    • Bovine milk-derived exosomes for drug delivery
    • [183] Munagala, R., Aqil, F., Jeyabalan, J., Gupta, R.C., Bovine milk-derived exosomes for drug delivery. Cancer Lett. 371 (2016), 48–61.
    • (2016) Cancer Lett. , vol.371 , pp. 48-61
    • Munagala, R.1    Aqil, F.2    Jeyabalan, J.3    Gupta, R.C.4
  • 185
    • 84895520502 scopus 로고    scopus 로고
    • Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers
    • [185] Jo, W., Jeong, D., Kim, J., Cho, S., Jang, S.C., Han, C., Kang, J.Y., Gho, Y.S., Park, J., Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers. Lab Chip 14 (2014), 1261–1269.
    • (2014) Lab Chip , vol.14 , pp. 1261-1269
    • Jo, W.1    Jeong, D.2    Kim, J.3    Cho, S.4    Jang, S.C.5    Han, C.6    Kang, J.Y.7    Gho, Y.S.8    Park, J.9
  • 186
  • 189
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naive CD4 + T cells by dendritic cell-derived exosomes
    • [189] Thery, C., Duban, L., Segura, E., Veron, P., Lantz, O., Amigorena, S., Indirect activation of naive CD4 + T cells by dendritic cell-derived exosomes. Nat. Immunol. 3 (2002), 1156–1162.
    • (2002) Nat. Immunol. , vol.3 , pp. 1156-1162
    • Thery, C.1    Duban, L.2    Segura, E.3    Veron, P.4    Lantz, O.5    Amigorena, S.6
  • 192
    • 59649100584 scopus 로고    scopus 로고
    • Anti-tumour effects of exosomes in combination with cyclophosphamide and polyinosinic-polycytidylic acid
    • [192] Guo, F., Chang, C.K., Fan, H.H., Nie, X.X., Ren, Y.N., Liu, Y.Y., Zhao, L.H., Anti-tumour effects of exosomes in combination with cyclophosphamide and polyinosinic-polycytidylic acid. J. Int. Med. Res. 36 (2008), 1342–1353.
    • (2008) J. Int. Med. Res. , vol.36 , pp. 1342-1353
    • Guo, F.1    Chang, C.K.2    Fan, H.H.3    Nie, X.X.4    Ren, Y.N.5    Liu, Y.Y.6    Zhao, L.H.7
  • 193
    • 84880049306 scopus 로고    scopus 로고
    • Synergistic induction of adaptive antitumor immunity by codelivery of antigen with alpha-galactosylceramide on exosomes
    • [193] Gehrmann, U., Hiltbrunner, S., Georgoudaki, A.M., Karlsson, M.C., Naslund, T.I., Gabrielsson, S., Synergistic induction of adaptive antitumor immunity by codelivery of antigen with alpha-galactosylceramide on exosomes. Cancer Res. 73 (2013), 3865–3876.
    • (2013) Cancer Res. , vol.73 , pp. 3865-3876
    • Gehrmann, U.1    Hiltbrunner, S.2    Georgoudaki, A.M.3    Karlsson, M.C.4    Naslund, T.I.5    Gabrielsson, S.6
  • 195
    • 84896725146 scopus 로고    scopus 로고
    • Functional prostate-specific membrane antigen is enriched in exosomes from prostate cancer cells
    • [195] Liu, T., Mendes, D.E., Berkman, C.E., Functional prostate-specific membrane antigen is enriched in exosomes from prostate cancer cells. Int. J. Oncol. 44 (2014), 918–922.
    • (2014) Int. J. Oncol. , vol.44 , pp. 918-922
    • Liu, T.1    Mendes, D.E.2    Berkman, C.E.3
  • 197
    • 84918815052 scopus 로고    scopus 로고
    • Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice
    • [197] Gu, X., Erb, U., Buchler, M.W., Zoller, M., Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice. Int. J. Cancer 136 (2014), 74–84.
    • (2014) Int. J. Cancer , vol.136 , pp. 74-84
    • Gu, X.1    Erb, U.2    Buchler, M.W.3    Zoller, M.4
  • 198
    • 84905052545 scopus 로고    scopus 로고
    • Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma
    • [198] Mahaweni, N., Lambers, M., Dekkers, J., Aerts, J., Hegmans, J., Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma. J. Extracell Vesicless, 2, 2013, 22492.
    • (2013) J. Extracell Vesicless , vol.2 , pp. 22492
    • Mahaweni, N.1    Lambers, M.2    Dekkers, J.3    Aerts, J.4    Hegmans, J.5
  • 199
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • [199] Dai, S., Wei, D., Wu, Z., Zhou, X., Wei, X., Huang, H., Li, G., Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol. Ther. 16 (2008), 782–790.
    • (2008) Mol. Ther. , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4    Wei, X.5    Huang, H.6    Li, G.7
  • 200
    • 84855573739 scopus 로고    scopus 로고
    • The roles of tumor-derived exosomes in cancer pathogenesis
    • [200] Yang, C., Robbins, P.D., The roles of tumor-derived exosomes in cancer pathogenesis. Clin. Dev. Immunol., 2011, 2011, 842849.
    • (2011) Clin. Dev. Immunol. , vol.2011 , pp. 842849
    • Yang, C.1    Robbins, P.D.2
  • 201
    • 59549104365 scopus 로고    scopus 로고
    • MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models
    • [201] Cho, J.A., Lee, Y.S., Kim, S.H., Ko, J.K., Kim, C.W., MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models. Cancer Lett. 275 (2009), 256–265.
    • (2009) Cancer Lett. , vol.275 , pp. 256-265
    • Cho, J.A.1    Lee, Y.S.2    Kim, S.H.3    Ko, J.K.4    Kim, C.W.5
  • 202
    • 34447549680 scopus 로고    scopus 로고
    • Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells
    • [202] Dai, S., Zhou, X., Wang, B., Wang, Q., Fu, Y., Chen, T., Wan, T., Yu, Y., Cao, X., Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells. J. Mol. Med. (Berl.) 84 (2006), 1067–1076.
    • (2006) J. Mol. Med. (Berl.) , vol.84 , pp. 1067-1076
    • Dai, S.1    Zhou, X.2    Wang, B.3    Wang, Q.4    Fu, Y.5    Chen, T.6    Wan, T.7    Yu, Y.8    Cao, X.9
  • 203
    • 74549132676 scopus 로고    scopus 로고
    • Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma
    • [203] Zhang, Y., Luo, C.L., He, B.C., Zhang, J.M., Cheng, G., Wu, X.H., Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma. Int. J. Oncol. 36 (2010), 133–140.
    • (2010) Int. J. Oncol. , vol.36 , pp. 133-140
    • Zhang, Y.1    Luo, C.L.2    He, B.C.3    Zhang, J.M.4    Cheng, G.5    Wu, X.H.6
  • 205
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • [205] Clayton, A., Mitchell, J.P., Court, J., Mason, M.D., Tabi, Z., Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res. 67 (2007), 7458–7466.
    • (2007) Cancer Res. , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 208
    • 0031760355 scopus 로고    scopus 로고
    • The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness
    • [208] Ginestra, A., La Placa, M.D., Saladino, F., Cassara, D., Nagase, H., Vittorelli, M.L., The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. Anticancer Res. 18 (1998), 3433–3437.
    • (1998) Anticancer Res. , vol.18 , pp. 3433-3437
    • Ginestra, A.1    La Placa, M.D.2    Saladino, F.3    Cassara, D.4    Nagase, H.5    Vittorelli, M.L.6
  • 209
    • 84863292705 scopus 로고    scopus 로고
    • Therapeutic effects of autologous tumor-derived nanovesicles on melanoma growth and metastasis
    • e33330
    • [209] Lee, E.Y., Park, K.S., Yoon, Y.J., Lee, J., Moon, H.G., Jang, S.C., Choi, K.H., Kim, Y.K., Gho, Y.S., Therapeutic effects of autologous tumor-derived nanovesicles on melanoma growth and metastasis. PLoS One, 7, 2012, e33330.
    • (2012) PLoS One , vol.7
    • Lee, E.Y.1    Park, K.S.2    Yoon, Y.J.3    Lee, J.4    Moon, H.G.5    Jang, S.C.6    Choi, K.H.7    Kim, Y.K.8    Gho, Y.S.9
  • 211
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • [211] Robbins, P.D., Morelli, A.E., Regulation of immune responses by extracellular vesicles. Nat. Rev. Immunol. 14 (2014), 195–208.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 212
    • 84946913090 scopus 로고    scopus 로고
    • Outer membrane vesicles as platform vaccine technology
    • [212] van der Pol, L., Stork, M., van der Ley, P., Outer membrane vesicles as platform vaccine technology. Biotechnol. J. 10 (2015), 1689–1706.
    • (2015) Biotechnol. J. , vol.10 , pp. 1689-1706
    • van der Pol, L.1    Stork, M.2    van der Ley, P.3
  • 215
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • [215] Burrell, R.A., McGranahan, N., Bartek, J., Swanton, C., The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501 (2013), 338–345.
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 216
    • 84904650776 scopus 로고    scopus 로고
    • Companion diagnostics for targeted cancer drugs - clinical and regulatory aspects
    • [216] Olsen, D., Jorgensen, J.T., Companion diagnostics for targeted cancer drugs - clinical and regulatory aspects. Front. Oncol., 4, 2014, 105.
    • (2014) Front. Oncol. , vol.4 , pp. 105
    • Olsen, D.1    Jorgensen, J.T.2
  • 218
    • 84878654194 scopus 로고    scopus 로고
    • Extracellular vesicles as prospective carriers of oncogenic protein signatures in adult and paediatric brain tumours
    • [218] Garnier, D., Jabado, N., Rak, J., Extracellular vesicles as prospective carriers of oncogenic protein signatures in adult and paediatric brain tumours. Proteomics 13 (2013), 1595–1607.
    • (2013) Proteomics , vol.13 , pp. 1595-1607
    • Garnier, D.1    Jabado, N.2    Rak, J.3
  • 220
    • 84874959843 scopus 로고    scopus 로고
    • Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models
    • [220] Suetsugu, A., Honma, K., Saji, S., Moriwaki, H., Ochiya, T., Hoffman, R.M., Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv. Drug Deliv. Rev. 65 (2013), 383–390.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 383-390
    • Suetsugu, A.1    Honma, K.2    Saji, S.3    Moriwaki, H.4    Ochiya, T.5    Hoffman, R.M.6
  • 226
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • [226] Al-Nedawi, K., Meehan, B., Micallef, J., Lhotak, V., May, L., Guha, A., Rak, J., Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 10 (2008), 619–624.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4    May, L.5    Guha, A.6    Rak, J.7
  • 227
    • 70349315105 scopus 로고    scopus 로고
    • Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8 + T lymphocytes
    • [227] Wieckowski, E.U., Visus, C., Szajnik, M., Szczepanski, M.J., Storkus, W.J., Whiteside, T.L., Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8 + T lymphocytes. J. Immunol. 183 (2009), 3720–3730.
    • (2009) J. Immunol. , vol.183 , pp. 3720-3730
    • Wieckowski, E.U.1    Visus, C.2    Szajnik, M.3    Szczepanski, M.J.4    Storkus, W.J.5    Whiteside, T.L.6
  • 229
    • 84866270576 scopus 로고    scopus 로고
    • Microvesicles: novel biomarkers for neurological disorders
    • [229] Colombo, E., Borgiani, B., Verderio, C., Furlan, R., Microvesicles: novel biomarkers for neurological disorders. Front. Physiol., 3, 2012, 63.
    • (2012) Front. Physiol. , vol.3 , pp. 63
    • Colombo, E.1    Borgiani, B.2    Verderio, C.3    Furlan, R.4
  • 230
    • 84867383019 scopus 로고    scopus 로고
    • Microvesicles/exosomes as potential novel biomarkers of metabolic diseases
    • [230] Muller, G., Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab. Syndr. Obes. 5 (2012), 247–282.
    • (2012) Diabetes Metab. Syndr. Obes. , vol.5 , pp. 247-282
    • Muller, G.1
  • 231
    • 84910010568 scopus 로고    scopus 로고
    • extracellular vesicles in heart disease: excitement for the future?
    • [231] Danielson, K.M., Das, S., extracellular vesicles in heart disease: excitement for the future?. Exosomes microvesicles, 2, 2014.
    • (2014) Exosomes microvesicles , vol.2
    • Danielson, K.M.1    Das, S.2
  • 233
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • [233] Taylor, D.D., Gercel-Taylor, C., MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 110 (2008), 13–21.
    • (2008) Gynecol. Oncol. , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 235
    • 84892940392 scopus 로고    scopus 로고
    • Peripheral blood microvesicles are potential biomarkers for hepatocellular carcinoma
    • [235] Wang, W., Li, H., Zhou, Y., Jie, S., Peripheral blood microvesicles are potential biomarkers for hepatocellular carcinoma. Cancer Biomark. 13 (2013), 351–357.
    • (2013) Cancer Biomark. , vol.13 , pp. 351-357
    • Wang, W.1    Li, H.2    Zhou, Y.3    Jie, S.4
  • 236
    • 84944355473 scopus 로고    scopus 로고
    • Physical exercise induces rapid release of small extracellular vesicles into the circulation
    • [236] Fruhbeis, C., Helmig, S., Tug, S., Simon, P., Kramer-Albers, E.M., Physical exercise induces rapid release of small extracellular vesicles into the circulation. J. Extracell Vesicles, 4, 2015, 28239.
    • (2015) J. Extracell Vesicles , vol.4 , pp. 28239
    • Fruhbeis, C.1    Helmig, S.2    Tug, S.3    Simon, P.4    Kramer-Albers, E.M.5
  • 237
    • 52049112613 scopus 로고    scopus 로고
    • Isolation and identification of potential urinary microparticle biomarkers of bladder cancer
    • [237] Smalley, D.M., Sheman, N.E., Nelson, K., Theodorescu, D., Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. J. Proteome Res. 7 (2008), 2088–2096.
    • (2008) J. Proteome Res. , vol.7 , pp. 2088-2096
    • Smalley, D.M.1    Sheman, N.E.2    Nelson, K.3    Theodorescu, D.4
  • 238
    • 84883373154 scopus 로고    scopus 로고
    • microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer
    • [238] Cazzoli, R., Buttitta, F., Di Nicola, M., Malatesta, S., Marchetti, A., Rom, W.N., Pass, H.I., microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J. Thorac. Oncol. 8 (2013), 1156–1162.
    • (2013) J. Thorac. Oncol. , vol.8 , pp. 1156-1162
    • Cazzoli, R.1    Buttitta, F.2    Di Nicola, M.3    Malatesta, S.4    Marchetti, A.5    Rom, W.N.6    Pass, H.I.7
  • 239
    • 84949020477 scopus 로고    scopus 로고
    • Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis
    • [239] An, T., Qin, S., Xu, Y., Tang, Y., Huang, Y., Situ, B., Inal, J.M., Zheng, L., Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis. J. Extracell Vesicles, 4, 2015, 27522.
    • (2015) J. Extracell Vesicles , vol.4 , pp. 27522
    • An, T.1    Qin, S.2    Xu, Y.3    Tang, Y.4    Huang, Y.5    Situ, B.6    Inal, J.M.7    Zheng, L.8
  • 240
    • 81155152351 scopus 로고    scopus 로고
    • Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases
    • [240] van Balkom, B.W., Pisitkun, T., Verhaar, M.C., Knepper, M.A., Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases. Kidney Int. 80 (2011), 1138–1145.
    • (2011) Kidney Int. , vol.80 , pp. 1138-1145
    • van Balkom, B.W.1    Pisitkun, T.2    Verhaar, M.C.3    Knepper, M.A.4
  • 241
    • 84859515309 scopus 로고    scopus 로고
    • The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities
    • [241] Pant, S., Hilton, H., Burczynski, M.E., The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities. Biochem. Pharmacol. 83 (2012), 1484–1494.
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 1484-1494
    • Pant, S.1    Hilton, H.2    Burczynski, M.E.3
  • 243
    • 85006071832 scopus 로고    scopus 로고
    • Label-free Detection and Manipulation of Single Biological Nanoparticles
    • Wiley Interdiscip Rev Nanomed Nanobiotechnol
    • [243] DeSantis, M.C., Cheng, W., Label-free Detection and Manipulation of Single Biological Nanoparticles. 2016, Wiley Interdiscip Rev Nanomed Nanobiotechnol.
    • (2016)
    • DeSantis, M.C.1    Cheng, W.2
  • 248
    • 84983028401 scopus 로고    scopus 로고
    • Exosome cancer diagnostic reaches market
    • [248] Sheridan, C., Exosome cancer diagnostic reaches market. Nat. Biotechnol. 34 (2016), 359–360.
    • (2016) Nat. Biotechnol. , vol.34 , pp. 359-360
    • Sheridan, C.1
  • 249
    • 84951787560 scopus 로고    scopus 로고
    • Biobanking of exosomes in the era of precision medicine: are we there yet?
    • [249] Mora, E.M., Alvarez-Cubela, S., Oltra, E., Biobanking of exosomes in the era of precision medicine: are we there yet?. Int. J. Mol. Sci., 17, 2015, 13.
    • (2015) Int. J. Mol. Sci. , vol.17 , pp. 13
    • Mora, E.M.1    Alvarez-Cubela, S.2    Oltra, E.3
  • 251
    • 77955415593 scopus 로고    scopus 로고
    • Pre-analytical and methodological challenges in red blood cell microparticle proteomics
    • [251] Rubin, O., Crettaz, D., Tissot, J.D., Lion, N., Pre-analytical and methodological challenges in red blood cell microparticle proteomics. Talanta 82 (2010), 1–8.
    • (2010) Talanta , vol.82 , pp. 1-8
    • Rubin, O.1    Crettaz, D.2    Tissot, J.D.3    Lion, N.4
  • 254
    • 84930225125 scopus 로고    scopus 로고
    • Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes
    • [254] Nakase, I., Futaki, S., Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes. Sci. Rep., 5, 2015, 10112.
    • (2015) Sci. Rep. , vol.5 , pp. 10112
    • Nakase, I.1    Futaki, S.2
  • 255
    • 79551625424 scopus 로고    scopus 로고
    • Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages
    • [255] Akao, Y., Iio, A., Itoh, T., Noguchi, S., Itoh, Y., Ohtsuki, Y., Naoe, T., Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. Mol. Ther. 19 (2011), 395–399.
    • (2011) Mol. Ther. , vol.19 , pp. 395-399
    • Akao, Y.1    Iio, A.2    Itoh, T.3    Noguchi, S.4    Itoh, Y.5    Ohtsuki, Y.6    Naoe, T.7
  • 257
    • 80053175966 scopus 로고    scopus 로고
    • Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
    • [257] Yang, M., Chen, J., Su, F., Yu, B., Su, F., Lin, L., Liu, Y., Huang, J.D., Song, E., Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol. Cancer, 10, 2011, 117.
    • (2011) Mol. Cancer , vol.10 , pp. 117
    • Yang, M.1    Chen, J.2    Su, F.3    Yu, B.4    Su, F.5    Lin, L.6    Liu, Y.7    Huang, J.D.8    Song, E.9
  • 258
    • 84896700643 scopus 로고    scopus 로고
    • Microvesicle-mediated delivery of transforming growth factor beta1 siRNA for the suppression of tumor growth in mice
    • [258] Zhang, Y., Li, L., Yu, J., Zhu, D., Zhang, Y., Li, X., Gu, H., Zhang, C.Y., Zen, K., Microvesicle-mediated delivery of transforming growth factor beta1 siRNA for the suppression of tumor growth in mice. Biomaterials 35 (2014), 4390–4400.
    • (2014) Biomaterials , vol.35 , pp. 4390-4400
    • Zhang, Y.1    Li, L.2    Yu, J.3    Zhu, D.4    Zhang, Y.5    Li, X.6    Gu, H.7    Zhang, C.Y.8    Zen, K.9


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