Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio Rerio

Pharmaceutical Research

Volumn 32, Issue 6, 2015, Pages 2003-2014

  Yang, Tianzhi ^a   Martin, Paige ^a   Fogarty, Brittany ^a   Brown, Alison ^a   Schurman, Kayla ^a   Phipps, Roger ^a   Yin, Viravuth P ^b   Lockman, Paul ^c   Bai, Shuhua ^a,b  

^a HUSSON UNIVERSITY   (United States)

^b MOUNT DESERT ISLAND BIOLOGICAL LABORATORY   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Blood brain barrier; Brain cancer; Drug delivery; Exosome; Zebrafish

Indexed keywords

CD63 ANTIGEN; DOXORUBICIN; PACLITAXEL; TETRASPANIN; ANTINEOPLASTIC AGENT; GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CANCER; BRAIN CELL CULTURE; BRAIN REGION; BRAIN TISSUE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER SIZE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG UPTAKE; EMBRYO; ENDOCYTOSIS; ENDOTHELIUM CELL; EXOSOME; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERAPY EFFECT; TRANSGENIC ZEBRAFISH; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; BRAIN NEOPLASMS; CANCER TRANSPLANTATION; CAPILLARY PERMEABILITY; CELL PROLIFERATION; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; MEDICINAL CHEMISTRY; METABOLISM; PATHOLOGY; PHARMACEUTICS; PROCEDURES; REPORTER GENE; TIME FACTOR; TRANSGENIC ANIMAL; TUMOR CELL LINE; TUMOR VOLUME; XENOGRAFT; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DISEASE MODELS, ANIMAL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; ENDOTHELIAL CELLS; EXOSOMES; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HETEROGRAFTS; HUMANS; NEOPLASM TRANSPLANTATION; PACLITAXEL; PARTICLE SIZE; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; TUMOR BURDEN; ZEBRAFISH;

EID: 84935026792     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1593-y     Document Type: Article

References (36)

1. Kooijmans SA, Vader P, van Dommelen SM, van Solinge WW, Schiffelers RM. Exosome mimetics: a novel class of drug delivery systems. Int J Nanomedicine. 2012;7:1525-41.
2. Lai RC, Yeo RW, Tan KH, Lim SK. Exosomes for drug delivery-A novel application for the mesenchymal stem cell. Biotechnol Adv. 2012.
3. van den Boorn JG, Dassler J, Coch C, Schlee M, Hartmann G. Exosomes as nucleic acid nanocarriers. Adv Drug Deliv Rev. 2013;65:331-5.
4. Lakhaland S, Wood MJ. Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers. BioEssays News RevMol Cell Dev Biol. 2011;33:737-41.
5. Lai RC, Yeo RW, Tan KH, LimSK. Exosomes for drug delivery-a novel application for the mesenchymal stem cell. Biotechnol Adv. 2013;31:543-51.
6. Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, et al. Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol JASN. 2009;20:363-79.
7. Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341-5.
8. Jang SC, Kim OY, Yoon CM, Choi DS, Roh TY, Park J, et al. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano. 2013;7:7698-710.
9. Yangand J, Aschner M. Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport. Neurotoxicology. 2003;24:741-5.
10. Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu C, et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther J Am Soc Gene Ther. 2010;18:1606-14.
11. Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther J Am Soc Gene Ther. 2011;19:1769-79.
12. Chenand Y, Liu L.Modern methods for delivery of drugs across the blood-brain barrier. Adv Drug Deliv Rev. 2012;64:640-65.
13. Morikawa A, PeereboomDM, ThorsheimHR, Samala R, BalyanR, Murphy CG, et al. Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study. Neuro-Oncol. 2014.
14. Lockman PR,Mittapalli RK, TaskarKS, Rudraraju V, Gril B, Bohn KA, et al. Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer. Clin Cancer Res Off J AmAssoc Cancer Res. 2010;16:5664-78.
15. Muldoon LL, Soussain C, Jahnke K, Johanson C, Siegal T, Smith QR, et al. Chemotherapy delivery issues in central nervous system malignancy: a reality check. J Clin Oncol Off J Am Soc Clin Oncol. 2007;25:2295-305.
16. Sathornsumeteeand S, Rich JN. New approaches to primary brain tumor treatment. Anti-Cancer Drugs. 2006;17:1003-16.
17. Yang T, Nyiawung D, Silber A, Hao J, Lai L, Bai S. Comparative studies on chitosan and polylactic-co-glycolic acid incorporated nanoparticles of low molecular weight heparin. AAPS PharmSciTech. 2012;13:1309-18.
18. Bai S, Yang T, Abbruscato TJ, Ahsan F. Evaluation of human nasal RPMI 2650 cells grown at an air-liquid interface as a model for nasal drug transport studies. J Pharm Sci. 2008;97:1165-78.
19. Mittal A, Chitkara D, Kumar N. HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix. J Chromatogr B Anal Technol Biomed Life Sci. 2007;855:211-9.
20. Iqbal T, KinjoM,DowlingTC.Determination of Rhodamine 123 in cell lysate by HPLC with visible wavelength detection. J Chromatogr B Anal Technol Biomed Life Sci. 2005;814:259-62.
21. Al-Abd AM, Kim NH, Song SC, Lee SJ, Kuh HJ. A simple HPLC method for doxorubicin in plasma and tissues of nude mice. Arch Pharm Res. 2009;32:605-11.
22. Yang T, Bantegui T, Pike K, Bloom R, Phipps R, Bai S. In vitro evaluation of optimized liposomes for delivery of small interfering RNA. J Liposome Res. 2014.
23. Westerfield M. The Zebrafish book: a guide for the laboratory use of zebrafish (Brachydanio rerio), University of Oregon Press, Eugene. Or.; 1993.
24. Jeong JY, Kwon HB, Ahn JC, Kang D, Kwon SH, Park JA, et al. Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res Bull. 2008;75:619-28.
25. Yang XJ, CuiW, Gu A, Xu C, Yu SC, Li TT, et al. A novel zebrafish xenotransplantation model for study of glioma stem cell invasion. PLoS One. 2013;8:e61801.
26. Pardridge WM. Blood-brain barrier delivery. Drug Discov Today. 2007;12:54-61.
27. Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx J Am Soc Exp Neurother. 2005;2:3-14.
28. Vlassov AV, Magdaleno S, Setterquist R, Conrad R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 2012;1820:940-8.
29. RecordM, Subra C, Silvente-Poirot S, PoirotM. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol. 2011;81:1171-82.
30. Schneiderand A, Simons M. Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders. Cell Tissue Res. 2013;352:33-47.
31. Simonsand M, Raposo G. Exosomes-vesicular carriers for intercellular communication. Curr Opin Cell Biol. 2009;21:575-81.
32. Haqqani AS, Delaney CE, Tremblay TL, Sodja C, Sandhu JK, Stanimirovic DB. Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells. Fluids Barriers CNS. 2013;10:4.
33. Taylorand DD, Gercel-Taylor C. Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Semin Immunopathol. 2011;33:441-54.
34. De Rosa G, Salzano G, Caraglia M, Abbruzzese A. Nanotechnologies: a strategy to overcome blood-brain barrier. Curr Drug Metab. 2012;13:61-9.
35. Umansand RA, Taylor MR. Zebrafish as a model to study drug transporters at the blood-brain barrier. Clin Pharmacol Ther. 2012;92:567-70.
36. Xie J, Farage E, Sugimoto M, Anand-Apte B. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. BMC Dev Biol. 2010;10:76.