PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

Journal of Controlled Release

Volumn 224, Issue , 2016, Pages 77-85

  Kooijmans, S A A ^a   Fliervoet, L A L ^b   Van Der Meel, R ^a,c   Fens, M H A M ^a   Heijnen, H F G ^a   Van Bergen En Henegouwen, P M P ^d   Vader, P ^a   Schiffelers, R M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Circulation time; Drug delivery; Extracellular vesicles; Nanobody; Polyethylene glycol; Targeting

Indexed keywords

BINS; CYTOLOGY; DRUG DELIVERY; LIGANDS; LIPIDS; MICELLES; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; POLYETHYLENES; TUMORS;

CIRCULATION TIME; EPIDERMAL GROWTH FACTOR RECEPTORS; EXTRACELLULAR; INTRAVENOUS INJECTIONS; NANOBODY; SHIELDING PROPERTIES; TARGETING; TEMPERATURE DEPENDENT;

CELLS;

EPIDERMAL GROWTH FACTOR RECEPTOR; MACROGOL; NANOBODY; PHOSPHOLIPID; EGFR PROTEIN, HUMAN; EXCIPIENT; LIGAND; MACROGOL DERIVATIVE; MICELLE; NANOPARTICLE;

ANIMAL EXPERIMENT; ARTICLE; CELL INTERACTION; CELL SPECIFICITY; CIRCULATION TIME; DRUG DELIVERY SYSTEM; EXOSOME; HUMAN; HUMAN CELL; MICELLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; TISSUE DISTRIBUTION; CELL LINE; CELL MEMBRANE; CHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PARTICLE SIZE; THROMBOCYTE; TUMOR CELL LINE;

ADMINISTRATION, INTRAVENOUS; BLOOD PLATELETS; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; DRUG DELIVERY SYSTEMS; EXCIPIENTS; EXTRACELLULAR VESICLES; HUMANS; LIGANDS; MICELLES; NANOPARTICLES; PARTICLE SIZE; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84954472576     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.01.009     Document Type: Article

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