Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

Stem Cell Research

Volumn 10, Issue 3, 2013, Pages 301-312

  Arslan, Fatih ^a,b   Lai, Ruenn Chai ^c,d   Smeets, Mirjam B ^a,b   Akeroyd, Lars ^a   Choo, Andre ^e   Aguor, Eissa N E ^a   Timmers, Leo ^a   van Rijen, Harold V ^a   Doevendans, Pieter A ^a   Pasterkamp, Gerard ^a   Lim, Sai Kiang ^c,f   de Kleijn, Dominique P ^a,b,f  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e AGENCY FOR SCIENCE   (Singapore)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; EXOSOME; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; EXOSOMES; GLYCOGEN SYNTHASE KINASE 3; HEART; MAGNETIC RESONANCE IMAGING; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; VENTRICULAR REMODELING;

EID: 84873919177     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2013.01.002     Document Type: Article

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