RNA-containing exosomes in human nasal secretions

American Journal of Rhinology and Allergy

Volumn 25, Issue 2, 2011, Pages 89-93

  Lässer, Cecilia ^a   O'Neil, Serena E ^a   Ekerljung, Linda ^a   Ekström, Karin ^b   Sjöstrand, Margareta ^a   Lötvall, Jan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CD63 ANTIGEN; CD81 ANTIGEN; CD9 ANTIGEN; RNA; TETRASPANIN; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN;

ARTICLE; CELL COMMUNICATION; CENTRIFUGATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTROPHORESIS; ENDOPLASMIC RETICULUM; EXOSOME; FILTRATION; FLOW CYTOMETRY; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; NORMAL HUMAN; NOSE MUCUS; NOSE SECRETION; ULTRACENTRIFUGATION; WESTERN BLOTTING;

ANTIGENS, CD; BIOLOGICAL MARKERS; BODILY SECRETIONS; CALNEXIN; CELL COMMUNICATION; CELL SEPARATION; DNA-BINDING PROTEINS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EXOSOMES; FLOW CYTOMETRY; HUMANS; MICROSCOPY, ELECTRON; NOSE; RNA; TRANSCRIPTION FACTORS; ULTRACENTRIFUGATION;

EID: 79953239744     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2011.25.3573     Document Type: Article

References (29)

1. Fokkens WJ, and Scheeren RA. Upper airway defense mechanisms. Paediatr Respir Rev 1:336-341, 2000.
2. Howarth PH, Persson CGA, Meltzer EO, et al. Objective monitoring of nasal airway inflammation in rhinitis. J Allergy Clin Immunol 115:S414-S441, 2005. (Pubitemid 40320994)
3. Schorey JS, and Bhatnagar S. Exosome function: From tumor immunology to pathogen biology. Traffic 9:871-881, 2008. (Pubitemid 351639493)
4. van Niel G, Porto-Carreiro I, Simoes S, et al. Exosomes: A common pathway for a specialized function. J Biochem 140:13-21, 2006. (Pubitemid 44433541)
5. Palanisamy V, Sharma S, Deshpande A, et al. Nanostructural and transcriptomic analyses of human saliva derived exosomes. PLoS ONE 5:e8577, 2010.
6. Caby M-P, Lankar D, Vincendeau-Scherrer C, et al. Exosomal-like vesicles are present in human blood plasma. Int. Immunol 17:879-887, 2005. (Pubitemid 41417955)
7. Pisitkun T, Shen R-F, and Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA 101:13368-13373, 2004. (Pubitemid 39209672)
8. Admyre C, Johansson SM, Qazi KR, et al. Exosomes with immune modulatory features are present in human breast milk. J Immunol 179:1969-1978, 2007.
9. Admyre C, Grunewald J, Thyberg J, et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J 22:578-583, 2003. (Pubitemid 37258532)
10. Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654-659, 2007. (Pubitemid 47214727)
11. Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470-1476, 2008.
12. Viaud S, Théry C, Ploix S, et al. Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next? Cancer Res 70:1281-1285, 2010.
13. Thery C, Ostrowski M, and Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9:581-593, 2009.
14. Sullivan R, Saez F, Girouard J, et al. Role of exosomes in sperm maturation during the transit along the male reproductive tract. Blood Cells Mol Dis 35:1-10, 2005. (Pubitemid 40931928)
15. Mincheva-Nilsson L, and Baranov V. The role of placental exosomes in reproduction. Am J Reprod Immunol 63:520-533, 2010.
16. Kesimer M, Scull M, Brighton B, et al. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: A possible role in innate defense. FASEB J 23:1858-1868, 2009.
17. Prado N, Marazuela EG, Segura E, et al. Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction. J Immunol 181:1519-1525, 2008.
18. Taylor DD, and Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110:13-21, 2008. (Pubitemid 351853251)
19. Lu Q, Zhang J, Allison R, et al. Identification of extracellular delta-catenin accumulation for prostate cancer detection. Prostate 69:411-418, 2009.
20. Kapsogeorgou EK, Abu-Helu RF, Moutsopoulos HM, et al. Salivary gland epithelial cell exosomes: A source of autoantigenic ribonucleoproteins. Arthritis Rheum 52:1517-1521, 2005. (Pubitemid 40663943)
21. Almqvist N, Lönnqvist A, Hultkrantz S, et al. Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology 125:21-27, 2008.
22. Bhatnagar S, and Schorey JS. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J Biol Chem 282:25779-25789, 2007. (Pubitemid 47372821)
23. Kim S-H, Lechman ER, Bianco N, et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol 174:6440-6448, 2005. (Pubitemid 40663838)
24. Qazi KR, Torregrosa Paredes P, Dahlberg B, et al. Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis. Thorax 65:1016-1024, 2010.
25. Viaud S, Terme M, Flament C, et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: A role for NKG2D ligands and IL-15Rα. PLoS ONE 4:e4942, 2009.
26. Esser J, Gehrmann U, D'Alexandri FL, et al. Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration. J Allergy Clin Immunol 126:1032-1040. e4, 2010.
27. Mallegol J, Van Niel G, Lebreton C, et al. T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology 132:1866-1876, 2007.
28. Thery C, Duban L, Segura E, et al. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat Immunol 3:1156-1162, 2002. (Pubitemid 35469700)
29. Zitvogel L, Regnault A, Lozier A, et al. Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes. Nat Med 4:594-600, 1998. (Pubitemid 28237359)