메뉴 건너뛰기




Volumn 65, Issue 3, 2013, Pages 336-341

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Author keywords

Drug delivery; Exosomes; Mesenchymal stem cells

Indexed keywords

BIOMEDICAL RESEARCH; DISEASE PROGRESSION; DRUG DELIVERY VEHICLES; EXOSOMES; HUMAN MESENCHYMAL STEM CELLS; MESENCHYMAL STEM CELL; POTENTIAL TARGETS; THERAPEUTIC INTERVENTION;

EID: 84874988827     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.07.001     Document Type: Review
Times cited : (661)

References (119)
  • 1
    • 0033168435 scopus 로고    scopus 로고
    • Selective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes
    • Symon Z. Selective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes. Cancer 1999, 86:72-78.
    • (1999) Cancer , vol.86 , pp. 72-78
    • Symon, Z.1
  • 2
    • 0036420885 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin (Doxil) for metastatic breast cancer: the Cancer Research Network, Inc., experience
    • Perez A.T., Domenech G.H., Frankel C., Vogel C.L. Pegylated liposomal doxorubicin (Doxil) for metastatic breast cancer: the Cancer Research Network, Inc., experience. Cancer Invest. 2002, 20:22-29.
    • (2002) Cancer Invest. , vol.20 , pp. 22-29
    • Perez, A.T.1    Domenech, G.H.2    Frankel, C.3    Vogel, C.L.4
  • 3
    • 0942277118 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin in the treatment of breast cancer
    • O'Shaughnessy J.A. Pegylated liposomal doxorubicin in the treatment of breast cancer. Clin. Breast Cancer 2003, 4:318-328.
    • (2003) Clin. Breast Cancer , vol.4 , pp. 318-328
    • O'Shaughnessy, J.A.1
  • 4
    • 0041527176 scopus 로고    scopus 로고
    • Phase I study of pegylated liposomal doxorubicin (Caelyx) in combination with carboplatin in patients with advanced solid tumors
    • Goncalves A. Phase I study of pegylated liposomal doxorubicin (Caelyx) in combination with carboplatin in patients with advanced solid tumors. Anticancer Res. 2003, 23:3543-3548.
    • (2003) Anticancer Res. , vol.23 , pp. 3543-3548
    • Goncalves, A.1
  • 5
    • 0034774382 scopus 로고    scopus 로고
    • Phase II study of pegylated liposomal doxorubicin (Caelyx) as induction chemotherapy for patients with squamous cell cancer of the head and neck
    • Harrington K.J. Phase II study of pegylated liposomal doxorubicin (Caelyx) as induction chemotherapy for patients with squamous cell cancer of the head and neck. Eur. J. Cancer 2001, 37:2015-2022.
    • (2001) Eur. J. Cancer , vol.37 , pp. 2015-2022
    • Harrington, K.J.1
  • 6
    • 0035556131 scopus 로고    scopus 로고
    • Pilot study with pegylated liposomal doxorubicin for advanced or unresectable hepatocellular carcinoma
    • Schmidinger M. Pilot study with pegylated liposomal doxorubicin for advanced or unresectable hepatocellular carcinoma. Br. J. Cancer 2001, 85:1850-1852.
    • (2001) Br. J. Cancer , vol.85 , pp. 1850-1852
    • Schmidinger, M.1
  • 7
    • 0033670039 scopus 로고    scopus 로고
    • Liposomal doxorubicin and weekly paclitaxel in the treatment of metastatic breast cancer
    • Schwonzen M., Kurbacher C.M., Mallmann P. Liposomal doxorubicin and weekly paclitaxel in the treatment of metastatic breast cancer. Anticancer Drugs 2000, 11:681-685.
    • (2000) Anticancer Drugs , vol.11 , pp. 681-685
    • Schwonzen, M.1    Kurbacher, C.M.2    Mallmann, P.3
  • 8
    • 1842425347 scopus 로고    scopus 로고
    • A phase II study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian cancer
    • Seiden M.V. A phase II study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian cancer. Gynecol. Oncol. 2004, 93:229-232.
    • (2004) Gynecol. Oncol. , vol.93 , pp. 229-232
    • Seiden, M.V.1
  • 9
    • 0037740979 scopus 로고    scopus 로고
    • Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma
    • Skubitz K.M. Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma. Cancer Invest. 2003, 21:167-176.
    • (2003) Cancer Invest. , vol.21 , pp. 167-176
    • Skubitz, K.M.1
  • 10
    • 0042388408 scopus 로고    scopus 로고
    • Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphoma
    • Wollina U. Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphoma. Cancer 2003, 98:993-1001.
    • (2003) Cancer , vol.98 , pp. 993-1001
    • Wollina, U.1
  • 11
    • 0035669577 scopus 로고    scopus 로고
    • Caelyx: phase II studies in ovarian cancer
    • Johnston S.R., Gore M.E. Caelyx: phase II studies in ovarian cancer. Eur. J. Cancer 2001, 37:S8-S14.
    • (2001) Eur. J. Cancer , vol.37
    • Johnston, S.R.1    Gore, M.E.2
  • 12
    • 0141788123 scopus 로고    scopus 로고
    • Single-dose liposomal amphotericin B in the treatment of visceral leishmaniasis in India: a multicenter study
    • Sundar S. Single-dose liposomal amphotericin B in the treatment of visceral leishmaniasis in India: a multicenter study. Clin. Infect. Dis. 2003, 37:800-804.
    • (2003) Clin. Infect. Dis. , vol.37 , pp. 800-804
    • Sundar, S.1
  • 13
    • 3042547606 scopus 로고    scopus 로고
    • A novel liposomal bupivacaine formulation to produce ultralong-acting analgesia
    • Grant G.J. A novel liposomal bupivacaine formulation to produce ultralong-acting analgesia. Anesthesiology 2004, 101:133-137.
    • (2004) Anesthesiology , vol.101 , pp. 133-137
    • Grant, G.J.1
  • 14
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • Torchilin V.P. Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discov. 2005, 4:145-160.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 145-160
    • Torchilin, V.P.1
  • 16
    • 67949097489 scopus 로고    scopus 로고
    • Exosomes - vesicular carriers for intercellular communication
    • Simons M., Raposo G. Exosomes - vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 2009, 21:575-581.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 575-581
    • Simons, M.1    Raposo, G.2
  • 18
    • 80052831943 scopus 로고    scopus 로고
    • Exosome nanotechnology: an emerging paradigm shift in drug delivery
    • Lakhal S., Wood M.J.A. Exosome nanotechnology: an emerging paradigm shift in drug delivery. Bioessays 2011, 33:737-741.
    • (2011) Bioessays , vol.33 , pp. 737-741
    • Lakhal, S.1    Wood, M.J.A.2
  • 19
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • Pan B.T., Johnstone R.M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 1983, 33:967-978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 20
    • 3142630225 scopus 로고    scopus 로고
    • Exosomes: endosomal-derived vesicles shipping extracellular messages
    • Fevrier B., Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 2004, 16:415-421.
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 415-421
    • Fevrier, B.1    Raposo, G.2
  • 24
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • Escola J.M., Kleijmeer M.J., Stoorvogel W., Griffith J.M., Yoshie O., Geuze H.J. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 1998, 273:20,121-20,127.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20121-20127
    • Escola, J.M.1    Kleijmeer, M.J.2    Stoorvogel, W.3    Griffith, J.M.4    Yoshie, O.5    Geuze, H.J.6
  • 29
    • 78650955813 scopus 로고    scopus 로고
    • Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles
    • Bakhti M., Winter C., Simons M. Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles. J. Biol. Chem. 2011, 286:787-796.
    • (2011) J. Biol. Chem. , vol.286 , pp. 787-796
    • Bakhti, M.1    Winter, C.2    Simons, M.3
  • 38
    • 34548512488 scopus 로고    scopus 로고
    • Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    • Bhatnagar S., Schorey J.S. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J. Biol. Chem. 2007, 282:25,779-25,789.
    • (2007) J. Biol. Chem. , vol.282 , pp. 25779-25789
    • Bhatnagar, S.1    Schorey, J.S.2
  • 39
    • 33746548361 scopus 로고    scopus 로고
    • Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes
    • Hao S., Ye Z., Li F., Meng Q., Qureshi M., Yang J., Xiang J. Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes. Exp. Oncol. 2006, 28:126-131.
    • (2006) Exp. Oncol. , vol.28 , pp. 126-131
    • Hao, S.1    Ye, Z.2    Li, F.3    Meng, Q.4    Qureshi, M.5    Yang, J.6    Xiang, J.7
  • 41
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-β-mediated suppressive activity on T lymphocytes
    • Valenti R., Huber V., Filipazzi P., Pilla L., Sovena G., Villa A., Corbelli A., Fais S., Parmiani G., Rivoltini L. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-β-mediated suppressive activity on T lymphocytes. Cancer Res. 2006, 66:9290-9298.
    • (2006) Cancer Res. , vol.66 , pp. 9290-9298
    • Valenti, R.1    Huber, V.2    Filipazzi, P.3    Pilla, L.4    Sovena, G.5    Villa, A.6    Corbelli, A.7    Fais, S.8    Parmiani, G.9    Rivoltini, L.10
  • 44
    • 55749112807 scopus 로고    scopus 로고
    • Proteomic profiling of exosomes: current perspectives
    • Simpson R.J., Jensen S.S., Lim J.W. Proteomic profiling of exosomes: current perspectives. Proteomics 2008, 8:4083-4099.
    • (2008) Proteomics , vol.8 , pp. 4083-4099
    • Simpson, R.J.1    Jensen, S.S.2    Lim, J.W.3
  • 45
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes
    • Thery C., Duban L., Segura E., Veron P., Lantz O., Amigorena S. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat. Immunol. 2002, 3:1156-1162.
    • (2002) Nat. Immunol. , vol.3 , pp. 1156-1162
    • Thery, C.1    Duban, L.2    Segura, E.3    Veron, P.4    Lantz, O.5    Amigorena, S.6
  • 47
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H., Ekstrom K., Bossios A., Sjostrand M., Lee J.J., Lotvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9:654-659.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 48
    • 79957879331 scopus 로고    scopus 로고
    • Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    • Hood J.L., San R.S., Wickline S.A. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 2011, 71:3792-3801.
    • (2011) Cancer Res. , vol.71 , pp. 3792-3801
    • Hood, J.L.1    San, R.S.2    Wickline, S.A.3
  • 50
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules
    • Heijnen H.F.G., Schiel A.E., Fijnheer R., Geuze H.J., Sixma J.J. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules. Blood 1999, 94:3791-3799.
    • (1999) Blood , vol.94 , pp. 3791-3799
    • Heijnen, H.F.G.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 52
    • 79959330841 scopus 로고    scopus 로고
    • Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy
    • Sokolova V., Ludwig A.-K., Hornung S., Rotan O., Horn P.A., Epple M., Giebel B. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf. B Biointerfaces 2011, 87:146-150.
    • (2011) Colloids Surf. B Biointerfaces , vol.87 , pp. 146-150
    • Sokolova, V.1    Ludwig, A.-K.2    Hornung, S.3    Rotan, O.4    Horn, P.A.5    Epple, M.6    Giebel, B.7
  • 53
    • 79960516623 scopus 로고    scopus 로고
    • Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production
    • Clayton A., Al-Taei S., Webber J., Mason M.D., Tabi Z. Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. J. Immunol. 2011, 187:676-683.
    • (2011) J. Immunol. , vol.187 , pp. 676-683
    • Clayton, A.1    Al-Taei, S.2    Webber, J.3    Mason, M.D.4    Tabi, Z.5
  • 54
    • 21644482022 scopus 로고    scopus 로고
    • Role of exosomes in sperm maturation during the transit along the male reproductive tract
    • Sullivan R., Saez F., Girouard J., Frenette G. Role of exosomes in sperm maturation during the transit along the male reproductive tract. Blood Cells Mol. Dis. 2005, 35:1-10.
    • (2005) Blood Cells Mol. Dis. , vol.35 , pp. 1-10
    • Sullivan, R.1    Saez, F.2    Girouard, J.3    Frenette, G.4
  • 55
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: extracellular organelles important in intercellular communication
    • Mathivanan S., Ji H., Simpson R.J. Exosomes: extracellular organelles important in intercellular communication. J. Proteomics 2010, 73:1907-1920.
    • (2010) J. Proteomics , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 56
  • 58
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • Pisitkun T., Shen R.F., Knepper M.A. Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:13,368-13,373.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 13368-13373
    • Pisitkun, T.1    Shen, R.F.2    Knepper, M.A.3
  • 60
    • 27144529107 scopus 로고    scopus 로고
    • More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells
    • Dai S., Wan T., Wang B., Zhou X., Xiu F., Chen T., Wu Y., Cao X. More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin. Cancer Res. 2005, 11:7554-7563.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7554-7563
    • Dai, S.1    Wan, T.2    Wang, B.3    Zhou, X.4    Xiu, F.5    Chen, T.6    Wu, Y.7    Cao, X.8
  • 61
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • Clayton A., Mitchell J.P., Court J., Mason M.D., Tabi Z. Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res. 2007, 67:7458-7466.
    • (2007) Cancer Res. , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 62
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • Taylor D.D., Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 2008, 110:13-21.
    • (2008) Gynecol. Oncol. , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 66
    • 77957091969 scopus 로고    scopus 로고
    • Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
    • Kosaka N., Iguchi H., Ochiya T. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 2010, 101:2087-2092.
    • (2010) Cancer Sci. , vol.101 , pp. 2087-2092
    • Kosaka, N.1    Iguchi, H.2    Ochiya, T.3
  • 67
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern S., Eichler H., Stoeve J., Kluter H., Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006, 24:1294-1301.
    • (2006) Stem Cells , vol.24 , pp. 1294-1301
    • Kern, S.1    Eichler, H.2    Stoeve, J.3    Kluter, H.4    Bieback, K.5
  • 69
    • 0037124308 scopus 로고    scopus 로고
    • Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation
    • Arai F., Ohneda O., Miyamoto T., Zhang X.Q., Suda T. Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J. Exp. Med. 2002, 195:1549-1563.
    • (2002) J. Exp. Med. , vol.195 , pp. 1549-1563
    • Arai, F.1    Ohneda, O.2    Miyamoto, T.3    Zhang, X.Q.4    Suda, T.5
  • 72
    • 37549009470 scopus 로고    scopus 로고
    • Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells
    • Roubelakis M.G., Pappa K.I., Bitsika V., Zagoura D., Vlahou A., Papadaki H.A., Antsaklis A., Anagnou N.P. Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev. 2007, 16:931-952.
    • (2007) Stem Cells Dev. , vol.16 , pp. 931-952
    • Roubelakis, M.G.1    Pappa, K.I.2    Bitsika, V.3    Zagoura, D.4    Vlahou, A.5    Papadaki, H.A.6    Antsaklis, A.7    Anagnou, N.P.8
  • 73
  • 74
    • 33748307606 scopus 로고    scopus 로고
    • Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells
    • Miao Z., Jin J., Chen L., Zhu J., Huang W., Zhao J., Qian H., Zhang X. Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells. Cell Biol. Int. 2006, 30:681-687.
    • (2006) Cell Biol. Int. , vol.30 , pp. 681-687
    • Miao, Z.1    Jin, J.2    Chen, L.3    Zhu, J.4    Huang, W.5    Zhao, J.6    Qian, H.7    Zhang, X.8
  • 76
    • 70349510607 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in Regenerative Medicine
    • Huang G.T.J., Gronthos S., Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in Regenerative Medicine. J. Dent. Res. 2009, 88:792-806.
    • (2009) J. Dent. Res. , vol.88 , pp. 792-806
    • Huang, G.T.J.1    Gronthos, S.2    Shi, S.3
  • 79
    • 84857032992 scopus 로고    scopus 로고
    • Mesenchymal stromal cell therapy: a revolution in regenerative medicine?
    • Bernardo M.E., Pagliara D., Locatelli F. Mesenchymal stromal cell therapy: a revolution in regenerative medicine?. Bone Marrow Transplant. 2012, 47:164-171.
    • (2012) Bone Marrow Transplant. , vol.47 , pp. 164-171
    • Bernardo, M.E.1    Pagliara, D.2    Locatelli, F.3
  • 80
    • 77950551326 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: current understanding and clinical status
    • Salem H.K., Thiemermann C. Mesenchymal stromal cells: current understanding and clinical status. Stem Cells 2010, 28:585-596.
    • (2010) Stem Cells , vol.28 , pp. 585-596
    • Salem, H.K.1    Thiemermann, C.2
  • 81
    • 37749033958 scopus 로고    scopus 로고
    • Human mesenchymal stem cells: from basic biology to clinical applications
    • Abdallah B.M., Kassem M. Human mesenchymal stem cells: from basic biology to clinical applications. Gene Ther. 2008, 15:109-116.
    • (2008) Gene Ther. , vol.15 , pp. 109-116
    • Abdallah, B.M.1    Kassem, M.2
  • 82
    • 4444269045 scopus 로고    scopus 로고
    • Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue
    • Lee R.H., Kim B., Choi I., Kim H., Choi H.S., Suh K., Bae Y.C., Jung J.S. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell. Physiol. Biochem. 2004, 14:311-324.
    • (2004) Cell. Physiol. Biochem. , vol.14 , pp. 311-324
    • Lee, R.H.1    Kim, B.2    Choi, I.3    Kim, H.4    Choi, H.S.5    Suh, K.6    Bae, Y.C.7    Jung, J.S.8
  • 83
    • 33847617021 scopus 로고    scopus 로고
    • From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells
    • Giordano A., Galderisi U., Marino I.R. From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells. J. Cell. Physiol. 2007, 211:27-35.
    • (2007) J. Cell. Physiol. , vol.211 , pp. 27-35
    • Giordano, A.1    Galderisi, U.2    Marino, I.R.3
  • 84
    • 17444410347 scopus 로고    scopus 로고
    • Mesenchymal stem cells: progress toward promise
    • Le Blanc K., Pittenger M.F. Mesenchymal stem cells: progress toward promise. Cytotherapy 2005, 7:36-45.
    • (2005) Cytotherapy , vol.7 , pp. 36-45
    • Le Blanc, K.1    Pittenger, M.F.2
  • 85
    • 77952319188 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy: two steps forward, one step back
    • Ankrum J., Karp J.M. Mesenchymal stem cell therapy: two steps forward, one step back. Trends Mol. Med. 2010, 16:203-209.
    • (2010) Trends Mol. Med. , vol.16 , pp. 203-209
    • Ankrum, J.1    Karp, J.M.2
  • 89
    • 79952155004 scopus 로고    scopus 로고
    • Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications
    • Wright K.T., El Masri W., Osman A., Chowdhury J., Johnson W.E.B. Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells 2011, 29:169-178.
    • (2011) Stem Cells , vol.29 , pp. 169-178
    • Wright, K.T.1    El Masri, W.2    Osman, A.3    Chowdhury, J.4    Johnson, W.E.B.5
  • 91
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair - current views
    • Phinney D.G., Prockop D.J. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair - current views. Stem Cells 2007, 25:2896-2902.
    • (2007) Stem Cells , vol.25 , pp. 2896-2902
    • Phinney, D.G.1    Prockop, D.J.2
  • 93
    • 55049092713 scopus 로고    scopus 로고
    • In search of the in vivo identity of mesenchymal stem cells
    • da Silva Meirelles L., Caplan A.I., Nardi N.B. In search of the in vivo identity of mesenchymal stem cells. Stem Cells 2008, 26:2287-2299.
    • (2008) Stem Cells , vol.26 , pp. 2287-2299
    • da Silva Meirelles, L.1    Caplan, A.I.2    Nardi, N.B.3
  • 94
    • 22144475112 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects
    • Dai W., Hale S.L., Martin B.J., Kuang J.Q., Dow J.S., Wold L.E., Kloner R.A. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation 2005, 112:214-223.
    • (2005) Circulation , vol.112 , pp. 214-223
    • Dai, W.1    Hale, S.L.2    Martin, B.J.3    Kuang, J.Q.4    Dow, J.S.5    Wold, L.E.6    Kloner, R.A.7
  • 95
    • 33751038565 scopus 로고    scopus 로고
    • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
    • Noiseux N., Gnecchi M., Lopez-Ilasaca M., Zhang L., Solomon S.D., Deb A., Dzau V.J., Pratt R.E. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol. Ther. 2006, 14:840-850.
    • (2006) Mol. Ther. , vol.14 , pp. 840-850
    • Noiseux, N.1    Gnecchi, M.2    Lopez-Ilasaca, M.3    Zhang, L.4    Solomon, S.D.5    Deb, A.6    Dzau, V.J.7    Pratt, R.E.8
  • 96
    • 78650923962 scopus 로고    scopus 로고
    • Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model
    • Katsha A.M., Ohkouchi S., Xin H., Kanehira M., Sun R., Nukiwa T., Saijo Y. Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model. Mol. Ther. 2011, 19:196-203.
    • (2011) Mol. Ther. , vol.19 , pp. 196-203
    • Katsha, A.M.1    Ohkouchi, S.2    Xin, H.3    Kanehira, M.4    Sun, R.5    Nukiwa, T.6    Saijo, Y.7
  • 97
    • 0037173116 scopus 로고    scopus 로고
    • Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone
    • Horwitz E.M., Gordon P.L., Koo W.K.K., Marx J.C., Neel M.D., McNall R.Y., Muul L., Hofmann T. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:8932-8937.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 8932-8937
    • Horwitz, E.M.1    Gordon, P.L.2    Koo, W.K.K.3    Marx, J.C.4    Neel, M.D.5    McNall, R.Y.6    Muul, L.7    Hofmann, T.8
  • 98
    • 0036142213 scopus 로고    scopus 로고
    • Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    • Toma C., Pittenger M.F., Cahill K.S., Byrne B.J., Kessler P.D. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002, 105:93-98.
    • (2002) Circulation , vol.105 , pp. 93-98
    • Toma, C.1    Pittenger, M.F.2    Cahill, K.S.3    Byrne, B.J.4    Kessler, P.D.5
  • 99
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan A.I., Dennis J.E. Mesenchymal stem cells as trophic mediators. J. Cell. Biochem. 2006, 98:1076-1084.
    • (2006) J. Cell. Biochem. , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 100
  • 102
    • 20844440562 scopus 로고    scopus 로고
    • Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
    • Togel F., Hu Z., Weiss K., Isaac J., Lange C., Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am. J. Physiol. Renal Physiol. 2005, 289:F31-F42.
    • (2005) Am. J. Physiol. Renal Physiol. , vol.289
    • Togel, F.1    Hu, Z.2    Weiss, K.3    Isaac, J.4    Lange, C.5    Westenfelder, C.6
  • 103
    • 44849121129 scopus 로고    scopus 로고
    • Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    • Chen L., Tredget E.E., Wu P.Y., Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008, 3:e1886.
    • (2008) PLoS One , vol.3
    • Chen, L.1    Tredget, E.E.2    Wu, P.Y.3    Wu, Y.4
  • 104
    • 58149265734 scopus 로고    scopus 로고
    • The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair
    • Arthur A., Zannettino A., Gronthos S. The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. J. Cell. Physiol. 2009, 218:237-245.
    • (2009) J. Cell. Physiol. , vol.218 , pp. 237-245
    • Arthur, A.1    Zannettino, A.2    Gronthos, S.3
  • 105
    • 39649113771 scopus 로고    scopus 로고
    • Mesenchymal stem cells in acute kidney injury
    • Humphreys B.D., Bonventre J.V. Mesenchymal stem cells in acute kidney injury. Annu. Rev. Med. 2008, 59:311-325.
    • (2008) Annu. Rev. Med. , vol.59 , pp. 311-325
    • Humphreys, B.D.1    Bonventre, J.V.2
  • 109
    • 85027926151 scopus 로고    scopus 로고
    • The immunomodulatory properties of mesenchymal stem cells
    • Marigo I., Dazzi F. The immunomodulatory properties of mesenchymal stem cells. Semin. Immunopathol. 2011, 33:593-602.
    • (2011) Semin. Immunopathol. , vol.33 , pp. 593-602
    • Marigo, I.1    Dazzi, F.2
  • 110
    • 0141886188 scopus 로고    scopus 로고
    • Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens
    • Potian J.A., Aviv H., Ponzio N.M., Harrison J.S., Rameshwar P. Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J. Immunol. 2003, 171:3426-3434.
    • (2003) J. Immunol. , vol.171 , pp. 3426-3434
    • Potian, J.A.1    Aviv, H.2    Ponzio, N.M.3    Harrison, J.S.4    Rameshwar, P.5
  • 111
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
    • Tse W.T., Pendleton J.D., Beyer W.M., Egalka M.C., Guinan E.C. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003, 75:389-397.
    • (2003) Transplantation , vol.75 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3    Egalka, M.C.4    Guinan, E.C.5
  • 113
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., Longoni P.D., Matteucci P., Grisanti S., Gianni A.M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002, 99:3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6    Grisanti, S.7    Gianni, A.M.8
  • 114
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    • Le Blanc K., Tammik L., Sundberg B., Haynesworth S.E., Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand. J. Immunol. 2003, 57:11-20.
    • (2003) Scand. J. Immunol. , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3    Haynesworth, S.E.4    Ringden, O.5
  • 115
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S., Pittenger M.F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105:1815-1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 118
    • 79960223740 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
    • Lai R.C., Chen T.S., Lim S.K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen. Med. 2011, 6:481-492.
    • (2011) Regen. Med. , vol.6 , pp. 481-492
    • Lai, R.C.1    Chen, T.S.2    Lim, S.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.