Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Journal of Controlled Release

Volumn 205, Issue , 2015, Pages 35-44

  Fuhrmann, Gregor ^a   Serio, Andrea ^a   Mazo, Manuel ^a   Nair, Rekha ^a   Stevens, Molly M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Drug loading; Exosomes; High content imaging; Photodynamic therapy; Porphyrins; Shedding microvesicles

Indexed keywords

CYTOLOGY; DISEASES; ENCAPSULATION; ENDOTHELIAL CELLS; HYDROPHILICITY; HYDROPHOBICITY; LIPOSOMES; METABOLITES; PHOSPHOLIPIDS; PHOTODYNAMIC THERAPY; PORPHYRINS; STEM CELLS;

DRUG LOADING; EXOSOMES; HIGH-CONTENT; HYDROPHOBIC COMPOUNDS; HYDROPHOBIC PORPHYRINS; MICROVESICLES; NATURAL COMPOSITION; PHOTODYNAMIC EFFECT;

DRUG THERAPY;

CHOLESTEROL; DRUG CARRIER; LIPOSOME; PHOSPHORYLCHOLINE; PORPHYRIN; SAPONIN;

BREAST NEOPLASMS; CHEMICAL PHENOMENA; CHEMISTRY; COMPARATIVE STUDY; ELECTROPORATION; EXOSOME; FEMALE; HUMAN; MEDICINAL CHEMISTRY; MEMBRANE MICROPARTICLE; METABOLISM; PHARMACEUTICS; PHOTOCHEMOTHERAPY; PROCEDURES; STEM CELL; TIME; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL-DERIVED MICROPARTICLES; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL; DRUG CARRIERS; ELECTROPORATION; EXOSOMES; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPOSOMES; PHOSPHORYLCHOLINE; PHOTOCHEMOTHERAPY; PORPHYRINS; SAPONINS; STEM CELLS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84936886409     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.11.029     Document Type: Article

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