The causes and consequences of genetic heterogeneity in cancer evolution

Nature

Volumn 501, Issue 7467, 2013, Pages 338-345

  Burrell, Rebecca A ^a   McGranahan, Nicholas ^a,b   Bartek, Jiri ^c,d   Swanton, Charles ^a,e  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^d PALACKÝ UNIVERSITY   (Czech Republic)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOPHOSMIN;

CANCER; EVOLUTION; GENETIC VARIATION; GENOME; HETEROGENEITY; MUTATION; PHENOTYPE;

BREAST CANCER; CANCER GROWTH; CANCER THERAPY; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; CHROMOSOME NUMBER; CHROMOSOME SEGREGATION; CHROMOSOME STRUCTURE; CHRONIC LYMPHATIC LEUKEMIA; COLORECTAL CANCER; COPY NUMBER VARIATION; DNA METHYLATION; DNA REPLICATION; EVOLUTION; EXCISION REPAIR; FRAMESHIFT MUTATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GENOMIC INSTABILITY; GLIOBLASTOMA; HETEROZYGOSITY LOSS; HOMOLOGOUS RECOMBINATION; HUMAN; M PHASE CELL CYCLE CHECKPOINT; MELANOMA CELL; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MUTATION RATE; NEOPLASM; NONHUMAN; ONCOGENE K RAS; OVARY CANCER; PANCREAS CANCER; PERSONALIZED MEDICINE; PHENOTYPIC VARIATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOMBINATION REPAIR; REVIEW; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE; WNT SIGNALING PATHWAY;

ANIMALS; DISEASE PROGRESSION; GENETIC HETEROGENEITY; GENOMIC INSTABILITY; HUMANS; NEOPLASMS;

EID: 84884365015     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12625     Document Type: Review

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