Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 18, 2013, Pages 7312-7317

  Kucharzewska, Paulina ^a   Christianson, Helena C ^a   Welch, Johanna E ^a   Svensson, Katrin J ^a   Fredlund, Erik ^b   Ringnér, Markus ^a   Mörgelin, Matthias ^a   Bourseau Guilmain, Erika ^a   Bengzon, Johan ^a,c   Belting, Mattias ^a,d  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Biomarker; Blood vessels; CNS

Indexed keywords

CAVEOLIN 1; INTERLEUKIN 8; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; PROTEIN LYSINE 6 OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL HYPOXIA; CONTROLLED STUDY; ENDOTHELIUM CELL; EXOSOME; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OXYGENATION; PERICYTE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANIMALS; AUTOCRINE COMMUNICATION; BLOOD VESSELS; BRAIN NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; ENDOTHELIAL CELLS; EXOSOMES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; MICE; MICE, SCID; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PARACRINE COMMUNICATION; PERICYTES; PROTEOME; SIGNAL TRANSDUCTION; TISSUE DONORS; TRANSCRIPTOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84876927914     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220998110     Document Type: Article

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