A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Biomaterials

Volumn 35, Issue 7, 2014, Pages 2383-2390

  Tian, Yanhua ^a,b   Li, Suping ^a   Song, Jian ^b   Ji, Tianjiao ^a   Zhu, Motao ^a   Anderson, Gregory J ^c   Wei, Jingyan ^b   Nie, Guangjun ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b JILIN UNIVERSITY   (China)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Doxorubicin; Exosome; IRGD; Tumor therapy; v Integrin positive cancer cells

Indexed keywords

CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; DISEASES; MAMMALS; MEDICAL IMAGING; TOXICITY; TUMORS;

DOXORUBICIN; EXOSOME; INTEGRINS; IRGD; TUMOR THERAPY;

TARGETED DRUG DELIVERY;

ARGINYLGLYCYLASPARTIC ACID; DOXORUBICIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG SAFETY; DRUG TARGETING; EXOSOME; FEMALE; FLUORESCENCE; HUMAN; HUMAN CELL; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VOLUME;

MUS MUSCULUS;

DOXORUBICIN; EXOSOME; IRGD; TUMOR THERAPY; ΑV INTEGRIN-POSITIVE CANCER CELLS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BASE SEQUENCE; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, AGAR GEL; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON; NEOPLASMS; OLIGODEOXYRIBONUCLEOTIDES;

EID: 84891372823     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.11.083     Document Type: Article

References (26)

1. Théry C., Zitvogel L., Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol 2002, 2(8):569-579.
2. Trajkovic K., Hsu C., Chiantia S., Rajendran L., Wenzel D., Wieland F., et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 2008, 319(5867):1244-1247.
3. Théry C., Ostrowski M., Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009, 9(8):581-593.
4. Valadi H., Ekström K., Bossios A., Sjöstrand M., Lee J.J., Lötvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9(6):654-659.
5. Alvarez-Erviti L., Seow Y., Yin H., Betts C., Lakhal S., Wood M.J. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 2011, 29(4):341-345.
6. Ohno S.I., Takanashi M., Sudo K., Ueda S., Ishikawa A., Matsuyama N., et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther 2012, 21(1):185-191. 2013.
7. Sun D., Zhang X., Xiang X., Liu Y., Zhang S., Liu C., et al. Anovel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther 2010, 18(9):1606-1614.
8. Tatischeff I., Annette A. Anew biological strategy for drug delivery: eucaryotic cell-derived nanovesicles. JBiomater Nanobiotechnol 2011, 2(5):494-499.
9. Hornung V., Bauernfeind F., Halle A., Samstad E.O., Kono H., Rock K.L., et al. Silica crystals and alumimum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008, 9(8):847-856.
10. van den Boorn J.G., Schlee M., Coch C., Hartmann G. SiRNA delivery with exosome nanoparticles. Nat Biotechnol 2011, 29(4):325-326.
11. Quah B.J., O'Neill H.C. The immunogenicity of dendritic cell-derived exosomes. Blood Cell Mol Dis 2005, 35(2):94-110.
12. Simhadri V.R., Reiners K.S., Hansen H.P., Topolar D., Simhadri V.L., Nohroudi K., et al. Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function. PLoS One 2008, 3(10):e3377.
13. Sugahara K.N., Teesalu T., Karmali P.P., Kotamraju V.R., Agemy L., Girard O.M., et al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 2009, 16(6):510-520.
14. Théry C., Amigorena S., Raposo G., Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol 2006, 30:3.22.1-3.22.29.
15. Kessler T., Bieker R., Padró T., Schwöppe C., Persigehl T., Bremer C., et al. Inhibition of tumor growth by RGD peptide-directed delivery of truncated tissue factor to the tumor vasculature. Clin Cancer Res 2005, 11(17):6317-6324.
16. Tian X., Zhu M., Tian Y., Grant A.R., Zhao Y., Nie G. Amembrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma. Biomaterials 2012, 33(26):6147-6154.
17. Eliceiri B.P. Integrin and growth factor receptor crosstalk. Circ Res 2001, 89(12):1104-1110.
18. Sloan E.K., Pouliot N., Stanley K.L., Chia J., Moseley J.M., Hards D.K., et al. Tumor-specific expression of αvβ3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res 2006, 8(2):R20.
19. Singal P.K., Iliskovic N. Doxorubicin-induced cardiomyopathy. NEngl J Med 1998, 339(13):900-905.
20. Wang H., Wu Y., Zhao R., Nie G. Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy. Adv Mater 2013, 25(11):1616-1622.
21. Minotti G., Menna P., Salvatorelli E., Cairo G., Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 2004, 56(2):185-229.
22. Bagalkot V., Farokhzad O.C., Langer R., Jon S. An Aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed 2006, 45(48):8149-8152.
23. Sugahara K.N., Teesalu T., Karmali P.P., Kotamraju V.R., Agemy L., Greenwald D.R., et al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 2010, 328(5918):1031-1035.
24. Morse M.A., Garst J., Osada T., Khan S., Hobeika A., Clay T.M., et al. Aphase 1 study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. JTransl Med 2005, 3(1):9.
25. Lamparski H.G., Metha-Damani A., Yao J.Y., Patel S., Hsu D.H., Ruegg C., et al. Production and characterization of clinical grade exosomes derived from dendritic cells. JImmunol Methods 2002, 270(2):211-226.
26. Lou K.J. No place like exosome. SciBX: Sci-Business eXchange 2011, 4(14).