Tetraspanins in viral infections: A fundamental role in viral biology?

Journal of Virology

Volumn 79, Issue 17, 2005, Pages 10839-10851

  Martin, F ^a   Roth, D M ^b,c   Jans, D A ^b   Pouton, C W ^c   Partridge, L J ^a   Monk, P N ^a   Moseley, G W ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD151 ANTIGEN; CD231 ANTIGEN; CD4 ANTIGEN; CD63 ANTIGEN; CD71 ANTIGEN; CD81 ANTIGEN; CD82 ANTIGEN; CD9 ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR; PERIPHERIN; PROTEIN ROM1; TETRASPANIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; COMPLEX FORMATION; FLAVIVIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNE RESPONSE; IMMUNOMODULATION; MOLECULAR INTERACTION; NONHUMAN; PARAMYXOVIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RETROVIRUS; SHORT SURVEY; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS PATHOGENESIS; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; HEPACIVIRUS; HUMANS; MEMBRANE GLYCOPROTEINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, VIRUS; RETROVIRIDAE; VIRUS DISEASES; VIRUS REPLICATION;

FLAVIVIRUS; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1; PARAMYXOVIRIDAE;

EID: 23844518308     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.17.10839-10851.2005     Document Type: Short Survey

References (176)

1. Allander, T., X. Forns, S. U. Emerson, R. H. Purcell, and J. Bukh. 2000. Hepatitis C virus envelope protein E2 hinds to CD81 of tamarins. Virology 277:358-367.
2. Reference deleted.
3. Amara, R. R., F. Villinger, J. D. Altman, S. L. Lydy, S. P. O'Neil, S. I. Staprans, D. C. Montefiori, Y. Xu, J. G. Herndon, L. S. Wyatt, M. A. Candido, N. L. Kozyr, P. L. Earl, J. M. Smith, H. L. Ma, B. D. Grimm, M. L. Hulsey, J. Miller, H. M. McClure, J. M. McNicholl, B. Moss, and H. L. Robinson. 2001. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292:69-74.
4. Andino, R., D. Silvera, S. D. Suggett, P. L. Achacoso, C. J. Miller, D. Baltimore, and M. B. Feinberg. 1994. Engineering poliovirus as a vaccine vector for the expression of diverse antigens. Science 265:1448-1451.
5. Ashman, L., S. Fitter, P. M. Sincock, L. Nguyen, and A. C. Cambareri. 1997. CD151 (PETA-3) workshop summary report, p. 681-683. In T. Kishimoto et al. (ed.), Leukocyte typing VI. Garland Publishing, New York, N.Y.
6. Baba, T. W., Y. S. Jeong, D. Pennick, R. Bronson, M. F. Greene, and R. M. Ruprecht. 1995. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267:1820-1825.
7. Barouch, D. H., S. Santra, M. J. Kuroda, J. E. Schmitz, R. Plishka, A. Buckler-White, A. E. Gaitan, R. Zin, J. H. Nam, L. S. Wyatt, M. A. Lifton, C. E. Nickerson, B. Moss, D. C. Montefiori, V. M. Hirsch, and N. L. Letvin. 2001. Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by rccombinant modified vaccinia virus Ankara vaccination. J. Virol. 75:5151-5158.
8. Bartosch, B., A. Vitelli, C. Granier, C. Goujon, J. Dubuisson, S. Pascale, E. Scarselli, R. Cortese, A. Nicosia, and F. L. Cosset. 2003. Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. J. Biol. Chem. 278:41624-41630.
9. Berditchevski, F. 2001. Complexes of tetraspanins with integrins: more than meets the eye. J. Cell Sci. 114:4143-4151.
10. α3β1 integrin and CD151-tetraspanin interactions by mutagencsis. J. Biol. Chem. 276:41165-41174.
11. Besson, C., Y. Plumelle, B. Arnulf, C. Gonin, G. Panelatti, A. Bazarbachi, and O. Hermine. 2001. Adult T-cell leukemia/lymphoma. Therapeutic aspects. Presse Med. 30:243-245. (In French.)
12. Boucheix, C., G. H. Due, C. Jasmin, and E. Rubinstein. 2001. Tetraspanins and malignancy. Expert Rev. Mol. Med. 31:1-17.
13. Cavrois, M., A. Gessain, S. Wain-Hobson, and E. Wattel. 1996. Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM. Oncogene 12:2419-2423.
14. Charrin, S., S. Manie, M. Oualid, M. Billard, C. Boucheix, and E. Rubinstein. 2002. Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. FEBS Lett. 516:139-144.
15. Chen, M. S., K. S. Tung, S. A. Coonrod, Y. Takahashi, D. Bigler, A. Chang, Y. Yamashita, P. W. Kincade, J. C. Herr, and J. M. White. 1999. Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin α6β1: implications for murine fertilization. Proc. Natl. Acad. Sci. USA 96:11830-11835.
16. Cherukuri, A., R. H. Carter, S. Brooks, W. Bornmann, R. Finn, C. S. Dowd, and S. K. Pierce. 2004. B cell signaling is regulated by induced palmitoylation of CD81. J. Biol. Chem. 279:31973-31982.
17. Cherukuri, A., T. Shoham, H. W. Sohn, S. Levy, S. Brooks, R. Carter, and S. K. Pierce. 2004. The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J. Immunol. 172:270-280.
18. Claas, C., C. S. Stipp, and M. E. Hemler. 2001. Evaluation of prototype transmcmbranc 4 superfamily protein complexes and their relation to lipid rafts. J. Biol. Chem. 276:7974-7984.
19. Clapham, P., K. Nagy, R. Cheingsong-Popov, M. Exley, and R. A. Weiss. 1983. Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line. Science 222:1125-1127.
20. Clark, K., A. Oelke, M. E. Johnson, K. D. Eilert, P. C. Simpson, and S. C. Todd. 2004. CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner. J. Biol. Chem. 279:19401-19406.
21. Crotta, S., A. Stilla, A. Wack, A. D'Andrea, S. Nuti, U. D'Oro, M. Mosca, F. Filliponi, R. M. Brunetto, F. Bonino, S. Abrignani, and N. M. Valiante. 2002. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J. Exp. Med. 195:35-41.
22. Daenke, S., S. A. McCracken, and S. Booth. 1999. Human T-cell leukaemia/lymphoma virus type 1 syncytium formation is regulated in a cell-specific manner by ICAM-1, ICAM-3 and VCAM-1 and can be inhibited by antibodies to integrin beta2 or beta?. J. Gen. Virol. 80:1429-1436.
23. Davis, N. L., I. J. Caley, K. W. Brown, M. R. Betts, D. M. Irlbeck, K. M. McGrath, M. J. Connell, D. C. Montefiori, J. A. Frelinger, R. Swanstrom, P. R. Johnson, and R. E. Johnston. 2000. Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. J. Virol. 74:371-378.
24. Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, R. Detels, and S. J. O'Brien. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273:1856-1862.
25. De Clercq, E. 2004. Antiviral drugs in current clinical use. J. Clin. Virol. 30:115-133.
26. Delaguillaumie, A., J. Harriague, S. Kohanna, G. Bismuth, E. Rubinstein, M. Seigneuret, and H. Conjeaud. 2004. Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation. J. Cell Sci. 117:5269-5282.
27. Delaguillaumie, A., Harriague, J., Kohanna, S., Bismuth, G., Rubinstein, E., Seigneuret, M., Conjeaud, H. 2004. Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation. J. Cell Sci. 117:5269-5282.
28. Deng, J., R. H. Dekruyff, G. J. Freeman, D. T. Umetsu, and S. Levy. 2002. Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses. Int. Immunol. 14:513-523.
29. de Parseval, A., D. L. Lerner, P. Borrow, B. J. Willett, and J. H. Elder. 1997. Blocking of feline immunodeficiency virus infection by a monoclonal antibody to CD9 is via inhibition of virus release rather than interference with receptor binding. J. Virol. 71:5742-5749.
30. Dhanasekaran, M., P. W. Baures, S. VanCompernolle, S. Todd, and O. Prakash. 2003. Structural characterization of peptide fragments from hCD81-LEL. J. Pept. Res. 61:80-89.
31. Drummer, H. E., K. A. Wilson, and P. Poumbourios. 2002. Identification of the hepatitis C virus E2 glycoprotein binding site on the large extracellular loop of CD81. J. Virol. 76:11143-11147.
32. Edlich, R. F., J. A. Arnette, and F. M. Williams. 2000. Global epidemic of human T-cell lymphotropic virus type-I (HTLV-I). J. Emerg. Med. 18:109-119.
33. Engering, A., and J. Pieters. 2001. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells. Int. Immunol. 13:1713-1723.
34. Finzi, D., and R. F. Siliciano. 1998. Viral dynamics in HIV-1 infection. Cell 93:665-671.
35. Flexner, C. 1998. HIV-protease inhibitors. N. Engl. J. Med. 338:1281-1292.
36. Flint, M., C. Maidens, L. D. Loomis-Price, C. Shotton, J. Dubuisson, P. Monk, A. Higginbottom, S. Levy, and J. A. McKeating. 1999. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor. CD81. J. Virol. 73:6235-6244.
37. Reference deleted.
38. Fukudome, K., M. Furuse, T. Imai, M. Nishimura, S. Takagi, Y. Hinuma, and O. Yoshie. 1992. Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. J. Virol. 66:1394-1401.
39. Geisert, E. J., R. W. Williams, G. R. Geisert, L. Fan, A. M. Asbury, H. T. Maecker, J. Deng, and S. Levy. 2002. Increased brain size and glial cell number in CD81-null mice. J. Comp. Neurol. 453:22-32.
40. Giri, M., K. E. Ugen, and D. B. Weiner. 2004. DNA vaccines against human immunodeficiency virus type 1 in the past decade. Clin. Microbiol. Rev. 17:370-389.
41. Gluschankof, P., I. Mondor, H. R. Gelderblom, and Q. J. Sattentau. 1997. Cell membrane vesicles are a major contaminant of gradient-enriched human immunodeficiency virus type-1 preparations. Virology 230:125-133.
42. Goldberg, A., and R. S. Molday. 1996. Defective subunit assembly underlies a digenic form of retinitis pigmentosa linked to mutations in peripherin/rds and rom-1. Proc. Natl. Acad. Sci. USA 26:13726-13730.
43. Gout, O., A. Gessain, M. Iba-Zizen, S. Kouzan, F. Bolgert, G. de The, and O. Lyon-Caen. 1991. The effect of zidovudine on chronic myelopathy associated with HTLV-1. J. Neurol. 238:108-109.
44. Greene, W. C. 2004. The brightening future of HIV therapeutics. Nat. Immunol. 5:867-871.
45. + T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity 13:657-664.
46. Harder, T. C., and A. D. Osterhaus. 1997. Canine distemper virus[em]a morbillivirus in search of new hosts? Trends Microbiol. 5:120-124.
47. 1 integrin and regulates adhesion of human T cell leukemia virus type 1-infected T cells to flbronectin. J. Immunol. 161:3087-3095.
48. Hasegawa, H., Y. Utsunomiya, K. Kishimoto, K. Yanagisawa, and S. Fujita. 1996. SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily. J. Virol. 70:3258-3263.
49. Hemler, M. 2003. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 19:397-422.
50. Higginbottom, A., E. R. Quinn, C. C. Kuo, M. Flint, L. H. Wilson, E. Bianchi, A. Nicosia, P. N. Monk, J. A. McKeating, and S. Levy. 2000. Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2. J. Virol. 74:3642-3649.
51. Higginbottom, A., Y. Takahashi, L. Boiling, S. A. Coonrod, J. M. White, L. J. Partridge, and P. N. Monk. 2003. Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. Biochem. Biophys. Res. Commun. 311:208-214.
52. Hildreth, J. E., A. Subramanium, and R. A. Hampton. 1997. Human T-cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation mediated by vascular cell adhesion molecule-1: evidence for involvement of cell adhesion molecules in HTLV-1 biology. J. Virol. 71:1173-1180.
53. Ho, D. D., A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126.
54. Hofmann-Lehmann, R., J. Vlasak, A. L. Williams, A. L. Chenine, H. M. McClure, D. C. Anderson, S. O'Neil, and R. M. Ruprecht. 2003. Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation. AIDS 17:157-166.
55. Hohdatsu, T., H. Hirabayashi, K. Motokawa, and H. Koyama. 1996. Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtypes A, B and D classified on the basis of the env gene V3-V5 sequence. J. Gen. Virol. 77:93-100.
56. Huerta, S., D. M. Harris, A. Jazirehi, B. Bonavida, D. Elashoff, E. H. Livingston, and D. Heber. 2003. Gene expression profile of metastatic colon cancer cells resistant to cisplatin-induced apoptosis. Int. J. Oncol. 22:663-670.
57. Imai, T., K. Fukudome, S. Takagi, M. Nagira, M. Furuse, N. Fukuhara, M. Nishimura, Y. Hinuma, and O. Yoshie. 1992. C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. J. Immunol. 149:2879-2886.
58. Ishibashi, T., L. Ding, K. Ikenaka, Y. Inoue, K. Miyado, E. Mekada, and H. Baba. 2004. Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. J. Neurosci. 24:96-102.
59. Israels, S., E. M. McMillan-Ward, J. Easton, C. Robertson, and A. McNicol. 2001. CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets. Thromb. Haemostasis 85:134-141.
60. Ivaska, J., R. D. Whelan, R. Watson, P. J. Parker. 2002. PKC epsilon controls the traffic of beta1 integrins in motile cells. EMBO J. 21:3608-3619.
61. Izumo, S., I. Goto, Y. Itoyama, T. Okajima, S. Watanabe, Y. Kuroda, S. Araki, M. Mori, S. Nagataki, S. Matsukura, T. Akamine, M. Nakagawa, I. Yamamoto, and M. Osame. 1996. Interferon-alpha is effective in HTLV-1-associated myelopathy: a multicenter, randomized, double-blind, controlled trial. Neurology 46:1016-1021.
62. Jacobson, J. M., R. J. Israel, I. Lowy, N. A. Ostrow, L. S. Vassilatos, M. Barish, D. N. Tran, B. M. Sullivan, T. J. Ketas, T. J. O'Neill, K. A. Nagashima, W. Huang, C. J. Petropoulos, J. P. Moore, P. J. Maddon, and W. C. Olson. 2004. Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542. Antimicrob. Agents Chemother. 48:423-429.
63. Jankowski, S. A., D. S. Mitchell, S. H. Smith, J. M. Trent, and P. S. Meltzer. 1994. SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Oncogene 9:1205-1211.
64. Jones, M., and D. Y. Mason. 1997. CD81 workshop panel report, p. 187-188. In T. Kishimoto et al. (ed.), Leukocyte typing VI. Garland Publishing, New York, N.Y.
65. Kaji, K., S. Oda, S. Miyazaki, and A. Kudo. 2002. Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion. Dev. Biol. 247:327-334.
66. Reference deleted.
67. Kim, F. J., N. Manel, Y. Boublik, J. L. Battini, and M. Sitbon. 2003. Human T-cell leukemia virus type 1 envelope-mediated syncytium formation can be activated in resistant mammalian cell lines by a carboxy-terminal truncation of the envelope cytoplasmic domain. J. Virol. 77:963-969.
68. Kitadokoro, K., D. Bordo, G. Galli, R. Petracca, F. Falugi, S. Abrignani, G. Grandi, and M. Bolognesi. 2001. CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. EMBO J. 20:12-18.
69. Kreidberg, J., M. J. Donovan, S. L. Goldstein, H. Rennke, K. Shepherd, R. C. Jones, and R. Jaenisch. 1996. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 122:3537-3547.
70. Kronenberger, B., C. Sarrazin, W. P. Hofmann, M. von Wagner, E. Herrmann, C. Welsch, R. Elez, B. Ruster, A. Piiper, and S. Zeuzem. 2004. Mutations in the putative HCV-E2 CD81 binding regions and correlation with cell surface CD81 expression. J. Viral Hepatol. 11:310-318.
71. Kuritzkes, D. R., J. Jacobson, W. G. Powderly, E. Godofsky, E. DeJesus, F. Haas, K. A. Reimann, J. L. Larson, P. O. Yarbough, V. Curt, and W. R. Shanahan, Jr. 2004. Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1. J. Infect. Dis. 189:286-291.
72. Kwong, P. D., M. L. Doyle, D. J. Casper, C. Cicala, S. A. Leavitt, S. Majeed, T. D. Steenbeke, M. Venturi, I. Chaiken, M. Fung, H. Katinger, P. W. Parren, J. Robinson, D. Van Ryk, L. Wang, D. R. Burton, E. Freire, R. Wyatt, J. Sodroski, W. A. Hendrickson, and J. Arthos. 2002. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature 420:678-682.
73. Kwong, P. D., R. Wyatt, J. Robinson, R. W. Sweet, J. Sodroski, and W. A. Hendrickson. 1998. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393:648-659.
74. Lagaudriere-Gesbert, C., and H. Conjeaud. 1997. CD82 workshop panel report, p. 189-190. In T. Kishimoto (ed.). Leukocyte typing VI. Garland Publishing, New York, N.Y.
75. Lagaudriere-Gesbert, C., F. Le Naour, S. Lebel-Binay, M. Billard, E. Lemichez, P. Boquet, C. Boucheix, H. Conjeaud, and E. Rubinstein. 1997. Functional analysis of four tetraspans, CD9, CD53, CD81, and CD82, suggests a common role in costimulation, cell adhesion, and migration: only CD9 upregulates HB-EGF activity. Cell. Immunol. 182:105-112.
76. Lammerding, J., A. R. Kazarov, H. Huang, R. T. Lee, and M. E. Hemler. 2003. Tetraspanin CD151 regulates α6β1 integrin adhesion strengthening. Proc. Natl. Acad. Sci. USA 100:7616-7621.
77. Lau, L., J. L. Wee, M. D. Wright, G. W. Moseley, P. M. Hogarth, L. K. Ashman, and D. E. Jackson. 2004. The tetraspanin superfamily member CD151 regulates outside-in integrin alphaIIbbeta3 signaling and platelet function. Blood 104:2368-2375.
78. Lauer, G. M., and B. D. Walker. 2001. Hepatitis C virus infection. N. Engl. J. Med. 345:41-52.
79. Le Naour, F., E. Rubinstein, C. Jasmin, M. Prenant, and C. Boucheix. 2000. Severely reduced female fertility in CD9-deficient mice. Science 287:319-321.
80. Levine, A. M., S. Groshen, J. Allen, K. M. Munson, D. J. Carlo, A. E. Daigle, F. Ferre, F. C. Jensen, S. P. Richieri, R. J. Trauger, J. W. Parker, P. L. Salk, and J. Salk. 1996. Initial studies on active immunization of HIV-infected subjects using a gp120-depleted HIV-1 immunogen: long-term follow-up. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 11:351-364.
81. Levy, S., S. C. Todd, and H. T. Maecker. 1998. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16:89-109.
82. Liu, X. L., K. R. Clark, and P. R. Johnson. 1999. Production of recombinant adeno-associated virus vectors using a packaging cell line and a hybrid recombinant adenovirus. Gene Ther. 6:293-299.
83. Löffler, S., F. Lottspeich, F. Lanza, D. O. Azorsa, V. ter Meulen, and J. Schneider-Schaulies. 1997. CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus. J. Virol. 71:42-49.
84. Lozach, P. Y., H. Lortat-Jacob, A. de Lacroix de Lavalette, I. Staropoli, S. Foung, A. Amara, C. Houles, F. Fieschi, O. Schwartz, J. L. Virelizier, F. Arenzana-Seisdedos, and R. Altmeyer. 2003. DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J. Biol. Chem. 278:20358-20366.
85. Lu, S., J. Arthos, D. C. Montefiori, Y. Yasutomi, K. Manson, F. Mustafa, E. Johnson, J. C. Santoro, J. Wissink, J. I. Mullins, J. R. Haynes, N. L. Litvin, M. Wyand, and H. L. Robinson. 1996. Simian immunodeficiency virus DNA vaccine trial in macaques. J. Virol. 70:3978-3991.
86. Maecker, H. 2003. Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation. BMC Immunol. 4:1.
87. Maecker, H., S. C. Todd, and S. Levy. 1997. The tetraspanin superfamily: molecular facilitators. FASEB J. 11:428-442.
88. Manel, N., F. J. Kim, S. Kinet, N. Taylor, M. Sitbon, and J. L. Battini. 2003. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115:449-459.
89. Mantegazza, A., M. M. Barrio, S. Moutel, L. Bover, M. Weck, P. Brossart, J. L. Teillaud, and J. Mordoh. 2004. CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells. Blood 104:1183-1190.
90. Marlink, R., P. Kanki, I. Thior, K. Travers, G. Eisen, T. Siby, I. Traore, C. C. Hsieh, M. C. Dia, and E, H. Gueye. 1994. Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science 265:1587-1590.
91. Masciopinto, F., S. Campagnoli, S. Abrignani, Y. Uematsu, and P. Pileri. 2001. The small extracellular loop of CD81 is necessary for optimal surface expression of the large loop, a putative HCV receptor. Virus Res. 80:1-10.
92. Masciopinto, F., C. Giovani, S. Campagnoli, L. Galli-Stampino, P. Colombatto, M. Brunetto, T. S. Yen, M. Houghton, P. Pileri, and S. Abrignani. 2004. Association of hepatitis C virus envelope proteins with exosomes. Eur. J. Immunol. 34:2834.
93. Masellis-Smith, A., and A. R. Shaw. 1994. CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J. Immunol. 152:2768-2777.
94. McKeating, J. A., L. Q. Zhang, C. Logvinoff, M. Flint, J. Zhang, J. Yu, D. Butera, D. D. Ho, L. B. Dustin, C. M. Rice, and P. Balfe. 2004. Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner. J. Virol. 78:8496-8505.
95. Meerloo, T., H. K. Parmentier, A. D. Osterhaus, J. Goudsmit, and H. J. Schuurman. 1992. Modulation of cell surface molecules during HIV-1 infection of H9 cells. An immunoelectron microscopic study. AIDS 6:1105-1116.
96. Meerloo, T., M. A. Sheikh, A. C. Bloem, A. de Ronde, M. Schutten, C. A. van Els, P. J. Roholl, P. Joling, J. Goudsmit, and H. J. Schuurman. 1993. Host cell membrane proteins on human immunodeficiency virus type 1 after in vitro infection of H9 cells and blood mononuclear cells. An immunoelectron microscopic study. J. Gen. Virol. 74:129-135.
97. Meola, A., A. Sbardellati, B. Bruni Ercole, M. Cerretani, M. Pezzanera, A. Ceccacci, A. Vitelli, S. Levy, A. Nicosia, C. Traboni, J. McKeating, and E. Scarselli. 2000. Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. J. Virol. 74:5933-5938.
98. Min, G., M. Stolz, G. Zhou, F. Liang, P. Sebbel, D. Stoffler, R. Glockshuber, T. T. Sun, U. Aebi, and X. P. Kong. 2002. Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle. J. Mol. Biol. 317:697-706.
99. Miyado, K., G. Yamada, S. Yamada, H. Hasuwa, Y. Nakamura, F. Ryu, K. Suzuki, K. Kosai, K. Inoue, A. Ogura, M. Okabe, and E. Mekada. 2000. Requirement of CD9 on the egg plasma membrane for fertilization. Science 287:321-324.
100. Miyazaki, T., U. Muller, and K. S. Campbell. 1997. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 16:4217-4225.
101. Mondal, D., L. Pradhan, M. Ali, and K. C. Agrawal. 2004. HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants. Cardiovasc. Toxicol. 4:287-302.
102. Moore, J. P., and R. W. Doms. 2003. The entry of entry inhibitors: a fusion of science and medicine. Proc. Natl. Acad. Sci USA 100:10598-10602.
103. Moseley, G. W. 2005. Tetraspanin-Fc receptor interactions. Platelets 16:3-11.
104. Moseley, G. W., J. Elliott, M. D. Wright, L. J. Partridge, and P. N. Monk. 2003. Interspecies contamination of the KM3 cell line: implications for CD63 function in melanoma metastasis. Int. J. Cancer 105:613-616.
105. Murphy, C. G., W. T. Lucas, R. E. Means, S. Czajak, C. L. Hale, J. D. Lifson, A. Kaur, R. P. Johnson, D. M. Knipe, and R. C. Desrosiers. 2000. Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus. J. Virol. 74:7745-7754.
106. Myszka, D. G., R. W. Sweet, P. Hensley, M. Brigham-Burke, P. D. Kwong, W. A. Hendrickson, R. Wyatt, J. Sodroski, and M. L. Doyle. 2000. Energetics of the HIV gp120-CD4 binding reaction. Proc. Natl. Acad. Sci. USA 97:9026-9031.
107. + T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood 98:1858-1861.
108. Nakamura, T., K. Shibayama, K. Nagasato, H. Matsuo, M. Tsujihata, and S. Nagataki. 1990. The efficacy of interferon-alpha treatment in human T-lymphotropic virus type-I-associated myelopathy. Jpn. J. Med. 29:362-367.
109. Nattermann, J., H. D. Nischalke, B. Kupfer, J. Rockstroh, L. Hess, T. Sauerbruch, and U. Spengler. 2003. Regulation of CC chemokine receptor 5 in hepatitis G virus infection. AIDS 17:1457-1462.
110. Odintsova, E., T. Sugiura, and F. Berditchevski. 2000. Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr. Biol. 10:1009-1012.
111. Ono, M., K. Handa, D. A. Withers, and S. Hakomori. 2000. Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional α3, α5-CD82 glycosylation complex in IdID 14 cells. Biochem. Biophys. Res. Commun. 279:744-750.
112. Ono, M., K. Handa, D. A. Withers, and S. Hakomori. 1999. Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation. Cancer Res. 59:2335-2339.
113. Reference deleted.
114. Orenstein, J. M., M. S. Meltzer, T. Phipps, and H. E. Gendelman. 1988. Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study. J. Virol. 62:2578-2586.
115. Palella, F. J., Jr., K. M. Delaney, A. C. Moorman, M. O. Loveless, J. Fuhrer, G. A. Satten, D. J. Aschman, and S. D. Holmberg. 1998. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N. Engl. J. Med. 338:853-860.
116. Parren, P. W., J. P. Moore, D. R. Burton, and Q. J. Sattentau. 1999. The neutralizing antibody response to HIV-1: viral evasion and escape from humoral immunity. AIDS 13(Suppl. A):S137-S162.
117. Pelchen-Matthews, A., B. Kramer, and M. Marsh. 2003. Infectious HIV-1 assembles in late endosomes in primary macrophages. J. Cell Biol. 162:443-455.
118. Penas, P., A. Garcia-Diez, F. Sanchez-Madrid, and M. Yanez-Mo. 2000. Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration. J. Investig. Dermatol. 114:1126-1135.
119. Perez-Bercoff, D., A. David, H. Sudry, F. Barré-Sinoussi, and G. Pancino. 2003. Fcγ receptor-mediated suppression of human immunodeficiency virus type 1 replication in primary human macrophages. J. Virol. 77:4081-4094.
120. Petracca, R., F. Falugi, G. Galli, N. Norais, D. Rosa, S. Campagnoli, V. Burgio, E. Di Stasio, B. Giardina, M. Houghton, S. Abrignani, and G. Grandi. 2000. Structure-function analysis of hepatitis C virus envelope-CD81 binding. J. Virol. 74:4824-4830.
121. Phillips, A. 2001. Will the drugs still work? Transmission of resistant HIV. Nat. Med. 7:993-994.
122. Pileri, P., Y. Uematsu, S. Campagnoli, G. Galli, F. Falugi, R. Petracca, A. J. Weiner, M. Houghton, D. Rosa, G. Grandi, and S. Abrignani. 1998. Binding of hepatitis C virus to CD81. Science 282:938-941.
123. Pinon, J. D., P. J. Klasse, S. R. Jassal, S. Welson, J. Weber, D. W. Brighty, and Q. J. Sattentau. 2003. Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans. J. Virol. 77:9922-9930.
124. Pique, C., C. Lagaudriere-Gesbert, L. Delamarre, A. R. Rosenberg, H. Conjeaud, and M. C. Dokhelar. 2000. Interaction of CD82 tetraspanin proteins with HTLV-1 envelope glycoproteins inhibits cell-to-cell fusion and virus transmission, Virology 276:455-465.
125. Poduri, C. D. 2003. Hepatitis C virus (HCV)[em]a review molecular biology of the virus, immunodiagnostics, genomic heterogeneity and the role of virus in hepatocellular carcinoma. Indian J. Exp. Biol. 41:549-562.
126. Pohlmann, S., J. Zhang, F. Baribaud, Z. Chen, G. J. Leslie, G. Lin, A. Granelli-Piperno, R. W. Doms, C. M. Rice, and J. A. McKeating. 2003. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J. Virol. 77:4070-4080.
127. Preston, B. D. 1997. Reverse transcriptase fidelity and HIV-1 variation. Science 275:228-231.
128. Raposo, G., M. Moore, D. Innes, R. Leijendekker, A. Leigh-Brown, P. Benaroch, and H. Geuze. 2002. Human macrophages accumulate HIV-1 particles in MHC II compartments. Traffic 3:718-729.
129. Rice, C. M. 1999. Is CD81 the key to hepatitis C virus entry? Hepatology 29:990-992.
130. Richardson, J. H., A. J. Edwards, J. K. Cruickshank, P. Rudge, and A. G. Dalgleish. 1990. In vivo cellular tropism of human T-cell leukemia virus type 1. J. Virol. 64:5682-5687.
131. Roccasecca, R., H. Ansuini, A. Vitelli, A. Meola, E. Scarselli, S. Acali, M. Pezzanera, B, B. Ercole, J. McKeating, A. Yagnik, A. Lahm, A. Tramontano, R. Cortese, and A. Nicosia. 2003. Binding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2. J. Virol. 77:1856-1867.
132. Rosa, D. 1996. E2 binds to chimpanzee mononuclear cells, whereas it does not bind to rat, rabbit, or green monkey mononuclear cells or hepatocytes. Proc. Natl. Acad. Sci. USA 93:1759.
133. Rose, N. F., P. A. Marx, A. Luckay, D. F. Nixon, W. J. Moretto, S. M. Donahoe, D. Montefiori, A. Roberts, L. Buonocore, and J. K. Rose. 2001. An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. Cell 106:539-549.
134. Rubinstein, E., F. Le Naour, M. Billard, M. Prenant, C. Boucheix. 1994. CD9 antigen is an accessory subunit of the VLA integrin complexes. Eur. J. Immunol. 24:3005-3013.
135. Rubinstein, E., F. Le Naour, C. Lagaudriere-Gesbert, M. Billard, H. Conjeaud, C. Boucheix. 1996. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur. J. Immunol. 26:2657-2665.
136. Sakuma, T., S. Higashiyama, S. Hosoe, S. Hayashi, and N. Taniguchi. 1997. CD9 antigen interacts with heparin-binding EGF-like growth factor through its heparin-binding domain. J. Biochem. 122:474-480.
137. Sasaki, M., K. Yamauchi, T. Nakanishi, Y. Kamogawa, and N. Hayashi. 2003. In vitro binding of hepatitis C virus to CD81-positive and -negative human cell lines. J. Gastroenterol. Hepatol. 18:74-79.
138. 491 in the Asn-Xaa-Cys motif of human transferrin. FEBS Lett. 576:51-56.
139. Scarselli, E., H. Ansuini, R. Cerino, R. M. Roccasecca, S. Acali, G. Filocamo, C. Traboni, A. Nicosia, R. Cortese, and A. Vitelli. 2002. The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. EMBO J. 21:5017-5025.
140. Scherberich, A., G. Giannone, E. Perennou, K. Takeda, C. Boucheix, E, Rubinstein, F. Lanza, and A. Beretz. 2002. FAK-mediated inhibition of vascular smooth muscle cell migration by the tetraspanin CD9. Thromb. Haemostasis 87:1043-1050.
141. Schmid, E., A. Zurbriggen, U. Gassen, B. Rima, V. ter Meulen, and J. Schneider-Schaulies. 2000. Antibodies to CD9, a tetraspan transmembrane protein, inhibit canine distemper virus-induced cell-cell fusion but not virus-cell fusion. J. Virol. 74:7554-7561.
142. Seigneuret, M., A. Delaguillaumie, C. Lagaudriere-Gesbert, and H. Conjeaud. 2001. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. J. Biol. Chem. 276:40055-40064.
143. Shaw, A., A. Domanska, A. Mak, A. Gilchrist, K. Dobler, L. Visser, S. Poppema, L. Fliegel, M. Letarte, and B. J. Willett. 1995. Ectopic expression of human and feline CD9 in a human B cell line confers beta 1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation. J. Biol. Chem. 270:24092-24099.
144. Shi, W., H. Fan, L. Shum, and R. Derynck. 2000. The tetraspanin CD9 associates with transmembrane TCP-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation. J. Cell Biol. 148:591-602.
145. Shibayama, K., T. Nakamura, K. Nagasato, S. Shirabe, M. Tsujihata, and S. Nagataki. 1991. Interferon-alpha treatment in HTLV-I-associated myelopathy. Studies of clinical and immunological aspects. J. Neurol. Sci. 106:186-192.
146. Shiver, J. W., T. M. Fu, L. Chen, D. R. Casimiro, M. E. Davies, R. K. Evans, Z. Q. Zhang, A. J. Simon, W. L. Trigona, S. A. Dubey, L. Huang, V. A. Harris, R. S. Long, X. Liang, L. Handt, W. A. Schleif, L. Zhu, D. C. Freed, N. V. Persaud, L. Guan, K. S. Punt, A. Tang, M. Chen, K. A. Wilson, K. B. Collins, G. J. Heidecker, V. R. Fernandez, H. C. Perry, J. G. Joyce, K. M. Grimm, J. C. Cook, P. M. Keller, D. S. Kresock, H. Mach, R. D. Troutman, L. A. Isopi, D. M. Williams, Z. Xu, K. E. Bohannon, D. B. Volkin, D. C. Montefiori, A. Miura, G. R. Krivulka, M. A. Lifton, M. J. Kuroda, J. E. Schmitz, N. L. Letvin, M. J. Caulfield, A. J. Bett, R. Youil, D. C. Kaslow, and E. A. Emini. 2002. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415:331-335.
147. Silvie, O., E. Rubinstein, J. F. Franetich, M. Prenant, E. Belnoue, L. Renia, L. Hannoun, W. Eling, S. Levy, C. Boucheix, and D. Mazier. 2003. Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii
148. Simon, F., S. Matheron, C. Tamalet, I. Loussert-Ajaka, S. Bartczak, J. M. Pepin, C. Dhiver, E. Gamba, C. Elbim, and J. A. Gastaut. 1993. Cellular and plasma viral load in patients infected with HIV-2. AIDS 7:1411-1417.
149. Simons, K., and E. Ikonen. 1997. Functional rafts in cell membranes. Nature 387:569-572.
150. Sincock, P., G. Mayrhofer, and L. K. Ashman. 1997. Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and α5β1 integrin. J. Histochem. Cytochem. 45:515-525.
151. -/- mice. J. Cell. Biochem. 92:1160-1170.
152. Stipp, C., T. V. Kolesnikova, and M. E. Hemler. 2003. Functional domains in tetraspanin proteins. Trends Biochem. Sci. 28:106-112.
153. Sutton, R. E., and D. R. Littman. 1996. Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system. J. Virol. 70:7322-7336.
154. Szollosi, J., V. Horejsi, L. Bene, P. Angelisova, and S. Danyanovich. 1996. Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J. Immunol. 157:2939-2946.
155. Tachibana, I., and M. E. Hemler, M. E. 1999. Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J. Cell Biol. 146:893-904.
156. Tan, Y. J., S. P. Lim, P. Ng, P. Y. Goh, S. G. Lim, Y. H. Tan, and W. Hong. 2003. CD81 engineered with endocytotic signals mediates HCV cell entry: implications for receptor usage by HCV in vivo. Virology 308:250-269.
157. Teoh, N. C., and G. C. Farrell. 2004. Management of chronic hepatitis C virus infection: a new era of disease control. Intern. Med. J. 34:324-337.
158. Trejo, S. R., and L. Ratner. 2000. The HTLV receptor is a widely expressed protein. Virology 268:41-48.
159. Tseng, C. T., and G. R. Klimpel. 2002. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J. Exp. Med. 195:43-49.
160. VanCompernolle, S. E., A. V. Wiznycla, J. R. Rush, M. Dhanasekaran, P. W. Baures, and S. C. Todd. 2003. Small molecule inhibition of hepatitis C virus E2 binding to CD81. Virology 314:371-380.
161. von Lindern, J. J., D. Rojo, K. Grovit-Ferbas, C. Yeramian, C. Deng, G. Herbein, M. R. Ferguson, T. C. Pappas, J. M. Decker, A. Singh, R. G. Collman, and W. A. O'Brien. 2003. Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophages. J. Virol. 77:3624-3633.
162. Watanabe, M. E. 2003. Skeptical scientists skewer VaxGen statistics. Nat. Med. 9:376.
163. Willett, B., M. Hosie, A. Shaw, and J. Neil. 1997. Inhibition of feline immunodeficiency virus infection by CD9 antibody operates after virus entry and is independent of virus tropism. J. Gen. Virol. 78:611-618.
164. Willett, B. J., M. J. Hosie, O. Jarrett, and J. C. Neil. 1994. Identification of a putative cellular receptor for feline immunodeficiency virus as the feline homologue of CD9. Immunology 81:228-233.
165. Wollscheid, V., R. Kuhne-Heid, I. Stein, L. Jansen, S. Kollner, A. Schneider, and M. Durst. 2002. Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intra-epithelial neoplasia and cervical carcinomas. Int. J. Cancer. 99:771-775.
166. Wright, M., S. M. Geary, S. Fitter, G. W. Moseley, L. M. Lau, K. C. Sheng, V. Apostolopoulos, E. G. Stanley, D. E. Jackson, and L. Ashman. 2004. Characterization of mice lacking the tetraspanin superfamily member CD151. Mol. Cell. Biol. 24:5978-5988.
167. Wright, M., G. W. Moseley, and A. B. VanSpriel. 2004. Tetraspanin microdomains in immune cell signalling and malignant disease. Tissue Antigens 64:533-542.
168. Wright, M., and M. Tomlinson. 1994. The ins and outs of the transmembrane-4 superfamily. Immunol. Today 15:588-594.
169. Wubbolts, R., R. S. Leckie, P. T. Veenhuizen, G. Schwarzmann, W. Mobius, J. Hoernschemeyer, J. W. Slot, H. J. Geuze, and W. Stoorvogel. 2003. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278:10963-10972.
170. Wunschmann, S., J. D. Medh, D. Klinzmann, W. N. Schmidt, and J. T. Stapleton. 2000. Characterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptor. J. Virol. 74:10055-10062.
171. Yamasaki, K., J. Kira, Y. Koyanagi, Y. Kawano, N. Miyano-Kurosaki, M. Nakamura, E. Baba, J. Suzuki, A. Yamamoto, N. Yamamoto, and T. Kobayashi. 1997. Long-term, high dose interferon-alpha treatment in HTLV-I-associated myelopathy/tropical spastic paraparesis: a combined clinical, virological and immunological study. J. Neurol. Sci. 147:135-144.
172. Yauch, R., and M. E. Hemler. 2000. Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem. J. 351:629-637.
173. 1 and TM4SF protein CD151. J. Biol. Chem. 275:9230-9238.
174. Zemni, R., T. Bienvenu, M. C. Vinet, A. Sefiani, A. Carrié, A., P. Billuart, N. McDonell, P. Couvert, F. Francis, P. Chafey, F. Fauchereau, G. Friocourt, V. des Portes, A. Cardona, S. Frints, A. Meindl, O. Brandau, N. Ronce, C. Moraine, H. van Bokhoven, H. H. Ropers, R. Sudbrak, A. Kahn, J. P. Fryns, C. Beldjord, and J. Chelly. 2000. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Nat. Genet. 24:167-170.
175. Zhang, J., G. Randall, A. Higginbottom, P. Monk, C. M. Rice, and J. A. McKeating. 2004. CD81 is required for hepatitis C virus glycoprotein-mediated viral infection. J. Virol. 78:1448-1455.
176. Zhang, X., A. L. Bontrager, and M. E. Hemler. 2001. Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific P1 integrins. J. Biol. Chem. 276:25005-25013.