-
1
-
-
47249099038
-
Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence
-
Banerjee, R., Pennington, M. W., Garza, A., and Owens, I. S. (2008). Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence. Biochemistry 47, 7385-7392. doi: 10.1021/bi8006127
-
(2008)
Biochemistry
, vol.47
, pp. 7385-7392
-
-
Banerjee, R.1
Pennington, M.W.2
Garza, A.3
Owens, I.S.4
-
2
-
-
0029862844
-
Evidence for an UDP-glucuronic acid/phenol glucuronide antiport in rat liver microsomal vesicles
-
Bánhegyi, G., Braun, L., Marcolongo, P., Csala, M., Fulceri, R., Mandl, J., et al. (1996). Evidence for an UDP-glucuronic acid/phenol glucuronide antiport in rat liver microsomal vesicles. Biochem. J. 315, 171-176. doi: 10.1042/bj3150171
-
(1996)
Biochem. J.
, vol.315
, pp. 171-176
-
-
Bánhegyi, G.1
Braun, L.2
Marcolongo, P.3
Csala, M.4
Fulceri, R.5
Mandl, J.6
-
3
-
-
0034007340
-
3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7)
-
Barbier, O., Turgeon, D., Girard, C., Green, M. D., Tephly, T. R., Hum, D. W., et al. (2000). 3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7). Drug Metab. Dispos. 28, 497-502.
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 497-502
-
-
Barbier, O.1
Turgeon, D.2
Girard, C.3
Green, M.D.4
Tephly, T.R.5
Hum, D.W.6
-
4
-
-
77950501858
-
Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions
-
Bellemare, J., Rouleau, M., Harvey, M., and Guillemette, C. (2010). Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions. J. Biol. Chem. 285, 3600-3607. doi: 10.1074/jbc. M109.083139
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 3600-3607
-
-
Bellemare, J.1
Rouleau, M.2
Harvey, M.3
Guillemette, C.4
-
5
-
-
3242695875
-
The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants
-
Bernard, O., and Guillemette, C. (2004). The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants. Drug Metab. Dispos. 32, 775-778. doi: 10.1124/dmd.32.8.775
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 775-778
-
-
Bernard, O.1
Guillemette, C.2
-
6
-
-
0032493441
-
Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?
-
Beutler, E., Gelbart, T., and Demina, A. (1998). Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc. Natl. Acad. Sci. U.S.A. 95, 8170-8174. doi: 10.1073/pnas.95.14.8170
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 8170-8174
-
-
Beutler, E.1
Gelbart, T.2
Demina, A.3
-
7
-
-
0028276410
-
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
-
Bosma, P. J., Seppen, J., Goldhoorn, B., Bakker, C., Elferink, R. O., Chowdhury, J. R., et al. (1994). Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J. Biol. Chem. 269, 17960-17964.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17960-17964
-
-
Bosma, P.J.1
Seppen, J.2
Goldhoorn, B.3
Bakker, C.4
Elferink, R.O.5
Chowdhury, J.R.6
-
8
-
-
84896446184
-
Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies
-
Chau, N., Elliot, D. J., Lewis, B. C., Burns, K., Johnston, M. R., Mackenzie, P. I., et al. (2014). Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies. J. Pharmacol. Exp. Ther. 349, 126-137. doi: 10.1124/jpet.113.212258
-
(2014)
J. Pharmacol. Exp. Ther.
, vol.349
, pp. 126-137
-
-
Chau, N.1
Elliot, D.J.2
Lewis, B.C.3
Burns, K.4
Johnston, M.R.5
Mackenzie, P.I.6
-
9
-
-
84888092572
-
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)
-
Chen, S., Yueh, M. F., Bigo, C., Barbier, O., Wang, K., Karin, M., et al. (2013). Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc. Natl. Acad. Sci. U.S.A. 110, 19143-19148. doi: 10.1073/pnas.1319123110
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 19143-19148
-
-
Chen, S.1
Yueh, M.F.2
Bigo, C.3
Barbier, O.4
Wang, K.5
Karin, M.6
-
10
-
-
30144436526
-
Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
-
Court, M. H. (2005). Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases. Methods Enzymol. 400, 104-116. doi: 10.1016/S0076-6879(05)00007-8
-
(2005)
Methods Enzymol.
, vol.400
, pp. 104-116
-
-
Court, M.H.1
-
11
-
-
4444357453
-
Evidence for multiple glucuronide transporters in rat liver microsomes
-
Csala, M., Staines, A. G., Bánhegyi, G., Mandl, J., Coughtrie, M. W., and Burchell, B. (2004). Evidence for multiple glucuronide transporters in rat liver microsomes. Biochem. Pharmacol. 68, 1353-1362. doi: 10.1016/j.bcp.2004.05.055
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 1353-1362
-
-
Csala, M.1
Staines, A.G.2
Bánhegyi, G.3
Mandl, J.4
Coughtrie, M.W.5
Burchell, B.6
-
12
-
-
84949032582
-
Xenobiotic metabolism in mice lacking the UDP-glucuronosyltransferase 2 family
-
Fay, M. J., Nguyen, M. T., Snouwaert, J. N., Dye, R., Grant, D. J., Bodnar, W. M., et al. (2015). Xenobiotic metabolism in mice lacking the UDP-glucuronosyltransferase 2 family. Drug Metab. Dispos. 43, 1838-1846. doi: 10.1124/dmd.115.065482
-
(2015)
Drug Metab. Dispos.
, vol.43
, pp. 1838-1846
-
-
Fay, M.J.1
Nguyen, M.T.2
Snouwaert, J.N.3
Dye, R.4
Grant, D.J.5
Bodnar, W.M.6
-
13
-
-
38849197491
-
The UDP-glucuronosyltransferases as oligomeric enzymes
-
Finel, M., and Kurkela, M. (2008). The UDP-glucuronosyltransferases as oligomeric enzymes. Curr. Drug Metab. 9, 70-76. doi: 10.2174/138920008783331158
-
(2008)
Curr. Drug Metab.
, vol.9
, pp. 70-76
-
-
Finel, M.1
Kurkela, M.2
-
14
-
-
11244283497
-
Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4
-
Fremont, J. J., Wang, R. W., and King, C. D. (2005). Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4. Mol. Pharmacol. 67, 260-262. doi: 10.1124/mol.104.006361
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 260-262
-
-
Fremont, J.J.1
Wang, R.W.2
King, C.D.3
-
15
-
-
83755172199
-
Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia
-
Fujiwara, R., Chen, S., Karin, M., and Tukey, R. H. (2012). Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology 142, 109-118. doi: 10.1053/j.gastro.2011.09.045
-
(2012)
Gastroenterology
, vol.142
, pp. 109-118
-
-
Fujiwara, R.1
Chen, S.2
Karin, M.3
Tukey, R.H.4
-
16
-
-
84903577746
-
Extensive protein-protein interactions involving UDP-glucuronosyltransferase (UGT) 2B7 in human liver microsomes
-
Fujiwara, R., and Itoh, T. (2014). Extensive protein-protein interactions involving UDP-glucuronosyltransferase (UGT) 2B7 in human liver microsomes. Drug Metab. Pharmacokinet. 29, 259-265. doi: 10.2133/dmpk. DMPK-13-RG-096
-
(2014)
Drug Metab. Pharmacokinet.
, vol.29
, pp. 259-265
-
-
Fujiwara, R.1
Itoh, T.2
-
17
-
-
84945483859
-
Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia
-
Fujiwara, R., Maruo, Y., Chen, S., and Tukey, R. H. (2015). Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol. Appl. Pharmacol. 289, 124-132. doi: 10.1016/j.taap.2015.08.018
-
(2015)
Toxicol. Appl. Pharmacol.
, vol.289
, pp. 124-132
-
-
Fujiwara, R.1
Maruo, Y.2
Chen, S.3
Tukey, R.H.4
-
18
-
-
73949088338
-
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes
-
Fujiwara, R., Nakajima, M., Oda, S., Yamanaka, H., Ikushiro, S. I., Sakaki, T., et al. (2010a). Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes. J. Pharm. Sci. 99, 442-454. doi: 10.1002/jps.21830
-
(2010)
J. Pharm. Sci.
, vol.99
, pp. 442-454
-
-
Fujiwara, R.1
Nakajima, M.2
Oda, S.3
Yamanaka, H.4
Ikushiro, S.I.5
Sakaki, T.6
-
19
-
-
69949169707
-
In silico and in vitro approaches to elucidate the thermal stability of human UDP-glucuronosyltransferase (UGT) 1A9
-
Fujiwara, R., Nakajima, M., Yamamoto, T., Nagao, H., and Yokoi, T. (2009a). In silico and in vitro approaches to elucidate the thermal stability of human UDP-glucuronosyltransferase (UGT) 1A9. Drug Metab. Pharmacokinet. 24, 235-244. doi: 10.2133/dmpk.24.235
-
(2009)
Drug Metab. Pharmacokinet.
, vol.24
, pp. 235-244
-
-
Fujiwara, R.1
Nakajima, M.2
Yamamoto, T.3
Nagao, H.4
Yokoi, T.5
-
20
-
-
34548097015
-
Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities
-
Fujiwara, R., Nakajima, M., Yamanaka, H., Katoh, M., and Yokoi, T. (2007a). Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities. Drug Metab. Dispos. 35, 1781-1787. doi: 10.1124/dmd.107.016402
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 1781-1787
-
-
Fujiwara, R.1
Nakajima, M.2
Yamanaka, H.3
Katoh, M.4
Yokoi, T.5
-
21
-
-
34247379533
-
Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms
-
Fujiwara, R., Nakajima, M., Yamanaka, H., Nakamura, A., Katoh, M., Ikushiro, S., et al. (2007b). Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms. Drug Metab. Dispos. 35, 747-757.
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 747-757
-
-
Fujiwara, R.1
Nakajima, M.2
Yamanaka, H.3
Nakamura, A.4
Katoh, M.5
Ikushiro, S.6
-
22
-
-
58149476402
-
Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT) 1A9 and UGT1A8
-
Fujiwara, R., Nakajima, M., Yamanaka, H., and Yokoi, T. (2009b). Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT) 1A9 and UGT1A8. Drug Metab. Dispos. 37, 41-46. doi: 10.1124/dmd.108.022913
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 41-46
-
-
Fujiwara, R.1
Nakajima, M.2
Yamanaka, H.3
Yokoi, T.4
-
23
-
-
77950407754
-
Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus
-
Fujiwara, R., Nguyen, N., Chen, S., and Tukey, R. H. (2010b). Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc. Natl. Acad. Sci. U.S.A. 107, 5024-5029. doi: 10.1073/pnas.0913290107
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 5024-5029
-
-
Fujiwara, R.1
Nguyen, N.2
Chen, S.3
Tukey, R.H.4
-
24
-
-
0035834673
-
Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications
-
Ghosh, S. S., Sappal, B. S., Kalpana, G. V., Lee, S. W., Chowdhury, J. R., and Chowdhury, N. R. (2001). Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications. J. Biol. Chem. 276, 42108-42115. doi: 10.1074/jbc. M106742200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42108-42115
-
-
Ghosh, S.S.1
Sappal, B.S.2
Kalpana, G.V.3
Lee, S.W.4
Chowdhury, J.R.5
Chowdhury, N.R.6
-
25
-
-
38449095074
-
Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity
-
Girard, H., Lévesque, E., Bellemare, J., Journault, K., Caillier, B., and Guillemette, C. (2007). Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Pharmacogenet. Genomics 17, 1077-1089. doi: 10.1097/FPC.0b013e3282f1f118
-
(2007)
Pharmacogenet. Genomics
, vol.17
, pp. 1077-1089
-
-
Girard, H.1
Lévesque, E.2
Bellemare, J.3
Journault, K.4
Caillier, B.5
Guillemette, C.6
-
26
-
-
0028116221
-
Radiation inactivation analysis of microsomal UDP-glucuronosyltransferases catalysing mono-and diglucuronide formation of 3, 6-dihydroxybenzo (a) pyrene and 3, 6-dihydroxychrysene
-
Gschaidmeier, H., and Bock, K. W. (1994). Radiation inactivation analysis of microsomal UDP-glucuronosyltransferases catalysing mono-and diglucuronide formation of 3, 6-dihydroxybenzo (a) pyrene and 3, 6-dihydroxychrysene. Biochem. Pharmacol. 48, 1545-1549. doi: 10.1016/0006-2952(94)90198-8
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1545-1549
-
-
Gschaidmeier, H.1
Bock, K.W.2
-
27
-
-
0035076242
-
Determination of UDP-glucuronosyltransferase UGT1A6 activity in human and rat liver microsomes by HPLC with UV detection
-
Hanioka, N., Jinno, H., Tanaka-Kagawa, T., Nishimura, T., and Ando, M. (2001). Determination of UDP-glucuronosyltransferase UGT1A6 activity in human and rat liver microsomes by HPLC with UV detection. J. Pharm. Biomed. Anal. 25, 65-75. doi: 10.1016/S0731-7085(00)00491-X
-
(2001)
J. Pharm. Biomed. Anal.
, vol.25
, pp. 65-75
-
-
Hanioka, N.1
Jinno, H.2
Tanaka-Kagawa, T.3
Nishimura, T.4
Ando, M.5
-
28
-
-
84984799760
-
Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity
-
Hirashima, R., Michimae, H., Takemoto, H., Sasaki, A., Kobayashi, Y., Itoh, T., et al. (2016). Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity. Mol. Pharmacol. 90, 265-274. doi: 10.1124/mol.116.104174
-
(2016)
Mol. Pharmacol.
, vol.90
, pp. 265-274
-
-
Hirashima, R.1
Michimae, H.2
Takemoto, H.3
Sasaki, A.4
Kobayashi, Y.5
Itoh, T.6
-
29
-
-
0031010059
-
Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes
-
Ikushiro, S., Emi, Y., and Iyanagi, T. (1997). Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes. Biochemistry 36, 7154-7161. doi: 10.1021/bi9702344
-
(1997)
Biochemistry
, vol.36
, pp. 7154-7161
-
-
Ikushiro, S.1
Emi, Y.2
Iyanagi, T.3
-
30
-
-
38449093974
-
Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex
-
Ishii, Y., Iwanaga, M., Nishimura, Y., Takeda, S., Ikushiro, S. I., Nagata, K., et al. (2007). Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex. Drug Metab. Pharmacokinet. 22, 367-376. doi: 10.2133/dmpk.22.367
-
(2007)
Drug Metab. Pharmacokinet.
, vol.22
, pp. 367-376
-
-
Ishii, Y.1
Iwanaga, M.2
Nishimura, Y.3
Takeda, S.4
Ikushiro, S.I.5
Nagata, K.6
-
31
-
-
84891757158
-
Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants
-
Ishii, Y., Koba, H., Kinoshita, K., Oizaki, T., Iwamoto, Y., Takeda, S., et al. (2014). Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants. Drug Metab. Dispos. 42, 229-238. doi: 10.1124/dmd.113.054833
-
(2014)
Drug Metab. Dispos.
, vol.42
, pp. 229-238
-
-
Ishii, Y.1
Koba, H.2
Kinoshita, K.3
Oizaki, T.4
Iwamoto, Y.5
Takeda, S.6
-
32
-
-
4644369770
-
Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation
-
Ishii, Y., Miyoshi, A., Maji, D., Yamada, H., and Oguri, K. (2004). Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation. Drug Metab. Dispos. 32, 1057-1060. doi: 10.1124/dmd.32.10
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1057-1060
-
-
Ishii, Y.1
Miyoshi, A.2
Maji, D.3
Yamada, H.4
Oguri, K.5
-
33
-
-
0034752769
-
Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation
-
Ishii, Y., Miyoshi, A., Watanabe, R., Tsuruda, K., Tsuda, M., Yamaguchi-Nagamatsu, Y., et al. (2001). Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation. Mol. Pharmacol. 60, 1040-1048.
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 1040-1048
-
-
Ishii, Y.1
Miyoshi, A.2
Watanabe, R.3
Tsuruda, K.4
Tsuda, M.5
Yamaguchi-Nagamatsu, Y.6
-
34
-
-
22144442645
-
Functional protein-protein interaction of drug metabolizing enzymes
-
Ishii, Y., Takeda, S., Yamada, H., and Oguri, K. (2005). Functional protein-protein interaction of drug metabolizing enzymes. Front. Biosci. 10:887-895. doi: 10.2741/1583
-
(2005)
Front. Biosci.
, vol.10
, pp. 887-895
-
-
Ishii, Y.1
Takeda, S.2
Yamada, H.3
Oguri, K.4
-
35
-
-
67650821911
-
Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers
-
Izukawa, T., Nakajima, M., Fujiwara, R., Yamanaka, H., Fukami, T., Takamiya, M., et al. (2009). Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers. Drug Metab. Dispos. 37, 1759-1768. doi: 10.1124/dmd.109.027227
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 1759-1768
-
-
Izukawa, T.1
Nakajima, M.2
Fujiwara, R.3
Yamanaka, H.4
Fukami, T.5
Takamiya, M.6
-
36
-
-
84969884406
-
Phase II drug metabolizing enzymes. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc
-
Jancova, P., Anzenbacher, P., and Anzenbacherova, E. (2010). Phase II drug metabolizing enzymes. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc. Czech. Repub. 154, 103-116. doi: 10.5507/bp.2010.017
-
(2010)
Czech. Repub.
, vol.154
, pp. 103-116
-
-
Jancova, P.1
Anzenbacher, P.2
Anzenbacherova, E.3
-
37
-
-
0035799707
-
Lethality and centrality in protein networks
-
Jeong, H., Mason, S. P., Barabási, A. L., and Oltvai, Z. N. (2001). Lethality and centrality in protein networks. Nature 411, 41-42. doi: 10.1038/35075138
-
(2001)
Nature
, vol.411
, pp. 41-42
-
-
Jeong, H.1
Mason, S.P.2
Barabási, A.L.3
Oltvai, Z.N.4
-
38
-
-
84879118456
-
Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4
-
Kato, Y., Izukawa, T., Oda, S., Fukami, T., Finel, M., Yokoi, T., et al. (2013). Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. Drug Metab. Dispos. 41, 1389-1397. doi: 10.1124/dmd.113.051565
-
(2013)
Drug Metab. Dispos.
, vol.41
, pp. 1389-1397
-
-
Kato, Y.1
Izukawa, T.2
Oda, S.3
Fukami, T.4
Finel, M.5
Yokoi, T.6
-
39
-
-
0018400554
-
Size determination of enzymes by radiation inactivation
-
Kempner, E. S., and Schlegel, W. (1979). Size determination of enzymes by radiation inactivation. Anal. Biochem. 92, 2-10. doi: 10.1016/0003-2697(79)90617-1
-
(1979)
Anal. Biochem.
, vol.92
, pp. 2-10
-
-
Kempner, E.S.1
Schlegel, W.2
-
40
-
-
70349089346
-
Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10
-
Kerdpin, O., Mackenzie, P. I., Bowalgaha, K., Finel, M., and Miners, J. O. (2009). Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10. Drug Metab. Dispos. 37, 1948-1955. doi: 10.1124/dmd.109.028225
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 1948-1955
-
-
Kerdpin, O.1
Mackenzie, P.I.2
Bowalgaha, K.3
Finel, M.4
Miners, J.O.5
-
41
-
-
0029972534
-
Crigler-Najjar syndrome type II is inherited both as a dominant and as a recessive trait
-
Koiwai, O., Aono, S., Adachi, Y., Kamisako, T., Yasui, Y., Nishizawa, M., et al. (1996). Crigler-Najjar syndrome type II is inherited both as a dominant and as a recessive trait. Hum. Mol. Genet. 5, 645-647. doi: 10.1093/hmg/5.5.645
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 645-647
-
-
Koiwai, O.1
Aono, S.2
Adachi, Y.3
Kamisako, T.4
Yasui, Y.5
Nishizawa, M.6
-
42
-
-
0038685671
-
Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6
-
Krishnaswamy, S., Duan, S. X., von Moltke, L. L., and Greenblatt, D. J. (2003). Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6. Drug Metab. Dispos. 31, 133-139. doi: 10.1124/dmd.31.1.133
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 133-139
-
-
Krishnaswamy, S.1
Duan, S.X.2
von Moltke, L.L.3
Greenblatt, D.J.4
-
43
-
-
19444375984
-
UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)
-
Krishnaswamy, S., Hao, Q., Al-Rohaimi, A., Hesse, L. M., von Moltke, L. L., and Greenblatt, D. J. (2005). UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J. Pharmacol. Exp. Ther. 313, 1340-1346. doi: 10.1124/jpet.104.081968
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.313
, pp. 1340-1346
-
-
Krishnaswamy, S.1
Hao, Q.2
Al-Rohaimi, A.3
Hesse, L.M.4
von Moltke, L.L.5
Greenblatt, D.J.6
-
44
-
-
0142150014
-
N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases
-
Kuehl, G. E., and Murphy, S. E. (2003). N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases. Drug Metab. Dispos. 31, 1361-1368. doi: 10.1124/dmd.31.11.1361
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1361-1368
-
-
Kuehl, G.E.1
Murphy, S.E.2
-
45
-
-
0037423299
-
Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs) UGT1A9. UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme
-
Kurkela, M., García-Horsman, J. A., Luukkanen, L., Mörsky, S., Taskinen, J., Baumann, M., et al. (2003). Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs) UGT1A9. UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme. J. Biol. Chem. 278, 3536-3544. doi: 10.1074/jbc. M206136200
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3536-3544
-
-
Kurkela, M.1
García-Horsman, J.A.2
Luukkanen, L.3
Mörsky, S.4
Taskinen, J.5
Baumann, M.6
-
46
-
-
8844283291
-
The interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specific, and may involve both monomers
-
Kurkela, M., Hirvonen, J., Kostiainen, R., and Finel, M. (2004). The interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specific, and may involve both monomers. Biochem. Pharmacol. 68, 2443-2450. doi: 10.1016/j.bcp.2004.08.019
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 2443-2450
-
-
Kurkela, M.1
Hirvonen, J.2
Kostiainen, R.3
Finel, M.4
-
47
-
-
84940376154
-
Expression of UDP-glucuronosyltransferase 1 (UGT1) and glucuronidation activity toward endogenous substances in humanized UGT1 mouse brain
-
Kutsuno, Y., Hirashima, R., Sakamoto, M., Ushikubo, H., Michimae, H., Itoh, T., et al. (2015). Expression of UDP-glucuronosyltransferase 1 (UGT1) and glucuronidation activity toward endogenous substances in humanized UGT1 mouse brain. Drug Metab. Dispos. 43, 1071-1076. doi: 10.1124/dmd.115.063719
-
(2015)
Drug Metab. Dispos.
, vol.43
, pp. 1071-1076
-
-
Kutsuno, Y.1
Hirashima, R.2
Sakamoto, M.3
Ushikubo, H.4
Michimae, H.5
Itoh, T.6
-
48
-
-
77952349321
-
A molecular model of the human UDP-glucuronosyltransferase 1A1, its membrane orientation, and the interactions between different parts of the enzyme
-
Laakkonen, L., and Finel, M. (2010). A molecular model of the human UDP-glucuronosyltransferase 1A1, its membrane orientation, and the interactions between different parts of the enzyme. Mol. Pharmacol. 77, 931-939. doi: 10.1124/mol.109.063289
-
(2010)
Mol. Pharmacol.
, vol.77
, pp. 931-939
-
-
Laakkonen, L.1
Finel, M.2
-
49
-
-
64549133772
-
Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment
-
Lankisch, T. O., Behrens, G., Ehmer, U., Möbius, U., Rockstroh, J., Wehmeier, M., et al. (2009). Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment. J. Hepatol. 50, 1010-1018. doi: 10.1016/S0168-8278(09)61009-6
-
(2009)
J. Hepatol.
, vol.50
, pp. 1010-1018
-
-
Lankisch, T.O.1
Behrens, G.2
Ehmer, U.3
Möbius, U.4
Rockstroh, J.5
Wehmeier, M.6
-
50
-
-
33846442350
-
Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus
-
Lévesque, E., Girard, H., Journault, K., Lépine, J., and Guillemette, C. (2007). Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus. Hepatology 45, 128-138. doi: 10.1002/hep.21464
-
(2007)
Hepatology
, vol.45
, pp. 128-138
-
-
Lévesque, E.1
Girard, H.2
Journault, K.3
Lépine, J.4
Guillemette, C.5
-
51
-
-
80555131097
-
Homodimerization of UDP-glucuronosyltransferase 2B7 (UGT2B7) and identification of a putative dimerization domain by protein homology modeling
-
Lewis, B. C., Mackenzie, P. I., and Miners, J. O. (2011). Homodimerization of UDP-glucuronosyltransferase 2B7 (UGT2B7) and identification of a putative dimerization domain by protein homology modeling. Biochem. Pharmacol. 82, 2016-2023. doi: 10.1016/j.bcp.2011.09.007
-
(2011)
Biochem. Pharmacol.
, vol.82
, pp. 2016-2023
-
-
Lewis, B.C.1
Mackenzie, P.I.2
Miners, J.O.3
-
52
-
-
34249946792
-
Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes
-
Li, C., and Wu, Q. (2007). Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. BMC Evol. Biol. 7:69. doi: 10.1186/1471-2148-7-1
-
(2007)
BMC Evol. Biol.
, vol.7
, pp. 69
-
-
Li, C.1
Wu, Q.2
-
53
-
-
84959563025
-
Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As)
-
Li, L., Huang, X. J., Peng, J. L., Zheng, M. Y., Zhong, D. F., Zhang, C. F., et al. (2016). Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As). Phytomedicine 23, 340-349. doi: 10.1016/j.phymed.2016.01.007
-
(2016)
Phytomedicine
, vol.23
, pp. 340-349
-
-
Li, L.1
Huang, X.J.2
Peng, J.L.3
Zheng, M.Y.4
Zhong, D.F.5
Zhang, C.F.6
-
54
-
-
0036890353
-
Complexities of glucuronidation affecting in vitro in vivo extrapolation
-
Lin, J. H., and Wong, B. K. (2002). Complexities of glucuronidation affecting in vitro in vivo extrapolation. Curr. Drug Metab. 3, 623-646. doi: 10.2174/1389200023336992
-
(2002)
Curr. Drug Metab.
, vol.3
, pp. 623-646
-
-
Lin, J.H.1
Wong, B.K.2
-
55
-
-
84952877285
-
Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis
-
Liu, M., Chen, S., Yueh, M. F., Wang, G., Hao, H., and Tukey, R. H. (2016). Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol. Gastroenterol. Hepatol. 2, 63-76. doi: 10.1016/j.jcmgh.2015.08.008
-
(2016)
Cell Mol. Gastroenterol. Hepatol.
, vol.2
, pp. 63-76
-
-
Liu, M.1
Chen, S.2
Yueh, M.F.3
Wang, G.4
Hao, H.5
Tukey, R.H.6
-
56
-
-
84953792117
-
New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases
-
Liu, X., Cao, Y. F., Ran, R. X., Dong, P. P., Gonzalez, F. J., Wu, X., et al. (2016). New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases. Chemosphere 144, 1966-1972. doi: 10.1016/j.chemosphere.2015.10.076
-
(2016)
Chemosphere
, vol.144
, pp. 1966-1972
-
-
Liu, X.1
Cao, Y.F.2
Ran, R.X.3
Dong, P.P.4
Gonzalez, F.J.5
Wu, X.6
-
57
-
-
84962428127
-
Dimerization of human uridine diphosphate glucuronosyltransferase allozymes 1A1 and 1A9 alters their quercetin glucuronidation activities
-
Liu, Y. Q., Yuan, L. M., Gao, Z. Z., Xiao, Y. S., Sun, H. Y., Yu, L. S., et al. (2016). Dimerization of human uridine diphosphate glucuronosyltransferase allozymes 1A1 and 1A9 alters their quercetin glucuronidation activities. Sci Rep 6:23763. doi: 10.1038/srep23763
-
(2016)
Sci Rep
, vol.6
, pp. 23763
-
-
Liu, Y.Q.1
Yuan, L.M.2
Gao, Z.Z.3
Xiao, Y.S.4
Sun, H.Y.5
Yu, L.S.6
-
58
-
-
33847027327
-
Comparative modelling of the human UDP-glucuronosyltransferases: insights into structure and mechanism
-
Locuson, C. W., and Tracy, T. S. (2007). Comparative modelling of the human UDP-glucuronosyltransferases: insights into structure and mechanism. Xenobiotica 37, 155-168. doi: 10.1080/00498250601129109
-
(2007)
Xenobiotica
, vol.37
, pp. 155-168
-
-
Locuson, C.W.1
Tracy, T.S.2
-
59
-
-
25144500468
-
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
-
Mackenzie, P. I., Bock, K. W., Burchell, B., Guillemette, C., Ikushiro, S. I., Iyanagi, T., et al. (2005). Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet. Genomics 15, 677-685. doi: 10.1097/01.fpc.0000173483.13689.56
-
(2005)
Pharmacogenet. Genomics
, vol.15
, pp. 677-685
-
-
Mackenzie, P.I.1
Bock, K.W.2
Burchell, B.3
Guillemette, C.4
Ikushiro, S.I.5
Iyanagi, T.6
-
60
-
-
8544224973
-
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence
-
Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., et al. (1997). The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenet Genomics 7, 255-269. doi: 10.1097/00008571-199708000-00001
-
(1997)
Pharmacogenet Genomics
, vol.7
, pp. 255-269
-
-
Mackenzie, P.I.1
Owens, I.S.2
Burchell, B.3
Bock, K.W.4
Bairoch, A.5
Belanger, A.6
-
61
-
-
8844224917
-
Effects of β-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9
-
Mano, Y., Usui, T., and Kamimura, H. (2004). Effects of β-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9. Biopharm. Drug Dispos. 25, 339-344. doi: 10.1002/bdd.418
-
(2004)
Biopharm. Drug Dispos.
, vol.25
, pp. 339-344
-
-
Mano, Y.1
Usui, T.2
Kamimura, H.3
-
62
-
-
0020287243
-
Isolation and characterization of rat liver microsomal UDP-glucuronosyltransferase activity toward chenodeoxycholic acid and testosterone as a single form of enzyme
-
Matern, H., Matern, S., and Gerok, W. (1982). Isolation and characterization of rat liver microsomal UDP-glucuronosyltransferase activity toward chenodeoxycholic acid and testosterone as a single form of enzyme. J. Biol. Chem. 257, 7422-7429.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 7422-7429
-
-
Matern, H.1
Matern, S.2
Gerok, W.3
-
63
-
-
0030846868
-
UDP-glucuronosyltransferase, the role of the amino terminus in dimerization
-
Meech, R., and Mackenzie, P. I. (1997). UDP-glucuronosyltransferase, the role of the amino terminus in dimerization. J. Biol. Chem. 272, 26913-26917. doi: 10.1074/jbc.272.43.26913
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 26913-26917
-
-
Meech, R.1
Mackenzie, P.I.2
-
64
-
-
80052722448
-
Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants
-
Ménard, V., Eap, O., Roberge, J., Harvey, M., Levesque, E., and Guillemette, C. (2011). Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants. Pharmacogenet. Genomics 21, 631-641. doi: 10.1097/FPC.0b013e3283498147
-
(2011)
Pharmacogenet. Genomics
, vol.21
, pp. 631-641
-
-
Ménard, V.1
Eap, O.2
Roberge, J.3
Harvey, M.4
Levesque, E.5
Guillemette, C.6
-
65
-
-
34247618754
-
Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7
-
Miley, M. J., Zielinska, A. K., Keenan, J. E., Bratton, S. M., Radominska-Pandya, A., and Redinbo, M. R. (2007). Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. J. Mol. Biol. 369, 498-511. doi: 10.1016/j.jmb.2007.03.066
-
(2007)
J. Mol. Biol.
, vol.369
, pp. 498-511
-
-
Miley, M.J.1
Zielinska, A.K.2
Keenan, J.E.3
Bratton, S.M.4
Radominska-Pandya, A.5
Redinbo, M.R.6
-
66
-
-
74549222703
-
The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potential
-
Miners, J. O., Mackenzie, P. I., and Knights, K. M. (2010). The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potential. Drug Metab. Rev. 42, 196-208. doi: 10.3109/03602530903210716
-
(2010)
Drug Metab. Rev.
, vol.42
, pp. 196-208
-
-
Miners, J.O.1
Mackenzie, P.I.2
Knights, K.M.3
-
67
-
-
84946560163
-
Suppression of cytochrome P450 3A4 function by UDP-glucuronosyltransferase 2B7 through a protein-protein interaction: cooperative roles of the cytosolic carboxyl-terminal domain and the luminal anchoring region
-
Miyauchi, Y., Nagata, K., Yamazoe, Y., Mackenzie, P. I., Yamada, H., and Ishii, Y. (2015). Suppression of cytochrome P450 3A4 function by UDP-glucuronosyltransferase 2B7 through a protein-protein interaction: cooperative roles of the cytosolic carboxyl-terminal domain and the luminal anchoring region. Mol. Pharmacol. 88, 800-812. doi: 10.1124/mol.115.098582
-
(2015)
Mol. Pharmacol.
, vol.88
, pp. 800-812
-
-
Miyauchi, Y.1
Nagata, K.2
Yamazoe, Y.3
Mackenzie, P.I.4
Yamada, H.5
Ishii, Y.6
-
68
-
-
67650591016
-
Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: a study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10
-
Mizuma, T. (2009). Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: a study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10. Int. J. Pharm. 378, 140-141. doi: 10.1016/j.ijpharm.2009.05.044
-
(2009)
Int. J. Pharm.
, vol.378
, pp. 140-141
-
-
Mizuma, T.1
-
69
-
-
80052638112
-
Transportsomes and channelsomes: are they functional units for physiological responses?
-
Mori, Y., Kiyonaka, S., and Kanai, Y. (2011). Transportsomes and channelsomes: are they functional units for physiological responses? Channels 5, 387-390. doi: 10.4161/chan.5.5.16466
-
(2011)
Channels
, vol.5
, pp. 387-390
-
-
Mori, Y.1
Kiyonaka, S.2
Kanai, Y.3
-
70
-
-
0041422391
-
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway
-
Mulichak, A. M., Losey, H. C., Lu, W., Wawrzak, Z., Walsh, C. T., and Garavito, R. M. (2003). Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. Proc. Natl. Acad. Sci. U.S.A. 100, 9238-9243. doi: 10.1073/pnas.1233577100
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 9238-9243
-
-
Mulichak, A.M.1
Losey, H.C.2
Lu, W.3
Wawrzak, Z.4
Walsh, C.T.5
Garavito, R.M.6
-
71
-
-
0035917894
-
Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity
-
Muraoka, M., Kawakita, M., and Ishida, N. (2001). Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity. FEBS Lett. 495, 87-93. doi: 10.1016/S0014-5793(01)02358-4
-
(2001)
FEBS Lett.
, vol.495
, pp. 87-93
-
-
Muraoka, M.1
Kawakita, M.2
Ishida, N.3
-
72
-
-
84940790979
-
Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective
-
Nair, P. C., Meech, R., Mackenzie, P. I., McKinnon, R. A., and Miners, J. O. (2015). Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective. Drug Metab. Rev. 47, 335-345. doi: 10.3109/03602532.2015.1071835
-
(2015)
Drug Metab. Rev.
, vol.47
, pp. 335-345
-
-
Nair, P.C.1
Meech, R.2
Mackenzie, P.I.3
McKinnon, R.A.4
Miners, J.O.5
-
73
-
-
34548055967
-
Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions
-
Nakajima, M., Yamanaka, H., Fujiwara, R., Katoh, M., and Yokoi, T. (2007). Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions. Drug Metab. Dispos. 35, 1679-1686. doi: 10.1124/dmd.107.015909
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 1679-1686
-
-
Nakajima, M.1
Yamanaka, H.2
Fujiwara, R.3
Katoh, M.4
Yokoi, T.5
-
74
-
-
47949110575
-
Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines
-
Nakamura, A., Nakajima, M., Yamanaka, H., Fujiwara, R., and Yokoi, T. (2008). Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab. Dispos. 36, 1461-1464. doi: 10.1124/dmd.108.021428
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 1461-1464
-
-
Nakamura, A.1
Nakajima, M.2
Yamanaka, H.3
Fujiwara, R.4
Yokoi, T.5
-
75
-
-
0037068964
-
Clinical importance of the cytochromes P450
-
Nebert, D. W., and Russell, D. W. (2002). Clinical importance of the cytochromes P450. Lancet 360, 1155-1162. doi: 10.1016/S0140-6736(02)11203-7
-
(2002)
Lancet
, vol.360
, pp. 1155-1162
-
-
Nebert, D.W.1
Russell, D.W.2
-
76
-
-
43149112558
-
Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease
-
Nguyen, N., Bonzo, J. A., Chen, S., Chouinard, S., Kelner, M. J., Hardiman, G., et al. (2008). Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J. Biol. Chem. 283, 7901-7911. doi: 10.1074/jbc. M709244200
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7901-7911
-
-
Nguyen, N.1
Bonzo, J.A.2
Chen, S.3
Chouinard, S.4
Kelner, M.J.5
Hardiman, G.6
-
77
-
-
84892984116
-
UDP-glucuronosyltransferase 2B15 (UGT2B15) is the major enzyme responsible for sipoglitazar glucuronidation in humans: Retrospective identification of the UGT isoform by in vitro analysis and the effect of UGT2B15* 2 mutation
-
Nishihara, M., Hiura, Y., Kawaguchi, N., Takahashi, J., and Asahi, S. (2013). UDP-glucuronosyltransferase 2B15 (UGT2B15) is the major enzyme responsible for sipoglitazar glucuronidation in humans: Retrospective identification of the UGT isoform by in vitro analysis and the effect of UGT2B15* 2 mutation. Drug Metab. Pharmacokinet. 28, 475-484. doi: 10.2133/dmpk. DMPK-13-RG-004
-
(2013)
Drug Metab. Pharmacokinet.
, vol.28
, pp. 475-484
-
-
Nishihara, M.1
Hiura, Y.2
Kawaguchi, N.3
Takahashi, J.4
Asahi, S.5
-
78
-
-
33645290775
-
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification
-
Offen, W., Martinez-Fleites, C., Yang, M., Kiat-Lim, E., Davis, B. G., Tarling, C. A., et al. (2006). Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification. EMBO J. 25, 1396-1405. doi: 10.1038/sj.emboj.7600970
-
(2006)
EMBO J.
, vol.25
, pp. 1396-1405
-
-
Offen, W.1
Martinez-Fleites, C.2
Yang, M.3
Kiat-Lim, E.4
Davis, B.G.5
Tarling, C.A.6
-
79
-
-
33947527347
-
Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo-and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation
-
Operaña, T. N., and Tukey, R. H. (2007). Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo-and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J. Biol. Chem. 282, 4821-4829. doi: 10.1074/jbc. M609417200
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 4821-4829
-
-
Operaña, T.N.1
Tukey, R.H.2
-
80
-
-
34548356391
-
The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site
-
Patana, A. S., Kurkela, M., Goldman, A., and Finel, M. (2007). The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site. Mol. Pharmacol. 72, 604-611. doi: 10.1124/mol.107.036871
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 604-611
-
-
Patana, A.S.1
Kurkela, M.2
Goldman, A.3
Finel, M.4
-
81
-
-
84859402733
-
Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemia
-
Peer, C. J., Sissung, T. M., Kim, A., Jain, L., Woo, S., Gardner, E. R., et al. (2012). Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemia. Clin. Cancer Res. 18, 2099-2107. doi: 10.1158/1078-0432.CCR-11-2484
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 2099-2107
-
-
Peer, C.J.1
Sissung, T.M.2
Kim, A.3
Jain, L.4
Woo, S.5
Gardner, E.R.6
-
82
-
-
0021133988
-
The molecular weights of UDP-glucuronyltransferase determined with radiation-inactivation analysis. A molecular model of bilirubin UDP-glucuronyltransferase
-
Peters, W. H., Jansen, P. L., and Nauta, H. (1984). The molecular weights of UDP-glucuronyltransferase determined with radiation-inactivation analysis. A molecular model of bilirubin UDP-glucuronyltransferase. J. Biol. Chem. 259, 11701-11705.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 11701-11705
-
-
Peters, W.H.1
Jansen, P.L.2
Nauta, H.3
-
83
-
-
84890735291
-
Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism
-
Rouleau, M., Roberge, J., Bellemare, J., and Guillemette, C. (2014). Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism. Mol. Pharmacol. 85, 29-36. doi: 10.1124/mol.113.089227
-
(2014)
Mol. Pharmacol.
, vol.85
, pp. 29-36
-
-
Rouleau, M.1
Roberge, J.2
Bellemare, J.3
Guillemette, C.4
-
84
-
-
33646784394
-
In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction
-
Rowland, A., Elliot, D. J., Williams, J. A., Mackenzie, P. I., Dickinson, R. G., and Miners, J. O. (2006). In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction. Drug Metab. Dispos. 34, 1055-1062.
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 1055-1062
-
-
Rowland, A.1
Elliot, D.J.2
Williams, J.A.3
Mackenzie, P.I.4
Dickinson, R.G.5
Miners, J.O.6
-
85
-
-
84898813968
-
Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry
-
Sato, Y., Nagata, M., Tetsuka, K., Tamura, K., Miyashita, A., Kawamura, A., et al. (2014). Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry. Drug Metab. Dispos. 42, 885-889. doi: 10.1124/dmd.113.056291
-
(2014)
Drug Metab. Dispos.
, vol.42
, pp. 885-889
-
-
Sato, Y.1
Nagata, M.2
Tetsuka, K.3
Tamura, K.4
Miyashita, A.5
Kawamura, A.6
-
86
-
-
0031800635
-
The mammalian carboxylesterases: from molecules to functions
-
Satoh, T., and Hosokawa, M. (1998). The mammalian carboxylesterases: from molecules to functions. Annu. Rev. Pharmacol. Toxicol. 38, 257-288. doi: 10.1146/annurev.pharmtox.38.1.257
-
(1998)
Annu. Rev. Pharmacol. Toxicol.
, vol.38
, pp. 257-288
-
-
Satoh, T.1
Hosokawa, M.2
-
87
-
-
84946601141
-
Statin lactonization by uridine 5'-diphospho-glucuronosyltransferases (UGTs)
-
Schirris, T. J., Ritschel, T., Bilos, A., Smeitink, J. A., and Russel, F. G. (2015). Statin lactonization by uridine 5'-diphospho-glucuronosyltransferases (UGTs). Mol. Pharm. 12, 4048-4055. doi: 10.1021/acs.molpharmaceut.5b00474
-
(2015)
Mol. Pharm.
, vol.12
, pp. 4048-4055
-
-
Schirris, T.J.1
Ritschel, T.2
Bilos, A.3
Smeitink, J.A.4
Russel, F.G.5
-
88
-
-
33645281589
-
Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula
-
Shao, H., He, X., Achnine, L., Blount, J. W., Dixon, R. A., and Wang, X. (2005). Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula. Plant Cell 17, 3141-3154. doi: 10.1105/tpc.105.035055
-
(2005)
Plant Cell
, vol.17
, pp. 3141-3154
-
-
Shao, H.1
He, X.2
Achnine, L.3
Blount, J.W.4
Dixon, R.A.5
Wang, X.6
-
89
-
-
84905408669
-
Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins
-
Shi, W. W., Jiang, Y. L., Zhu, F., Yang, Y. H., Shao, Q. Y., Yang, H. B., et al. (2014). Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J. Biol. Chem. 289, 20898-20907. doi: 10.1074/jbc. M114.581934
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 20898-20907
-
-
Shi, W.W.1
Jiang, Y.L.2
Zhu, F.3
Yang, Y.H.4
Shao, Q.Y.5
Yang, H.B.6
-
90
-
-
0242668347
-
Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity
-
Smith, P. A., Sorich, M. J., McKinnon, R. A., and Miners, J. O. (2003). Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity. J. Med. Chem. 46, 1617-1626. doi: 10.1021/jm020397c
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1617-1626
-
-
Smith, P.A.1
Sorich, M.J.2
McKinnon, R.A.3
Miners, J.O.4
-
91
-
-
73949103669
-
Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3
-
Sneitz, N., Court, M. H., Zhang, X., Laajanen, K., Yee, K. K., Dalton, P., et al. (2009). Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. Pharmacogenet. Genomics 19, 923-934. doi: 10.1097/FPC.0b013e3283330767
-
(2009)
Pharmacogenet. Genomics
, vol.19
, pp. 923-934
-
-
Sneitz, N.1
Court, M.H.2
Zhang, X.3
Laajanen, K.4
Yee, K.K.5
Dalton, P.6
-
92
-
-
84943582013
-
Inhibition of UDP-glucuronosyltransferases (UGTs) activity by constituents of Schisandra chinensis
-
Song, J. H., Cui, L., An, L. B., Li, W. T., Fang, Z. Z., Zhang, Y. Y., et al. (2015). Inhibition of UDP-glucuronosyltransferases (UGTs) activity by constituents of Schisandra chinensis. Phytother. Res. 29, 1658-1664. doi: 10.1002/ptr.5395
-
(2015)
Phytother. Res.
, vol.29
, pp. 1658-1664
-
-
Song, J.H.1
Cui, L.2
An, L.B.3
Li, W.T.4
Fang, Z.Z.5
Zhang, Y.Y.6
-
93
-
-
0030800075
-
Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
-
Strassburg, C. P., Oldhafer, K., Manns, M. P., and Tukey, R. H. (1997). Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol. Pharmacol. 52, 212-220.
-
(1997)
Mol. Pharmacol.
, vol.52
, pp. 212-220
-
-
Strassburg, C.P.1
Oldhafer, K.2
Manns, M.P.3
Tukey, R.H.4
-
94
-
-
84886067237
-
Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia
-
Sumida, K., Kawana, M., Kouno, E., Itoh, T., Takano, S., Narawa, T., et al. (2013). Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol. Pharmacol. 84, 679-686. doi: 10.1124/mol.113.088112
-
(2013)
Mol. Pharmacol.
, vol.84
, pp. 679-686
-
-
Sumida, K.1
Kawana, M.2
Kouno, E.3
Itoh, T.4
Takano, S.5
Narawa, T.6
-
95
-
-
14944354806
-
Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4
-
Takeda, S., Ishii, Y., Iwanaga, M., Mackenzie, P. I., Nagata, K., Yamazoe, Y., et al. (2005). Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. Mol. Pharmacol. 67, 665-672. doi: 10.1124/mol.104.007641
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 665-672
-
-
Takeda, S.1
Ishii, Y.2
Iwanaga, M.3
Mackenzie, P.I.4
Nagata, K.5
Yamazoe, Y.6
-
96
-
-
63849272821
-
Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction
-
Takeda, S., Ishii, Y., Iwanaga, M., Nurrochmad, A., Ito, Y., Mackenzie, P. I., et al. (2009). Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction. Mol. Pharmacol. 75, 956-964. doi: 10.1124/mol.108.052001
-
(2009)
Mol. Pharmacol.
, vol.75
, pp. 956-964
-
-
Takeda, S.1
Ishii, Y.2
Iwanaga, M.3
Nurrochmad, A.4
Ito, Y.5
Mackenzie, P.I.6
-
97
-
-
0034647835
-
Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase
-
Taura, K. I., Yamada, H., Hagino, Y., Ishii, Y., Mori, M. A., and Oguri, K. (2000). Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase. Biochem. Biophys. Res. Commun. 273, 1048-1052. doi: 10.1006/bbrc.2000.3076
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 1048-1052
-
-
Taura, K.I.1
Yamada, H.2
Hagino, Y.3
Ishii, Y.4
Mori, M.A.5
Oguri, K.6
-
98
-
-
84956834927
-
Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing
-
Tourancheau, A., Margaillan, G., Rouleau, M., Gilbert, I., Villeneuve, L., Lévesque, E., et al. (2016). Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing. Pharm. J. 16, 60-70. doi: 10.1038/tpj.2015.20
-
(2016)
Pharm. J.
, vol.16
, pp. 60-70
-
-
Tourancheau, A.1
Margaillan, G.2
Rouleau, M.3
Gilbert, I.4
Villeneuve, L.5
Lévesque, E.6
-
99
-
-
84943353279
-
Predicting substrate selectivity between UGT1A9 and UGT1A10 using molecular modelling and molecular dynamics approach
-
Tripathi, S. P., Prajapati, R., Verma, N., and Sangamwar, A. T. (2016). Predicting substrate selectivity between UGT1A9 and UGT1A10 using molecular modelling and molecular dynamics approach. Mol. Simul. 42, 270-288. doi: 10.1080/08927022.2015.1044451
-
(2016)
Mol. Simul.
, vol.42
, pp. 270-288
-
-
Tripathi, S.P.1
Prajapati, R.2
Verma, N.3
Sangamwar, A.T.4
-
100
-
-
0019478572
-
Purification of properties of rabbit liver estrone and p-nitrophenol UDP-glucuronyltransferases
-
Tukey, R. H., and Tephly, T. R. (1981). Purification of properties of rabbit liver estrone and p-nitrophenol UDP-glucuronyltransferases. Arch. Biochem. Biophys. 209, 565-578. doi: 10.1016/0003-9861(81)90314-3
-
(1981)
Arch. Biochem. Biophys.
, vol.209
, pp. 565-578
-
-
Tukey, R.H.1
Tephly, T.R.2
-
101
-
-
0037403749
-
Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics
-
Turgeon, D., Carrier, J. S., Chouinard, S., and Bélanger, A. (2003). Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics. Drug Metab. Dispos. 31, 670-676. doi: 10.1124/dmd.31.5.670
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 670-676
-
-
Turgeon, D.1
Carrier, J.S.2
Chouinard, S.3
Bélanger, A.4
-
102
-
-
0037404036
-
Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1
-
Watanabe, Y., Nakajima, M., Ohashi, N., Kume, T., and Yokoi, T. (2003). Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1. Drug Metab. Dispos. 31, 589-595. doi: 10.1124/dmd.31.5.589
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 589-595
-
-
Watanabe, Y.1
Nakajima, M.2
Ohashi, N.3
Kume, T.4
Yokoi, T.5
-
103
-
-
77949498141
-
Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase
-
Widmer, C. C., Pereira, C. P., Gehrig, P., Vallelian, F., Schoedon, G., Buehler, P. W., et al. (2010). Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase. Antioxid. Redox. Signal. 12, 185-198. doi: 10.1089/ars.2009.2826
-
(2010)
Antioxid. Redox. Signal.
, vol.12
, pp. 185-198
-
-
Widmer, C.C.1
Pereira, C.P.2
Gehrig, P.3
Vallelian, F.4
Schoedon, G.5
Buehler, P.W.6
-
104
-
-
6944221357
-
Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
-
Williams, J. A., Hyland, R., Jones, B. C., Smith, D. A., Hurst, S., Goosen, T. C., et al. (2004). Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab. Dispos. 32, 1201-1208. doi: 10.1124/dmd.104.000794
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1201-1208
-
-
Williams, J.A.1
Hyland, R.2
Jones, B.C.3
Smith, D.A.4
Hurst, S.5
Goosen, T.C.6
-
105
-
-
84862780693
-
Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches
-
Wu, B., Wang, X., Zhang, S., and Hu, M. (2012). Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches. Pharm. Res. 29, 1544-1561. doi: 10.1007/s11095-012-0666-z
-
(2012)
Pharm. Res.
, vol.29
, pp. 1544-1561
-
-
Wu, B.1
Wang, X.2
Zhang, S.3
Hu, M.4
-
106
-
-
33144483681
-
Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis
-
Xiong, Y., Bernardi, D., Bratton, S., Ward, M. D., Battaglia, E., Finel, M., et al. (2006). Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis. Biochemistry 45, 2322-2332. doi: 10.1021/bi0519001
-
(2006)
Biochemistry
, vol.45
, pp. 2322-2332
-
-
Xiong, Y.1
Bernardi, D.2
Bratton, S.3
Ward, M.D.4
Battaglia, E.5
Finel, M.6
-
107
-
-
84946230342
-
Chiral inhibition of rivaroxaban derivatives towards UDP-glucuronosyltransferase (UGT) isoforms
-
Yao, Z., Liu, Y. Z., Ma, A. L., Wang, S. F., Lu, D., Hu, C. M., et al. (2015). Chiral inhibition of rivaroxaban derivatives towards UDP-glucuronosyltransferase (UGT) isoforms. Chirality 27, 936-943. doi: 10.1002/chir.22505
-
(2015)
Chirality
, vol.27
, pp. 936-943
-
-
Yao, Z.1
Liu, Y.Z.2
Ma, A.L.3
Wang, S.F.4
Lu, D.5
Hu, C.M.6
-
108
-
-
84930921828
-
Homo-and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity
-
Yuan, L., Qian, S., Xiao, Y., Sun, H., and Zeng, S. (2015). Homo-and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity. Biochem. Pharmacol. 95, 58-70. doi: 10.1016/j.bcp.2015.03.002
-
(2015)
Biochem. Pharmacol.
, vol.95
, pp. 58-70
-
-
Yuan, L.1
Qian, S.2
Xiao, Y.3
Sun, H.4
Zeng, S.5
-
109
-
-
84954039605
-
Strong specific inhibition of UDP-glucuronosyltransferase 2B7 by atractylenolide I and III
-
Zhang, Q., Cao, Y. F., Ran, R. X., Li, R. S., Wu, X., Dong, P. P., et al. (2016). Strong specific inhibition of UDP-glucuronosyltransferase 2B7 by atractylenolide I and III. Phytother. Res. 30, 25-30. doi: 10.1002/ptr.5496
-
(2016)
Phytother. Res.
, vol.30
, pp. 25-30
-
-
Zhang, Q.1
Cao, Y.F.2
Ran, R.X.3
Li, R.S.4
Wu, X.5
Dong, P.P.6
|