Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

Journal of Biological Chemistry

Volumn 285, Issue 6, 2010, Pages 3600-3607

  Bellemare, Judith ^a   Rouleau, Mélanie ^a   Harvey, Mario ^a   Guillemette, Chantal ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR RESPONSE; CO-EXPRESSION; CO-IMMUNOPRECIPITATION EXPERIMENTS; CO-SUBSTRATE; COMPETITIVE BINDING; GLUCURONIDATION; GLUCURONIDES; HEK293 CELLS; HETEROLOGOUS SYSTEMS; HUMAN TISSUES; IN-DEPTH INVESTIGATION; INDUCIBLE SYSTEMS; ISOFORMS; MOLECULAR MECHANISM; PROTEIN-PROTEIN INTERACTIONS; REGULATORY EFFECTS; REGULATORY MECHANISM; RELATIVE ABUNDANCE; UDP-GLUCURONIC ACID;

COMPLEXATION; GLUCOSE; PROTEINS;

SUBSTRATES;

GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE 1A; GLUCURONOSYLTRANSFERASE 1A I1; GLUCURONOSYLTRANSFERASE 1A I2; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLYCOSYLTRANSFERASE; POLYPEPTIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; BILIRUBIN URIDINE DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; BILIRUBIN URIDINE-DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; ECDYSONE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; ISOENZYME; PEPTIDE; UDP GLUCURONOSYLTRANSFERASE, UGT1A8; UDP-GLUCURONOSYLTRANSFERASE, UGT1A8; UGT1A7 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CELLULAR IMMUNITY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME KINETICS; ENZYME REGULATION; GLUCURONIDATION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INHIBITION KINETICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; CELL LINE; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; IMMUNOPRECIPITATION; KINETICS; METABOLISM; PROTEIN BINDING; PROTEIN MULTIMERIZATION; WESTERN BLOTTING;

ALTERNATIVE SPLICING; BLOTTING, WESTERN; CELL LINE; ECDYSONE; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNOPRECIPITATION; ISOENZYMES; KINETICS; PEPTIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 77950501858     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.083139     Document Type: Article

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