메뉴 건너뛰기




Volumn 37, Issue 8, 2009, Pages 1759-1768

Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A5; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B10; GLUCURONOSYLTRANSFERASE 2B11; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B17; GLUCURONOSYLTRANSFERASE 2B28; GLUCURONOSYLTRANSFERASE 2B4; GLUCURONOSYLTRANSFERASE 2B7; GLYCERALDEHYDE 3 PHOSPHATE; MESSENGER RNA; OXIDOREDUCTASE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

EID: 67650821911     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027227     Document Type: Article
Times cited : (199)

References (36)
  • 1
    • 38449087463 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers
    • Aueviriyavit S, Furihata T, Morimoto K, Kobayashi K, and Chiba K (2007) Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers. Drug Metab Pharmacokinet 22:391-398.
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 391-398
    • Aueviriyavit, S.1    Furihata, T.2    Morimoto, K.3    Kobayashi, K.4    Chiba, K.5
  • 3
    • 0344784391 scopus 로고    scopus 로고
    • Isolation and characterization of human orphan UDP-glucuronosyltransferase, UGT2B11
    • Beaulieu M, Lévesque E, Hum DW, and Bélanger A (1998) Isolation and characterization of human orphan UDP-glucuronosyltransferase, UGT2B11. Biochem Biophys Res Commun 248:44-50.
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 44-50
    • Beaulieu, M.1    Lévesque, E.2    Hum, D.W.3    Bélanger, A.4
  • 4
    • 0032817021 scopus 로고    scopus 로고
    • Activation of the mouse TATA-less and human TATA-containing UDP- glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1
    • Bernard P, Goudonnet H, Artur Y, Desvergne B, and Wahli W (1999) Activation of the mouse TATA-less and human TATA-containing UDP- glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1. Mol Pharmacol 56:526-536.
    • (1999) Mol Pharmacol , vol.56 , pp. 526-536
    • Bernard, P.1    Goudonnet, H.2    Artur, Y.3    Desvergne, B.4    Wahli, W.5
  • 6
    • 50449083633 scopus 로고    scopus 로고
    • Novel polymorphic human UDP-glucuronosyltransferase 2A3: Cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction
    • Court MH, Hazarika S, Krishnaswamy S, Finel M, and Williams JA (2008) Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. Mol Pharmacol 74:744-754.
    • (2008) Mol Pharmacol , vol.74 , pp. 744-754
    • Court, M.H.1    Hazarika, S.2    Krishnaswamy, S.3    Finel, M.4    Williams, J.A.5
  • 9
    • 0035209568 scopus 로고    scopus 로고
    • The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism
    • Fisher MB, Paine MF, Strelevitz TJ, and Wrighton SA (2001) The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism. Drug Metab Rev 33:273-297.
    • (2001) Drug Metab Rev , vol.33 , pp. 273-297
    • Fisher, M.B.1    Paine, M.F.2    Strelevitz, T.J.3    Wrighton, S.A.4
  • 11
    • 33846691233 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4α
    • Gardner-Stephen DA and Mackenzie PI (2007) Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4α. Pharmacogenet Genomics 17:25-36.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 25-36
    • Gardner-Stephen, D.A.1    Mackenzie, P.I.2
  • 13
    • 1842480998 scopus 로고    scopus 로고
    • Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1αand the caudal-related homeodomain protein 2
    • Gregory PA, Lewinsky RH, Gardner-Stephen DA, and Mackenzie PI (2004) Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1αand the caudal-related homeodomain protein 2. Mol Pharmacol 65:953-963.
    • (2004) Mol Pharmacol , vol.65 , pp. 953-963
    • Gregory, P.A.1    Lewinsky, R.H.2    Gardner-Stephen, D.A.3    Mackenzie, P.I.4
  • 15
    • 33645995117 scopus 로고    scopus 로고
    • Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms
    • Ikushiro S, Emi Y, Kato Y, Yamada S, and Sakaki T (2006) Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms. Drug Metab Pharmacokinet 21:70-74.
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 70-74
    • Ikushiro, S.1    Emi, Y.2    Kato, Y.3    Yamada, S.4    Sakaki, T.5
  • 16
    • 0034057412 scopus 로고    scopus 로고
    • Octamer transcription factor-1 enhances hepatic nuclear factor-1α-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter
    • Ishii Y, Hansen AJ, and Mackenzie PI (2000) Octamer transcription factor-1 enhances hepatic nuclear factor-1α-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter. Mol Pharmacol 57:940-947.
    • (2000) Mol Pharmacol , vol.57 , pp. 940-947
    • Ishii, Y.1    Hansen, A.J.2    Mackenzie, P.I.3
  • 17
    • 63849180294 scopus 로고    scopus 로고
    • Dopamine is a low affinity and high specificity substrate for the human UDP-glucuronosyltransferase 1A10
    • Itäaho K, Court MH, Uutela P, Kostiainen R, Radominska-Pandya A, and Finel M (2009) Dopamine is a low affinity and high specificity substrate for the human UDP-glucuronosyltransferase 1A10. Drug Metab Dispos 37:768-775.
    • (2009) Drug Metab Dispos , vol.37 , pp. 768-775
    • Itäaho, K.1    Court, M.H.2    Uutela, P.3    Kostiainen, R.4    Radominska-Pandya, A.5    Finel, M.6
  • 19
    • 40949134240 scopus 로고    scopus 로고
    • Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate
    • Karypidis AH, Olsson M, Andersson SO, Rane A, and Ekström L (2008) Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate. Pharmacogenomics J 8:147-151.
    • (2008) Pharmacogenomics J , vol.8 , pp. 147-151
    • Karypidis, A.H.1    Olsson, M.2    Andersson, S.O.3    Rane, A.4    Ekström, L.5
  • 20
    • 19444377994 scopus 로고    scopus 로고
    • UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5′-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation
    • Krishnaswamy S, Hao Q, Al-Rohaimi A, Hesse LM, von Moltke LL, Greenblatt DJ, and Court MH (2005) UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5′-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation. J Pharmacol Exp Ther 313:1331-1339.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 1331-1339
    • Krishnaswamy, S.1    Hao, Q.2    Al-Rohaimi, A.3    Hesse, L.M.4    von Moltke, L.L.5    Greenblatt, D.J.6    Court, M.H.7
  • 22
    • 55749116357 scopus 로고    scopus 로고
    • Genetic polymorphisms in the 5′-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation
    • Nakamura A, Nakajima M, Higashi E, Yamanaka H, and Yokoi T (2008a) Genetic polymorphisms in the 5′-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation. Pharmacogenet Genomics 18:709-720.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 709-720
    • Nakamura, A.1    Nakajima, M.2    Higashi, E.3    Yamanaka, H.4    Yokoi, T.5
  • 23
    • 47949110575 scopus 로고    scopus 로고
    • Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines
    • Nakamura A, Nakajima M, Yamanaka H, Fujiwara R, and Yokoi T (2008b) Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab Dispos 36:1461-1464.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1461-1464
    • Nakamura, A.1    Nakajima, M.2    Yamanaka, H.3    Fujiwara, R.4    Yokoi, T.5
  • 24
    • 58149467072 scopus 로고    scopus 로고
    • Determination of mRNA expression of human UGTs and application for localization in various human tissues by real time RT-PCR
    • Ohno S and Nakajin S (2009) Determination of mRNA expression of human UGTs and application for localization in various human tissues by real time RT-PCR. Drug Metab Dispos 37:32-40.
    • (2009) Drug Metab Dispos , vol.37 , pp. 32-40
    • Ohno, S.1    Nakajin, S.2
  • 25
    • 40949130482 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver
    • Ramírez J, Mirkov S, Zhang W, Chen P, Das S, Liu W, Ratain MJ, and Innocenti F (2008) Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver. Pharmacogenomics J 8:152-161.
    • (2008) Pharmacogenomics J , vol.8 , pp. 152-161
    • Ramírez, J.1    Mirkov, S.2    Zhang, W.3    Chen, P.4    Das, S.5    Liu, W.6    Ratain, M.J.7    Innocenti, F.8
  • 26
    • 0034680792 scopus 로고    scopus 로고
    • Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
    • Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, and Manns MP (2000) Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 275:36164-36171.
    • (2000) J Biol Chem , vol.275 , pp. 36164-36171
    • Strassburg, C.P.1    Kneip, S.2    Topp, J.3    Obermayer-Straub, P.4    Barut, A.5    Tukey, R.H.6    Manns, M.P.7
  • 27
    • 0030790857 scopus 로고    scopus 로고
    • Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer
    • Strassburg CP, Manns MP, and Tukey RH (1997a) Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Cancer Res 57:2979-2985.
    • (1997) Cancer Res , vol.57 , pp. 2979-2985
    • Strassburg, C.P.1    Manns, M.P.2    Tukey, R.H.3
  • 28
    • 0030800075 scopus 로고    scopus 로고
    • Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: Identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
    • Strassburg CP, Oldhafer K, Manns MP, and Tukey RH (1997b) Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol 52:212-220.
    • (1997) Mol Pharmacol , vol.52 , pp. 212-220
    • Strassburg, C.P.1    Oldhafer, K.2    Manns, M.P.3    Tukey, R.H.4
  • 30
    • 3042544338 scopus 로고    scopus 로고
    • Bioactivation of capecitabine in human liver: Involvement of the cytosolic enzyme on 5′-deoxy-5-fluorocytidine formation
    • Tabata T, Katoh M, Tokudome S, Hosakawa M, Chiba K, Nakajima M, and Yokoi T (2004) Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5′-deoxy-5-fluorocytidine formation. Drug Metab Dispos 32:762-767.
    • (2004) Drug Metab Dispos , vol.32 , pp. 762-767
    • Tabata, T.1    Katoh, M.2    Tokudome, S.3    Hosakawa, M.4    Chiba, K.5    Nakajima, M.6    Yokoi, T.7
  • 31
    • 0035115599 scopus 로고    scopus 로고
    • Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
    • Tukey RH and Strassburg CP (2001) Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 59:405-414.
    • (2001) Mol Pharmacol , vol.59 , pp. 405-414
    • Tukey, R.H.1    Strassburg, C.P.2
  • 32
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • Tukey RH and Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581-616.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 35
    • 0036204296 scopus 로고    scopus 로고
    • Glucuronidation: An important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues
    • Zheng Z, Fang JL, and Lazarus P (2002) Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. Drug Metab Dispos 30:397-403.
    • (2002) Drug Metab Dispos , vol.30 , pp. 397-403
    • Zheng, Z.1    Fang, J.L.2    Lazarus, P.3
  • 36
    • 23144464155 scopus 로고    scopus 로고
    • Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyltransferases
    • Zhou J, Zhang J, and Xie W (2005) Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyltransferases. Curr Drug Metab 6:289-298.
    • (2005) Curr Drug Metab , vol.6 , pp. 289-298
    • Zhou, J.1    Zhang, J.2    Xie, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.