-
1
-
-
84925018693
-
A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
-
Oda, S., Fukami, T., Yokoi, T. & Nakajima, M. A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metab. Pharmacok. 30, 30-51 (2015).
-
(2015)
Drug Metab. Pharmacok
, vol.30
, pp. 30-51
-
-
Oda, S.1
Fukami, T.2
Yokoi, T.3
Nakajima, M.4
-
2
-
-
33847358669
-
UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: Structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics
-
Wen, Z., Tallman, M. N., Ali, S. Y. & Smith, P. C. UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab. Dispos. 35, 371-380 (2007).
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 371-380
-
-
Wen, Z.1
Tallman, M.N.2
Ali, S.Y.3
Smith, P.C.4
-
3
-
-
0036765343
-
Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity
-
Tukey, R. H., Strassburg, C. P. & Mackenzie, P. I. Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity. Mol Pharmacol 62, 446-450 (2002).
-
(2002)
Mol Pharmacol
, vol.62
, pp. 446-450
-
-
Tukey, R.H.1
Strassburg, C.P.2
Mackenzie, P.I.3
-
4
-
-
3242695875
-
The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants
-
Bernard, O. & Guillemette, C. The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants. Drug Metab. Dispos. 32, 775-778 (2004).
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 775-778
-
-
Bernard, O.1
Guillemette, C.2
-
5
-
-
0025136702
-
Chromosomal mapping of a human phenol UDPglucuronosyltransferase
-
Harding, D., Jeremiah Sj Fau-Povey, S., Povey S Fau-Burchell, B. & Burchell, B. Chromosomal mapping of a human phenol UDPglucuronosyltransferase, GNT1. Ann. Hum. Genet. 54, 17-21 (1990).
-
(1990)
GNT1. Ann. Hum. Genet
, vol.54
, pp. 17-21
-
-
Harding, D.1
Jeremiah Sj Fau-Povey, S.2
Povey Fau-Burchell S, B.3
Burchell, B.4
-
6
-
-
0026668559
-
Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type i
-
Bosma, P. J. et al. Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I. FASEB J. 6, 2859-2863 (1992).
-
(1992)
FASEB J
, vol.6
, pp. 2859-2863
-
-
Bosma, P.J.1
-
7
-
-
0036332675
-
Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer
-
Vogel, A. et al. Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer. Z. Gastroenterol. 40, 497-502 (2002).
-
(2002)
Z. Gastroenterol
, vol.40
, pp. 497-502
-
-
Vogel, A.1
-
8
-
-
0037223551
-
Genetic variation of human UDP-glucuronosyltransferase: Implications in disease and drug glucuronidation
-
Burchell, B. Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation. Am. J. Pharmacogenomics 3, 37-52 (2003).
-
(2003)
Am. J. Pharmacogenomics
, vol.3
, pp. 37-52
-
-
Burchell, B.1
-
9
-
-
84866619971
-
Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients
-
Chu, X. M. et al. Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients. Eur. J. Clin. Pharmacol. 68, 1395-1401 (2012).
-
(2012)
Eur. J. Clin. Pharmacol
, vol.68
, pp. 1395-1401
-
-
Chu, X.M.1
-
10
-
-
33846442350
-
Regulation of the UGT1A1 bilirubin-conjugating pathway: Role of a new splicing event at the UGT1A locus
-
Lévesque, E., Girard, H., Journault, K., Lépine, J. & G., C. Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus. Hepatology 45, 128-138 (2007).
-
(2007)
Hepatology
, vol.45
, pp. 128-138
-
-
Lévesque, E.1
Girard, H.2
Journault, K.3
Lépine, J.4
G, C.5
-
11
-
-
80255122759
-
Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen
-
Wang, H., Yuan, L. & Zeng, S. Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen. Biochem. Pharmacol. 82, 1757-1763 (2011).
-
(2011)
Biochem. Pharmacol
, vol.82
, pp. 1757-1763
-
-
Wang, H.1
Yuan, L.2
Zeng, S.3
-
12
-
-
0141519502
-
Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10- hydroxycamptothecin and Flavopiridol Anticancer Drugs
-
Villeneuve, L., Girard, H., Fortier, L. C., Gagné, J. F. & G., C. Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10- hydroxycamptothecin and Flavopiridol Anticancer Drugs. J. Pharmacol. Exp. Ther. 307, 117-128 (2003).
-
(2003)
J. Pharmacol. Exp. Ther
, vol.307
, pp. 117-128
-
-
Villeneuve, L.1
Girard, H.2
Fortier, L.C.3
Gagné, J.F.4
G, C.5
-
13
-
-
0037960948
-
Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients
-
Jinno, H. et al. Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients. J. Pharmacol. Exp. Ther. 306, 688-693 (2003).
-
(2003)
J. Pharmacol. Exp. Ther
, vol.306
, pp. 688-693
-
-
Jinno, H.1
-
14
-
-
70349294431
-
Functional Characterization of Low-Prevalence Missense Polymorphisms in the UDP-Glucuronosyltransferase 1A9 Gene
-
Olson, K. C. et al. Functional Characterization of Low-Prevalence Missense Polymorphisms in the UDP-Glucuronosyltransferase 1A9 Gene. Drug Metab. Dispos. 37, 1999-2007 (2009).
-
(2009)
Drug Metab. Dispos
, vol.37
, pp. 1999-2007
-
-
Olson, K.C.1
-
15
-
-
30344456999
-
Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDPglucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters
-
Chen, Y. K., Chen, S., Li, X. & Zeng, S. Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDPglucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters. Xenobiotica 35, 943-954 (2005).
-
(2005)
Xenobiotica
, vol.35
, pp. 943-954
-
-
Chen, Y.K.1
Chen, S.2
Li, X.3
Zeng, S.4
-
16
-
-
33747847155
-
Genetic variants of human UGT1A3: Functional characterization and frequency distribution in a Chinese Han population
-
Chen, Y. K., Chen, S. Q., Li, X., Wang, X. & Zeng, S. Genetic variants of human UGT1A3: functional characterization and frequency distribution in a Chinese Han population. Drug Metab. Dispos. 34, 1462-1467 (2006).
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 1462-1467
-
-
Chen, Y.K.1
Chen, S.Q.2
Li, X.3
Wang, X.4
Zeng, S.5
-
17
-
-
0035834673
-
Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications
-
Ghosh, S. S. et al. Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications. J. Biol. Chem. 276, 42108-42115 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 42108-42115
-
-
Ghosh, S.S.1
-
18
-
-
0037423299
-
Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme
-
Kurkela, M. et al. Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme. J. Biol. Chem. 278, 3536-3544 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 3536-3544
-
-
Kurkela, M.1
-
19
-
-
33947527347
-
Oligomerization of the UDP-glucuronosyltransferase 1A proteins: Homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation
-
Operaña, T. N. & Tukey, R. H. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J. Biol. Chem. 282, 4821-4829 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 4821-4829
-
-
Operaña, T.N.1
Tukey, R.H.2
-
20
-
-
34247379533
-
Effects of Coexpression of UGT1A9 on Enzymatic Activities of Human UGT1A Isoforms
-
Fujiwara, R. et al. Effects of Coexpression of UGT1A9 on Enzymatic Activities of Human UGT1A Isoforms. Drug Metab.d Dispos. 35, 747-757 (2007).
-
(2007)
Drug Metab.d Dispos
, vol.35
, pp. 747-757
-
-
Fujiwara, R.1
-
21
-
-
34548097015
-
Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities
-
Fujiwara, R., Nakajima, M., Yamanaka, H., Katoh, M. & Y., T. Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities. Drug Metab.d Dispos. 35, 1781-1787 (2007).
-
(2007)
Drug Metab.d Dispos
, vol.35
, pp. 1781-1787
-
-
Fujiwara, R.1
Nakajima, M.2
Yamanaka, H.3
Katoh, M.4
Y, T.5
-
22
-
-
84871219252
-
Comprehensive Analysis of UGT1A1 Genetic Polymorphisms in Chinese Tibetan and Han Populations
-
Zhang, X., Meng, X., Wang, Y., Yan, W. & Yang, J. Comprehensive Analysis of UGT1A1 Genetic Polymorphisms in Chinese Tibetan and Han Populations. Biochem. Genet. 50, 967-977 (2012).
-
(2012)
Biochem. Genet
, vol.50
, pp. 967-977
-
-
Zhang, X.1
Meng, X.2
Wang, Y.3
Yan, W.4
Yang, J.5
-
23
-
-
2942527225
-
UGT1A1 Haplotypes Associated with Reduced Glucuronidation and Increased Serum Bilirubin in Irinotecanadministered Japanese Patients with Cancer
-
Sai, K. et al. UGT1A1 Haplotypes Associated with Reduced Glucuronidation and Increased Serum Bilirubin in Irinotecanadministered Japanese Patients with Cancer. Clin. Pharmacol. Ther. 75, 501-515 (2004).
-
(2004)
Clin. Pharmacol. Ther
, vol.75
, pp. 501-515
-
-
Sai, K.1
-
24
-
-
59749087186
-
Close Association of UGT1A9 IVS1 + 399C > T with UGT1A1∗28,∗ 6, or∗60 Haplotype and Its Apparent Influence on 7-Ethyl-10-hydroxycamptothecin (SN-38) Glucuronidation in Japanese
-
Saito, Y. et al. Close Association of UGT1A9 IVS1 + 399C > T with UGT1A1∗28,∗6, or∗60 Haplotype and Its Apparent Influence on 7-Ethyl-10-hydroxycamptothecin (SN-38) Glucuronidation in Japanese. Drug Metab.d Dispos. 37, 272-276 (2009).
-
(2009)
Drug Metab.d Dispos
, vol.37
, pp. 272-276
-
-
Saito, Y.1
-
25
-
-
84910076472
-
Molecular dynamics simulation of configurational ensembles compatible with experimental FRET efficiency data through a restraint on instantaneous FRET efficiencies
-
Reif, M. M. & Oostenbrink, C. Molecular dynamics simulation of configurational ensembles compatible with experimental FRET efficiency data through a restraint on instantaneous FRET efficiencies. J. Comp. Chem. 35, 2319-2332 (2014).
-
(2014)
J. Comp. Chem
, vol.35
, pp. 2319-2332
-
-
Reif, M.M.1
Oostenbrink, C.2
-
26
-
-
0028884014
-
Fluorescence resonance energy transfer spectroscopy is a reliable "ruler" for measuring structural changes in proteins. Dispelling the problem of the unknown orientation factor
-
dos Remedios, C. G. & Moens, P. D. Fluorescence resonance energy transfer spectroscopy is a reliable "ruler" for measuring structural changes in proteins. Dispelling the problem of the unknown orientation factor. J. Struct. Biol. 115, 175-185 (1995).
-
(1995)
J. Struct. Biol
, vol.115
, pp. 175-185
-
-
Dos Remedios, C.G.1
Moens, P.D.2
-
27
-
-
84893484061
-
Kinetics of fast changing intramolecular distance distributions obtained by combined analysis of FRET efficiency kinetics and time-resolved FRET equilibrium measurements
-
Lerner, E., Orevi, T., Ben Ishay, E., Amir, D. & Haas, E. Kinetics of fast changing intramolecular distance distributions obtained by combined analysis of FRET efficiency kinetics and time-resolved FRET equilibrium measurements. Biophys. J. 106, 667-676 (2014).
-
(2014)
Biophys. J
, vol.106
, pp. 667-676
-
-
Lerner, E.1
Orevi, T.2
Ben Ishay, E.3
Amir, D.4
Haas, E.5
-
28
-
-
84897800778
-
Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints
-
Jayasundar, J. J., Xing, J., Robinson, J. M., Cheung, H. C. & Dong, W. J. Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints. PloS one 9, e87135 (2014).
-
(2014)
PloS One
, vol.9
-
-
Jayasundar, J.J.1
Xing, J.2
Robinson, J.M.3
Cheung, H.C.4
Dong, W.J.5
-
29
-
-
84863151462
-
Determination of cellulase colocalization on cellulose fiber with quantitative FRET measured by acceptor photobleaching and spectrally unmixing fluorescence microscopy
-
Wang, L., Wang, Y. & Ragauskas, A. J. Determination of cellulase colocalization on cellulose fiber with quantitative FRET measured by acceptor photobleaching and spectrally unmixing fluorescence microscopy. Analyst 137, 1319-1324 (2012).
-
(2012)
Analyst
, vol.137
, pp. 1319-1324
-
-
Wang, L.1
Wang, Y.2
Ragauskas, A.J.3
-
30
-
-
84921901073
-
A structural mechanism for calcium transporter headpiece closure
-
Smolin, N. & Robia, S. L. A structural mechanism for calcium transporter headpiece closure. J. Phys. chem. B 119, 1407-1415 (2015).
-
(2015)
J. Phys. Chem. B
, vol.119
, pp. 1407-1415
-
-
Smolin, N.1
Robia, S.L.2
-
31
-
-
78650592884
-
Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drugmetabolizing tissues in humans
-
Bellemare, J. et al. Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drugmetabolizing tissues in humans. J. Pathol. 223, 425-435 (2011).
-
(2011)
J. Pathol
, vol.223
, pp. 425-435
-
-
Bellemare, J.1
-
32
-
-
73949088338
-
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes
-
Fujiwara, R. et al. Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes. J. Pharm. Sci. 99, 442-454 (2010).
-
(2010)
J. Pharm. Sci
, vol.99
, pp. 442-454
-
-
Fujiwara, R.1
-
33
-
-
84930921828
-
Homo-and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity
-
Yuan, L., Qian, S., Xiao, Y., Sun, H. & Z., S. Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity. Biochem. Pharmacol. 95, 58-70 (2015).
-
(2015)
Biochem. Pharmacol
, vol.95
, pp. 58-70
-
-
Yuan, L.1
Qian, S.2
Xiao, Y.3
Sun, H.4
Z, S.5
-
34
-
-
77952349321
-
A Molecular Model of the Human UDP-Glucuronosyltransferase 1A1, Its Membrane Orientation, and the Interactions between Different Parts of the Enzyme
-
Laakkonen, L. & Finel, M. A Molecular Model of the Human UDP-Glucuronosyltransferase 1A1, Its Membrane Orientation, and the Interactions between Different Parts of the Enzyme. Mol. Pharmacol. 77, 931-939 (2010).
-
(2010)
Mol. Pharmacol
, vol.77
, pp. 931-939
-
-
Laakkonen, L.1
Finel, M.2
-
35
-
-
84868504292
-
Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity
-
Korprasertthaworn, P. et al. Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity. Biochem. Pharmacol. 84, 1511-1521 (2012).
-
(2012)
Biochem. Pharmacol
, vol.84
, pp. 1511-1521
-
-
Korprasertthaworn, P.1
-
36
-
-
33645120407
-
Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer
-
Nagar, S. & Remmel, R. P. Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer. Oncogene 25, 1659-1672 (2000).
-
(2000)
Oncogene
, vol.25
, pp. 1659-1672
-
-
Nagar, S.1
Remmel, R.P.2
-
38
-
-
0034105896
-
In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model
-
Houston, J. B. & Kenworthy, K. E. In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model. Drug Metab. Dispos. 28, 246-254 (2000).
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 246-254
-
-
Houston, J.B.1
Kenworthy, K.E.2
|