메뉴 건너뛰기




Volumn 142, Issue 1, 2012, Pages

Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia

Author keywords

Gene Regulation; Mouse Model; Neonatal Jaundice; Nursing

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; GLUCURONOSYLTRANSFERASE 1A1; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PREGNANE X RECEPTOR;

EID: 83755172199     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.09.045     Document Type: Article
Times cited : (51)

References (50)
  • 1
    • 35748974401 scopus 로고    scopus 로고
    • Hyperbilirubinemia and bilirubin toxicity in the late preterm infant
    • J.F. Watchko Hyperbilirubinemia and bilirubin toxicity in the late preterm infant Clin Perinatol 33 2006 839 852
    • (2006) Clin Perinatol , vol.33 , pp. 839-852
    • Watchko, J.F.1
  • 2
    • 46049098575 scopus 로고    scopus 로고
    • Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants > or = 35 weeks gestation
    • V.K. Bhutani, M.J. Maisels, A.R. Stark Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants > or = 35 weeks gestation Neonatology 94 2008 63 67
    • (2008) Neonatology , vol.94 , pp. 63-67
    • Bhutani, V.K.1    Maisels, M.J.2    Stark, A.R.3
  • 3
    • 38049064898 scopus 로고    scopus 로고
    • A comparison of alternative risk-assessment strategies for predicting significant neonatal hyperbilirubinemia in term and near-term infants
    • R. Keren, X. Luan, S. Friedman A comparison of alternative risk-assessment strategies for predicting significant neonatal hyperbilirubinemia in term and near-term infants Pediatrics 121 2008 e170 e179
    • (2008) Pediatrics , vol.121
    • Keren, R.1    Luan, X.2    Friedman, S.3
  • 4
    • 0018249119 scopus 로고
    • Bilirubin UDP-glucuronyltransferase activity in human fetal liver homogenates
    • I. Grimmer, R. Moller, D. Gmyrek Bilirubin UDP-glucuronyltransferase activity in human fetal liver homogenates Acta Biol Med Ger 37 1978 131 135
    • (1978) Acta Biol Med Ger , vol.37 , pp. 131-135
    • Grimmer, I.1    Moller, R.2    Gmyrek, D.3
  • 5
    • 0019860388 scopus 로고
    • The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver
    • N. Kawade, S. Onishi The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver Biochem J 196 1981 257 260
    • (1981) Biochem J , vol.196 , pp. 257-260
    • Kawade, N.1    Onishi, S.2
  • 6
    • 0028276410 scopus 로고
    • Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
    • P.J. Bosma, J. Seppen, B. Goldhoorn Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man J Biol Chem 269 1994 17960 17964
    • (1994) J Biol Chem , vol.269 , pp. 17960-17964
    • Bosma, P.J.1    Seppen, J.2    Goldhoorn, B.3
  • 7
    • 0017387087 scopus 로고
    • Enzymatic conversion of bilirubin monoglucuronide to diglucuronide by rat liver plasma membranes
    • P.L.M. Jansen, J.R. Chowdhury, E.B. Fischberg Enzymatic conversion of bilirubin monoglucuronide to diglucuronide by rat liver plasma membranes J Biol Chem 252 1977 2710 2716
    • (1977) J Biol Chem , vol.252 , pp. 2710-2716
    • Jansen, P.L.M.1    Chowdhury, J.R.2    Fischberg, E.B.3
  • 8
    • 18544409633 scopus 로고    scopus 로고
    • Imbalance between production and conjugation of bilirubin: A fundamental concept in the mechanism of neonatal jaundice
    • M. Kaplan, M. Muraca, C. Hammerman Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice Pediatrics 110 2002 e47
    • (2002) Pediatrics , vol.110 , pp. 47
    • Kaplan, M.1    Muraca, M.2    Hammerman, C.3
  • 9
    • 0346995454 scopus 로고    scopus 로고
    • Bilirubin toxicity in the developing nervous system
    • S.M. Shapiro Bilirubin toxicity in the developing nervous system Pediatr Neurol 29 2003 410 421
    • (2003) Pediatr Neurol , vol.29 , pp. 410-421
    • Shapiro, S.M.1
  • 10
    • 13444282640 scopus 로고    scopus 로고
    • Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND)
    • S.M. Shapiro Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND) J Perinatol 25 2005 54 59
    • (2005) J Perinatol , vol.25 , pp. 54-59
    • Shapiro, S.M.1
  • 11
    • 77953478352 scopus 로고    scopus 로고
    • Chronic bilirubin encephalopathy: Diagnosis and outcome
    • S.M. Shapiro Chronic bilirubin encephalopathy: diagnosis and outcome Semin Fetal Neonatal Med 15 2010 157 163
    • (2010) Semin Fetal Neonatal Med , vol.15 , pp. 157-163
    • Shapiro, S.M.1
  • 13
    • 0000543678 scopus 로고
    • Diagnosis of kernicterus in the neonatal period
    • P.R. Van Diagnosis of kernicterus in the neonatal period Pediatrics 28 1961 870 876
    • (1961) Pediatrics , vol.28 , pp. 870-876
    • Van, P.R.1
  • 14
    • 0025817284 scopus 로고
    • Variation of initial serum bilirubin rise in newborn infants with type of illness
    • D.A. Benaron, F.W. Bowen Variation of initial serum bilirubin rise in newborn infants with type of illness Lancet 338 1991 78 81
    • (1991) Lancet , vol.338 , pp. 78-81
    • Benaron, D.A.1    Bowen, F.W.2
  • 15
    • 0028470711 scopus 로고
    • The protective role of bilirubin in oxygen-radical diseases of the preterm infant
    • T. Hegyi, E. Goldie, M. Hiatt The protective role of bilirubin in oxygen-radical diseases of the preterm infant J Perinatol 14 1994 296 300
    • (1994) J Perinatol , vol.14 , pp. 296-300
    • Hegyi, T.1    Goldie, E.2    Hiatt, M.3
  • 16
    • 0035678766 scopus 로고    scopus 로고
    • Serum bilirubin and 10-year mortality risk in a Belgian population
    • E.H. Temme, J. Zhang, E.G. Schouten Serum bilirubin and 10-year mortality risk in a Belgian population Cancer Causes Control 12 2001 887 894
    • (2001) Cancer Causes Control , vol.12 , pp. 887-894
    • Temme, E.H.1    Zhang, J.2    Schouten, E.G.3
  • 17
    • 0036182831 scopus 로고    scopus 로고
    • Gilbert syndrome and ischemic heart disease: A protective effect of elevated bilirubin levels
    • L. Vitek, M. Jirsa, M. Brodanova Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels Atherosclerosis 160 2002 449 456
    • (2002) Atherosclerosis , vol.160 , pp. 449-456
    • Vitek, L.1    Jirsa, M.2    Brodanova, M.3
  • 18
    • 0028148503 scopus 로고
    • Is bilirubin protective against coronary artery disease?
    • L.H. Breimer, K.A. Spyropolous, A.F. Winder Is bilirubin protective against coronary artery disease? Clin Chem 40 1994 1987 1988
    • (1994) Clin Chem , vol.40 , pp. 1987-1988
    • Breimer, L.H.1    Spyropolous, K.A.2    Winder, A.F.3
  • 19
    • 0000789337 scopus 로고
    • Hyperbilirubinemia in breast-fed infants
    • A.J. Newman, S. Gross Hyperbilirubinemia in breast-fed infants Pediatrics 32 1963 995 1001
    • (1963) Pediatrics , vol.32 , pp. 995-1001
    • Newman, A.J.1    Gross, S.2
  • 20
    • 0000621679 scopus 로고
    • Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steriod, pregnane-3(alpha), 20(beta)-diol, in maternal milk that inhibits glucuronide formation in vitro
    • I.M. Arias, L.M. Gartner, S. Seifter Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steriod, pregnane-3(alpha), 20(beta)-diol, in maternal milk that inhibits glucuronide formation in vitro J Clin Invest 43 1964 2037 2047
    • (1964) J Clin Invest , vol.43 , pp. 2037-2047
    • Arias, I.M.1    Gartner, L.M.2    Seifter, S.3
  • 21
    • 0022577995 scopus 로고
    • Breast milk jaundice in the newborn A real entity
    • A.P. Schneider Breast milk jaundice in the newborn A real entity JAMA 255 1986 3270 3274
    • (1986) JAMA , vol.255 , pp. 3270-3274
    • Schneider, A.P.1
  • 22
    • 34547616815 scopus 로고    scopus 로고
    • Cytokines in human colostrum and neonatal jaundice
    • V. Zanardo, R. Golin, M. Amato Cytokines in human colostrum and neonatal jaundice Pediatr Res 62 2007 191 194
    • (2007) Pediatr Res , vol.62 , pp. 191-194
    • Zanardo, V.1    Golin, R.2    Amato, M.3
  • 23
    • 70349912195 scopus 로고    scopus 로고
    • Breast milk jaundice correlates with high levels of epidermal growth factor
    • A. Kumral, H. Ozkan, N. Duman Breast milk jaundice correlates with high levels of epidermal growth factor Pediatr Res 66 2009 218 221
    • (2009) Pediatr Res , vol.66 , pp. 218-221
    • Kumral, A.1    Ozkan, H.2    Duman, N.3
  • 24
    • 43149112558 scopus 로고    scopus 로고
    • Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type i disease
    • N. Nguyen, J.A. Bonzo, S. Chen Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type I disease J Biol Chem 283 2008 7901 7911
    • (2008) J Biol Chem , vol.283 , pp. 7901-7911
    • Nguyen, N.1    Bonzo, J.A.2    Chen, S.3
  • 25
    • 27844536927 scopus 로고    scopus 로고
    • Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus
    • S. Chen, D. Beaton, N. Nguyen Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus J Biol Chem 280 2005 37547 37557
    • (2005) J Biol Chem , vol.280 , pp. 37547-37557
    • Chen, S.1    Beaton, D.2    Nguyen, N.3
  • 26
    • 77950407754 scopus 로고    scopus 로고
    • Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus
    • R. Fujiwara, N. Nguyen, S. Chen Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus Proc Natl Acad Sci U S A 107 2010 5024 5029
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5024-5029
    • Fujiwara, R.1    Nguyen, N.2    Chen, S.3
  • 27
    • 0029121161 scopus 로고
    • Kernicterus in otherwise healthy, breast-fed term newborns
    • M.J. Maisels, T.B. Newman Kernicterus in otherwise healthy, breast-fed term newborns Pediatrics 96 1995 730 733
    • (1995) Pediatrics , vol.96 , pp. 730-733
    • Maisels, M.J.1    Newman, T.B.2
  • 28
    • 0036259008 scopus 로고    scopus 로고
    • Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR
    • A. Ueda, S. Kakizaki, M. Negishi Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR Mol Pharmacol 61 2002 1284 1288
    • (2002) Mol Pharmacol , vol.61 , pp. 1284-1288
    • Ueda, A.1    Kakizaki, S.2    Negishi, M.3
  • 29
    • 0034721159 scopus 로고    scopus 로고
    • Humanized xenobiotic response in mice expressing nuclear receptor SXR
    • W. Xie, J.L. Barwick, M. Downes Humanized xenobiotic response in mice expressing nuclear receptor SXR Nature 406 2000 435 439
    • (2000) Nature , vol.406 , pp. 435-439
    • Xie, W.1    Barwick, J.L.2    Downes, M.3
  • 30
    • 0038587747 scopus 로고    scopus 로고
    • The two faces of IKK and NF-kappaB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    • L.W. Chen, L. Egan, Z.W. Li The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion Nat Med 9 2003 575 581
    • (2003) Nat Med , vol.9 , pp. 575-581
    • Chen, L.W.1    Egan, L.2    Li, Z.W.3
  • 31
    • 0038236664 scopus 로고    scopus 로고
    • Involvement of the xenobiotic response element (XRE) in a receptor-mediated induction of human UDP-glucuronosyltransferase 1A1
    • M.F. Yueh, Y.H. Huang, A. Hiller Involvement of the xenobiotic response element (XRE) in a receptor-mediated induction of human UDP- glucuronosyltransferase 1A1 J Biol Chem 278 2003 15001 15006
    • (2003) J Biol Chem , vol.278 , pp. 15001-15006
    • Yueh, M.F.1    Huang, Y.H.2    Hiller, A.3
  • 32
    • 14944341677 scopus 로고    scopus 로고
    • Transcriptional regulation of human UGT1A1 gene expression: Activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1
    • J. Sugatani, S. Nishitani, K. Yamakawa Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1 Mol Pharmacol 67 2005 845 855
    • (2005) Mol Pharmacol , vol.67 , pp. 845-855
    • Sugatani, J.1    Nishitani, S.2    Yamakawa, K.3
  • 33
    • 33847421803 scopus 로고    scopus 로고
    • Expression of the human UGT1 locus in transgenic mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor {alpha} activation
    • K. Senekeo-Effenberger, S. Chen, E. Brace-Sinnokrak Expression of the human UGT1 locus in transgenic mice by 4-Chloro-6-(2,3-xylidino)-2- pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor {alpha} activation Drug Metab Dispos 35 2007 419 427
    • (2007) Drug Metab Dispos , vol.35 , pp. 419-427
    • Senekeo-Effenberger, K.1    Chen, S.2    Brace-Sinnokrak, E.3
  • 34
    • 0025655498 scopus 로고
    • Differential enzyme induction of mouse liver and lung following a single low or high dose of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)
    • L. Beebe, S.S. Park, L.M. Anderson Differential enzyme induction of mouse liver and lung following a single low or high dose of 2,3,7,8- tetrachlorodibenzo- p-dioxin (TCDD) J Biochem Toxicol 5 1990 211 219
    • (1990) J Biochem Toxicol , vol.5 , pp. 211-219
    • Beebe, L.1    Park, S.S.2    Anderson, L.M.3
  • 35
    • 0034687397 scopus 로고    scopus 로고
    • The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    • P. Wei, J. Zhang, M. Egan-Hafley The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism Nature 407 2000 920 923
    • (2000) Nature , vol.407 , pp. 920-923
    • Wei, P.1    Zhang, J.2    Egan-Hafley, M.3
  • 36
    • 0035853165 scopus 로고    scopus 로고
    • The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    • J.L. Staudinger, B. Goodwin, S.A. Jones The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Proc Natl Acad Sci U S A 98 2001 3369 3374
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3369-3374
    • Staudinger, J.L.1    Goodwin, B.2    Jones, S.A.3
  • 37
    • 0032806042 scopus 로고    scopus 로고
    • Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent
    • T.B. Barclay, J.M. Peters, M.B. Sewer Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent J Pharmacol Exp Ther 290 1999 1250 1257
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 1250-1257
    • Barclay, T.B.1    Peters, J.M.2    Sewer, M.B.3
  • 38
    • 0141788827 scopus 로고    scopus 로고
    • Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain
    • E. Hanko, S. Tommarello, J.F. Watchko Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain Pediatr Res 54 2003 441 445
    • (2003) Pediatr Res , vol.54 , pp. 441-445
    • Hanko, E.1    Tommarello, S.2    Watchko, J.F.3
  • 39
    • 77949398878 scopus 로고    scopus 로고
    • Xenobiotic, bile acid, and cholesterol transporters: Function and regulation
    • C.D. Klaassen, L.M. Aleksunes Xenobiotic, bile acid, and cholesterol transporters: function and regulation Pharmacol Rev 62 2010 1 96
    • (2010) Pharmacol Rev , vol.62 , pp. 1-96
    • Klaassen, C.D.1    Aleksunes, L.M.2
  • 40
    • 6044232031 scopus 로고    scopus 로고
    • Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells
    • R. Minekawa, T. Takeda, M. Sakata Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells Am J Physiol Cell Physiol 287 2004 C1404 C1411
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Minekawa, R.1    Takeda, T.2    Sakata, M.3
  • 41
    • 1442306054 scopus 로고    scopus 로고
    • IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium
    • L.J. Egan, L. Eckmann, F.R. Greten IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium Proc Natl Acad Sci U S A 101 2004 2452 2457
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2452-2457
    • Egan, L.J.1    Eckmann, L.2    Greten, F.R.3
  • 42
    • 34147113866 scopus 로고    scopus 로고
    • Cadmium induces interleukin-8 production via NF-kappaB activation in the human intestinal epithelial cell, Caco-2
    • J.S. Hyun, H. Satsu, M. Shimizu Cadmium induces interleukin-8 production via NF-kappaB activation in the human intestinal epithelial cell, Caco-2 Cytokine 37 2007 26 34
    • (2007) Cytokine , vol.37 , pp. 26-34
    • Hyun, J.S.1    Satsu, H.2    Shimizu, M.3
  • 43
    • 3042834731 scopus 로고    scopus 로고
    • Cadmium stimulates the expression of ICAM-1 via NF-kappaB activation in cerebrovascular endothelial cells
    • E.M. Jeong, C.H. Moon, C.S. Kim Cadmium stimulates the expression of ICAM-1 via NF-kappaB activation in cerebrovascular endothelial cells Biochem Biophys Res Commun 320 2004 887 892
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 887-892
    • Jeong, E.M.1    Moon, C.H.2    Kim, C.S.3
  • 44
    • 4544224979 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression
    • J.L. Luo, S. Maeda, L.C. Hsu Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression Cancer Cell 6 2004 297 305
    • (2004) Cancer Cell , vol.6 , pp. 297-305
    • Luo, J.L.1    Maeda, S.2    Hsu, L.C.3
  • 45
    • 0018574014 scopus 로고
    • Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver
    • S. Onishi, N. Kawade, S. Itoh Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver Biochem J 184 1979 705 707
    • (1979) Biochem J , vol.184 , pp. 705-707
    • Onishi, S.1    Kawade, N.2    Itoh, S.3
  • 46
    • 67651065517 scopus 로고    scopus 로고
    • Breast-feeding: A commentary by the ESPGHAN Committee on Nutrition
    • C. Agostoni, C. Braegger, T. Decsi Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition J Pediatr Gastroenterol Nutr 49 2009 112 125
    • (2009) J Pediatr Gastroenterol Nutr , vol.49 , pp. 112-125
    • Agostoni, C.1    Braegger, C.2    Decsi, T.3
  • 47
    • 0024253406 scopus 로고
    • Reduced risk of IDDM among breast-fed children the Colorado IDDM Registry
    • E.J. Mayer, R.F. Hamman, E.C. Gay Reduced risk of IDDM among breast-fed children The Colorado IDDM Registry Diabetes 37 1988 1625 1632
    • (1988) Diabetes , vol.37 , pp. 1625-1632
    • Mayer, E.J.1    Hamman, R.F.2    Gay, E.C.3
  • 48
    • 0030738495 scopus 로고    scopus 로고
    • Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians
    • D.J. Pettitt, M.R. Forman, R.L. Hanson Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians Lancet 350 1997 166 168
    • (1997) Lancet , vol.350 , pp. 166-168
    • Pettitt, D.J.1    Forman, M.R.2    Hanson, R.L.3
  • 49
    • 0028828520 scopus 로고
    • Breastfeeding as prophylaxis against atopic disease: Prospective follow-up study until 17 years old
    • U.M. Saarinen, M. Kajosaari Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old Lancet 346 1995 1065 1069
    • (1995) Lancet , vol.346 , pp. 1065-1069
    • Saarinen, U.M.1    Kajosaari, M.2
  • 50
    • 69249211059 scopus 로고    scopus 로고
    • Systematic review: The role of breastfeeding in the development of pediatric inflammatory bowel disease
    • A.R. Barclay, R.K. Russell, M.L. Wilson Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease J Pediatr 155 2009 421 426
    • (2009) J Pediatr , vol.155 , pp. 421-426
    • Barclay, A.R.1    Russell, R.K.2    Wilson, M.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.